B-cell targeting in chronic graft-versus-host disease.

Journal Article (Journal Article;Review)

Over the last decade, our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.

Full Text

Duke Authors

Cited Authors

  • Zeiser, R; Sarantopoulos, S; Blazar, BR

Published Date

  • March 29, 2018

Published In

Volume / Issue

  • 131 / 13

Start / End Page

  • 1399 - 1405

PubMed ID

  • 29437591

Pubmed Central ID

  • PMC6031308

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

Digital Object Identifier (DOI)

  • 10.1182/blood-2017-11-784017


  • eng

Conference Location

  • United States