The junctophilin family of proteins: from bench to bedside.

Journal Article (Journal Article;Review)

Excitable tissues rely on junctional membrane complexes to couple cell surface signals to intracellular channels. The junctophilins have emerged as a family of proteins critical in coordinating the maturation and maintenance of this cellular ultrastructure. Within skeletal and cardiac muscle, junctophilin 1 and junctophilin 2, respectively, couple sarcolemmal and intracellular calcium channels. In neuronal tissue, junctophilin 3 and junctophilin 4 may have an emerging role in coupling membrane neurotransmitter receptors and intracellular calcium channels. These important physiological roles are highlighted by the pathophysiology which results when these proteins are perturbed, and a growing body of literature has associated junctophilins with the pathogenesis of human disease.

Full Text

Duke Authors

Cited Authors

  • Landstrom, AP; Beavers, DL; Wehrens, XHT

Published Date

  • June 2014

Published In

Volume / Issue

  • 20 / 6

Start / End Page

  • 353 - 362

PubMed ID

  • 24636942

Pubmed Central ID

  • PMC4041816

Electronic International Standard Serial Number (EISSN)

  • 1471-499X

Digital Object Identifier (DOI)

  • 10.1016/j.molmed.2014.02.004


  • eng

Conference Location

  • England