Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report.

Journal Article (Journal Article;Multicenter Study)

PURPOSE: The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors. METHODS: Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms. RESULTS: Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning. CONCLUSION: This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.

Full Text

Duke Authors

Cited Authors

  • Meeske, K; Smith, AW; Alfano, CM; McGregor, BA; McTiernan, A; Baumgartner, KB; Malone, KE; Reeve, BB; Ballard-Barbash, R; Bernstein, L

Published Date

  • August 2007

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 947 - 960

PubMed ID

  • 17457697

International Standard Serial Number (ISSN)

  • 0962-9343

Digital Object Identifier (DOI)

  • 10.1007/s11136-007-9215-3


  • eng

Conference Location

  • Netherlands