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Evan Kharasch

Merel H. Harmel Distinguished Professor of Anesthesiology
Anesthesiology, General, Vascular, High Risk Transplant & Critical Care
Box 3094, Anesthesiology, Durham, NC 27710
Department of Anesthesiology, Box 3094, 905 S. LaSalle, GSRB1 Room 2031, Durham, NC 27710

Current Appointments & Affiliations


Merel H. Harmel Distinguished Professor of Anesthesiology · 2019 - Present Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology

In the News


Published November 16, 2023
Which Duke Scholars Made the Most Cited List?
Published May 7, 2019
Duke Adds 21 Faculty to Distinguished Faculty Rank

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Recent Publications


The Nine Lives of Ketamine: From CI-581 to Present Day Clinical Application-Commentary on Domino et al.

Journal Article Clinical pharmacology and therapeutics · June 2025 The classic article by Domino et al. was the first clinical report and presented the first-in-human study of what would become the drug ketamine. Ketamine has become an analgesic, anesthetic, antidepressant, and drug of misuse. It remains today the only "d ... Full text Cite

Evaluating respiratory depression after methadone administration in surgical patients: protocol for a systematic review and meta-analysis.

Journal Article BMJ open · May 2025 IntroductionMethadone has emerged as a promising option for perioperative pain management, primarily due to its rapid onset of action and prolonged duration of effect, which provides sustained analgesic benefits. Despite its clinical advantages an ... Full text Cite
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Recent Grants


Revolutionizing Pediatric Tonsillectomy Pharmacology and Therapeutics

ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2024 - 2029

Optimizing Pain Management in Infants and Young Children Undergoing Cleft Palate Repair

ResearchCo Investigator · Awarded by Gerber Foundation · 2026 - 2028

Integrated Training in Anesthesiology Research

Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2026

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Education, Training & Certifications


Northwestern University · 1984 M.D.
Northwestern University · 1983 Ph.D.