Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.


Journal Article

The authors previously discovered that genes for the bradykinin-1 (B1) receptor and the transient receptor potential vanilloid subtype 1 (TRPV1) were overexpressed in animals exhibiting thermal hyperalgesia (TH) following spinal cord injury (SCI). They now report the effect of TRPV1 (AMG9810) and B1 (Lys-[Des-Arg9,Leu8]-bradykinin) antagonists on TH in animals following SCI.The rats were subjected to contusion SCI and then divided into groups in which TH did or did not develop. The animals from both groups were given either AMG9810, Lys-(Des-Arg9,Leu8)-bradykinin, or the drug-specific vehicle (control groups). Animals were tested for TH preinjury and at regular intervals after SCI by using the hindlimb withdrawal latency test.The administration of AMG9810 likely improves TH as a result of a generalized analgesic effect, whereas the effect of Lys-(Des-Arg9,Leu8)-bradykinin appears more specific to the reversal of TH. This information has potential usefulness in the development of treatment strategies for post-SCI neuropathic pain.

Full Text

Duke Authors

Cited Authors

  • Rajpal, S; Gerovac, TA; Turner, NA; Tilghman, JI; Allcock, BK; McChesney, SL; Miranpuri, GS; Park, SW; Resnick, DK

Published Date

  • May 2007

Published In

Volume / Issue

  • 6 / 5

Start / End Page

  • 420 - 424

PubMed ID

  • 17542507

Pubmed Central ID

  • 17542507

Electronic International Standard Serial Number (EISSN)

  • 1547-5646

International Standard Serial Number (ISSN)

  • 1547-5654

Digital Object Identifier (DOI)

  • 10.3171/spi.2007.6.5.420


  • eng