Evan Kharasch | Scholars@Duke

Evan Kharasch
Merel H. Harmel Distinguished Professor of Anesthesiology

Current Appointments & Affiliations

Merel H. Harmel Distinguished Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2019
Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2018

Contact Information

Box 3094, Anesthesiology, Durham, NC 27710
Department of Anesthesiology, Box 3094, 905 S. Lasalle, GSRB1 Room 2031, Durham, NC 27710
evan.kharasch@duke.edu (919) 613-1154

Background
Education, Training, & Certifications
- M.D., Northwestern University 1984
- Ph.D., Northwestern University 1983
Previous Appointments & Affiliations
- Instructor in the Department of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2018
Recognition
In the News
- MAY 7, 2019
  
  Duke Adds 21 Faculty to Distinguished Faculty Rank
Awards & Honors
Research
Selected Grants
- Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
- Editor-In-Chief of The American Society of Anesthesiologists awarded by American Society of Anesthesiologists 2021 - 2025
- Pain Control with Regional Anesthesia following Pediatric Cardiac Surgery: A Randomized Double-Blinded Pilot Study awarded by Society for Pediatric Anesthesia 2023
- OPTIMIZING OUTPATIENT ANESTHESIA: IMPROVING ANALGESIA AND REDUCING OPIOID MISADVENTURE awarded by National Institutes of Health 2018 - 2021
External Relationships
- American Society of Anesthesiologists
- Auragent Bioscience
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Hannam, Jacqueline A., Kimmo T. Murto, Brian J. Anderson, Gregory Dembo, and Evan D. Kharasch. “Modeling adult COX-2 cerebrospinal fluid pharmacokinetics to inform pediatric investigation.” Paediatr Anaesth 33, no. 4 (April 2023): 291–302. https://doi.org/10.1111/pan.14590.
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  - Kharasch, Evan D. “Anesthesiology 2023: Ch-ch-ch-ch-changes.” Anesthesiology 138, no. 1 (January 1, 2023): 1–3. https://doi.org/10.1097/ALN.0000000000004430.
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  - Wang, Pan-Fen, Anshuman Sharma, Michael Montana, Alicia Neiner, Lindsay Juriga, Kavya Narayana Reddy, Dani Tallchief, Jane Blood, and Evan D. Kharasch. “Methadone pharmacogenetics in vitro and in vivo: Metabolism by CYP2B6 polymorphic variants and genetic variability in paediatric disposition.” Br J Clin Pharmacol 88, no. 11 (November 2022): 4881–93. https://doi.org/10.1111/bcp.15393.
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  - Kharasch, Evan D. “Anesthetic MAC: Origin, Utility, and Nomenclature Revisited.” Anesthesiology 136, no. 6 (June 1, 2022): 885–87. https://doi.org/10.1097/ALN.0000000000004217.
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  - Kharasch, Evan D. “Authorship and Publication Matters: Reply.” Anesthesiology 136, no. 1 (January 1, 2022): 245. https://doi.org/10.1097/ALN.0000000000004048.
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  - Kharasch, Evan D., J David Clark, and Jerome M. Adams. “Opioids and Public Health: The Prescription Opioid Ecosystem and Need for Improved Management.” Anesthesiology 136, no. 1 (January 1, 2022): 10–30. https://doi.org/10.1097/ALN.0000000000004065.
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  - Crews, Kristine R., Andrew A. Monte, Rachel Huddart, Kelly E. Caudle, Evan D. Kharasch, Andrea Gaedigk, Henry M. Dunnenberger, et al. “Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.” Clin Pharmacol Ther 110, no. 4 (October 2021): 888–96. https://doi.org/10.1002/cpt.2149.
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  - Kharasch, Evan D. “Anesthesiology: Reflecting and Leading.” Anesthesiology 135, no. 4 (October 1, 2021): 551–54. https://doi.org/10.1097/ALN.0000000000003958.
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  - Kharasch, Evan D., and J David Clark. “Opioid-free Anesthesia: Reply.” Anesthesiology 135, no. 4 (October 1, 2021): 759–60. https://doi.org/10.1097/ALN.0000000000003912.
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  - Kharasch, Evan D. “Scientific Integrity and Misconduct-Yet Again.” Anesthesiology 135, no. 3 (September 1, 2021): 377–79. https://doi.org/10.1097/ALN.0000000000003916.
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  - Kharasch, Evan D., Michael J. Avram, Brian T. Bateman, J David Clark, Deborah J. Culley, Andrew J. Davidson, Timothy T. Houle, et al. “Authorship and Publication Matters: Credit and Credibility.” Anesthesiology 135, no. 1 (July 1, 2021): 1–8. https://doi.org/10.1097/ALN.0000000000003830.
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  - Kharasch, Evan D. “Non-Peer-reviewed Preprint Articles as References in Anesthesiology: Reply.” Anesthesiology 134, no. 5 (May 1, 2021): 821. https://doi.org/10.1097/ALN.0000000000003715.
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  - Kharasch, Evan D., and J David Clark. “Methadone and Ketamine: Boosting Benefits and Still More to Learn.” Anesthesiology 134, no. 5 (May 1, 2021): 676–79. https://doi.org/10.1097/ALN.0000000000003752.
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  - Kharasch, Evan D., and J David Clark. “Opioid-free Anesthesia: Time to Regain Our Balance.” Anesthesiology 134, no. 4 (April 1, 2021): 509–14. https://doi.org/10.1097/ALN.0000000000003705.
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  - Siegel, Joshua S., Ben J. A. Palanca, Beau M. Ances, Evan D. Kharasch, Julie A. Schweiger, Michael D. Yingling, Abraham Z. Snyder, Ginger E. Nicol, Eric J. Lenze, and Nuri B. Farber. “Prolonged ketamine infusion modulates limbic connectivity and induces sustained remission of treatment-resistant depression.” Psychopharmacology (Berl) 238, no. 4 (April 2021): 1157–69. https://doi.org/10.1007/s00213-021-05762-6.
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  - Liang, Chao, Jingyi Luan, Zheyu Wang, Qisheng Jiang, Rohit Gupta, Sisi Cao, Keng-Ku Liu, et al. “Gold Nanorod Size-Dependent Fluorescence Enhancement for Ultrasensitive Fluoroimmunoassays.” Acs Appl Mater Interfaces 13, no. 9 (March 10, 2021): 11414–23. https://doi.org/10.1021/acsami.0c20303.
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  - Chiang, Manting D., Karen Frey, Chris Lee, Evan D. Kharasch, Dani Tallchief, Christopher Sawyer, Jane Blood, Hyunmoon Back, Leonid Kagan, and Simon Haroutounian. “Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans.” Br J Clin Pharmacol 87, no. 2 (February 2021): 516–26. https://doi.org/10.1111/bcp.14412.
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  - Kharasch, Evan D., Michael J. Avram, J David Clark, Andrew J. Davidson, Timothy T. Houle, Jerrold H. Levy, Martin J. London, Daniel I. Sessler, and Laszlo Vutskits. “Peer Review Matters: Research Quality and the Public Trust.” Anesthesiology 134, no. 1 (January 1, 2021): 1–6. https://doi.org/10.1097/ALN.0000000000003608.
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  - Kharasch, Evan D. “Uncertainty and Certainty: Reply.” Anesthesiology 133, no. 6 (December 1, 2020): 1311. https://doi.org/10.1097/ALN.0000000000003563.
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  - Kharasch, Evan D., Alicia Neiner, Kristin Kraus, Jane Blood, Angela Stevens, J Philip Miller, and Eric J. Lenze. “Stereoselective Steady-State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults.” Clin Pharmacol Ther 108, no. 5 (November 2020): 1036–48. https://doi.org/10.1002/cpt.1888.
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  - Kharasch, Evan D., Michael J. Avram, and J David Clark. “Rational Perioperative Opioid Management in the Era of the Opioid Crisis: Reply.” Anesthesiology 133, no. 4 (October 1, 2020): 942–43. https://doi.org/10.1097/ALN.0000000000003497.
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  - Avram, Michael J., Deborah J. Culley, Evan D. Kharasch, Jerrold H. Levy, Martin J. London, Daniel I. Sessler, and Hannah Wunsch. “Journal-related Activities and Other Special Activities at the 2020 American Society of Anesthesiologists Meeting.” Anesthesiology 133, no. 4 (October 1, 2020): 711–17. https://doi.org/10.1097/ALN.0000000000003537.
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  - Todd, Michael M., and Evan D. Kharasch. “Ru-Rong Ji, Ph.D., Recipient of the 2020 Excellence in Research Award.” Anesthesiology 133, no. 4 (October 1, 2020): 718–19. https://doi.org/10.1097/ALN.0000000000003536.
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  - Kharasch, Evan D., J David Clark, and Sachin Kheterpal. “Perioperative Gabapentinoids: Deflating the Bubble.” Anesthesiology 133, no. 2 (August 2020): 251–54. https://doi.org/10.1097/ALN.0000000000003394.
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  - Kharasch, Evan D. “Uncertainty and Certainty.” Anesthesiology 133, no. 1 (July 2020): 1–4. https://doi.org/10.1097/ALN.0000000000003388.
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  - Wang, Pan-Fen, Alicia Neiner, and Evan D. Kharasch. “Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants.” Drug Metab Dispos 48, no. 6 (June 2020): 438–45. https://doi.org/10.1124/dmd.119.090407.
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  - Kharasch, Evan D., and J David Clark. “Persistent Postoperative Opioid Use: Perception, Progress, and Promise.” Anesthesiology 132, no. 6 (June 2020): 1304–6. https://doi.org/10.1097/ALN.0000000000003298.
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  - Kharasch, Evan D., and Yandong Jiang. “Novel Coronavirus 2019 and Anesthesiology.” Anesthesiology 132, no. 6 (June 2020): 1289–91. https://doi.org/10.1097/ALN.0000000000003302.
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  - Kharasch, Evan D. “Comment on "Postoperative Opioid Prescribing and Pain".” Ann Surg 271, no. 5 (May 2020): e125. https://doi.org/10.1097/SLA.0000000000003654.
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  - Kharasch, Evan D., Michael J. Avram, and J David Clark. “Rational Perioperative Opioid Management in the Era of the Opioid Crisis.” Anesthesiology 132, no. 4 (April 2020): 603–5. https://doi.org/10.1097/ALN.0000000000003166.
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  - Loughren, Michael J., Evan D. Kharasch, Megan C. Kelton-Rehkopf, Karen L. Syrjala, and Danny D. Shen. “Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial.” Anesthesiology 132, no. 3 (March 2020): 491–503. https://doi.org/10.1097/ALN.0000000000003065.
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  - Cavallone, Laura F., Michael C. Montana, Karen Frey, Dorina Kallogjeri, James M. Wages, Thomas L. Rodebaugh, Tina Doshi, Evan D. Kharasch, and Robert W. Gereau. “The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects.” Pain 161, no. 1 (January 2020): 135–46. https://doi.org/10.1097/j.pain.0000000000001695.
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  - Kharasch, Evan D. “Innovation in Clinical Research Regulation.” Anesthesiology 132, no. 1 (January 2020): 1–4. https://doi.org/10.1097/ALN.0000000000003026.
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  - Talal, Andrew H., Yuxin Ding, Charles S. Venuto, Lindsay M. Chakan, Anthony McLeod, Arpan Dharia, Gene D. Morse, Lawrence S. Brown, Marianthi Markatou, and Evan D. Kharasch. “Toward precision prescribing for methadone: Determinants of methadone deposition.” Plos One 15, no. 4 (2020): e0231467. https://doi.org/10.1371/journal.pone.0231467.
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  - Hu, Rong, Rohit Gupta, Zheyu Wang, Congzhou Wang, Hongcheng Sun, Srikanth Singamaneni, Evan D. Kharasch, and Jeremiah J. Morrissey. “Bioplasmonic paper-based assay for perilipin-2 non-invasively detects renal cancer.” Kidney Int 96, no. 6 (December 2019): 1417–21. https://doi.org/10.1016/j.kint.2019.08.020.
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  - Vutskits, Laszlo, J David Clark, and Evan D. Kharasch. “Reporting Laboratory and Animal Research in ANESTHESIOLOGY: The Importance of Sex as a Biologic Variable.” Anesthesiology 131, no. 5 (November 2019): 949–52. https://doi.org/10.1097/ALN.0000000000002945.
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  - Wang, Pan-Fen, Alicia Neiner, and Evan D. Kharasch. “Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry.” Drug Metab Dispos 47, no. 10 (October 2019): 1195–1205. https://doi.org/10.1124/dmd.119.086348.
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  - Kharasch, Evan D., and David J. Greenblatt. “Methadone Disposition: Implementing Lessons Learned.” J Clin Pharmacol 59, no. 8 (August 2019): 1044–48. https://doi.org/10.1002/jcph.1427.
