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Michael J. Therien

William R. Kenan, Jr. Distinguished Professor of Chemistry
Chemistry
Box 90346, Durham, NC 27708-0346
5330 French Family Science Cen, Durham, NC 27708

Overview


Our research involves the synthesis of compounds, supermolecular assemblies, nano-scale objects, and electronic materials with unusual ground-and excited-state characteristics, and interrogating these structures using state-of-the-art transient optical, spectroscopic, photophysical, and electrochemical methods. Research activities span physical inorganic chemistry, physical organic chemistry, synthetic chemistry, bioinorganic chemistry, spectroscopy, photophysics, excited-state dynamics, spintronics, and imaging. My laboratory: (i) designs chromophores and supermolecules that display exceptional opto-electronic properties and elucidates their excited-state dynamics, (ii) engineers highly conjugated molecular structures for optical limiting, specialized emission, and high charge mobility, (iii) designs conjugated materials and hybrid molecular-nanoscale structures for energy conversion reactions, (iv) develops molecular wires that propagate spin-polarized currents, (v) fabricates emissive nanoscale structures for in vivo optical imaging, (vi) engineers de novo transition metal cofactor-binding proteins that test light-driven biological energy transducing mechanisms and realize opto-electronic functionalities not found in nature, and (vii) designs and interrogates complex molecular and nanoscale assemblies in which ultrafast energy and charge migration reactions are controlled by quantum coherence effects.

Current Appointments & Affiliations


William R. Kenan, Jr. Distinguished Professor of Chemistry · 2009 - Present Chemistry, Trinity College of Arts & Sciences
Professor of Chemistry · 2008 - Present Chemistry, Trinity College of Arts & Sciences
Member of the Duke Cancer Institute · 2008 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published August 21, 2025
Four Duke Chemistry Professors on What Clean Energy Could Look Like
Published March 11, 2024
Tiny Tunable Nanotubes
Published March 9, 2022
Duke Scientists Received $1 Million from Keck Foundation to Develop Nature-Inspired Super-Efficient Catalysts

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Recent Publications


Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain.

Journal Article Biomaterials · April 2026 By improving the delivery and tumor retention of chemotherapeutics, nanomedicines hold potential for cancer treatment. The usefulness of nanoparticle (NP)-encapsulated analgesics for the cancer pain treatment is comparatively unexplored. We investigated wh ... Full text Cite

Hydroxy-substituted electron deficient Pd porphyrin cofactors illuminate ultrafast proton transfer reactions.

Journal Article Journal of inorganic biochemistry · February 2026 Coordinated electron and proton movement drive bioenergetic functions. Relative to electron transfer reactions, tracking proton transport over fast-to-ultrafast time scales is challenging. Optical resolution of proton transfer dynamics can take advantage o ... Full text Cite

Driving Force Dependent Photoinduced Charge Transfer Dynamics in Polymer-Wrapped Semiconducting Single-Walled Carbon Nanotubes.

Journal Article Journal of the American Chemical Society · November 2025 We investigate the thermodynamic driving-force dependences of photoinduced charge separation (CS) and subsequent charge transfer dynamics in single-walled carbon nanotube (SWNT)-perylenediimide (PDI) donor-acceptor (D-A) superstructures. Pump-probe spectro ... Full text Cite
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Recent Grants


Collaborative Research: De Novo Protein Constructs for Photosynthetic Energy Transduction

ResearchPrincipal Investigator · Awarded by National Science Foundation · 2014 - 2028

Organic, Nanoscale, & Self-Assembled Structures Relevant to Solar Energy Conversion

ResearchPrincipal Investigator · Awarded by Department of Energy · 2009 - 2028

Ideas Labs: USPRD: De Novo Design and Evolution of Enzymes for Biomass Upcycling to Surfactants and Fuels

ResearchPrincipal Investigator · Awarded by University of California - Santa Barbara · 2025 - 2027

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Education, Training & Certifications


University of California, San Diego · 1987 Ph.D.
University of St. Andrews (United Kingdom) · 1982 B.S.