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Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism.

Publication ,  Journal Article
Palmer, RB; Mautz, DS; Cox, K; Kharasch, ED
Published in: Am J Emerg Med
March 1998

The purpose of this study was to determine if flumazenil is absorbed from broncho-pulmonary tissue after intratracheal administration and whether therapeutically significant plasma concentrations can be obtained. Six elective surgical patients received a dose of 1.0 mg flumazenil in 10 mL saline intratracheally during general anesthesia. Blood samples were drawn for 6 hours after administration and plasma concentrations were determined by gas chromatography-mass spectrometry (GC-MS). An average peak plasma flumazenil concentration of 65.9 +/- 43.1 ng/mL was attained within 1 minute after administration. No patients reported chest discomfort or dyspnea upon awakening and there were no other side effects noted. Administration of flumazenil via an endotracheal tube results in rapid attainment of therapeutic blood levels.

Duke Scholars

Published In

Am J Emerg Med

DOI

ISSN

0735-6757

Publication Date

March 1998

Volume

16

Issue

2

Start / End Page

170 / 172

Location

United States

Related Subject Headings

  • Trachea
  • Time Factors
  • Middle Aged
  • Male
  • Lung
  • Intubation, Intratracheal
  • Humans
  • Gas Chromatography-Mass Spectrometry
  • GABA Modulators
  • Follow-Up Studies
 

Citation

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ICMJE
MLA
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Palmer, R. B., Mautz, D. S., Cox, K., & Kharasch, E. D. (1998). Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism. Am J Emerg Med, 16(2), 170–172. https://doi.org/10.1016/s0735-6757(98)90039-0
Palmer, R. B., D. S. Mautz, K. Cox, and E. D. Kharasch. “Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism.Am J Emerg Med 16, no. 2 (March 1998): 170–72. https://doi.org/10.1016/s0735-6757(98)90039-0.
Palmer RB, Mautz DS, Cox K, Kharasch ED. Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism. Am J Emerg Med. 1998 Mar;16(2):170–2.
Palmer, R. B., et al. “Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism.Am J Emerg Med, vol. 16, no. 2, Mar. 1998, pp. 170–72. Pubmed, doi:10.1016/s0735-6757(98)90039-0.
Palmer RB, Mautz DS, Cox K, Kharasch ED. Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism. Am J Emerg Med. 1998 Mar;16(2):170–172.
Journal cover image

Published In

Am J Emerg Med

DOI

ISSN

0735-6757

Publication Date

March 1998

Volume

16

Issue

2

Start / End Page

170 / 172

Location

United States

Related Subject Headings

  • Trachea
  • Time Factors
  • Middle Aged
  • Male
  • Lung
  • Intubation, Intratracheal
  • Humans
  • Gas Chromatography-Mass Spectrometry
  • GABA Modulators
  • Follow-Up Studies