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  - Kharasch, Evan D. “Observations and Observational Research.” Anesthesiology 131, no. 1 (July 2019): 1–4. https://doi.org/10.1097/ALN.0000000000002818.
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  - Montana, Michael C., Lindsay Juriga, Anshuman Sharma, and Evan D. Kharasch. “Opioid Sensitivity in Children with and without Obstructive Sleep Apnea.” Anesthesiology 130, no. 6 (June 2019): 936–45. https://doi.org/10.1097/ALN.0000000000002664.
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  - Kharasch, Evan D., Alicia Neiner, Kristin Kraus, Jane Blood, Angela Stevens, Julia Schweiger, J Philip Miller, and Eric J. Lenze. “Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial.” Clin Pharmacol Ther 105, no. 5 (May 2019): 1164–74. https://doi.org/10.1002/cpt.1309.
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  - Bloom, A Joseph, Pramod Upadhyaya, and Evan D. Kharasch. “Strain-specific altered nicotine metabolism in 3,3'-diindolylmethane (DIM) exposed mice.” Biopharm Drug Dispos 40, no. 5–6 (May 2019): 188–94. https://doi.org/10.1002/bdd.2182.
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  - Bloom, Adam Joseph, Pan-Fen Wang, and Evan D. Kharasch. “Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes.” Pharmacol Res Perspect 7, no. 2 (April 2019): e00468. https://doi.org/10.1002/prp2.468.
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  - Komen, Helga, L Michael Brunt, Elena Deych, Jane Blood, and Evan D. Kharasch. “Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study.” Anesth Analg 128, no. 4 (April 2019): 802–10. https://doi.org/10.1213/ANE.0000000000003464.
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  - Wang, Pan-Fen, Alicia Neiner, Thomas R. Lane, Kimberley M. Zorn, Sean Ekins, and Evan D. Kharasch. “Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches.” Mol Pharm 16, no. 2 (February 4, 2019): 898–906. https://doi.org/10.1021/acs.molpharmaceut.8b01214.
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  - Kharasch, Evan D. “Understanding Research Methods and the Readers' Toolbox: A New Article Type.” Anesthesiology 130, no. 2 (February 2019): 181–82. https://doi.org/10.1097/ALN.0000000000002588.
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  - Song, Joseph B., Jeremiah J. Morrissey, Jonathan M. Mobley, Karen G. Figenshau, Joel M. Vetter, Sam B. Bhayani, Evan D. Kharasch, and Robert Sherburne Figenshau. “Urinary aquaporin 1 and perilipin 2: Can these novel markers accurately characterize small renal masses and help guide patient management?” Int J Urol 26, no. 2 (February 2019): 260–65. https://doi.org/10.1111/iju.13854.
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  - Lin, Chemin, Helmet T. Karim, Marta Pecina, Howard J. Aizenstein, Eric J. Lenze, Daniel M. Blumberger, Benoit H. Mulsant, Evan D. Kharasch, Charles F. Reynolds Iii, and Jordan F. Karp. “Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression.” Neuroimage Clin 21 (2019): 101679. https://doi.org/10.1016/j.nicl.2019.101679.
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  - Kharasch, Evan D. “Trusted Evidence: Discovery to Practice.” Anesthesiology 130, no. 1 (January 2019): 1–2. https://doi.org/10.1097/ALN.0000000000002535.
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  - Kharasch, Evan D., and Amanda Crafford. “Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition.” Clin Pharmacol Ther 105, no. 1 (January 2019): 142–52. https://doi.org/10.1002/cpt.1116.
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  - Luan, J., J. J. Morrissey, Z. Wang, H. G. Derami, K. K. Liu, S. Cao, Q. Jiang, et al. “Add-on plasmonic patch as a universal fluorescence enhancer.” Light: Science and Applications 7, no. 1 (December 1, 2018). https://doi.org/10.1038/s41377-018-0027-8.
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  - Cole, Daniel J., and Evan D. Kharasch. “Postoperative Brain Function: Toward a Better Understanding and the American Society of Anesthesiologists Perioperative Brain Health Initiative.” Anesthesiology 129, no. 5 (November 2018): 861–63. https://doi.org/10.1097/ALN.0000000000002085.
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  - Wang, Congzhou, Gail Sudlow, Zheyu Wang, Sisi Cao, Qisheng Jiang, Alicia Neiner, Jeremiah J. Morrissey, Evan D. Kharasch, Samuel Achilefu, and Srikanth Singamaneni. “Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics.” Adv Healthc Mater 7, no. 22 (November 2018): e1800950. https://doi.org/10.1002/adhm.201800950.
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  - Wang, Pan-Fen, Alicia Neiner, and Evan D. Kharasch. “Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase.” Anesthesiology 129, no. 4 (October 2018): 756–68. https://doi.org/10.1097/ALN.0000000000002371.
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  - Kharasch, Evan D., and Timothy T. Houle. “In Reply.” Anesthesiology 129, no. 3 (September 2018): 614. https://doi.org/10.1097/ALN.0000000000002355.
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  - Luan, Jingyi, Ting Xu, John Cashin, Jeremiah J. Morrissey, Evan D. Kharasch, and Srikanth Singamaneni. “Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody.” Anal Chem 90, no. 13 (July 3, 2018): 7880–87. https://doi.org/10.1021/acs.analchem.7b05470.
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  - Haroutounian, Simon, Andria L. Ford, Karen Frey, Lone Nikolajsen, Nanna B. Finnerup, Alicia Neiner, Evan D. Kharasch, Pall Karlsson, and Michael M. Bottros. “How central is central poststroke pain? The role of afferent input in poststroke neuropathic pain: a prospective, open-label pilot study.” Pain 159, no. 7 (July 2018): 1317–24. https://doi.org/10.1097/j.pain.0000000000001213.
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  - Kharasch, Evan D. “Editor's Note: ANESTHESIOLOGY 2018: Inspiring Investigation and Education.” Anesthesiology 129, no. 1 (July 2018): 1–4. https://doi.org/10.1097/ALN.0000000000002264.
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  - Rathmell, James P., and Evan D. Kharasch. “Frontiers in Opioid Pharmacology.” Anesthesiology 128, no. 5 (May 2018): 865–66. https://doi.org/10.1097/ALN.0000000000002193.
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  - Kharasch, Evan D. “The Challenges of Translation.” Anesthesiology 128, no. 4 (April 2018): 693–96. https://doi.org/10.1097/ALN.0000000000002122.
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  - Wang, C., H. Sun, J. Luan, Q. Jiang, S. Tadepalli, J. J. Morrissey, E. D. Kharasch, and S. Singamaneni. “Metal-Organic Framework Encapsulation for Biospecimen Preservation.” Chemistry of Materials 30, no. 4 (February 27, 2018): 1291–1300. https://doi.org/10.1021/acs.chemmater.7b04713.
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  - Wang, Congzhou, Lu Wang, Sirimuvva Tadepalli, Jeremiah J. Morrissey, Evan D. Kharasch, Rajesh R. Naik, and Srikanth Singamaneni. “Ultrarobust Biochips with Metal-Organic Framework Coating for Point-of-Care Diagnosis.” Acs Sens 3, no. 2 (February 23, 2018): 342–51. https://doi.org/10.1021/acssensors.7b00762.
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  - Kharasch, E. D., and T. T. Houle. “Seeking and reporting apparent research misconduct: errors and integrity.” Anaesthesia 73, no. 1 (January 2018): 125–26. https://doi.org/10.1111/anae.14147.
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  - Teitelbaum, A. M., S. E. Murphy, G. Akk, T. B. Baker, A. Germann, L. B. von Weymarn, L. J. Bierut, A. Goate, E. D. Kharasch, and A. J. Bloom. “Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain.” Pharmacogenomics J 18, no. 1 (January 2018): 136–43. https://doi.org/10.1038/tpj.2016.92.
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  - Kharasch, Evan D., and Timothy T. Houle. “Errors and Integrity in Seeking and Reporting Apparent Research Misconduct.” Anesthesiology 127, no. 5 (November 2017): 733–37. https://doi.org/10.1097/ALN.0000000000001875.
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  - Avram, M. J., E. D. Kharasch, S. Kheterpal, J. P. Rathmell, and D. I. Sessler. “Journal-related Activities and Other Special Activities at the 2017 American Society of Anesthesiologists Meeting.” Anesthesiology 127, no. 4 (October 1, 2017): 601–8. https://doi.org/10.1097/ALN.0000000000001832.
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  - Jiang, Q., Y. J. Chandar, S. Cao, E. D. Kharasch, S. Singamaneni, and J. J. Morrissey. “Rapid, Point-of-Care, Paper-Based Plasmonic Biosensor for Zika Virus Diagnosis.” Advanced Biosystems 1, no. 9 (September 1, 2017). https://doi.org/10.1002/adbi.201700096.
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  - Kharasch, Evan D. “Editor's Note: ANESTHESIOLOGY 2017: Expanding the Richness and Reach.” Anesthesiology 127, no. 1 (July 2017): 1–2. https://doi.org/10.1097/ALN.0000000000001701.
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  - Luan, J., R. Hu, S. Tadepalli, J. J. Morrissey, E. D. Kharasch, and S. Singamaneni. “Amplification of Refractometric Biosensor Response through Biomineralization of Metal–Organic Framework Nanocrystals.” Advanced Materials Technologies 2, no. 7 (July 1, 2017). https://doi.org/10.1002/admt.201700023.
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  - Hicks, J. K., K. Sangkuhl, J. J. Swen, V. L. Ellingrod, D. J. Müller, K. Shimoda, J. R. Bishop, et al. “Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.” Clin Pharmacol Ther 102, no. 1 (July 2017): 37–44. https://doi.org/10.1002/cpt.597.
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  - Horst, Jennifer, and Evan D. Kharasch. “Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.” Pediatr Blood Cancer 64, no. 5 (May 2017). https://doi.org/10.1002/pbc.26343.
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  - Wang, Congzhou, Rong Hu, Jeremiah J. Morrissey, Evan D. Kharasch, and Srikanth Singamaneni. “Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction.” Small 13, no. 19 (May 2017). https://doi.org/10.1002/smll.201604255.
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  - Kharasch, Evan D. “Current Concepts in Methadone Metabolism and Transport.” Clin Pharmacol Drug Dev 6, no. 2 (March 2017): 125–34. https://doi.org/10.1002/cpdd.326.
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  - Wang, Congzhou, Sirimuvva Tadepalli, Jingyi Luan, Keng-Ku Liu, Jeremiah J. Morrissey, Evan D. Kharasch, Rajesh R. Naik, and Srikanth Singamaneni. “Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.” Adv Mater 29, no. 7 (February 2017). https://doi.org/10.1002/adma.201604433.
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  - Hu, Rong, Jingyi Luan, Evan D. Kharasch, Srikanth Singamaneni, and Jeremiah J. Morrissey. “Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors.” Acs Appl Mater Interfaces 9, no. 1 (January 11, 2017): 145–51. https://doi.org/10.1021/acsami.6b12505.
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  - Horst, Jennifer, Melissa Frei-Jones, Elena Deych, William Shannon, and Evan D. Kharasch. “Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease.” Pediatr Blood Cancer 63, no. 12 (December 2016): 2123–30. https://doi.org/10.1002/pbc.26207.
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  - Rao, Lesley K., Alicia M. Flaker, Christina C. Friedel, and Evan D. Kharasch. “Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance.” Anesthesiology 125, no. 6 (December 2016): 1103–12. https://doi.org/10.1097/ALN.0000000000001392.
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  - Teitelbaum, Aaron M., and Evan D. Kharasch. “Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics.” Drug Metab Dispos 44, no. 11 (November 2016): 1851. https://doi.org/10.1124/dmd.116.072892.
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  - Wang, Congzhou, Jingyi Luan, Sirimuvva Tadepalli, Keng-Ku Liu, Jeremiah J. Morrissey, Evan D. Kharasch, Rajesh R. Naik, and Srikanth Singamaneni. “Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability.” Acs Appl Mater Interfaces 8, no. 40 (October 12, 2016): 26493–500. https://doi.org/10.1021/acsami.6b07362.
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  - Luan, Jingyi, Keng-Ku Liu, Sirimuvva Tadepalli, Qisheng Jiang, Jeremiah J. Morrissey, Evan D. Kharasch, and Srikanth Singamaneni. “PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.” Acs Appl Mater Interfaces 8, no. 36 (September 14, 2016): 23509–16. https://doi.org/10.1021/acsami.6b07252.
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  - Teitelbaum, Aaron M., Alicia M. Flaker, and Evan D. Kharasch. “Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.” J Chromatogr B Analyt Technol Biomed Life Sci 1027 (August 1, 2016): 239–53. https://doi.org/10.1016/j.jchromb.2016.05.036.
