Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.
OBJECT: The authors previously discovered that genes for the bradykinin-1 (B1) receptor and the transient receptor potential vanilloid subtype 1 (TRPV1) were overexpressed in animals exhibiting thermal hyperalgesia (TH) following spinal cord injury (SCI). They now report the effect of TRPV1 (AMG9810) and B1 (Lys-[Des-Arg9,Leu8]-bradykinin) antagonists on TH in animals following SCI. METHODS: The rats were subjected to contusion SCI and then divided into groups in which TH did or did not develop. The animals from both groups were given either AMG9810, Lys-(Des-Arg9,Leu8)-bradykinin, or the drug-specific vehicle (control groups). Animals were tested for TH preinjury and at regular intervals after SCI by using the hindlimb withdrawal latency test. CONCLUSIONS: The administration of AMG9810 likely improves TH as a result of a generalized analgesic effect, whereas the effect of Lys-(Des-Arg9,Leu8)-bradykinin appears more specific to the reversal of TH. This information has potential usefulness in the development of treatment strategies for post-SCI neuropathic pain.
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- TRPV Cation Channels
- Spinal Cord Injuries
- Rats, Sprague-Dawley
- Rats
- Orthopedics
- Male
- Kallidin
- Hyperalgesia
- Bridged Bicyclo Compounds, Heterocyclic
- Bradykinin Receptor Antagonists
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- TRPV Cation Channels
- Spinal Cord Injuries
- Rats, Sprague-Dawley
- Rats
- Orthopedics
- Male
- Kallidin
- Hyperalgesia
- Bridged Bicyclo Compounds, Heterocyclic
- Bradykinin Receptor Antagonists