Andrew Paul Landstrom
Assistant Professor of Pediatrics
I am a pediatric cardiologist and cardiovascular geneticist with both clinical and research interests in the genetic and molecular mechanisms of sudden cardiac arrest in children. As a physician-scientist, I am trained at the confluence of pediatric cardiology, clinical electrophysiology, human genetics, and molecular biology which I apply towards the care for children with heritable arrhythmic disease of the heart. I run a basic science research lab exploring the genetic and molecular causes of sudden cardiac death in children and young adults. These include cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy) and channelopathies (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome). In our lab, we utilize human induced pluripotent stem cells, mouse models, and in vitro cellular models of disease. Further, I have an active translational research interest in the interpretation of cardiovascular genetic testing and clarifying “variants of unknown significance”. Overall, I hope to 1) utilize human genetics and functional genomics to more accurately diagnosis, risk stratify, and treat children and young adults at risk for these diseases and 2) determine the underlying molecular mechanisms of these complex and deadly diseases to identify novel patient-specific therapies.
Current Appointments & Affiliations
- Assistant Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2018
- Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2019
Contact Information
- Duke University Medical Center, Box 2652, Durham, NC 27710
- Duke University Medical Center, Box 2652, Durham, NC 27710
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andrew.landstrom@duke.edu
(919) 684-3028
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Landstrom Lab Website
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ORCiD Profile
- Background
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Education, Training, & Certifications
- Pediatric Cardiology Certification, American Board of Pediatrics 2018 - 2099
- General Pediatrics Certification, American Board of Pediatrics 2015 - 2099
- Advanced Clinical Fellowship, Pediatrics/Electrophysiology, Baylor College of Medicine 2017 - 2018
- Post-Doctoral Research Fellowship, Molecular Physiology And Biophysics, Baylor College of Medicine 2013 - 2018
- Clinical Fellowship, Pediatrics/Cardiology, Baylor College of Medicine 2014 - 2017
- Residency, Pediatrics, Baylor College of Medicine 2013 - 2014
- Internship, Pediatrics, Baylor College of Medicine 2012 - 2013
- M.D., Mayo School of Health Sciences 2012
- Ph.D., Mayo School of Health Sciences 2012
- Recognition
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In the News
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JUN 24, 2019 Duke Children's -
JAN 31, 2019 Duke Dept of Pediatrics -
JAN 23, 2019 Duke Research Blog -
NOV 15, 2018 Duke Dept of Pediatrics -
NOV 9, 2018 Duke Dept of Pediatrics
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Awards & Honors
- Young Investigator Award. American Heart Association, Council on Cardiovascular Disease in the Young. 2018
- Best Poster Award. Baylor College of Medicine 6th Annual Cardiovascular Research Institute Symposium. 2017
- Dan G. McNamara Fellow of the Year Award. Baylor College of Medicine, Dept of Pediatrics, Section of Cardiology. 2017
- Top Abstract Award. Baylor College of Medicine 5th Annual Cardiovascular Research Institute Symposium. 2016
- Outstanding Fellow in Pediatrics. Baylor College of Medicine, Dept of Pediatrics House Officers. 2015
- Adam Cohen Professionalism Award. Baylor College of Medicine, Dept of Pediatrics . 2014
- Distinguished Educator Award. Baylor College of Medicine, Dept of Pediatrics. 2014
- Jan Goddard-Finegold Award in Developmental Pediatrics. Baylor College of Medicine, Dept of Pediatrics. 2014
- Gold Humanism in Medicine Honor Society Inductee. Baylor College of Medicine. 2013
- Expertise
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Subject Headings
- Arrhythmia
- Brugada Syndrome
- Calcium
- Cardiac arrest
- Cardiomyopathy, Dilated
- Cardiomyopathy, Hypertrophic
- Cardiomyopathy, Hypertrophic, Familial
- Death, Sudden
- Electrophysiology
- Gene Silencing
- Genetic Background
- Genetic Carrier Screening
- Genetic Counseling
- Genetic Testing
- Genetic polymorphisms
- Genetics