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  - Kharasch, Evan D. “Changes: Handing Off and the Future of ANESTHESIOLOGY.” Anesthesiology 125, no. 1 (July 2016): 4–6. https://doi.org/10.1097/ALN.0000000000001150.
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  - Kharasch, Evan D., Vicki Tedeschi, and George Kendall. “Changes: Thank You, Dr. Eisenach.” Anesthesiology 125, no. 1 (July 2016): 1–3. https://doi.org/10.1097/ALN.0000000000001149.
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  - Kharasch, Evan D., and L Michael Brunt. “Perioperative Opioids and Public Health.” Anesthesiology 124, no. 4 (April 2016): 960–65. https://doi.org/10.1097/ALN.0000000000001012.
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  - Lenze, Eric J., Nuri B. Farber, Evan Kharasch, Julie Schweiger, Michael Yingling, John Olney, and John W. Newcomer. “Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial.” World J Biol Psychiatry 17, no. 3 (April 2016): 230–38. https://doi.org/10.3109/15622975.2016.1142607.
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  - Teitelbaum, Aaron M., Alicia M. Flaker, and Evan D. Kharasch. “Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma.” J Chromatogr B Analyt Technol Biomed Life Sci 1017–1018 (April 1, 2016): 101–13. https://doi.org/10.1016/j.jchromb.2016.02.032.
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  - Welch, Timothy P., Michael J. Wallendorf, Evan D. Kharasch, Jeffrey R. Leonard, Allan Doctor, and Jose A. Pineda. “Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury.” Crit Care Med 44, no. 4 (April 2016): 809–18. https://doi.org/10.1097/CCM.0000000000001558.
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  - Kharasch, Evan D., and James C. Eisenach. “Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?” Anesthesiology 124, no. 1 (January 2016): 10–12. https://doi.org/10.1097/ALN.0000000000000914.
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  - Brier, Matthew R., Qian Wu, Aaron B. Tanenbaum, Elizabeth T. Westerhaus, Evan D. Kharasch, and Beau M. Ances. “Effect of HAART on Brain Organization and Function in HIV-Negative Subjects.” J Neuroimmune Pharmacol 10, no. 4 (December 2015): 517–21. https://doi.org/10.1007/s11481-015-9634-9.
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  - Tadepalli, Sirimuvva, Zhifeng Kuang, Qisheng Jiang, Keng-Ku Liu, Marilee A. Fisher, Jeremiah J. Morrissey, Evan D. Kharasch, Joseph M. Slocik, Rajesh R. Naik, and Srikanth Singamaneni. “Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices.” Sci Rep 5 (November 10, 2015): 16206. https://doi.org/10.1038/srep16206.
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  - Kharasch, Evan D., Karen J. Regina, Jane Blood, and Christina Friedel. “Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism.” Anesthesiology 123, no. 5 (November 2015): 1142–53. https://doi.org/10.1097/ALN.0000000000000867.
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  - Tian, L., S. Tadepalli, M. Fei, J. J. Morrissey, E. D. Kharasch, and S. Singamaneni. “Off-Resonant Gold Superstructures as Ultrabright Minimally Invasive Surface-Enhanced Raman Scattering (SERS) Probes.” Chemistry of Materials 27, no. 16 (August 25, 2015): 5678–84. https://doi.org/10.1021/acs.chemmater.5b02100.
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  - Tian, Limei, Max Fei, Sirimuvva Tadepalli, Jeremiah J. Morrissey, Evan D. Kharasch, and Srikanth Singamaneni. “Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots.” Adv Healthc Mater 4, no. 10 (July 15, 2015): 1502–1423. https://doi.org/10.1002/adhm.201500227.
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  - Gadel, Sarah, Christina Friedel, and Evan D. Kharasch. “Differences in Methadone Metabolism by CYP2B6 Variants.” Drug Metab Dispos 43, no. 7 (July 2015): 994–1001. https://doi.org/10.1124/dmd.115.064352.
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  - Duma, Andreas, Christopher Cartmill, Jane Blood, Anshuman Sharma, Evan D. Kharasch, and Peter Nagele. “The hematological effects of nitrous oxide anesthesia in pediatric patients.” Anesth Analg 120, no. 6 (June 2015): 1325–30. https://doi.org/10.1213/ANE.0000000000000642.
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  - Campbell, Scott D., Sarah Gadel, Christina Friedel, Amanda Crafford, Karen J. Regina, and Evan D. Kharasch. “Influence of HIV antiretrovirals on methadone N-demethylation and transport.” Biochem Pharmacol 95, no. 2 (May 15, 2015): 115–25. https://doi.org/10.1016/j.bcp.2015.03.007.
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  - Kharasch, Evan D. “Opioid Half-lives and Hemlines: The Long and Short of Fashion.” Anesthesiology 122, no. 5 (May 2015): 969–70. https://doi.org/10.1097/ALN.0000000000000634.
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  - Morrissey, Jeremiah J., Vincent M. Mellnick, Jingqin Luo, Marilyn J. Siegel, R Sherburne Figenshau, Sam Bhayani, and Evan D. Kharasch. “Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study.” Jama Oncol 1, no. 2 (May 2015): 204–12. https://doi.org/10.1001/jamaoncol.2015.0213.
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  - Kharasch, Evan D., and Markus W. Hollmann. “Steroid Anesthesia Revisited: Again.” Anesth Analg 120, no. 5 (May 2015): 983–84. https://doi.org/10.1213/ANE.0000000000000667.
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  - Morrissey, Jeremiah J., Jonathan Mobley, R Sherburne Figenshau, Joel Vetter, Sam Bhayani, and Evan D. Kharasch. “Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer.” Mayo Clin Proc 90, no. 1 (January 2015): 35–42. https://doi.org/10.1016/j.mayocp.2014.10.005.
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  - Meissner, Konrad, Jane Blood, Amber M. Francis, Viktar Yermolenka, and Evan D. Kharasch. “Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics.” Anesthesiology 121, no. 6 (December 2014): 1281–91. https://doi.org/10.1097/ALN.0000000000000391.
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  - Tian, Limei, Sirimuvva Tadepalli, Sang Hyun Park, Keng-Ku Liu, Jeremiah J. Morrissey, Evan D. Kharasch, Rajesh R. Naik, and Srikanth Singamaneni. “Bioplasmonic calligraphy for multiplexed label-free biodetection.” Biosens Bioelectron 59 (September 15, 2014): 208–15. https://doi.org/10.1016/j.bios.2014.03.043.
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  - Kaspera, Rüdiger, Brian J. Kirby, Tariku Sahele, Ann C. Collier, Evan D. Kharasch, Jashvant D. Unadkat, and Rheem A. Totah. “Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo.” Biochem Pharmacol 91, no. 1 (September 1, 2014): 109–18. https://doi.org/10.1016/j.bcp.2014.06.020.
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  - Sai, Kiran Kumar Solingapuram, Jinda Fan, Zhude Tu, Patrick Zerkel, Robert H. Mach, and Evan D. Kharasch. “Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).” Appl Radiat Isot 91 (September 2014): 135–40. https://doi.org/10.1016/j.apradiso.2014.05.019.
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  - Crews, K. R., A. Gaedigk, H. M. Dunnenberger, J. S. Leeder, T. E. Klein, K. E. Caudle, C. E. Haidar, et al. “Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.” Clin Pharmacol Ther 95, no. 4 (April 2014): 376–82. https://doi.org/10.1038/clpt.2013.254.
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  - Campbell, Scott D., Karen J. Regina, and Evan D. Kharasch. “Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay.” J Biomol Screen 19, no. 3 (March 2014): 437–44. https://doi.org/10.1177/1087057113497981.
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  - Tian, L., K. K. Liu, J. J. Morrissey, N. Gandra, E. D. Kharasch, and S. Singamaneni. “Gold nanocages with built-in artificial antibodies for label-free plasmonic biosensing.” Journal of Materials Chemistry B 2, no. 2 (January 14, 2014): 167–70. https://doi.org/10.1039/c3tb21551b.
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  - Morrissey, Jeremiah J., Jonathan Mobley, Joseph Song, Joel Vetter, Jingqin Luo, Sam Bhayani, R Sherburne Figenshau, and Evan D. Kharasch. “Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade.” Urology 83, no. 1 (January 2014): 256.e9-256.14. https://doi.org/10.1016/j.urology.2013.09.026.
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  - Kharasch, Evan D., and Kristi Stubbert. “Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir.” Drug Metab Dispos 41, no. 12 (December 2013): 2166–74. https://doi.org/10.1124/dmd.113.053991.
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  - Regina, Karen J., and Evan D. Kharasch. “High-sensitivity analysis of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in plasma and urine by liquid chromatography-mass spectrometry.” J Chromatogr B Analyt Technol Biomed Life Sci 939 (November 15, 2013): 23–31. https://doi.org/10.1016/j.jchromb.2013.09.004.
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  - Kharasch, Evan D., and Craig M. Coopersmith. “Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis.” Anesthesiology 119, no. 4 (October 2013): 755–56. https://doi.org/10.1097/ALN.0b013e3182a2a3a4.
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  - Meissner, Konrad, Michael J. Avram, Viktar Yermolenka, Amber M. Francis, Jane Blood, and Evan D. Kharasch. “Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics.” Anesthesiology 119, no. 4 (October 2013): 941–53. https://doi.org/10.1097/ALN.0b013e3182a05bd3.
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  - Kharasch, E. D., and C. E. Rosow. “Assessing the utility of the utility function.” Anesthesiology 119, no. 3 (September 1, 2013): 504–6. https://doi.org/10.1097/ALN.0b013e31829ce70b.
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  - Blake, C. M., E. D. Kharasch, M. Schwab, and P. Nagele. “A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics.” Clin Pharmacol Ther 94, no. 3 (September 2013): 394–99. https://doi.org/10.1038/clpt.2013.96.
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  - Campbell, Scott D., Amanda Crafford, Brian L. Williamson, and Evan D. Kharasch. “Mechanism of autoinduction of methadone N-demethylation in human hepatocytes.” Anesth Analg 117, no. 1 (July 2013): 52–60. https://doi.org/10.1213/ANE.0b013e3182918252.
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  - Hicks, J. K., J. J. Swen, C. F. Thorn, K. Sangkuhl, E. D. Kharasch, V. L. Ellingrod, T. C. Skaar, et al. “Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.” Clin Pharmacol Ther 93, no. 5 (May 2013): 402–8. https://doi.org/10.1038/clpt.2013.2.
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  - Morrissey, Jeremiah J., and Evan D. Kharasch. “The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma.” J Urol 189, no. 5 (May 2013): 1913–20. https://doi.org/10.1016/j.juro.2012.11.034.
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  - Abbas, A., L. Tian, J. J. Morrissey, E. D. Kharasch, and S. Singamaneni. “Hot spot-localized artificial antibodies for label-free plasmonic biosensing.” Advanced Functional Materials 23, no. 14 (April 12, 2013): 1789–97. https://doi.org/10.1002/adfm.201202370.
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  - Gadel, Sarah, Amanda Crafford, Karen Regina, and Evan D. Kharasch. “Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.” Drug Metab Dispos 41, no. 4 (April 2013): 709–13. https://doi.org/10.1124/dmd.112.050625.
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  - Kharasch, Evan D., and Kristi Stubbert. “Role of cytochrome P4502B6 in methadone metabolism and clearance.” J Clin Pharmacol 53, no. 3 (March 2013): 305–13. https://doi.org/10.1002/jcph.1.
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  - Tian, Limei, Jeremiah J. Morrissey, Ramesh Kattumenu, Naveen Gandra, Evan D. Kharasch, and Srikanth Singamaneni. “Bioplasmonic paper as a platform for detection of kidney cancer biomarkers.” Anal Chem 84, no. 22 (November 20, 2012): 9928–34. https://doi.org/10.1021/ac302332g.
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  - Brown, Sarah M., Scott D. Campbell, Amanda Crafford, Karen J. Regina, Michael J. Holtzman, and Evan D. Kharasch. “P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception.” J Pharmacol Exp Ther 343, no. 1 (October 2012): 53–61. https://doi.org/10.1124/jpet.112.193433.
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  - Olofsen, Erik, Ingeborg Noppers, Marieke Niesters, Evan Kharasch, Leon Aarts, Elise Sarton, and Albert Dahan. “Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers.” Anesthesiology 117, no. 2 (August 2012): 353–64. https://doi.org/10.1097/ALN.0b013e31825b6c91.
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  - Sharma, A., and E. D. Kharasch. “In reply.” Anesthesiology 116, no. 6 (June 1, 2012): 1401. https://doi.org/10.1097/ALN.0b013e31825580de.
