Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity.
Publication
, Journal Article
Dong, M; Chen, X-Q; Chen, C-H; Li, R-T
Published in: Chem Biodivers
May 2018
Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3β-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α,16α,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC50 = 1.38 μm).
Duke Scholars
Published In
Chem Biodivers
DOI
EISSN
1612-1880
Publication Date
May 2018
Volume
15
Issue
5
Start / End Page
e1700560
Location
Switzerland
Related Subject Headings
- Virus Replication
- Terpenes
- Structure-Activity Relationship
- Molecular Structure
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- Humans
- HIV-1
- Euphorbia
- Dose-Response Relationship, Drug
Citation
APA
Chicago
ICMJE
MLA
NLM
Dong, M., Chen, X.-Q., Chen, C.-H., & Li, R.-T. (2018). Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity. Chem Biodivers, 15(5), e1700560. https://doi.org/10.1002/cbdv.201700560
Dong, Miao, Xuan-Qin Chen, Chin-Ho Chen, and Rong-Tao Li. “Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity.” Chem Biodivers 15, no. 5 (May 2018): e1700560. https://doi.org/10.1002/cbdv.201700560.
Dong M, Chen X-Q, Chen C-H, Li R-T. Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity. Chem Biodivers. 2018 May;15(5):e1700560.
Dong, Miao, et al. “Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity.” Chem Biodivers, vol. 15, no. 5, May 2018, p. e1700560. Pubmed, doi:10.1002/cbdv.201700560.
Dong M, Chen X-Q, Chen C-H, Li R-T. Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity. Chem Biodivers. 2018 May;15(5):e1700560.
Published In
Chem Biodivers
DOI
EISSN
1612-1880
Publication Date
May 2018
Volume
15
Issue
5
Start / End Page
e1700560
Location
Switzerland
Related Subject Headings
- Virus Replication
- Terpenes
- Structure-Activity Relationship
- Molecular Structure
- Microbial Sensitivity Tests
- Medicinal & Biomolecular Chemistry
- Humans
- HIV-1
- Euphorbia
- Dose-Response Relationship, Drug