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Andrew Paul Landstrom

Associate Professor of Pediatrics
Pediatrics, Cardiology
Duke University Medical Center, Box 2652, Durham, NC 27710
Duke University Medical Center, Box 2652, Durham, NC 27710

Overview


Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart.  He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome.  He also specializes in the evaluation of children following a cardiac arrest or after the sudden and unexplained death of a family member.  He has expertise in cardiovascular genetics and uses it to identify individuals in a family who may be at risk of a disease, even if all clinical testing is negative.  As a scientist, he is trained in genetics and cell biology.  He runs a research lab exploring the genetic and molecular causes of arrhythmias, sudden unexplained death syndromes, and heart muscle disease (cardiomyopathies).  He utilizes patient-derived induced pluripotent stem cells and genetic mouse models to identify the mechanisms of cardiovascular genetic disease with the goal of developing novel therapies.

Current Appointments & Affiliations


Associate Professor of Pediatrics · 2024 - Present Pediatrics, Cardiology, Pediatrics
Director of the Duke Pediatric Research Scholars Program for Physician-Scientist Development · 2021 - Present Pediatrics, Clinical Science Departments
Associate Professor in Cell Biology · 2021 - Present Cell Biology, Basic Science Departments

In the News


Published June 24, 2019
The Heart of the Matter
Published January 31, 2019
Faculty Spotlight: Andrew Landstrom, MD, PhD
Published January 23, 2019
Using Genetic Clues to Reform Cardiac Care

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Recent Publications


TAX1BP3 Causes TRPV4-Mediated Autosomal Recessive Arrhythmogenic Cardiomyopathy.

Journal Article Circ Res · March 28, 2025 BACKGROUND: Arrhythmogenic cardiomyopathy (ACM) is one of the leading causes of sudden cardiac death in children, young adults, and athletes and is characterized by the fibro-fatty replacement of the myocardium, predominantly of the right ventricle. Sixty ... Full text Link to item Cite
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Recent Grants


PRIORITY: cardio-laminoPathy: fRom pathomechanIsms tO peRsonalIzed TherapY

ResearchPrincipal Investigator · Awarded by Institute of Myology · 2025 - 2030

The North Carolina Congenital Heart Disease Surveillance Network

Public ServiceCollaborating Investigator · Awarded by Centers for Disease Control and Prevention · 2024 - 2029

Determining the genetic and social determinants of heart failure and mortality in patients with congenital heart disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2028

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Education, Training & Certifications


Mayo School of Health Sciences · 2012 M.D.
Mayo School of Health Sciences · 2012 Ph.D.