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  - Kharasch, E. D., D. Whittington, D. Ensign, C. Hoffer, P. S. Bedynek, S. Campbell, K. Stubbert, A. Crafford, A. London, and T. Kim. “Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.” Clin Pharmacol Ther 91, no. 4 (April 2012): 673–84. https://doi.org/10.1038/clpt.2011.276.
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  - Kharasch, Evan D. “Getting oil and water to mix.” Anesthesiology 116, no. 3 (March 2012): 504–6. https://doi.org/10.1097/ALN.0b013e3182475d80.
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  - Kirby, Brian J., Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel, and Jashvant D. Unadkat. “Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion.” Drug Metab Dispos 40, no. 3 (March 2012): 610–16. https://doi.org/10.1124/dmd.111.042705.
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  - Crews, K. R., A. Gaedigk, H. M. Dunnenberger, T. E. Klein, D. D. Shen, J. T. Callaghan, E. D. Kharasch, T. C. Skaar, and T. C. Clinical Pharmacogenetics Implementation Consortium. “Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.” Clin Pharmacol Ther 91, no. 2 (February 2012): 321–26. https://doi.org/10.1038/clpt.2011.287.
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  - Kharasch, Evan D., Pamela Sheffels Bedynek, Christine Hoffer, Alysa Walker, and Dale Whittington. “Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).” Anesthesiology 116, no. 2 (February 2012): 432–47. https://doi.org/10.1097/ALN.0b013e3182423478.
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  - Brown, Sarah M., Michael Holtzman, Thomas Kim, and Evan D. Kharasch. “Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active.” Anesthesiology 115, no. 6 (December 2011): 1251–60. https://doi.org/10.1097/ALN.0b013e318238fea0.
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  - Kirby, Brian J., Ann C. Collier, Evan D. Kharasch, Vaishali Dixit, Pankaj Desai, Dale Whittington, Kenneth E. Thummel, and Jashvant D. Unadkat. “Complex drug interactions of HIV protease inhibitors 2: in vivo induction and in vitro to in vivo correlation of induction of cytochrome P450 1A2, 2B6, and 2C9 by ritonavir or nelfinavir.” Drug Metab Dispos 39, no. 12 (December 2011): 2329–37. https://doi.org/10.1124/dmd.111.038646.
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  - Sharma, Anshuman, Danielle Tallchief, Jane Blood, Thomas Kim, Amy London, and Evan D. Kharasch. “Perioperative pharmacokinetics of methadone in adolescents.” Anesthesiology 115, no. 6 (December 2011): 1153–61. https://doi.org/10.1097/ALN.0b013e318238fec5.
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  - Toma, Octavian, Patty Suntrup, Andrei Stefanescu, Amy London, Matthew Mutch, and Evan Kharasch. “Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection.” Anesth Analg 113, no. 4 (October 2011): 730–37. https://doi.org/10.1213/ANE.0b013e31821fff74.
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  - Nagele, Peter, Danielle Tallchief, Jane Blood, Anshuman Sharma, and Evan D. Kharasch. “Nitrous oxide anesthesia and plasma homocysteine in adolescents.” Anesth Analg 113, no. 4 (October 2011): 843–48. https://doi.org/10.1213/ANE.0b013e31822402f5.
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  - Bloom, Joseph, Anthony L. Hinrichs, Jen C. Wang, Linda B. von Weymarn, Evan D. Kharasch, Laura J. Bierut, Alison Goate, and Sharon E. Murphy. “The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.” Pharmacogenet Genomics 21, no. 7 (July 2011): 403–16. https://doi.org/10.1097/FPC.0b013e328346e8c0.
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  - Kharasch, E. D., A. Francis, A. London, K. Frey, T. Kim, and J. Blood. “Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.” Clin Pharmacol Ther 90, no. 1 (July 2011): 100–108. https://doi.org/10.1038/clpt.2011.59.
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  - Schwedt, Todd J., Robert W. Gereau, Karen Frey, and Evan D. Kharasch. “Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis.” Cephalalgia 31, no. 10 (July 2011): 1082–89. https://doi.org/10.1177/0333102411398155.
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  - Kim, Thomas, Amy London, and Evan D. Kharasch. “Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.” J Pharm Biomed Anal 55, no. 3 (June 1, 2011): 487–93. https://doi.org/10.1016/j.jpba.2011.01.040.
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  - Kirby, Brian J., Ann C. Collier, Evan D. Kharasch, Dale Whittington, Kenneth E. Thummel, and Jashvant D. Unadkat. “Complex drug interactions of HIV protease inhibitors 1: inactivation, induction, and inhibition of cytochrome P450 3A by ritonavir or nelfinavir.” Drug Metab Dispos 39, no. 6 (June 2011): 1070–78. https://doi.org/10.1124/dmd.110.037523.
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  - Noppers, Ingeborg, Erik Olofsen, Marieke Niesters, Leon Aarts, René Mooren, Albert Dahan, Evan Kharasch, and Elise Sarton. “Effect of rifampicin on S-ketamine and S-norketamine plasma concentrations in healthy volunteers after intravenous S-ketamine administration.” Anesthesiology 114, no. 6 (June 2011): 1435–45. https://doi.org/10.1097/ALN.0b013e318218a881.
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  - Fan, Jinda, Sarah M. Brown, Zhude Tu, and Evan D. Kharasch. “Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.” Bioconjug Chem 22, no. 4 (April 20, 2011): 752–58. https://doi.org/10.1021/bc100550u.
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  - Kharasch, E. D., S. Vangveravong, N. Buck, A. London, T. Kim, J. Blood, and R. H. Mach. “Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.” Clin Pharmacol Ther 89, no. 4 (April 2011): 562–70. https://doi.org/10.1038/clpt.2010.313.
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  - Fan, Jinda, Konrad Meissner, Gregory G. Gaehle, Shihong Li, Evan D. Kharasch, Robert H. Mach, and Zhude Tu. “Automated radiosynthesis of [11C]morphine for clinical investigation.” Appl Radiat Isot 69, no. 2 (February 2011): 431–35. https://doi.org/10.1016/j.apradiso.2010.11.003.
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  - Kharasch, Evan D. “Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?” Anesth Analg 112, no. 1 (January 2011): 13–16. https://doi.org/10.1213/ANE.0b013e3181fec9a3.
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  - Morrissey, Jeremiah J., Amy N. London, Matthew C. Lambert, and Evan D. Kharasch. “Sensitivity and specificity of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 for the diagnosis of renal cell carcinoma.” Am J Nephrol 34, no. 5 (2011): 391–98. https://doi.org/10.1159/000330851.
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  - Joy, Melanie S., Reginald F. Frye, Kristi Stubbert, Kim R. Brouwer, Ronald J. Falk, and Evan D. Kharasch. “Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases.” J Clin Pharmacol 50, no. 6 (June 2010): 714–20. https://doi.org/10.1177/0091270009353031.
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  - Kharasch, E. D., G. N. Subbarao, K. R. Cromack, D. A. Stephens, and M. D. Saltarelli. “In response.” Anesthesia and Analgesia 110, no. 1 (January 1, 2010): 254–55. https://doi.org/10.1213/ANE.0b013e3181c13653.
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  - Morrissey, J. J., A. N. London, J. Luo, and E. D. Kharasch. “Urinary biomarkers for the early diagnosis of kidney cancer.” Mayo Clinic Proceedings 85, no. 5 (January 1, 2010): 413–21. https://doi.org/10.4065/mcp.2009.0709.
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  - Morrissey, J. J., and E. D. Kharasch. “In reply.” Mayo Clinic Proceedings 85, no. 8 (January 1, 2010): 769. https://doi.org/10.4065/mcp.2010.0396.
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  - Bowdle, Andrew, Evan Kharasch, and Howard Schwid. “Pressure waveform monitoring during central venous catheterization.” Anesth Analg 109, no. 6 (December 2009): 2030–31. https://doi.org/10.1213/ANE.0b013e3181bea01d.
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  - Pickrell, Jacqueline E., Kazuo Hosaka, Douglass L. Jackson, Masahiro Heima, Evan Kharasch, and Peter M. Milgrom. “Expanded studies of the pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.” J Clin Psychopharmacol 29, no. 5 (October 2009): 426–31. https://doi.org/10.1097/JCP.0b013e3181b5f45e.
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  - Montana, Michael C., Laura F. Cavallone, Kristi K. Stubbert, Andrei D. Stefanescu, Evan D. Kharasch, and Robert W. Gereau. “The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.” J Pharmacol Exp Ther 330, no. 3 (September 2009): 834–43. https://doi.org/10.1124/jpet.109.154138.
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  - Lanier, William L., and Evan D. Kharasch. “Contemporary clinical opioid use: opportunities and challenges.” Mayo Clin Proc 84, no. 7 (July 2009): 572–75. https://doi.org/10.1016/S0025-6196(11)60744-1.
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  - Kharasch, Evan D., Gowdahalli N. Subbarao, Keith R. Cromack, Dennis A. Stephens, and Mario D. Saltarelli. “Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers.” Anesth Analg 108, no. 6 (June 2009): 1796–1802. https://doi.org/10.1213/ane.0b013e3181a3d72b.
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  - Kharasch, Evan D., Alysa Walker, Dale Whittington, Christine Hoffer, and Pamela Sheffels Bedynek. “Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.” Drug Alcohol Depend 101, no. 3 (May 1, 2009): 158–68. https://doi.org/10.1016/j.drugalcdep.2008.12.009.
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  - Kharasch, Evan D., Christine Hoffer, Dale Whittington, Alysa Walker, and Pamela Sheffels Bedynek. “Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir.” Anesthesiology 110, no. 3 (March 2009): 660–72. https://doi.org/10.1097/ALN.0b013e3181986a9a.
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  - Kharasch, E. D., P. S. Bedynek, A. Walker, D. Whittington, and C. Hoffer. “Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.” Clin Pharmacol Ther 84, no. 4 (October 2008): 506–12. https://doi.org/10.1038/clpt.2008.102.
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  - Kharasch, E. D., P. S. Bedynek, S. Park, D. Whittington, A. Walker, and C. Hoffer. “Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance.” Clin Pharmacol Ther 84, no. 4 (October 2008): 497–505. https://doi.org/10.1038/clpt.2008.104.
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  - Kharasch, Evan D. “Mutations in a molecule: the virtues of antagonism.” Mayo Clin Proc 83, no. 10 (October 2008): 1083–86. https://doi.org/10.4065/83.10.1083.
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  - Lerman, Jerrold, Evan D. Kharasch, James C. Eisenach, Mark A. Warner, Vesna Jevtovic-Todorovic, Piyush M. Patel, and Lena S. Sun. “Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting.” Anesthesiology 109, no. 3 (September 2008): 365. https://doi.org/10.1097/aln.0b013e318183452b.
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  - Kharasch, E. D. “Adverse drug reactions with halogenated anesthetics.” Clin Pharmacol Ther 84, no. 1 (July 2008): 158–62. https://doi.org/10.1038/clpt.2008.97.
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  - Coles, Rebecka, and Evan D. Kharasch. “Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes.” Pharm Res 25, no. 6 (June 2008): 1405–11. https://doi.org/10.1007/s11095-008-9535-1.
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  - Ekins, Sean, Manisha Iyer, Matthew D. Krasowski, and Evan D. Kharasch. “Molecular characterization of CYP2B6 substrates.” Curr Drug Metab 9, no. 5 (June 2008): 363–73. https://doi.org/10.2174/138920008784746346.
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  - Kharasch, Evan D., Darain Mitchell, Rebecka Coles, and Roberto Blanco. “Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.” Antimicrob Agents Chemother 52, no. 5 (May 2008): 1663–69. https://doi.org/10.1128/AAC.01600-07.
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  - Kharasch, Evan D., Darain Mitchell, and Rebecka Coles. “Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity.” J Clin Pharmacol 48, no. 4 (April 2008): 464–74. https://doi.org/10.1177/0091270008314254.
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  - Totah, Rheem A., Pamela Sheffels, Toni Roberts, Dale Whittington, Kenneth Thummel, and Evan D. Kharasch. “Role of CYP2B6 in stereoselective human methadone metabolism.” Anesthesiology 108, no. 3 (March 2008): 363–74. https://doi.org/10.1097/ALN.0b013e3181642938.
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  - Templeton, I. E., K. E. Thummel, E. D. Kharasch, K. L. Kunze, C. Hoffer, W. L. Nelson, and N. Isoherranen. “Contribution of itraconazole metabolites to inhibition of CYP3A4 in vivo.” Clin Pharmacol Ther 83, no. 1 (January 2008): 77–85. https://doi.org/10.1038/sj.clpt.6100230.
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  - Kharasch, E. D., A. Walker, N. Isoherranen, C. Hoffer, P. Sheffels, K. Thummel, D. Whittington, and D. Ensign. “Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam.” Clin Pharmacol Ther 82, no. 4 (October 2007): 410–26. https://doi.org/10.1038/sj.clpt.6100237.
