Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism.

Published

Journal Article

The purpose of this study was to determine if flumazenil is absorbed from broncho-pulmonary tissue after intratracheal administration and whether therapeutically significant plasma concentrations can be obtained. Six elective surgical patients received a dose of 1.0 mg flumazenil in 10 mL saline intratracheally during general anesthesia. Blood samples were drawn for 6 hours after administration and plasma concentrations were determined by gas chromatography-mass spectrometry (GC-MS). An average peak plasma flumazenil concentration of 65.9 +/- 43.1 ng/mL was attained within 1 minute after administration. No patients reported chest discomfort or dyspnea upon awakening and there were no other side effects noted. Administration of flumazenil via an endotracheal tube results in rapid attainment of therapeutic blood levels.

Full Text

Duke Authors

Cited Authors

  • Palmer, RB; Mautz, DS; Cox, K; Kharasch, ED

Published Date

  • March 1, 1998

Published In

Volume / Issue

  • 16 / 2

Start / End Page

  • 170 - 172

PubMed ID

  • 9517696

Pubmed Central ID

  • 9517696

International Standard Serial Number (ISSN)

  • 0735-6757

Digital Object Identifier (DOI)

  • 10.1016/s0735-6757(98)90039-0

Language

  • eng

Conference Location

  • United States