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Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain.

Publication ,  Journal Article
Cano, G; Suárez-Roca, H; Bonilla, E
Published in: Investigacion clinica
December 1996

Manganese (Mn) poisoning is characterized by central nervous system manifestations, including psychiatric disturbances and extrapyramidal disorders. This metal is thought to produce neuronal degeneration due to cytotoxic products originated by oxidative stress and through an indirect excitotoxic process. In previous studies, we have found a reduction in the density of N-methyl-D-aspartate (NMDA) recognition sites in some brain areas of Mn-treated mice. Due to the close relationship between NMDA sites and strychnine-insensitive glycine (Gly) modulatory sites in the NMDA receptor complex, the [3H]-glycine ([3H]-Gly) binding was analyzed by autoradiographic methods in the brain of mice treated with manganese chloride for 8 weeks. Among all analyzed areas, only the globus pallidus showed a significant reduction in [3H]-Gly binding (27-28%). The Gly binding decrease, focalized in the globus pallidus, could reflect a degeneration of structures containing strychnine-insensitive Gly receptors, since this area is the most frequently reported damaged brain region in Mn intoxication. However, it might also be due to a Gly receptor down-regulation to control NMDA complex activation during Mn poisoning.

Duke Scholars

Published In

Investigacion clinica

ISSN

0535-5133

Publication Date

December 1996

Volume

37

Issue

4

Start / End Page

209 / 219

Related Subject Headings

  • Strychnine
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Glycine
  • Mice
  • Manganese Poisoning
  • Manganese
  • Male
  • Globus Pallidus
  • General Clinical Medicine
  • Animals
 

Citation

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MLA
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Cano, G., Suárez-Roca, H., & Bonilla, E. (1996). Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain. Investigacion Clinica, 37(4), 209–219.
Cano, G., H. Suárez-Roca, and E. Bonilla. “Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain.Investigacion Clinica 37, no. 4 (December 1996): 209–19.
Cano G, Suárez-Roca H, Bonilla E. Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain. Investigacion clinica. 1996 Dec;37(4):209–19.
Cano, G., et al. “Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain.Investigacion Clinica, vol. 37, no. 4, Dec. 1996, pp. 209–19.
Cano G, Suárez-Roca H, Bonilla E. Manganese poisoning reduces strychnine-insensitive glycine binding sites in the globus pallidus of the mouse brain. Investigacion clinica. 1996 Dec;37(4):209–219.

Published In

Investigacion clinica

ISSN

0535-5133

Publication Date

December 1996

Volume

37

Issue

4

Start / End Page

209 / 219

Related Subject Headings

  • Strychnine
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, Glycine
  • Mice
  • Manganese Poisoning
  • Manganese
  • Male
  • Globus Pallidus
  • General Clinical Medicine
  • Animals