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Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report.

Publication ,  Journal Article
Meeske, K; Smith, AW; Alfano, CM; McGregor, BA; McTiernan, A; Baumgartner, KB; Malone, KE; Reeve, BB; Ballard-Barbash, R; Bernstein, L
Published in: Qual Life Res
August 2007

PURPOSE: The purpose of this study was to estimate prevalence of fatigue, identify correlates of fatigue and evaluate the relationship between fatigue and health-related quality of life (HRQOL) in a large cohort of disease-free breast cancer survivors. METHODS: Participants are enrolled in the HEAL Study, a multi-center prospective study of women diagnosed with in-situ to Stage IIIA breast cancer. HEAL participants (n = 1183) completed a baseline and a 24-month follow-up interview. Women in this report (n = 800) also completed a quality of life questionnaire that included the Piper Fatigue Scale and the RAND SF-36 two to five years after diagnosis. Multivariate regression methods were used to identify significant factors associated with fatigue. SF-36 scores for fatigued survivors were compared to non-fatigued survivor scores and population norms. RESULTS: Forty-one percent of the breast cancer survivors were fatigued. Significant correlates of fatigue included pain, cognitive problems, physical inactivity, weight gain/personal appearance and antidepressant use. Fatigue was associated with poorer HRQOL, most notably in areas of role and social functioning. CONCLUSION: This study provides further support for the conclusion that a significant proportion of breast cancer survivors experience fatigue that compromises HRQOL two to five years post-diagnosis.

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Published In

Qual Life Res

DOI

ISSN

0962-9343

Publication Date

August 2007

Volume

16

Issue

6

Start / End Page

947 / 960

Location

Netherlands

Related Subject Headings

  • Washington
  • Survivors
  • Sickness Impact Profile
  • Severity of Illness Index
  • SEER Program
  • Quality of Life
  • Psychometrics
  • Prospective Studies
  • Prevalence
  • New Mexico
 

Citation

APA
Chicago
ICMJE
MLA
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Meeske, K., Smith, A. W., Alfano, C. M., McGregor, B. A., McTiernan, A., Baumgartner, K. B., … Bernstein, L. (2007). Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report. Qual Life Res, 16(6), 947–960. https://doi.org/10.1007/s11136-007-9215-3
Meeske, Kathleen, Ashley Wilder Smith, Catherine M. Alfano, Bonnie A. McGregor, Anne McTiernan, Kathy B. Baumgartner, Kathleen E. Malone, Bryce B. Reeve, Rachel Ballard-Barbash, and Leslie Bernstein. “Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report.Qual Life Res 16, no. 6 (August 2007): 947–60. https://doi.org/10.1007/s11136-007-9215-3.
Meeske K, Smith AW, Alfano CM, McGregor BA, McTiernan A, Baumgartner KB, et al. Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report. Qual Life Res. 2007 Aug;16(6):947–60.
Meeske, Kathleen, et al. “Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report.Qual Life Res, vol. 16, no. 6, Aug. 2007, pp. 947–60. Pubmed, doi:10.1007/s11136-007-9215-3.
Meeske K, Smith AW, Alfano CM, McGregor BA, McTiernan A, Baumgartner KB, Malone KE, Reeve BB, Ballard-Barbash R, Bernstein L. Fatigue in breast cancer survivors two to five years post diagnosis: a HEAL Study report. Qual Life Res. 2007 Aug;16(6):947–960.
Journal cover image

Published In

Qual Life Res

DOI

ISSN

0962-9343

Publication Date

August 2007

Volume

16

Issue

6

Start / End Page

947 / 960

Location

Netherlands

Related Subject Headings

  • Washington
  • Survivors
  • Sickness Impact Profile
  • Severity of Illness Index
  • SEER Program
  • Quality of Life
  • Psychometrics
  • Prospective Studies
  • Prevalence
  • New Mexico