- Genetics, Medical
- Genomics
- Heart Failure
- Heart failure in children
- Heart--Hypertrophy
- Human chromosome abnormalities--Diagnosis
- Induced Pluripotent Stem Cells
- Long QT Syndrome
- Mutation
- Mutation, Missense
- Myocardium--Diseases
- Pediatric cardiology
- Pediatric cardiology--Diagnosis
- Ryanodine Receptor Calcium Release Channel
- Ryanodine--Receptors
- Sudden infant death syndrome
- Ventricular Fibrillation
- Ventricular Remodeling
- Ventricular tachycardia
- Research
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Selected Grants
- The North Carolina Congenital Heart Disease Surveillance Network 2019 - 2024
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- The Role of Junctophilin Type 2 in Cardiac Node Automaticity awarded by National Institutes of Health 2018 - 2022
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Fellowships, Supported Research, & Other Grants
- In vivo evaluation of novel anti-arrhythmic compounds to terminate potentially fatal tachyarrhythmia awarded by Mike Hogg Fund 2018
- The role of junctophilin-2 in the development of youthful sinus and atrioventricular nodal disease awarded by Pediatric and Congenital Electrophysiology Society 2016 - 2017
- The role of RyR2-Asn4643del in CPVT with emotionally-triggered sudden death awarded by National Institutes of Health 2015 - 2017
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Jones, Edward G., Neda Mazaheri, Reza Maroofian, Mina Zamani, Tahereh Seifi, Alireza Sedaghat, Gholamreza Shariati, et al. “Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy..” Sci Rep 9, no. 1 (June 21, 2019). https://doi.org/10.1038/s41598-019-44987-6.Full Text Link to Item
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Headrick, Andrew T., Jill A. Rosenfeld, Yaping Yang, Hari Tunuguntla, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim, and Andrew P. Landstrom. “Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation..” Mol Genet Genomic Med 7, no. 6 (June 2019). https://doi.org/10.1002/mgg3.593.Full Text Link to Item
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Jones, Edward G., and Andrew P. Landstrom. “Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation..” J Vis Exp, no. 143 (January 16, 2019). https://doi.org/10.3791/58907.Full Text Link to Item
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Connell, Patrick S., Aamir Jeewa, Debra L. Kearney, Hari Tunuguntla, Susan W. Denfield, Hugh D. Allen, and Andrew P. Landstrom. “A 14-year-old in heart failure with multiple cardiomyopathy variants illustrates a role for signal-to-noise analysis in gene test re-interpretation..” Clinical Case Reports 7, no. 1 (January 2019): 211–17. https://doi.org/10.1002/ccr3.1920.Full Text
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Valdés, Santiago O., Christina Y. Miyake, Mary C. Niu, Caridad M. de la Uz, S Yukiko Asaki, Andrew P. Landstrom, Andrew E. Schneider, et al. “Early experience with intravenous sotalol in children with and without congenital heart disease..” Heart Rhythm 15, no. 12 (December 2018): 1862–69. https://doi.org/10.1016/j.hrthm.2018.07.010.Full Text Link to Item
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Dailey-Schwartz, Andrew L., Hanna J. Tadros, Mahshid Sababi Azamian, Seema R. Lalani, Shaine A. Morris, Hugh D. Allen, Jeffrey J. Kim, and Andrew P. Landstrom. “Copy Number Variants of Undetermined Significance Are Not Associated with Worse Clinical Outcomes in Hypoplastic Left Heart Syndrome..” J Pediatr 202 (November 2018): 206-211.e2. https://doi.org/10.1016/j.jpeds.2018.07.022.Full Text Link to Item
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Valdés, Santiago O., Andrew P. Landstrom, Andrew E. Schneider, Christina Y. Miyake, Caridad M. de la Uz, and Jeffrey J. Kim. “Intravenous sotalol for the management of postoperative junctional ectopic tachycardia..” Heartrhythm Case Rep 4, no. 8 (August 2018): 375–77. https://doi.org/10.1016/j.hrcr.2018.05.007.Full Text Link to Item
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Landstrom, Andrew P., Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, and Jeffrey J. Kim. “Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise..” Heart Rhythm 15, no. 7 (July 2018): 1042–50. https://doi.org/10.1016/j.hrthm.2018.02.031.Full Text Link to Item
