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Michael J. Therien

William R. Kenan, Jr. Distinguished Professor of Chemistry
Chemistry
Box 90346, Durham, NC 27708-0346
5330 French Family Science Cen, Durham, NC 27708

Overview


Our research involves the synthesis of compounds, supermolecular assemblies, nano-scale objects, and electronic materials with unusual ground-and excited-state characteristics, and interrogating these structures using state-of-the-art transient optical, spectroscopic, photophysical, and electrochemical methods. Research activities span physical inorganic chemistry, physical organic chemistry, synthetic chemistry, bioinorganic chemistry, spectroscopy, photophysics, excited-state dynamics, spintronics, and imaging. My laboratory: (i) designs chromophores and supermolecules that display exceptional opto-electronic properties and elucidates their excited-state dynamics, (ii) engineers highly conjugated molecular structures for optical limiting, specialized emission, and high charge mobility, (iii) designs conjugated materials and hybrid molecular-nanoscale structures for energy conversion reactions, (iv) develops molecular wires that propagate spin-polarized currents, (v) fabricates emissive nanoscale structures for in vivo optical imaging, (vi) engineers de novo transition metal cofactor-binding proteins that test light-driven biological energy transducing mechanisms and realize opto-electronic functionalities not found in nature, and (vii) designs and interrogates complex molecular and nanoscale assemblies in which ultrafast energy and charge migration reactions are controlled by quantum coherence effects.

Current Appointments & Affiliations


William R. Kenan, Jr. Distinguished Professor of Chemistry · 2009 - Present Chemistry, Trinity College of Arts & Sciences
Professor of Chemistry · 2008 - Present Chemistry, Trinity College of Arts & Sciences
Member of the Duke Cancer Institute · 2008 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published March 11, 2024
Tiny Tunable Nanotubes
Published March 9, 2022
Duke Scientists Received $1 Million from Keck Foundation to Develop Nature-Inspired Super-Efficient Catalysts
Published February 1, 2022
New Super-Conducting Technology Takes Data Beyond Zeroes and Ones

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Recent Publications


De Novo Design of Proteins That Bind Naphthalenediimides, Powerful Photooxidants with Tunable Photophysical Properties.

Journal Article Journal of the American Chemical Society · March 2025 De novo protein design provides a framework to test our understanding of protein function and build proteins with cofactors and functions not found in nature. Here, we report the design of proteins designed to bind powerful photooxidants and the eva ... Full text Cite

Coherence in Chemistry: Foundations and Frontiers.

Journal Article Chemical reviews · November 2024 Coherence refers to correlations in waves. Because matter has a wave-particle nature, it is unsurprising that coherence has deep connections with the most contemporary issues in chemistry research (e.g., energy harvesting, femtosecond spectroscopy, molecul ... Full text Cite

Fluence-Dependent Photoinduced Charge Transfer Dynamics in Polymer-Wrapped Semiconducting Single-Walled Carbon Nanotubes.

Journal Article Journal of the American Chemical Society · November 2024 Because an individual single-walled carbon nanotube (SWNT) can absorb multiple photons, the exciton density within a single tube depends upon excitation conditions. In SWNT-based energy conversion systems, interactions between excitons and charges make it ... Full text Cite
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Recent Grants


Electron Spin Selectivity of Chiral Matter, from Molecules and Supramolecular Assemblies to Life

ResearchPrincipal Investigator · Awarded by University of Pittsburgh · 2023 - 2026

De Novo Protein Energy Transducing Biomachines Enabled via Controlled Bifurcon Flow

ResearchPrincipal Investigator · Awarded by W.M. Keck Foundation · 2022 - 2025

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Education, Training & Certifications


University of California, San Diego · 1987 Ph.D.
University of St. Andrews (United Kingdom) · 1982 B.S.