Real-World Simulation of an Alternative Retinopathy of Prematurity Screening System in Thailand: A Pilot Study.

Journal Article (Journal Article)

PURPOSE: To evaluate an alternative retinopathy of prematurity (ROP) screening system that identifies infants meriting examination by an ophthalmologist in a middle-income country. METHODS: The authors hypothesized that grading posterior pole images for the presence of pre-plus or plus disease has high sensitivity to identify infants with type 1 ROP that requires treatment. Part 1 of the study evaluated the feasibility of having a non-ophthalmologist health care worker obtain retinal images of prematurely born infants using a non-contact retinal camera (Pictor; Volk Optical, Inc., Mentor, OH) that were of sufficient quality to grade for pre-plus or plus disease. Part 2 investigated the accuracy of grading these images to identify infants with type 1 ROP. The authors prospectively recruited infants at Chulalongkorn University Hospital (Bangkok, Thailand). On days infants underwent routine ROP screening, a trained health care worker imaged their retinas with Pictor. Two ROP experts graded these serial images from a remote location for image gradability and posterior pole disease. RESULTS: Fifty-six infants were included. Overall, 69.4% of infant imaging sessions were gradable. Among gradable images, the sensitivity of both graders for identifying an infant with type 1 ROP by grading for the presence of pre-plus or plus disease was 1.0 (95% confidence interval [CI]: 0.31 to 1.0) for grader 1 and 1.0 (95% CI: 0.40 to 1.0) for grader 2. The specificity was 0.93 (95% CI: 0.76 to 0.99) for grader 1 and 0.74 (95% CI: 0.53 to 0.88) for grader 2. CONCLUSIONS: It was feasible for a trained non-ophthalmologist health care worker to obtain retinal images of infants using the Pictor that were of sufficient quality to identify infants with type 1 ROP. [J Pediatr Ophthalmol Strabismus. 2018;55(4):245-253.].

Full Text

Duke Authors

Cited Authors

  • Prakalapakorn, SG; Freedman, SF; Hutchinson, AK; Saehout, P; Cetinkaya-Rundel, M; Wallace, DK; Kulvichit, K

Published Date

  • July 1, 2018

Published In

Volume / Issue

  • 55 / 4

Start / End Page

  • 245 - 253

PubMed ID

  • 29809267

Pubmed Central ID

  • PMC6482815

Electronic International Standard Serial Number (EISSN)

  • 1938-2405

Digital Object Identifier (DOI)

  • 10.3928/01913913-20180327-04


  • eng

Conference Location

  • United States