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Progression of Treated versus Untreated Liver Imaging Reporting and Data System Category 4 Masses after Transcatheter Arterial Embolization Therapy.

Publication ,  Journal Article
Ronald, J; Gupta, RT; Marin, D; Wang, Q; Durocher, NS; Suhocki, PV; Kim, CY
Published in: J Vasc Interv Radiol
May 2018

PURPOSE: To compare outcomes of treated vs untreated Liver Imaging Reporting and Data System category 4 (LR-4) masses after transcatheter arterial embolization. MATERIALS AND METHODS: In 167 patients undergoing embolization for HCC from January 2005 to December 2012, LR-4 masses were retrospectively identified on CT and MR imaging examinations performed before embolization. In 149 patients undergoing embolization from January 2013 to December 2016, masses prospectively classified as LR-4 were identified. In total, there were 81 LR-4 masses in 62 patients (16 women; mean age 62 y; range 29-83 y). Procedures were reviewed to determine whether LR-4 masses were within or outside the liver volume that received embolization during treatment of dominant masses. Time to progression to LR-5 and by modified Response Evaluation Criteria in Solid Tumors (mRECIST) was estimated for treated vs untreated LR-4 masses using the Kaplan-Meier method and compared using the log rank test. RESULTS: LR-4 masses averaged 1.8 cm; 88%, 60%, 14%, and 14% demonstrated arterial phase hyperenhancement, washout, a capsule, and growth. Of LR-4 masses, 62 were within the liver volume that received embolization and considered treated, and 19 were outside and considered untreated. Response rates according to mRECIST were 37% vs 21% for treated vs untreated masses (P = .27). The 6- and 12-month rates of progression to LR-5 were 7% and 26% for treated masses vs 27% and 75% for untreated masses (P = .001). According to mRECIST, 7% and 27% of treated masses progressed vs 30% and 65% of untreated masses (P = .001). CONCLUSIONS: LR-4 masses that receive embolization in the setting of dominant masses elsewhere show lower rates of progression compared with untreated masses.

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Published In

J Vasc Interv Radiol

DOI

EISSN

1535-7732

Publication Date

May 2018

Volume

29

Issue

5

Start / End Page

598 / 606

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ronald, J., Gupta, R. T., Marin, D., Wang, Q., Durocher, N. S., Suhocki, P. V., & Kim, C. Y. (2018). Progression of Treated versus Untreated Liver Imaging Reporting and Data System Category 4 Masses after Transcatheter Arterial Embolization Therapy. J Vasc Interv Radiol, 29(5), 598–606. https://doi.org/10.1016/j.jvir.2017.11.027
Ronald, James, Rajan T. Gupta, Daniele Marin, Qi Wang, Nicholas S. Durocher, Paul V. Suhocki, and Charles Y. Kim. “Progression of Treated versus Untreated Liver Imaging Reporting and Data System Category 4 Masses after Transcatheter Arterial Embolization Therapy.J Vasc Interv Radiol 29, no. 5 (May 2018): 598–606. https://doi.org/10.1016/j.jvir.2017.11.027.
Ronald J, Gupta RT, Marin D, Wang Q, Durocher NS, Suhocki PV, et al. Progression of Treated versus Untreated Liver Imaging Reporting and Data System Category 4 Masses after Transcatheter Arterial Embolization Therapy. J Vasc Interv Radiol. 2018 May;29(5):598–606.
Ronald, James, et al. “Progression of Treated versus Untreated Liver Imaging Reporting and Data System Category 4 Masses after Transcatheter Arterial Embolization Therapy.J Vasc Interv Radiol, vol. 29, no. 5, May 2018, pp. 598–606. Pubmed, doi:10.1016/j.jvir.2017.11.027.
Ronald J, Gupta RT, Marin D, Wang Q, Durocher NS, Suhocki PV, Kim CY. Progression of Treated versus Untreated Liver Imaging Reporting and Data System Category 4 Masses after Transcatheter Arterial Embolization Therapy. J Vasc Interv Radiol. 2018 May;29(5):598–606.
Journal cover image

Published In

J Vasc Interv Radiol

DOI

EISSN

1535-7732

Publication Date

May 2018

Volume

29

Issue

5

Start / End Page

598 / 606

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Retrospective Studies
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Humans
  • Female