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Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.

Publication ,  Journal Article
Guevara, C; Fernandez, AC; Cardenas, R; Suarez-Roca, H
Published in: Neuroscience letters
March 2015

We evaluated the association between spinal PGE2 and thermal hyperalgesia following repeated stress. Thermal nociception was determined in male Sprague-Dawley rats using the hot-plate test, before and after forced-swimming; non-conditioned rats served as controls. Animals were pretreated with ketoprofen or meloxicam, preferential COX-1 and COX-2 inhibitors, respectively. After the second hot-plate test, we measured serum corticosterone (stress marker), and lumbar spinal PGE2 (neuroinflammation marker) under peripheral inflammation (1% formalin plantar injection). Stressed rats displayed response latencies 40% shorter and inflammatory spinal PGE2 levels 95% higher than controls. Pretreatment with ketoprofen or meloxicam prevented hyperalgesia and elevation of spinal PGE2, increasing the escape behavior time during forced swimming 95% respect to saline-treated rats. Corticosterone levels in stressed rats were 97% higher than controls; COX inhibitors reduced them by 84%. PGE2 could participate in stress-induced hyperalgesia, learned helplessness, and corticosterone production, supporting the use of non-steroidal anti-inflammatory drugs (NSAIDs) for persistent pain associated with chronic stress and depression.

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Published In

Neuroscience letters

DOI

EISSN

1872-7972

ISSN

0304-3940

Publication Date

March 2015

Volume

591

Start / End Page

110 / 114

Related Subject Headings

  • Thiazoles
  • Thiazines
  • Swimming
  • Stress, Psychological
  • Spinal Cord
  • Rats, Sprague-Dawley
  • Meloxicam
  • Male
  • Ketoprofen
  • Hyperalgesia
 

Citation

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Guevara, C., Fernandez, A. C., Cardenas, R., & Suarez-Roca, H. (2015). Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia. Neuroscience Letters, 591, 110–114. https://doi.org/10.1016/j.neulet.2015.02.035
Guevara, Coram, Ana Cristina Fernandez, Ricardo Cardenas, and Heberto Suarez-Roca. “Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.Neuroscience Letters 591 (March 2015): 110–14. https://doi.org/10.1016/j.neulet.2015.02.035.
Guevara C, Fernandez AC, Cardenas R, Suarez-Roca H. Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia. Neuroscience letters. 2015 Mar;591:110–4.
Guevara, Coram, et al. “Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.Neuroscience Letters, vol. 591, Mar. 2015, pp. 110–14. Epmc, doi:10.1016/j.neulet.2015.02.035.
Guevara C, Fernandez AC, Cardenas R, Suarez-Roca H. Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia. Neuroscience letters. 2015 Mar;591:110–114.
Journal cover image

Published In

Neuroscience letters

DOI

EISSN

1872-7972

ISSN

0304-3940

Publication Date

March 2015

Volume

591

Start / End Page

110 / 114

Related Subject Headings

  • Thiazoles
  • Thiazines
  • Swimming
  • Stress, Psychological
  • Spinal Cord
  • Rats, Sprague-Dawley
  • Meloxicam
  • Male
  • Ketoprofen
  • Hyperalgesia