Overview
Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart. He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. He also specializes in the evaluation of children following a cardiac arrest or after the sudden and unexplained death of a family member. He has expertise in cardiovascular genetics and uses it to identify individuals in a family who may be at risk of a disease, even if all clinical testing is negative. As a scientist, he is trained in genetics and cell biology. He runs a research lab exploring the genetic and molecular causes of arrhythmias, sudden unexplained death syndromes, and heart muscle disease (cardiomyopathies). He utilizes patient-derived induced pluripotent stem cells and genetic mouse models to identify the mechanisms of cardiovascular genetic disease with the goal of developing novel therapies.
Current Appointments & Affiliations
Recent Publications
Clinical Validity of Autosomal Dominant ALPK3 Loss-of-Function Variants as a Cause of Hypertrophic Cardiomyopathy.
Journal Article Circ Genom Precis Med · April 21, 2025 Full text Link to item CiteDeletion of Exon 51 in a Humanized Duchenne Muscular Dystrophy Mouse Model Abolishes Ventricular Arrhythmia Predisposition.
Journal Article Circulation. Genomic and precision medicine · April 2025 Full text CiteTAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic Cardiomyopathy.
Journal Article Circ Res · March 28, 2025 BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is one of the leading causes of sudden cardiac death in children, young adults, and athletes and is characterized by the fibro-fatty replacement of the myocardium, predominantly of the right ventricle. Sixty ... Full text Link to item CiteRecent Grants
PRIORITY: cardio-laminoPathy: fRom pathomechanIsms tO peRsonalIzed TherapY
ResearchPrincipal Investigator · Awarded by Institute of Myology · 2025 - 2030The North Carolina Congenital Heart Disease Surveillance Network
Public ServiceCollaborating Investigator · Awarded by Centers for Disease Control and Prevention · 2024 - 2029Determining the genetic and social determinants of heart failure and mortality in patients with congenital heart disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2028View All Grants