Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.

Journal Article (Journal Article)

OBJECT: The authors previously discovered that genes for the bradykinin-1 (B1) receptor and the transient receptor potential vanilloid subtype 1 (TRPV1) were overexpressed in animals exhibiting thermal hyperalgesia (TH) following spinal cord injury (SCI). They now report the effect of TRPV1 (AMG9810) and B1 (Lys-[Des-Arg9,Leu8]-bradykinin) antagonists on TH in animals following SCI. METHODS: The rats were subjected to contusion SCI and then divided into groups in which TH did or did not develop. The animals from both groups were given either AMG9810, Lys-(Des-Arg9,Leu8)-bradykinin, or the drug-specific vehicle (control groups). Animals were tested for TH preinjury and at regular intervals after SCI by using the hindlimb withdrawal latency test. CONCLUSIONS: The administration of AMG9810 likely improves TH as a result of a generalized analgesic effect, whereas the effect of Lys-(Des-Arg9,Leu8)-bradykinin appears more specific to the reversal of TH. This information has potential usefulness in the development of treatment strategies for post-SCI neuropathic pain.

Full Text

Duke Authors

Cited Authors

  • Rajpal, S; Gerovac, TA; Turner, NA; Tilghman, JI; Allcock, BK; McChesney, SL; Miranpuri, GS; Park, SW; Resnick, DK

Published Date

  • May 2007

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 420 - 424

PubMed ID

  • 17542507

International Standard Serial Number (ISSN)

  • 1547-5654

Digital Object Identifier (DOI)

  • 10.3171/spi.2007.6.5.420

Language

  • eng

Conference Location

  • United States