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Hildebrandt, Michelle A. T., Monica Reyes, Xifeng Wu, Xia Pu, Kara A. Thompson, Jianzhong Ma, Andrew P. Landstrom, Alanna C. Morrison, and Joann L. Ater. “Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors..” Sci Rep 7, no. 1 (August 29, 2017). https://doi.org/10.1038/s41598-017-09517-2.Full Text Link to Item
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Landstrom, Andrew P., Dobromir Dobrev, and Xander H. T. Wehrens. “Calcium Signaling and Cardiac Arrhythmias..” Circ Res 120, no. 12 (June 9, 2017): 1969–93. https://doi.org/10.1161/CIRCRESAHA.117.310083.Full Text Link to Item
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Landstrom, Andrew P., Andrew L. Dailey-Schwartz, Jill A. Rosenfeld, Yaping Yang, Margaret J. McLean, Christina Y. Miyake, Santiago O. Valdes, et al. “Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals..” Circ Arrhythm Electrophysiol 10, no. 4 (April 2017). https://doi.org/10.1161/CIRCEP.116.004742.Full Text Link to Item
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Quick, Ann P., Andrew P. Landstrom, Qiongling Wang, David L. Beavers, Julia O. Reynolds, Giselle Barreto-Torres, Viet Tran, et al. “Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction..” Jacc Basic Transl Sci 2, no. 1 (February 2017): 56–67. https://doi.org/10.1016/j.jacbts.2016.11.004.Full Text Link to Item
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Veltri, Tiago, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P Bryant Chase, and Jose R. Pinto. “Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation..” Front Physiol 8 (2017). https://doi.org/10.3389/fphys.2017.00221.Full Text Link to Item
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Landstrom, Andrew P., Nicole J. Boczek, Dan Ye, Christina Y. Miyake, Caridad M. De la Uz, Hugh D. Allen, Michael J. Ackerman, and Jeffrey J. Kim. “Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current..” Int J Cardiol 220 (October 1, 2016): 290–98. https://doi.org/10.1016/j.ijcard.2016.06.081.Full Text Link to Item
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Quick, Ann P., Andrew P. Landstrom, and Xander H. T. Wehrens. “Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling..” Heart Rhythm 13, no. 3 (March 2016): 753–54. https://doi.org/10.1016/j.hrthm.2015.11.026.Full Text Link to Item
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Landstrom, Andrew P., Jenny J. Sun, Russell S. Ray, and Xander H. T. Wehrens. “It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias..” Heart Rhythm 12, no. 11 (November 2015): 2294–95. https://doi.org/10.1016/j.hrthm.2015.07.008.Full Text Link to Item
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Wang, Wei, Andrew P. Landstrom, Qiongling Wang, Michelle L. Munro, David Beavers, Michael J. Ackerman, Christian Soeller, and Xander H. T. Wehrens. “Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice..” Am J Physiol Heart Circ Physiol 307, no. 9 (November 1, 2014): H1317–26. https://doi.org/10.1152/ajpheart.00413.2014.Full Text Link to Item
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Beavers, David L., Andrew P. Landstrom, David Y. Chiang, and Xander H. T. Wehrens. “Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases..” Cardiovasc Res 103, no. 2 (July 15, 2014): 198–205. https://doi.org/10.1093/cvr/cvu151.Full Text Link to Item
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Landstrom, Andrew P., David L. Beavers, and Xander H. T. Wehrens. “The junctophilin family of proteins: from bench to bedside..” Trends Mol Med 20, no. 6 (June 2014): 353–62. https://doi.org/10.1016/j.molmed.2014.02.004.Full Text Link to Item
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Kapplinger, Jamie D., Andrew P. Landstrom, J Martijn Bos, Benjamin A. Salisbury, Thomas E. Callis, and Michael J. Ackerman. “Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise..” J Cardiovasc Transl Res 7, no. 3 (April 2014): 347–61. https://doi.org/10.1007/s12265-014-9542-z.Full Text Link to Item
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Beavers, David L., Wei Wang, Sameer Ather, Niels Voigt, Alejandro Garbino, Sayali S. Dixit, Andrew P. Landstrom, et al. “Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization..” J Am Coll Cardiol 62, no. 21 (November 19, 2013): 2010–19. https://doi.org/10.1016/j.jacc.2013.06.052.Full Text Link to Item
