3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
Journal Article (Journal Article)
The introduction of a hydroxyl group into the 5-position of the diaryl furanone system provides highly selective inhibitors of cyclooxygenase-2. These molecules can be converted into their sodium salts which are water soluble, facilitating intravenous formulation. These salts show excellent potency in rat models of pain, fever and inflammation.
Full Text
Duke Authors
Cited Authors
- Black, WC; Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Gordon, R; Grimm, EL; Hughes, G; Leger, S; Li, CS; Riendeau, D; Thérien, M; Wang, Z; Xu, LJ; Prasit, P
Published Date
- March 2003
Published In
Volume / Issue
- 13 / 6
Start / End Page
- 1195 - 1198
PubMed ID
- 12643942
Pubmed Central ID
- 12643942
Electronic International Standard Serial Number (EISSN)
- 1464-3405
International Standard Serial Number (ISSN)
- 0960-894X
Digital Object Identifier (DOI)
- 10.1016/s0960-894x(03)00046-5
Language
- eng