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  - Coles, Rebecka, and Evan D. Kharasch. “Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS.” J Chromatogr B Analyt Technol Biomed Life Sci 857, no. 1 (September 15, 2007): 67–75. https://doi.org/10.1016/j.jchromb.2007.07.007.
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  - Feierman, Dennis E., Giuseppe Trunfio, Anand Morankar, and Evan Kharasch. “More than polymorphism.” Anesth Analg 104, no. 6 (June 2007): 1605. https://doi.org/10.1213/01.ane.0000268664.65621.91.
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  - Kharasch, Evan D. “Every breath you take, we'll be watching you.” Anesthesiology 106, no. 4 (April 2007): 652–54. https://doi.org/10.1097/01.anes.0000264752.39511.05.
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  - Totah, Rheem A., Kyle E. Allen, Pamela Sheffels, Dale Whittington, and Evan D. Kharasch. “Enantiomeric metabolic interactions and stereoselective human methadone metabolism.” J Pharmacol Exp Ther 321, no. 1 (April 2007): 389–99. https://doi.org/10.1124/jpet.106.117580.
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  - Bruce, R Douglas, Elinore McCance-Katz, Evan D. Kharasch, David E. Moody, and Gene D. Morse. “Pharmacokinetic interactions between buprenorphine and antiretroviral medications.” Clin Infect Dis 43 Suppl 4 (December 15, 2006): S216–23. https://doi.org/10.1086/508186.
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  - Kirby, Brian, Evan D. Kharasch, Kenneth T. Thummel, Vishal S. Narang, Christine J. Hoffer, and Jashvant D. Unadkat. “Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities.” J Clin Pharmacol 46, no. 11 (November 2006): 1313–19. https://doi.org/10.1177/0091270006292625.
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  - Kharasch, Evan D., Jesara L. Schroeder, H Denny Liggitt, Dustin Ensign, and Dale Whittington. “New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.” Anesthesiology 105, no. 4 (October 2006): 737–45. https://doi.org/10.1097/00000542-200610000-00020.
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  - Kharasch, Evan D., Jesara L. Schroeder, H Denny Liggitt, Sang B. Park, Dale Whittington, and Pamela Sheffels. “New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.” Anesthesiology 105, no. 4 (October 2006): 726–36. https://doi.org/10.1097/00000542-200610000-00019.
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  - Lalovic, Bojan, Evan Kharasch, Christine Hoffer, Linda Risler, Lee-Yuan Liu-Chen, and Danny D. Shen. “Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites.” Clin Pharmacol Ther 79, no. 5 (May 2006): 461–79. https://doi.org/10.1016/j.clpt.2006.01.009.
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  - Kharasch, Evan D., Jesara L. Schroeder, Theo Bammler, Richard Beyer, and Sengkeo Srinouanprachanh. “Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.” Toxicol Sci 90, no. 2 (April 2006): 419–31. https://doi.org/10.1093/toxsci/kfj088.
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  - Kunze, Kent L., Wendel L. Nelson, Evan D. Kharasch, Kenneth E. Thummel, and Nina Isoherranen. “Stereochemical aspects of itraconazole metabolism in vitro and in vivo.” Drug Metab Dispos 34, no. 4 (April 2006): 583–90. https://doi.org/10.1124/dmd.105.008508.
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  - Jackson, Douglass L., Peter Milgrom, Gail A. Heacox, and Evan D. Kharasch. “Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.” J Clin Psychopharmacol 26, no. 1 (February 2006): 4–8. https://doi.org/10.1097/01.jcp.0000186742.07148.da.
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  - Chaobal, Harshvardhan N., and Evan D. Kharasch. “Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.” Clin Pharmacol Ther 78, no. 5 (November 2005): 529–39. https://doi.org/10.1016/j.clpt.2005.08.004.
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  - Kharasch, Evan D., Alysa Walker, Christine Hoffer, and Pamela Sheffels. “Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.” J Clin Pharmacol 45, no. 10 (October 2005): 1187–97. https://doi.org/10.1177/0091270005280077.
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  - Kharasch, Evan D., Kenneth E. Thummel, and Paul B. Watkins. “CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition.” Mol Interv 5, no. 3 (June 2005): 151–53. https://doi.org/10.1124/mi.5.3.3.
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  - Klees, Theresa Mariero, Pamela Sheffels, Ola Dale, and Evan D. Kharasch. “Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.” Drug Metab Dispos 33, no. 3 (March 2005): 303–11. https://doi.org/10.1124/dmd.104.002709.
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  - Dembo, Gregory, Sang B. Park, and Evan D. Kharasch. “Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.” Anesthesiology 102, no. 2 (February 2005): 409–15. https://doi.org/10.1097/00000542-200502000-00026.
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  - Kharasch, E. D., J. L. Schroeder, P. Sheffels, and H. D. Liggitt. “Influence of sevoflurane on the metabolism and renal effects of compound a in rats.” Anesthesiology 103, no. 6 (January 1, 2005): 1183–88. https://doi.org/10.1097/00000542-200512000-00012.
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  - Kharasch, Evan D., Dale Whittington, Christine Hoffer, Kevin Krudys, Keith Craig, Paolo Vicini, Pam Sheffels, and Bojan Lalovic. “Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.” Clin Pharmacokinet 44, no. 7 (2005): 731–51. https://doi.org/10.2165/00003088-200544070-00005.
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  - Kharasch, Evan D., Alysa Walker, Christine Hoffer, and Pamela Sheffels. “Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination.” J Clin Pharmacol 45, no. 1 (January 2005): 79–88. https://doi.org/10.1177/0091270004269705.
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  - Dai, Yang, Kazunori Iwanaga, Yvonne S. Lin, Mary F. Hebert, Connie L. Davis, Weili Huang, Evan D. Kharasch, and Kenneth E. Thummel. “In vitro metabolism of cyclosporine A by human kidney CYP3A5.” Biochem Pharmacol 68, no. 9 (November 1, 2004): 1889–1902. https://doi.org/10.1016/j.bcp.2004.07.012.
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  - Kharasch, Evan D., Alysa Walker, Christine Hoffer, and Pamela Sheffels. “Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.” Clin Pharmacol Ther 76, no. 5 (November 2004): 452–66. https://doi.org/10.1016/j.clpt.2004.07.006.
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  - Whittington, Dale, Pam Sheffels, and Evan D. Kharasch. “Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry.” J Chromatogr B Analyt Technol Biomed Life Sci 809, no. 2 (October 5, 2004): 313–21. https://doi.org/10.1016/j.jchromb.2004.06.041.
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  - Kharasch, Evan D., Christine Hoffer, Dale Whittington, and Pamela Sheffels. “Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.” Clin Pharmacol Ther 76, no. 3 (September 2004): 250–69. https://doi.org/10.1016/j.clpt.2004.05.003.
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  - Kharasch, Evan D., Christine Hoffer, and Dale Whittington. “Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.” Anesthesiology 101, no. 3 (September 2004): 738–43. https://doi.org/10.1097/00000542-200409000-00023.
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  - Kharasch, Evan D., Dale Whittington, and Christine Hoffer. “Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.” Anesthesiology 101, no. 3 (September 2004): 729–37. https://doi.org/10.1097/00000542-200409000-00022.
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  - Sheffels, Pam, Jesara L. Schroeder, T Gul Altuntas, H Denny Liggitt, and Evan D. Kharasch. “Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.” Chem Res Toxicol 17, no. 9 (September 2004): 1177–89. https://doi.org/10.1021/tx049899e.
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  - Dale, Ola, Pamela Sheffels, and Evan D. Kharasch. “Bioavailabilities of rectal and oral methadone in healthy subjects.” Br J Clin Pharmacol 58, no. 2 (August 2004): 156–62. https://doi.org/10.1111/j.1365-2125.2004.02116.x.
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  - Kharasch, E. D., M. Mulroy, and J. L. Apfelbaum. “Commentary.” Aesthetic Surgery Journal 24, no. 4 (July 1, 2004): 311–13. https://doi.org/10.1016/j.asj.2004.06.006.
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  - Kharasch, Evan D., Christine Hoffer, and Dale Whittington. “The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone.” Br J Clin Pharmacol 57, no. 5 (May 2004): 600–610. https://doi.org/10.1111/j.1365-2125.2003.02053.x.
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  - Altuntas, T Gul, Sang B. Park, and Evan D. Kharasch. “Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).” Chem Res Toxicol 17, no. 3 (March 2004): 435–45. https://doi.org/10.1021/tx034254k.
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  - Kharasch, Evan D., Christine Hoffer, T Gul Altuntas, and Dale Whittington. “Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl.” J Clin Pharmacol 44, no. 3 (March 2004): 224–33. https://doi.org/10.1177/0091270003262075.
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  - Kharasch, Evan D. “Perioperative COX-2 inhibitors: knowledge and challenges.” Anesth Analg 98, no. 1 (January 2004): 1–3. https://doi.org/10.1213/01.ANE.0000100738.05755.6F.
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  - Fitzgibbon, Dermot, Donna Morgan, Deanna Dockter, Chris Barry, and Evan D. Kharasch. “Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients.” Pain 106, no. 3 (December 2003): 309–15. https://doi.org/10.1016/S0304-3959(03)00318-X.
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  - Kharasch, Evan D., Christine Hoffer, Dale Whittington, and Pam Sheffels. “Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.” Clin Pharmacol Ther 74, no. 6 (December 2003): 543–54. https://doi.org/10.1016/j.clpt.2003.08.011.
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  - Altuntas, T Gul, Richard A. Zager, and Evan D. Kharasch. “Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.” Toxicol Appl Pharmacol 193, no. 1 (November 15, 2003): 55–65. https://doi.org/10.1016/s0041-008x(03)00336-3.
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  - Whittington, Dale, and Evan D. Kharasch. “Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography-electrospray ionization mass spectrometry.” J Chromatogr B Analyt Technol Biomed Life Sci 796, no. 1 (October 25, 2003): 95–103. https://doi.org/10.1016/j.jchromb.2003.08.007.
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  - Saidman, Lawrence J., and Edmond I. Eger. “Safety of low-flow sevoflurane anesthesia in patients with chronically impaired renal function is not proven.” Anesthesiology 99, no. 3 (September 2003): 752. https://doi.org/10.1097/00000542-200309000-00035.
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  - Emery, Maurice G., Jeannine M. Fisher, Jenny Y. Chien, Evan D. Kharasch, E Patchen Dellinger, Kris V. Kowdley, and Kenneth E. Thummel. “CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease.” Hepatology 38, no. 2 (August 2003): 428–35. https://doi.org/10.1053/jhep.2003.50342.
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  - Spracklin, D. K., M. E. Emery, K. E. Thummel, and E. D. Kharasch. “Concordance between trifluoroacetic acid and hepatic protein trifluoroacetylation after disulfiram inhibition of halothane metabolism in rats.” Acta Anaesthesiol Scand 47, no. 6 (July 2003): 765–70. https://doi.org/10.1034/j.1399-6576.2003.00126.x.
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  - McIlroy, David R., and Evan D. Kharasch. “Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia.” Anesth Analg 96, no. 6 (June 2003): 1572–77. https://doi.org/10.1213/01.ANE.0000061460.59320.B0.
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  - Ibrahim, Andra E., Jennifer Feldman, Aziz Karim, and Evan D. Kharasch. “Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.” Anesthesiology 98, no. 4 (April 2003): 853–61. https://doi.org/10.1097/00000542-200304000-00011.
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  - Kharasch, Evan D., Christine Hoffer, Alysa Walker, and Pamela Sheffels. “Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity.” Clin Pharmacol Ther 73, no. 3 (March 2003): 199–208. https://doi.org/10.1067/mcp.2003.30.
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  - Pleym, H., O. Spigset, E. D. Kharasch, and O. Dale. “Gender differences in drug effects: implications for anesthesiologists.” Acta Anaesthesiol Scand 47, no. 3 (March 2003): 241–59. https://doi.org/10.1034/j.1399-6576.2003.00036.x.
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  - Yao, C., K. L. Kunze, E. D. Kharasch, Y. Wang, W. F. Trager, I. Ragueneau, and R. H. Levy. “Erratum: Fluvoxamine-theophylline interaction: Gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2 (Clinical Pharmacology and Therapeutics (2001) 70 (415-424)).” Clinical Pharmacology and Therapeutics 72, no. 5 (November 1, 2002): 523.
  - Dale, Ola, Christine Hoffer, Pamela Sheffels, and Evan D. Kharasch. “Disposition of nasal, intravenous, and oral methadone in healthy volunteers.” Clin Pharmacol Ther 72, no. 5 (November 2002): 536–45. https://doi.org/10.1067/mcp.2002.128386.
