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Atrial fibrillation in an African-American cohort: The Jackson Heart Study.

Publication ,  Journal Article
Austin, TR; Wiggins, KL; Blackshear, C; Yang, Y; Benjamin, EJ; Curtis, LH; Sotoodehnia, N; Correa, A; Heckbert, SR
Published in: Clin Cardiol
August 2018

BACKGROUND: Atrial fibrillation (AF) is an important public health problem across race/ethnic groups. Data from US cohort studies initiated in the 1980s suggest a higher prevalence of AF risk factors among African-Americans (AAs) than whites, but lower AF incidence. The Jackson Heart Study (JHS) is a community-based study of 5306 AAs recruited starting in 2000. HYPOTHESIS: Demographic, anthropometric, cardiovascular, and/or electrocardiographic factors are associated with AF incidence in JHS. METHODS: Using baseline participant characteristics and incident AF identified through hospital surveillance, study electrocardiogram, and Medicare claims, we estimated age- and sex-specific AF incidence rates, compared them with rates in AA participants in the Multi-Ethnic Study of Atherosclerosis (MESA) and Cardiovascular Health Study (CHS), and examined associations of cardiovascular risk factors with AF. RESULTS: A total of 66 participants had prevalent AF at baseline. Over an average follow-up of 8.5 years, 242 cases of incident AF were identified. Age- and sex-specific AF incidence rates in JHS were similar to those among AAs in MESA and appeared slightly lower than those among AAs in CHS. In an age- and sex-adjusted model, associations with incident AF were observed for modifiable risk factors: high body weight (HR = 1.23 per 15 kg, 95%CI 1.13-1.35), systolic blood pressure (HR = 1.29 per 20 mmHg, 95%CI 1.13-1.47), and current smoking (HR = 1.80, 95%CI 1.27-2.55). Risk estimates associated with these risk factors were only slightly attenuated after multivariable adjustments. CONCLUSIONS: These findings underscore the potential additional benefits of interventions for weight management, control of hypertension, and smoking cessation for the prevention of AF among AAs.

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Published In

Clin Cardiol

DOI

EISSN

1932-8737

Publication Date

August 2018

Volume

41

Issue

8

Start / End Page

1049 / 1054

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Prognosis
  • Prevalence
  • Middle Aged
  • Male
  • Incidence
  • Humans
 

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Austin, T. R., Wiggins, K. L., Blackshear, C., Yang, Y., Benjamin, E. J., Curtis, L. H., … Heckbert, S. R. (2018). Atrial fibrillation in an African-American cohort: The Jackson Heart Study. Clin Cardiol, 41(8), 1049–1054. https://doi.org/10.1002/clc.23020
Austin, Thomas R., Kerri L. Wiggins, Chad Blackshear, Yi Yang, Emelia J. Benjamin, Lesley H. Curtis, Nona Sotoodehnia, Adolfo Correa, and Susan R. Heckbert. “Atrial fibrillation in an African-American cohort: The Jackson Heart Study.Clin Cardiol 41, no. 8 (August 2018): 1049–54. https://doi.org/10.1002/clc.23020.
Austin TR, Wiggins KL, Blackshear C, Yang Y, Benjamin EJ, Curtis LH, et al. Atrial fibrillation in an African-American cohort: The Jackson Heart Study. Clin Cardiol. 2018 Aug;41(8):1049–54.
Austin, Thomas R., et al. “Atrial fibrillation in an African-American cohort: The Jackson Heart Study.Clin Cardiol, vol. 41, no. 8, Aug. 2018, pp. 1049–54. Pubmed, doi:10.1002/clc.23020.
Austin TR, Wiggins KL, Blackshear C, Yang Y, Benjamin EJ, Curtis LH, Sotoodehnia N, Correa A, Heckbert SR. Atrial fibrillation in an African-American cohort: The Jackson Heart Study. Clin Cardiol. 2018 Aug;41(8):1049–1054.
Journal cover image

Published In

Clin Cardiol

DOI

EISSN

1932-8737

Publication Date

August 2018

Volume

41

Issue

8

Start / End Page

1049 / 1054

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Prognosis
  • Prevalence
  • Middle Aged
  • Male
  • Incidence
  • Humans