Adiposity in juvenile psoriatic arthritis
Copyright © 2018 The Journal of Rheumatology. All rights reserved. Objective. Adult patients with psoriatic arthritis are at increased risk for obesity and metabolic syndrome, but data regarding adiposity in children with juvenile psoriatic arthritis (JPsA) are limited. Our study assessed adiposity in children with JPsA in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry. Methods. Patients with JPsA in the CARRA registry were divided into nonoverweight and overweight groups using recommendations from the US Centers for Disease Control, and differences in demographic and clinical characteristics between groups at baseline and after 1-year followup were assessed using chi-square test, Fisher's exact test, T test, or Mann-Whitney U test, as appropriate. The prevalence of overweight status in the JPsA registry patients was compared to rheumatoid factor-positive and -negative polyarticular juvenile idiopathic arthritis (RF+polyJIA; RF-polyJIA) registry cohorts and the US pediatric population, using a chi-square goodness-of-fit test. Results. Overweight children represented 36.3% of this JPsA cohort (n = 320). Compared to nonoverweight children, they were significantly older at symptom onset and rheumatologist's first assessment, and scored significantly worse on patient/physician outcome measures. At 1-year followup, changes in body mass index were not associated with changes in clinical features or outcome measures. The prevalence of overweight and obesity in patients with JPsA was significantly higher than in RF+polyJIA patients, RF-polyJIA patients, and the US pediatric population. Conclusion. In this registry, almost 1 in 5 patients with JPsA were obese and more than one-third were overweight. This is significantly more than expected compared to the US pediatric population, and appropriate longterm followup of this JPsA subgroup is warranted.
Samad, A; Stoll, ML; Lavi, I; Hsu, JJ; Strand, V; Robinson, TN; Mellins, ED; Zisman, D; Abramson, L; Anderson, E; Andrew, M; Battle, N; Becker, M; Benham, H; Beukelman, T; Birmingham, J; Blier, P; Brown, A; Brunner, H; Cabrera, A; Canter, D; Carlton, D; Caruso, B; Ceracchio, L; Chalom, E; Chang, J; Charpentier, P; Clark, K; Dean, J; Dedeoglu, F; Feldman, B; Ferguson, P; Fox, M; Francis, K; Gervasini, M; Goldsmith, D; Gorton, G; Gottlieb, B; Graham, T; Griffin, T; Grosbein, H; Guppy, S; Haftel, H; Helfrich, D; Higgins, G; Hillard, A; Hollister, JR; Hsu, J; Hudgins, A; Hung, C; Huttenlocher, A; Ilowite, N; Imlay, A; Imundo, L; Inman, CJ; Jaqith, J; Jerath, R; Jung, L; Kahn, P; Kapedani, A; Kingsbury, D; Klein, K; Klein-Gitelman, M; Kunkel, A; Lapidus, S; Layburn, S; Lehman, T; Lindsley, C; MacGregor-Hannah, M; Malloy, M; Mawhorter, C; McCurdy, D; Mims, K; Moorthy, N; Morus, D; Muscal, E; Natter, M; Olson, J; O'Neil, K; Onel, K; Orlando, M; Palmquist, J; Phillips, M; Ponder, L; Prahalad, S; Punaro, M; Puplava, D; Quinn, S; Quintero, A; Rabinovich, C; Reed, A; Reed, C; Ringold, S; Riordan, M; Roberson, S; Robinson, A; Rossette, J; Rothman, D; Russo, D; Ruth, N
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