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  - Conzen, Peter F., Evan D. Kharasch, Stephan F. A. Czerner, Alan A. Artru, Florian M. Reichle, Piotr Michalowski, G Alec Rooke, Branko M. Weiss, and Thomas J. Ebert. “Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency.” Anesthesiology 97, no. 3 (September 2002): 578–84. https://doi.org/10.1097/00000542-200209000-00010.
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  - Dale, O., R. Hjortkjaer, and E. D. Kharasch. “Nasal administration of opioids for pain management in adults.” Acta Anaesthesiol Scand 46, no. 7 (August 2002): 759–70. https://doi.org/10.1034/j.1399-6576.2002.460702.x.
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  - Gul Altuntas, T., and Evan D. Kharasch. “Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.” Drug Metab Dispos 30, no. 2 (February 2002): 148–54. https://doi.org/10.1124/dmd.30.2.148.
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  - Ibrahim, A., A. Karim, J. Feldman, and E. Kharasch. “The influence of parecoxib: A parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.” Anesthesia and Analgesia 95, no. 3 (January 1, 2002): 667–73. https://doi.org/10.1213/00000539-200209000-00032.
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  - Ibrahim, A., S. Park, J. Feldman, A. Karim, and E. D. Kharasch. “Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol.” Anesthesiology 96, no. 1 (January 1, 2002): 88–95. https://doi.org/10.1097/00000542-200201000-00020.
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  - Kharasch, Evan D., Karen M. Powers, and Alan A. Artru. “Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo.” Anesthesiology 96, no. 1 (January 2002): 173–82. https://doi.org/10.1097/00000542-200201000-00031.
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  - Thummel, K. E., C. Brimer, K. Yasuda, J. Thottassery, T. Senn, Y. Lin, H. Ishizuka, E. Kharasch, J. Schuetz, and E. Schuetz. “Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.” Mol Pharmacol 60, no. 6 (December 2001): 1399–1406. https://doi.org/10.1124/mol.60.6.1399.
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  - Altuntas, T. G., and E. D. Kharasch. “Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.” Toxicol Appl Pharmacol 177, no. 2 (December 1, 2001): 85–93. https://doi.org/10.1006/taap.2001.9302.
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  - Kharasch, E. D., E. J. Frink, A. Artru, P. Michalowski, G. A. Rooke, and W. Nogami. “Long-duration low-flow sevoflurane and isoflurane effects on postoperative renal and hepatic function.” Anesth Analg 93, no. 6 (December 2001): 1511–20. https://doi.org/10.1097/00000539-200112000-00036.
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  - Lin, Y. S., G. F. Lockwood, M. A. Graham, W. R. Brian, C. M. Loi, M. R. Dobrinska, D. D. Shen, et al. “In-vivo phenotyping for CYP3A by a single-point determination of midazolam plasma concentration.” Pharmacogenetics 11, no. 9 (December 2001): 781–91. https://doi.org/10.1097/00008571-200112000-00006.
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  - Phimmasone, S., and E. D. Kharasch. “A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.” Clin Pharmacol Ther 70, no. 6 (December 2001): 505–17. https://doi.org/10.1067/mcp.2001.119994.
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  - Yao, C., K. L. Kunze, E. D. Kharasch, Y. Wang, W. F. Trager, I. Ragueneau, and R. H. Levy. “Fluvoxamine-theophylline interaction: gap between in vitro and in vivo inhibition constants toward cytochrome P4501A2.” Clin Pharmacol Ther 70, no. 5 (November 2001): 415–24. https://doi.org/10.1067/mcp.2001.119724.
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  - Castillo, J. L., P. Milgrom, E. Kharasch, K. Izutsu, and M. Fey. “Evaluation of fluoride release from commercially available fluoride varnishes.” J Am Dent Assoc 132, no. 10 (October 2001): 1389–92. https://doi.org/10.14219/jada.archive.2001.0053.
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  - Oda, Y., and E. D. Kharasch. “Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.” J Pharmacol Exp Ther 298, no. 3 (September 2001): 1021–32.
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  - Tweedy, C. M., P. Milgrom, E. D. Kharasch, T. Kaakko, M. Spieker, and S. E. Coldwell. “Pharmacokinetics and clinical effects of sublingual triazolam in pediatric dental patients.” J Clin Psychopharmacol 21, no. 3 (June 2001): 268–72. https://doi.org/10.1097/00004714-200106000-00004.
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  - Oda, Y., and E. D. Kharasch. “Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites.” J Pharmacol Exp Ther 297, no. 1 (April 2001): 410–22.
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  - Ibrahim, A. E., J. K. Taraday, and E. D. Kharasch. “Bispectral index monitoring during sedation with sevoflurane, midazolam, and propofol.” Anesthesiology 95, no. 5 (January 1, 2001): 1151–59. https://doi.org/10.1097/00000542-200111000-00019.
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  - Minoda, Y., and E. D. Kharasch. “Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6).” Anesthesiology 95, no. 2 (January 1, 2001): 509–14. https://doi.org/10.1097/00000542-200108000-00037.
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  - Ibrahim, A. E., M. M. Ghoneim, E. D. Kharasch, R. H. Epstein, S. B. Groudine, T. J. Ebert, W. B. Binstock, B. K. Philip, and B. K. Sevoflurane Sedation Study Group. “Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam.” Anesthesiology 94, no. 1 (January 2001): 87–94. https://doi.org/10.1097/00000542-200101000-00018.
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  - Manyike, P. T., E. D. Kharasch, T. F. Kalhorn, and J. T. Slattery. “Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.” Clin Pharmacol Ther 67, no. 3 (March 2000): 275–82. https://doi.org/10.1067/mcp.2000.104736.
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  - Palmer, R. B., D. S. Mautz, K. Cox, and E. D. Kharasch. “Endotracheal lidocaine administration via an esophageal combitube.” J Emerg Med 18, no. 2 (February 2000): 153–57. https://doi.org/10.1016/s0736-4679(99)00186-9.
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  - Kharasch, E. D., D. C. Hankins, and J. K. Taraday. “Single-dose methoxsalen effects on human cytochrome P-450 2A6 activity.” Drug Metab Dispos 28, no. 1 (January 2000): 28–33.
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  - Kharasch, E. D., D. C. Hankins, K. Fenstamaker, and K. Cox. “Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4.” Eur J Clin Pharmacol 55, no. 11–12 (2000): 853–59. https://doi.org/10.1007/s002280050707.
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  - Davis, C. L., A. T. Kausz, R. A. Zager, E. D. Kharasch, and R. P. Cochran. “Acute renal failure after cardiopulmonary bypass in related to decreased serum ferritin levels.” J Am Soc Nephrol 10, no. 11 (November 1999): 2396–2402. https://doi.org/10.1681/ASN.V10112396.
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  - Kharasch, E. D., and C. Jubert. “Compound A uptake and metabolism to mercapturic acids and 3,3,3-trifluoro-2-fluoromethoxypropanoic acid during low-flow sevoflurane anesthesia: biomarkers for exposure, risk assessment, and interspecies comparison.” Anesthesiology 91, no. 5 (November 1999): 1267–78. https://doi.org/10.1097/00000542-199911000-00017.
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  - Kharasch, E. D. “Putting the brakes on anesthetic breakdown.” Anesthesiology 91, no. 5 (November 1999): 1192–94. https://doi.org/10.1097/00000542-199911000-00008.
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  - Emery, M. G., C. Jubert, K. E. Thummel, and E. D. Kharasch. “Duration of cytochrome P-450 2E1 (CYP2E1) inhibition and estimation of functional CYP2E1 enzyme half-life after single-dose disulfiram administration in humans.” J Pharmacol Exp Ther 291, no. 1 (October 1999): 213–19.
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  - Kharasch, E. D., C. Jubert, D. K. Spracklin, and G. M. Hoffman. “Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.” Toxicol Appl Pharmacol 160, no. 1 (October 1, 1999): 49–59. https://doi.org/10.1006/taap.1999.8751.
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  - Kharasch, E. D., C. Jubert, T. Senn, T. A. Bowdle, and K. E. Thummel. “Intraindividual variability in male hepatic CYP3A4 activity assessed by alfentanil and midazolam clearance.” J Clin Pharmacol 39, no. 7 (July 1999): 664–69. https://doi.org/10.1177/00912709922008290.
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  - Kharasch, E. D., D. C. Hankins, C. Jubert, K. E. Thummel, and J. K. Taraday. “Lack of single-dose disulfiram effects on cytochrome P-450 2C9, 2C19, 2D6, and 3A4 activities: evidence for specificity toward P-450 2E1.” Drug Metab Dispos 27, no. 6 (June 1999): 717–23.
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  - Groudine, S. B., R. J. Fragen, E. D. Kharasch, T. S. Eisenman, E. J. Frink, and S. McConnell. “Comparison of renal function following anesthesia with low-flow sevoflurane and isoflurane.” J Clin Anesth 11, no. 3 (May 1999): 201–7. https://doi.org/10.1016/s0952-8180(99)00027-6.
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  - Kharasch, E. D., D. Mautz, T. Senn, G. Lentz, and K. Cox. “Menstrual cycle variability in midazolam pharmacokinetics.” J Clin Pharmacol 39, no. 3 (March 1999): 275–80.
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  - Njoku, D. B., J. L. Martin, and L. R. Pohl. “Renal cysteine conjugate beta-lyase and compound A nephrotoxicity: minimal evidence for an association.” Anesthesiology 90, no. 3 (March 1999): 921–22. https://doi.org/10.1097/00000542-199903000-00043.
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  - Kharasch, E. D., D. C. Hankins, and K. Cox. “Clinical isoflurane metabolism by cytochrome P450 2E1.” Anesthesiology 90, no. 3 (March 1999): 766–71. https://doi.org/10.1097/00000542-199903000-00019.
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  - Kharasch, E. D. “[Compound A: toxicology and clinical relevance].” Anaesthesist 47 Suppl 1 (November 1998): S7-10. https://doi.org/10.1007/pl00002502.
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  - Radant, A. D., T. A. Bowdle, D. S. Cowley, E. D. Kharasch, and P. P. Roy-Byrne. “Does ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities?” Neuropsychopharmacology 19, no. 5 (November 1998): 434–44. https://doi.org/10.1016/S0893-133X(98)00030-X.
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  - Baxter, P. J., K. Garton, and E. D. Kharasch. “Mechanistic aspects of carbon monoxide formation from volatile anesthetics.” Anesthesiology 89, no. 4 (October 1998): 929–41. https://doi.org/10.1097/00000542-199810000-00018.
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  - Kharasch, E. D., D. C. Hankins, P. J. Baxter, and K. E. Thummel. “Single-dose disulfiram does not inhibit CYP2A6 activity.” Clin Pharmacol Ther 64, no. 1 (July 1998): 39–45. https://doi.org/10.1016/S0009-9236(98)90020-0.
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  - Weiner, A. L., and C. A. McKay. “Endotracheal administration of flumazenil.” Am J Emerg Med 16, no. 4 (July 1998): 436–37. https://doi.org/10.1016/s0735-6757(98)90153-x.
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  - Spracklin, D. K., and E. D. Kharasch. “Human halothane reduction in vitro by cytochrome P450 2A6 and 3A4: identification of low and high KM isoforms.” Drug Metab Dispos 26, no. 6 (June 1998): 605–7.
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  - Kharasch, E. D., G. M. Hoffman, D. Thorning, D. C. Hankins, and C. G. Kilty. “Role of the renal cysteine conjugate beta-lyase pathway in inhaled compound A nephrotoxicity in rats.” Anesthesiology 88, no. 6 (June 1998): 1624–33. https://doi.org/10.1097/00000542-199806000-00027.
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  - Bishop, M. J., and E. D. Kharasch. “Is the Combitube a useful emergency airway device for anesthesiologists?” Anesth Analg 86, no. 5 (May 1998): 1141–42. https://doi.org/10.1097/00000539-199805000-00045.
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  - Ebert, T. J., E. J. Frink, and E. D. Kharasch. “Absence of biochemical evidence for renal and hepatic dysfunction after 8 hours of 1.25 minimum alveolar concentration sevoflurane anesthesia in volunteers.” Anesthesiology 88, no. 3 (March 1998): 601–10. https://doi.org/10.1097/00000542-199803000-00008.
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  - Palmer, R. B., D. S. Mautz, K. Cox, and E. D. Kharasch. “Endotracheal flumazenil: a new route of administration for benzodiazepine antagonism.” Am J Emerg Med 16, no. 2 (March 1998): 170–72. https://doi.org/10.1016/s0735-6757(98)90039-0.
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  - Lochhead, K. M., E. D. Kharasch, and R. A. Zager. “Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.” J Am Soc Nephrol 9, no. 2 (February 1998): 305–9. https://doi.org/10.1681/ASN.V92305.