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Reynolds, Julia O., David Y. Chiang, Wei Wang, David L. Beavers, Sayali S. Dixit, Darlene G. Skapura, Andrew P. Landstrom, Long-Sheng Song, Michael J. Ackerman, and Xander H. T. Wehrens. “Junctophilin-2 is necessary for T-tubule maturation during mouse heart development..” Cardiovasc Res 100, no. 1 (October 1, 2013): 44–53. https://doi.org/10.1093/cvr/cvt133.Full Text Link to Item
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Parvatiyar, Michelle S., Andrew P. Landstrom, Cicero Figueiredo-Freitas, James D. Potter, Michael J. Ackerman, and Jose Renato Pinto. “A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation..” J Biol Chem 287, no. 38 (September 14, 2012): 31845–55. https://doi.org/10.1074/jbc.M112.377713.Full Text Link to Item
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Landstrom, A. P., and M. J. Ackerman. “Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins..” Curr Mol Med 12, no. 5 (June 2012): 507–18. https://doi.org/10.2174/156652412800620020.Full Text Link to Item
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Landstrom, A. P., D. J. Tester, and M. J. Ackerman. “Role of genetic testing for sudden death predisposing heart conditions in athletes,” December 1, 2011, 85–100. https://doi.org/10.1007/978-0-387-92775-6_5.Full Text
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Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise..” Clin Pharmacol Ther 90, no. 4 (October 2011): 496–99. https://doi.org/10.1038/clpt.2011.192.Full Text Link to Item
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Kapplinger, Jamie D., Andrew P. Landstrom, Benjamin A. Salisbury, Thomas E. Callis, Guido D. Pollevick, David J. Tester, Moniek G. P. J. Cox, et al. “Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associated mutations from background genetic noise..” J Am Coll Cardiol 57, no. 23 (June 7, 2011): 2317–27. https://doi.org/10.1016/j.jacc.2010.12.036.Full Text Link to Item
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Waddell, Leigh B., Frances A. Lemckert, Xi F. Zheng, Jenny Tran, Frances J. Evesson, Joanne M. Hawkes, Angela Lek, et al. “Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch..” J Neuropathol Exp Neurol 70, no. 4 (April 2011): 302–13. https://doi.org/10.1097/NEN.0b013e31821350b0.Full Text Link to Item
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Oort, Ralph J. van, Alejandro Garbino, Wei Wang, Sayali S. Dixit, Andrew P. Landstrom, Namit Gaur, Angela C. De Almeida, et al. “Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice..” Circulation 123, no. 9 (March 8, 2011): 979–88. https://doi.org/10.1161/CIRCULATIONAHA.110.006437.Full Text Link to Item
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Landstrom, Andrew P., Cherisse A. Kellen, Sayali S. Dixit, Ralph J. van Oort, Alejandro Garbino, Noah Weisleder, Jianjie Ma, Xander H. T. Wehrens, and Michael J. Ackerman. “Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling..” Circ Heart Fail 4, no. 2 (March 2011): 214–23. https://doi.org/10.1161/CIRCHEARTFAILURE.110.958694.Full Text Link to Item
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Landstrom, Andrew P., Babatunde A. Adekola, J Martijn Bos, Steve R. Ommen, and Michael J. Ackerman. “PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing..” Am Heart J 161, no. 1 (January 2011): 165–71. https://doi.org/10.1016/j.ahj.2010.08.001.Full Text Link to Item
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Ho, Carolyn Y. “Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy..” Circulation 122, no. 23 (December 7, 2010): 2430–40. https://doi.org/10.1161/CIRCULATIONAHA.110.978924.Full Text Link to Item
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Landstrom, Andrew P., and Michael J. Ackerman. “Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy..” Circulation 122, no. 23 (December 7, 2010): 2441–49. https://doi.org/10.1161/CIRCULATIONAHA.110.954446.Full Text Link to Item
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Landstrom, Andrew P., and Michael J. Ackerman. “Is genotype clinically useful in predicting prognosis in hypertrophic cardiomyopathy? Genetics and Clinical Destiny: Improving Care in Hypertrophic Cardiomyopathy Response.” Circulation 122, no. 23 (December 7, 2010): 2440–2440.Link to Item
