Terpenes from Euphorbia antiquorum and Their in Vitro Anti-HIV Activity.

Published

Journal Article

Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3β-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α,16α,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC50 = 1.38 μm).

Full Text

Duke Authors

Cited Authors

  • Dong, M; Chen, X-Q; Chen, C-H; Li, R-T

Published Date

  • May 2018

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • e1700560 -

PubMed ID

  • 29569369

Pubmed Central ID

  • 29569369

Electronic International Standard Serial Number (EISSN)

  • 1612-1880

Digital Object Identifier (DOI)

  • 10.1002/cbdv.201700560

Language

  • eng

Conference Location

  • Switzerland