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  - Coldwell, S. E., E. Kaufman, P. Milgrom, E. D. Kharasch, P. Chen, D. Mautz, and D. S. Ramsay. “Acute tolerance and reversal of the motor control effects of midazolam.” Pharmacol Biochem Behav 59, no. 2 (February 1998): 537–45. https://doi.org/10.1016/s0091-3057(97)00458-9.
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  - Bowdle, T. A., A. D. Radant, D. S. Cowley, E. D. Kharasch, R. J. Strassman, and P. P. Roy-Byrne. “Psychedelic effects of ketamine in healthy volunteers: relationship to steady-state plasma concentrations.” Anesthesiology 88, no. 1 (January 1998): 82–88. https://doi.org/10.1097/00000542-199801000-00015.
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  - Woehlck, H. “Optimal rehydration of desiccated CO2 absorbents.” Anesthesiology 87, no. 6 (December 1997): 1590–91. https://doi.org/10.1097/00000542-199712000-00052.
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  - Ebert, T. J., E. D. Kharasch, G. A. Rooke, A. Shroff, and M. Muzi. “Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncardiac surgery with sevoflurane and isoflurane. Sevoflurane Ischemia Study Group.” Anesth Analg 85, no. 5 (November 1997): 993–99. https://doi.org/10.1097/00000539-199711000-00007.
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  - Freund, P. R., T. A. Bowdle, K. L. Posner, E. D. Kharasch, and V. D. Burkhart. “Cost-effective reduction of neuromuscular-blocking drug expenditures.” Anesthesiology 87, no. 5 (November 1997): 1044–49. https://doi.org/10.1097/00000542-199711000-00006.
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  - Labroo, R. B., M. F. Paine, K. E. Thummel, and E. D. Kharasch. “Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, efficacy, and drug interactions.” Drug Metab Dispos 25, no. 9 (September 1997): 1072–80.
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  - Kharasch, E. D. “Keep the blood red...the right way.” Anesthesiology 87, no. 2 (August 1997): 202–3. https://doi.org/10.1097/00000542-199708000-00005.
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  - Bowdle, T. A., L. B. Ready, E. D. Kharasch, W. W. Nichols, and K. Cox. “Transition to post-operative epidural or patient-controlled intravenous analgesia following total intravenous anaesthesia with remifentanil and propofol for abdominal surgery.” Eur J Anaesthesiol 14, no. 4 (July 1997): 374–79. https://doi.org/10.1046/j.1365-2346.1997.t01-1-00109.x.
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  - Kharasch, E. D., M. Russell, D. Mautz, K. E. Thummel, K. L. Kunze, A. Bowdle, and K. Cox. “The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions.” Anesthesiology 87, no. 1 (July 1997): 36–50. https://doi.org/10.1097/00000542-199707000-00006.
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  - Kharasch, E. D., M. Russell, K. Garton, G. Lentz, T. A. Bowdle, and K. Cox. “Assessment of cytochrome P450 3A4 activity during the menstrual cycle using alfentanil as a noninvasive probe.” Anesthesiology 87, no. 1 (July 1997): 26–35. https://doi.org/10.1097/00000542-199707000-00005.
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  - Lochhead, K. M., E. D. Kharasch, and R. A. Zager. “Spectrum and subcellular determinants of fluorinated anesthetic-mediated proximal tubular injury.” Am J Pathol 150, no. 6 (June 1997): 2209–21.
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  - Karl, H. W., P. Milgrom, P. Domoto, E. D. Kharasch, S. E. Coldwell, P. Weinstein, B. Leroux, K. Awamura, and D. Mautz. “Pharmacokinetics of oral triazolam in children.” J Clin Psychopharmacol 17, no. 3 (June 1997): 169–72. https://doi.org/10.1097/00004714-199706000-00005.
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  - Kharasch, E. D., E. J. Frink, R. Zager, T. A. Bowdle, A. Artru, and W. M. Nogami. “Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.” Anesthesiology 86, no. 6 (June 1997): 1238–53. https://doi.org/10.1097/00000542-199706000-00004.
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  - Hankins, D. C., and E. D. Kharasch. “Determination of the halothane metabolites trifluoroacetic acid and bromide in plasma and urine by ion chromatography.” J Chromatogr B Biomed Sci Appl 692, no. 2 (May 9, 1997): 413–18. https://doi.org/10.1016/s0378-4347(96)00527-0.
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  - Spracklin, D. K., D. C. Hankins, J. M. Fisher, K. E. Thummel, and E. D. Kharasch. “Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.” J Pharmacol Exp Ther 281, no. 1 (April 1997): 400–411.
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  - Baxter, P. J., and E. D. Kharasch. “Erratum: Rehydration of desiccated baralyme prevents carbon monoxide formation from desflurance in an anesthesia machine (Anesthesiology (1997) 86 (1061-1065)).” Anesthesiology 87, no. 3 (January 1, 1997): 729.
  - Baxter, P. J., and E. D. Kharasch. “Rehydration of desiccated baralyme prevents carbon monoxide formation from desflurane in an anesthesia machine.” Anesthesiology 86, no. 5 (January 1, 1997): 1061–65. https://doi.org/10.1097/00000542-199705000-00009.
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  - Kharasch, E. D. “Cytochrome P450 and volatile anesthetic metabolism: From benchtop to bedside.” Anesthesia and Resuscitation 33, no. 1 (January 1, 1997): 65–72.
  - Kharasch, E. D. “Pharmacovigilance and safety aspects of sevoflurane.” Acta Anaesthesiol Scand Suppl 111 (1997): 146–48.
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  - Kharasch, E. D., D. Thorning, K. Garton, D. C. Hankins, and C. G. Kilty. “Role of renal cysteine conjugate beta-lyase in the mechanism of compound A nephrotoxicity in rats.” Anesthesiology 86, no. 1 (January 1997): 160–71. https://doi.org/10.1097/00000542-199701000-00020.
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  - Bowdle, T. A., A. D. Radant, D. S. Cowley, E. D. Kharasch, and P. P. Roy-Byrne. “Psychotomimetic effects of subanesthetic doses of ketamine: Dose versus effect relationships.” Proceedings of the Western Pharmacology Society 39 (December 1, 1996): 95.
  - Kharasch, E. D. “Renal metabolism and factors affecting the degradation of sevoflurane.” Acta Anaesthesiologica Scandinavica, Supplement 40, no. 109 (December 1, 1996).
  - Spracklin, D. K., K. E. Thummel, and E. D. Kharasch. “Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4.” Drug Metab Dispos 24, no. 9 (September 1996): 976–83.
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  - Kharasch, E. D., and D. C. Hankins. “P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.” Drug Metab Dispos 24, no. 6 (June 1996): 649–54.
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  - Rooke, G. A., T. Ebert, M. Muzi, and E. D. Kharasch. “The hemodynamic and renal effects of sevoflurane and isoflurane in patients with coronary artery disease and chronic hypertension. Sevoflurane Ischemia Study Group.” Anesth Analg 82, no. 6 (June 1996): 1159–65. https://doi.org/10.1097/00000539-199606000-00010.
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  - Spracklin, D. K., and E. D. Kharasch. “Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.” Chem Res Toxicol 9, no. 4 (June 1996): 696–702. https://doi.org/10.1021/tx9502103.
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  - Kharasch, E. D., D. Hankins, D. Mautz, and K. E. Thummel. “Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis.” Lancet 347, no. 9012 (May 18, 1996): 1367–71. https://doi.org/10.1016/s0140-6736(96)91011-9.
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  - Jin, L., M. R. Davis, E. D. Kharasch, G. A. Doss, and T. A. Baillie. “Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.” Chem Res Toxicol 9, no. 2 (March 1996): 555–61. https://doi.org/10.1021/tx950162m.
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  - Mitra, A. K., K. E. Thummel, T. F. Kalhorn, E. D. Kharasch, J. D. Unadkat, and J. T. Slattery. “Inhibition of sulfamethoxazole hydroxylamine formation by fluconazole in human liver microsomes and healthy volunteers.” Clin Pharmacol Ther 59, no. 3 (March 1996): 332–40. https://doi.org/10.1016/S0009-9236(96)80011-7.
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  - Kharasch, E. D., and M. Sivarajan. “Gastroesophageal perforation after intraoperative transesophageal echocardiography.” Anesthesiology 85, no. 2 (January 1, 1996): 426–28. https://doi.org/10.1097/00000542-199608000-00027.
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  - Garton, K. J., P. Yuen, J. Meinwald, K. E. Thummel, and E. D. Kharasch. “Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.” Drug Metab Dispos 23, no. 12 (December 1995): 1426–30.
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  - Kharasch, E. D. “Biotransformation of sevoflurane.” Anesth Analg 81, no. 6 Suppl (December 1995): S27–38. https://doi.org/10.1097/00000539-199512001-00005.
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  - Yin, H., M. W. Anders, K. R. Korzekwa, L. Higgins, K. E. Thummel, E. D. Kharasch, and J. P. Jones. “Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes.” Proc Natl Acad Sci U S A 92, no. 24 (November 21, 1995): 11076–80. https://doi.org/10.1073/pnas.92.24.11076.
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  - Mitra, A. K., K. E. Thummel, T. F. Kalhorn, E. D. Kharasch, J. D. Unadkat, and J. T. Slattery. “Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo.” Clin Pharmacol Ther 58, no. 5 (November 1995): 556–66. https://doi.org/10.1016/0009-9236(95)90176-0.
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  - DeLima, L. G., E. D. Kharasch, and S. Butler. “Successful pharmacologic treatment of massive atenolol overdose: sequential hemodynamics and plasma atenolol concentrations.” Anesthesiology 83, no. 1 (July 1995): 204–7. https://doi.org/10.1097/00000542-199507000-00025.
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  - Tinker, J. H., and M. T. Baker. “Sevoflurane, fluoride ion, and renal toxicity.” Anesthesiology 83, no. 1 (July 1995): 232–35. https://doi.org/10.1097/00000542-199507000-00047.
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  - Kharasch, E. D., A. S. Armstrong, K. Gunn, A. Artru, K. Cox, and M. D. Karol. “Clinical sevoflurane metabolism and disposition. II. The role of cytochrome P450 2E1 in fluoride and hexafluoroisopropanol formation.” Anesthesiology 82, no. 6 (June 1995): 1379–88. https://doi.org/10.1097/00000542-199506000-00009.
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  - Kharasch, E. D., M. D. Karol, C. Lanni, and R. Sawchuk. “Clinical sevoflurane metabolism and disposition. I. Sevoflurane and metabolite pharmacokinetics.” Anesthesiology 82, no. 6 (June 1995): 1369–78. https://doi.org/10.1097/00000542-199506000-00008.
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  - Jin, L., T. A. Baillie, M. R. Davis, and E. D. Kharasch. “Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.” Biochem Biophys Res Commun 210, no. 2 (May 16, 1995): 498–506. https://doi.org/10.1006/bbrc.1995.1688.
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  - Labroo, R. B., K. E. Thummel, K. L. Kunze, T. Podoll, W. F. Trager, and E. D. Kharasch. “Catalytic role of cytochrome P4503A4 in multiple pathways of alfentanil metabolism.” Drug Metab Dispos 23, no. 4 (April 1995): 490–96.
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  - Kharasch, E. D., D. C. Hankins, and K. E. Thummel. “Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.” Anesthesiology 82, no. 3 (March 1995): 689–99. https://doi.org/10.1097/00000542-199503000-00011.
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  - Labroo, R., and E. D. Kharasch. “Gas chromatographic-mass spectrometric analysis of alfentanil metabolites. Application to human liver microsomal alfentanil biotransformation.” J Chromatogr B Biomed Appl 660, no. 1 (October 3, 1994): 85–94. https://doi.org/10.1016/0378-4347(94)00263-0.
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  - Mautz, D. S., R. Labroo, and E. D. Kharasch. “Determination of alfentanil and noralfentanil in human plasma by gas chromatography-mass spectrometry.” J Chromatogr B Biomed Appl 658, no. 1 (August 5, 1994): 149–53. https://doi.org/10.1016/0378-4347(94)00201-0.
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  - Kharasch, E. D., K. E. Thummel, D. Mautz, and S. Bosse. “Clinical enflurane metabolism by cytochrome P450 2E1.” Clin Pharmacol Ther 55, no. 4 (April 1994): 434–40. https://doi.org/10.1038/clpt.1994.53.
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  - Kharasch, E. D., and K. E. Thummel. “Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.” Anesthesiology 79, no. 4 (October 1993): 795–807. https://doi.org/10.1097/00000542-199310000-00023.
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  - Kharasch, E. D., K. E. Thummel, J. Mhyre, and J. H. Lillibridge. “Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1.” Clin Pharmacol Ther 53, no. 6 (June 1993): 643–50. https://doi.org/10.1038/clpt.1993.85.
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  - Kharasch, E. D., and K. E. Thummel. “Human alfentanil metabolism by cytochrome P450 3A3/4. An explanation for the interindividual variability in alfentanil clearance?” Anesth Analg 76, no. 5 (May 1993): 1033–39. https://doi.org/10.1213/00000539-199305000-00022.
