Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis.

Journal Article (Clinical Trial;Journal Article)

OBJECTIVE: To analyze headache patterns prior to and following treatment of unruptured intracranial aneurysms and identify factors associated with different headache outcomes. METHODS: A prospective observational study of patients being treated for unruptured intracranial aneurysms. Headache patterns were established prior to aneurysm treatment and for 6 months following treatment. Factors associated with different headache outcomes were investigated. RESULTS: In all patients (n = 44), 90-day headache frequency decreased from an average of 31 days prior to aneurysm treatment to 17 days following treatment (p < 0.001). In patients with active pretreatment headaches (n = 28), 90-day headache frequency decreased from 49 days to 26 days (p = 0.002). Headache frequency was reduced in 68% of patients, while 9% of patients had new or worsened headaches following aneurysm treatment. Pretreatment migraine, more severe pretreatment headaches, higher pretreatment trait anxiety, and stent-assisted aneurysm coiling were associated with a lack of headache improvement. CONCLUSIONS: The majority of patients with headaches at the time of aneurysm treatment had reductions in headache frequency during the 6 months following treatment. Potential risk factors for poor headache outcomes were identified but need to be studied further.

Full Text

Duke Authors

Cited Authors

  • Schwedt, TJ; Gereau, RW; Frey, K; Kharasch, ED

Published Date

  • July 2011

Published In

Volume / Issue

  • 31 / 10

Start / End Page

  • 1082 - 1089

PubMed ID

  • 21398420

Pubmed Central ID

  • PMC3593349

Electronic International Standard Serial Number (EISSN)

  • 1468-2982

Digital Object Identifier (DOI)

  • 10.1177/0333102411398155


  • eng

Conference Location

  • England