Chemical sintering generates uniform porous hyaluronic acid hydrogels.

Journal Article (Journal Article)

The implantation of scaffolds for tissue repair has achieved only limited success due primarily to the inability to achieve vascularization within the construct. Many strategies have therefore moved to incorporate pores into the scaffolds to encourage rapid cellular infiltration and subsequent vascular ingrowth. We utilized an efficient chemical sintering technique to create a uniform network of polymethyl methacrylate (PMMA) microspheres for porous hyaluronic acid hydrogel formation. The porous hydrogels generated from chemical sintering possessed pore uniformity and interconnectivity comparable to the commonly used non- and heat sintering techniques. Moreover, a similar cell response to the porous hydrogels generated from each sintering approach was observed in cell viability, spreading and proliferation in vitro, as well as cellular invasion in vivo. We propose chemical sintering of PMMA microspheres using a dilute acetone solution as an alternative method to generate porous hyaluronic acid hydrogels since it requires equal or 10-fold less processing time as the currently used non-sintering or heat sintering technique, respectively.

Full Text

Duke Authors

Cited Authors

  • Cam, C; Segura, T

Published Date

  • January 2014

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 205 - 213

PubMed ID

  • 24120847

Pubmed Central ID

  • PMC3941472

Electronic International Standard Serial Number (EISSN)

  • 1878-7568

International Standard Serial Number (ISSN)

  • 1742-7061

Digital Object Identifier (DOI)

  • 10.1016/j.actbio.2013.10.002


  • eng