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  - Thummel, K. E., E. D. Kharasch, T. Podoll, and K. Kunze. “Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1.” Drug Metab Dispos 21, no. 2 (1993): 350–57.
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  - Kharasch, E. D., S. Herrmann, and R. Labroo. “Ketamine as a probe for medetomidine stereoisomer inhibition of human liver microsomal drug metabolism.” Anesthesiology 77, no. 6 (December 1992): 1208–14. https://doi.org/10.1097/00000542-199212000-00023.
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  - Kharasch, E. D., and R. Labroo. “Metabolism of ketamine stereoisomers by human liver microsomes.” Anesthesiology 77, no. 6 (December 1992): 1201–7. https://doi.org/10.1097/00000542-199212000-00022.
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  - Maves, K. K., and J. M. Weiler. “Angioedema of the tongue--cause?” Anesth Analg 75, no. 4 (October 1992): 645–46. https://doi.org/10.1213/00000539-199210000-00051.
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  - Du Pen, Stuart L., Evan D. Kharasch, Anna Williams, Donald G. Peterson, Dean C. Sloan, Hans Hasche-Klunder, and Alexander W. Krembs. “Chronic epidural bupivacaine-opioid infusion in intractable cancer pain.” Pain 49, no. 3 (June 1992): 293–300. https://doi.org/10.1016/0304-3959(92)90234-3.
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  - Kharasch, E. D. “Angiotensin-converting enzyme inhibitor-induced angioedema associated with endotracheal intubation.” Anesth Analg 74, no. 4 (April 1992): 602–4. https://doi.org/10.1213/00000539-199204000-00023.
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  - Kharasch, E. D., H. F. Hill, and A. C. Eddy. “Influence of dexmedetomidine and clonidine on human liver microsomal alfentanil metabolism.” Anesthesiology 75, no. 3 (September 1991): 520–24. https://doi.org/10.1097/00000542-199109000-00020.
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  - Kharasch, E. D., and M. Sivarajan. “Aerosol propellant interference with clinical mass spectrometers.” J Clin Monit 7, no. 2 (April 1991): 172–74. https://doi.org/10.1007/BF01618118.
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  - Kharasch, E. D., and T. A. Bowdle. “Hypokalemia before induction of anesthesia and prevention by beta 2 adrenoceptor antagonism.” Anesth Analg 72, no. 2 (February 1991): 216–20. https://doi.org/10.1213/00000539-199102000-00014.
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  - Kharasch, E. D. “Reply.” Canadian Journal of Anaesthesia 37, no. 4 (May 1, 1990): 489. https://doi.org/10.1007/BF03005640.
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  - Kharasch, E. D. “Atrial natriuretic factor and cardiopulmonary bypass (I: Reply).” Canadian Journal of Anaesthesia 37, no. 4 I (January 1, 1990): 489.
  - Kharasch, E. D., K. T. Yeo, M. A. Kenny, and D. W. Amory. “Errata.” Canadian Journal of Anaesthesia 37, no. 1 (January 1, 1990): 147. https://doi.org/10.1007/BF03007501.
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  - Slattery, J. T., T. I. McRorie, R. Reynolds, T. F. Kalhorn, E. D. Kharasch, and A. C. Eddy. “Lack of effect of cimetidine on acetaminophen disposition in humans.” Clin Pharmacol Ther 46, no. 5 (November 1989): 591–97. https://doi.org/10.1038/clpt.1989.190.
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  - Kharasch, E. D., K. T. Yeo, M. A. Kenny, and D. W. Amory. “Influence of hypothermic cardiopulmonary bypass on atrial natriuretic factor levels.” Can J Anaesth 36, no. 5 (September 1989): 545–53. https://doi.org/10.1007/BF03005384.
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  - Kharasch, E. D., K. T. Yeo, M. A. Kenny, and C. W. Buffington. “Atrial natriuretic factor may mediate the renal effects of PEEP ventilation.” Anesthesiology 69, no. 6 (December 1988): 862–69. https://doi.org/10.1097/00000542-198812000-00010.
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  - Novak, R. F., E. D. Kharasch, and N. K. Wendel. “Nitrofurantoin-stimulated proteolysis in human erythrocytes: a novel index of toxic insult by nitroaromatics.” J Pharmacol Exp Ther 247, no. 2 (November 1988): 439–44.
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  - Rooke, G. A., and E. D. Kharasch. “Left ventricular free wall rupture in acute myocardial infarction-a spectrum of severity.” Journal of Cardiothoracic Anesthesia 2, no. 2 (January 1, 1988): 218–22. https://doi.org/10.1016/0888-6296(88)90275-X.
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  - Kharasch, E. D., N. K. Wendel, and R. F. Novak. “Anthracenedione antineoplastic agent effects on drug metabolism in vitro and in vivo: relationship between structure and mechanism of inhibition.” Fundam Appl Toxicol 9, no. 1 (July 1987): 18–25. https://doi.org/10.1016/0272-0590(87)90149-7.
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  - Kharasch, E. D., and R. F. Novak. “Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation.” J Biol Chem 260, no. 19 (September 5, 1985): 10645–52.
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  - Novak, R. F., and E. D. Kharasch. “Mitoxantrone: propensity for free radical formation and lipid peroxidation--implications for cardiotoxicity.” Invest New Drugs 3, no. 2 (1985): 95–99. https://doi.org/10.1007/BF00174155.
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  - Kharasch, E. D., and R. F. Novak. “Spectroscopic evidence for anthracenedione antineoplastic agent self-association and complex formation with flavin nucleotides.” Arch Biochem Biophys 234, no. 2 (November 1, 1984): 497–512. https://doi.org/10.1016/0003-9861(84)90297-2.
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  - Kharasch, E. D., and R. F. Novak. “Inhibitory effects of anthracenedione antineoplastic agents on hepatic and cardiac lipid peroxidation.” J Pharmacol Exp Ther 226, no. 2 (August 1983): 500–506.
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  - Kharasch, E. D., and R. F. Novak. “Bis(alkylamino)anthracenedione antineoplastic agent metabolic activation by NADPH-cytochrome P-450 reductase and NADH dehydrogenase: diminished activity relative to anthracyclines.” Arch Biochem Biophys 224, no. 2 (July 15, 1983): 682–94. https://doi.org/10.1016/0003-9861(83)90256-4.
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  - Kharasch, E. D., and R. F. Novak. “Inhibition of adriamycin-stimulated microsomal lipid peroxidation by mitoxantrone and ametantrone, two new anthracenedione antineoplastic agents.” Biochem Biophys Res Commun 108, no. 3 (October 15, 1982): 1346–52. https://doi.org/10.1016/0006-291x(82)92148-9.
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  - Kharasch, E. D., and R. F. Novak. “Inhibition of microsomal oxidative drug metabolism by 1,4-bis (2-[(2-hydroxyethyl)amino]-ethylamino)-9,10-anthracenedione diacetate, a new antineoplastic agent.” Mol Pharmacol 22, no. 2 (September 1982): 471–78.
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  - Kharasch, E., N. I. Cook, and R. F. Novak. “Anthracenedione antineoplastic agent inhibition of microsomal drug metabolism.” Federation Proceedings 41, no. 5 (January 1, 1982): 7611.
  - Kharasch, E. D., and R. F. Novak. “The molecular basis for complexation of adriamycin with flavin mononucleotide and flavin adenine dinucleotide.” Arch Biochem Biophys 212, no. 1 (November 1981): 20–36. https://doi.org/10.1016/0003-9861(81)90339-8.
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  - Kharasch, E. D., and R. F. Novak. “Anthracenedione activation by NADPH-cytochrome P-450 reductase; comparison with anthracyclines.” Biochem Pharmacol 30, no. 20 (October 1981): 2881–84. https://doi.org/10.1016/0006-2952(81)90433-0.
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  - Kharasch, E. D., A. M. Mellow, and E. M. Silinsky. “Intracellular magnesium does not antagonize calcium-dependent acetylcholine secretion.” J Physiol 314 (May 1981): 255–63. https://doi.org/10.1113/jphysiol.1981.sp013705.
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  - Kharasch, E. D., and R. F. Novak. “Flavin mononucleotide complexation with dihydroxyanthraquinone, a new antineoplastic agent.” Biophysical Journal 33, no. 2 II (January 1, 1981).
  - Kharasch, E. D., and R. F. Novak. “Comparative metabolism of anthracycline and anthracenedione antineoplastic agents.” Pharmacologist 23, no. 3 (January 1, 1981).
  - Kharasch, E. D., and R. F. Novak. “Ring current effects in adriamycin-flavin mononucleotide complexation as observed by 1H FT NMR spectroscopy.” Biochem Biophys Res Commun 92, no. 4 (February 27, 1980): 1320–26. https://doi.org/10.1016/0006-291x(80)90430-1.
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  - Kharasch, E. D., and R. F. Novak. “³¹P FT NMR analysis of adriamycin-induced alteration in cardiac energy metabolism.” Federation Proceedings 38, no. 3 I (January 1, 1979).
- Book Sections
  - Meissner, K., and E. D. Kharasch. “Pain and anesthesia.” In Principles of Pharmacogenetics and Pharmacogenomics, 224–37, 2012. https://doi.org/10.1017/CBO9781139051194.023.
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  - Davis, P. J., A. Bosenberg, A. Davidson, N. Jimenez, E. Kharasch, A. M. Lynn, S. P. Tofovic, and S. Woelfel. “Pharmacology of Pediatric Anesthesia.” In Smith’s Anesthesia for Infants and Children, 179–261, 2011. https://doi.org/10.1016/B978-0-323-06612-9.00007-9.
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  - Davis, P. J., A. Bosenberg, A. Davidson, N. Jimenez, E. Kharasch, A. M. Lynn, S. P. Tofovic, and S. Woelfel. “Pharmacology of Pediatric Anesthesia.” In Smith’s Anesthesia for Infants and Children: Expert Consult Premium Edition - Enhanced Online Features and Print, 179–261, 2011. https://doi.org/10.1016/B978-0-323-06612-9.00007-9.
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  - Kharasch, E. D. “Volatile anesthetics: Organ toxicity.” In Complications in Anesthesia, 66–68, 2007. https://doi.org/10.1016/B978-1-4160-2215-2.50022-3.
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  - Kharasch, E. D. “Volatile Anesthetics: Organ Toxicity.” In Complications in Anesthesia, 66–68, 2006. https://doi.org/10.1016/B978-1-4160-2215-2.50022-3.
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- Conference Papers
  - Jiang, Q., Y. J. Chandar, S. Cao, E. D. Kharasch, S. Singamaneni, and J. J. Morrissey. “Rapid, point-of-care, thermally stable paper-based plasmonic assay for Zika virus diagnosis.” In Optics Infobase Conference Papers, Vol. Part F58-Sensors 2017, 2017. https://doi.org/10.1364/SENSORS.2017.SeTu1E.2.
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  - Wang, C., J. J. Morrissey, E. D. Kharasch, and S. Singamaneni. “Plasmonic biosensors in resource-limited settings.” In Optics Infobase Conference Papers, Vol. Part F58-Sensors 2017, 2017. https://doi.org/10.1364/SENSORS.2017.SeTu1E.6.
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  - Benzinger, Tammie L. S., David Brody, Sylvain Cardin, Kenneth C. Curley, Mark A. Mintun, Seong K. Mun, Kenneth H. Wong, and Jean R. Wrathall. “Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. Louis workshop.” In J Neurotrauma, 26:2127–44, 2009. https://doi.org/10.1089/neu.2009.0885.
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  - Kharasch, E. D. “Special issue on pharmacogenomics and anesthesia: Work Presented at the 2004 Journal Symposium.” In Anesthesiology, 102:493–94, 2005. https://doi.org/10.1097/00000542-200503000-00002.
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  - Klees, Theresa Mariero, Pamela Sheffels, Kenneth E. Thummel, and Evan D. Kharasch. “Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.” In Anesthesiology, 102:550–56, 2005. https://doi.org/10.1097/00000542-200503000-00012.
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  - Yao, Caiping, Kent L. Kunze, William F. Trager, Evan D. Kharasch, and René H. Levy. “Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19.” In Drug Metab Dispos, 31:565–71, 2003. https://doi.org/10.1124/dmd.31.5.565.
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  - Gonzalez, T. G., C. Jubert, M. Emery, K. E. Thummel, and E. D. Kharasch. “Mechanism of disulfiram inhibition of P450 2E1 in human liver microsomes.” In Journal of Investigative Medicine, Vol. 47, 1999.
  - Kharasch, E. D. “Metabolism and toxicity of the new anesthetic agents.” In Acta Anaesthesiol Belg, 47:7–14, 1996.
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