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Landstrom, Andrew P., and Michael J. Ackerman. “GWAS or Gee Whiz, PSAS or Pshaw: elucidating the biologic and clinical significance of genetic variation in cardiovascular disease..” Heart Rhythm 6, no. 12 (December 2009): 1751–53. https://doi.org/10.1016/j.hrthm.2009.09.016.Full Text Link to Item
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Garbino, Alejandro, Ralph J. van Oort, Sayali S. Dixit, Andrew P. Landstrom, Michael J. Ackerman, and Xander H. T. Wehrens. “Molecular evolution of the junctophilin gene family..” Physiol Genomics 37, no. 3 (May 13, 2009): 175–86. https://doi.org/10.1152/physiolgenomics.00017.2009.Full Text Link to Item
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Landstrom, Andrew P., Michelle S. Parvatiyar, Jose R. Pinto, Michelle L. Marquardt, J Martijn Bos, David J. Tester, Steve R. Ommen, James D. Potter, and Michael J. Ackerman. “Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C..” J Mol Cell Cardiol 45, no. 2 (August 2008): 281–88. https://doi.org/10.1016/j.yjmcc.2008.05.003.Full Text Link to Item
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Ackerman, Michael J., and Andrew P. Landstrom. “Detection of subclinical fabry disease in patients presenting with hypertrophic cardiomyopathy..” J Am Coll Cardiol 50, no. 25 (December 18, 2007): 2404–5. https://doi.org/10.1016/j.jacc.2007.09.022.Full Text Link to Item
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Landstrom, Andrew P., Ryan A. Knudson, Gordon W. Dewald, Rhett P. Ketterling, and Ayalew Tefferi. “Philadelphia chromosome mosaicism at diagnosis in chronic myeloid leukemia: clinical correlates and effect on imatinib mesylate treatment outcome..” Leuk Lymphoma 48, no. 11 (November 2007): 2137–40. https://doi.org/10.1080/10428190701618284.Full Text Link to Item
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Pandit, Bhaswati, Anna Sarkozy, Len A. Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A. Pogna, et al. “Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy..” Nat Genet 39, no. 8 (August 2007): 1007–12. https://doi.org/10.1038/ng2073.Full Text Link to Item
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Landstrom, Andrew P., Noah Weisleder, Karin B. Batalden, J Martijn Bos, David J. Tester, Steve R. Ommen, Xander H. T. Wehrens, et al. “Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans..” J Mol Cell Cardiol 42, no. 6 (June 2007): 1026–35. https://doi.org/10.1016/j.yjmcc.2007.04.006.Full Text Link to Item
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Landstrom, Andrew P., Rhett P. Ketterling, Ryan A. Knudson, and Ayalew Tefferi. “Utility of peripheral blood dual color, double fusion fluorescent in situ hybridization for BCR/ABL fusion to assess cytogenetic remission status in chronic myeloid leukemia..” Leuk Lymphoma 47, no. 10 (October 2006): 2055–61. https://doi.org/10.1080/10428190600783551.Full Text Link to Item
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Landstrom, Andrew P., and Ayalew Tefferi. “Fluorescent in situ hybridization in the diagnosis, prognosis, and treatment monitoring of chronic myeloid leukemia..” Leuk Lymphoma 47, no. 3 (March 2006): 397–402. https://doi.org/10.1080/10428190500353133.Full Text Link to Item
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- Teaching & Mentoring
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Advising & Mentoring
- I always enjoy hearing from clinicians and scientists in training of all levels who are interested in our research directions. I have experience mentoring medical students, residents, and clinical fellows as well as graduate students and post-doctoral research fellows. Please take a look at our lab website for more information.
- Scholarly, Clinical, & Service Activities
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Academic & Administrative Activities
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Research Mentor, Human Genetics and Genomics Study Program, Duke University School of Medicine
Research Mentor, Cardiovascular Study Program, Duke University School of Medicine
Curriculum Committee, Duke University School of Medicine Medical School
Admissions Committee, Duke University Medical Scientist Training Program
Admissions Committee, Duke University School of Medicine Medical School
Research Mentor, Duke Pediatric Research Scholars Program for Physician-Scientist Development
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