Andrew Paul Landstrom | Scholars@Duke

Andrew Paul Landstrom
Assistant Professor of Pediatrics

Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart. He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. He also specializes in the evaluation of children following a cardiac arrest or after the sudden and unexplained death of a family member. He has expertise in cardiovascular genetics and uses it to identify individuals in a family who may be at risk of a disease, even if all clinical testing is negative. As a scientist, he is trained in genetics and cell biology. He runs a research lab exploring the genetic and molecular causes of arrhythmias, sudden unexplained death syndromes, and heart muscle disease (cardiomyopathies). He utilizes patient-derived induced pluripotent stem cells and genetic mouse models to identify the mechanisms of cardiovascular genetic disease with the goal of developing novel therapies.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2018
Director of the Duke Pediatric Research Scholars Program for Physician-Scientist Development, Pediatrics, Clinical Science Departments 2021
Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2019

Contact Information

Duke University Medical Center, Box 2652, Durham, NC 27710
Duke University Medical Center, Box 2652, Durham, NC 27710
andrew.landstrom@duke.edu (919) 684-3028
Landstrom Lab Website
ORCiD Profile

Background
Education, Training, & Certifications
- Pediatric Cardiology Certification, American Board of Pediatrics 2018 - 2099
- General Pediatrics Certification, American Board of Pediatrics 2015 - 2099
- Advanced Clinical Fellowship, Pediatrics/Electrophysiology, Baylor College of Medicine 2017 - 2018
- Post-Doctoral Research Fellowship, Molecular Physiology And Biophysics, Baylor College of Medicine 2013 - 2018
- Clinical Fellowship, Pediatrics/Cardiology, Baylor College of Medicine 2014 - 2017
- Residency, Pediatrics, Baylor College of Medicine 2013 - 2014
- Internship, Pediatrics, Baylor College of Medicine 2012 - 2013
- M.D., Mayo School of Health Sciences 2012
- Ph.D., Mayo School of Health Sciences 2012
Leadership & Clinical Positions at Duke
- Associate Director, Duke Pediatric Research Scholars Program
  Associate Director for Physician-Scientist Development, Duke Pediatric Residency Program
Academic Positions Outside Duke
- Co-Chair, Data Science and Precision Medicine Science Subcommittee, Council on Genomic and Precision and Council on Clinical Cardiology, Institute on Precision Cardiovascular Medicine, American Heart Association. 2020 - 2022
- Member, Leadership Committee, Council on Genomic and Precision Medicine, American Heart Association. 2020 - 2022
- Member, Early Career and Mentoring Committee, Council on Lifelong Congenital Heart Disease and Heart Health in the Young, American Heart Association. 2020 - 2024
- American Heart Association Representative, Inter-Society Coordinating Committee for Practitioner Education in Genomics, NHGRI, NIH. 2020 - 2024
- Chair, Cardiovascular Genomics Certificate Development Working Group, American Heart Association. 2019 - 2021
- Member, Professional Practice & Social Implications Committee, American Society for Human Genetics. 2019 - 2023
- Vice-Chair, Early Career Committee, Council on Genomic and Precision Medicine, American Heart Association. 2016 - 2022
- Member, Early Career Workgroup, Section on Cardiology and Cardiothoracic Surgery, American Academy of Pediatrics. 2015 - 2022
Recognition
In the News
- JUN 24, 2019 Duke Children's
  
  The Heart of the Matter
- JAN 31, 2019 Duke Dept of Pediatrics
  
  Faculty Spotlight: Andrew Landstrom, MD, PhD
- JAN 23, 2019 Duke Research Blog
  
  Using Genetic Clues to Reform Cardiac Care
- NOV 15, 2018 Duke Dept of Pediatrics
  
  Landstrom wins AHA Early Career Investigator Award
- NOV 9, 2018 Duke Dept of Pediatrics
  
  Two from Pediatrics win 2018 MEDx pilot project grants
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- The North Carolina Congenital Heart Disease Surveillance Network awarded by Centers for Disease Control and Prevention 2019 - 2024
- Unified Program for Therapeutics in Children awarded by National Institutes of Health 2019 - 2024
- Targeting Wnt-signaling to prevent sudden death in pediatric arrhythmic cardiomyopathyTBD awarded by Doris Duke Charitable Foundation, Inc. 2019 - 2023
- Establishing Wnt signaling-mediated pro-arrhythmic cardiac remodeling awarded by American Heart Association 2021 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- The Role of Junctophilin Type 2 in Cardiac Node Automaticity awarded by National Institutes of Health 2018 - 2022
- Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2021
- The role of PRDM16 in Cardiac Development and Cardiomyopathy awarded by University of Utah 2020 - 2021
- Cord blood-based biomarker discovery for sudden infant death syndrome risk awarded by American SIDS Institute 2020 - 2021
- Determining the role of PRDM16 in rapidly progressive pediatric cardiomyopathy awarded by American Academy of Pediatrics 2019 - 2021
Fellowships, Supported Research, & Other Grants
- In vivo evaluation of novel anti-arrhythmic compounds to terminate potentially fatal tachyarrhythmia awarded by Mike Hogg Fund 2018
- The role of junctophilin-2 in the development of youthful sinus and atrioventricular nodal disease awarded by Pediatric and Congenital Electrophysiology Society 2016 - 2017
- The role of RyR2-Asn4643del in CPVT with emotionally-triggered sudden death awarded by National Institutes of Health 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Markunas, Alexandra M., Perathu K. R. Manivannan, Jordan E. Ezekian, Agnim Agarwal, William Eisner, Katherina Alsina, Hugh D. Allen, et al. “TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death.” Am J Med Genet A 185, no. 3 (March 2021): 923–29. https://doi.org/10.1002/ajmg.a.62037.
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  - Connell, Patrick S., Amy M. Berkman, BriAnna M. Souder, Elisa J. Pirozzi, Julia J. Lovin, Jill A. Rosenfeld, Pengfei Liu, et al. “Amino Acid-Level Signal-to-Noise Analysis Aids in Pathogenicity Prediction of Incidentally Identified TTN-Encoded Titin Truncating Variants.” Circ Genom Precis Med 14, no. 1 (February 2021): e003131. https://doi.org/10.1161/CIRCGEN.120.003131.
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  - Parker, Lauren E., and Andrew P. Landstrom. “Genetic Etiology of Left-Sided Obstructive Heart Lesions: A Story in Development.” J Am Heart Assoc 10, no. 2 (January 19, 2021): e019006. https://doi.org/10.1161/JAHA.120.019006.
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  - Valera, Isela C., Amanda L. Wacker, Hyun Seok Hwang, Christina Holmes, Orlando Laitano, Andrew P. Landstrom, and Michelle S. Parvatiyar. “Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies.” Adv Med Sci 66, no. 1 (December 30, 2020): 52–71. https://doi.org/10.1016/j.advms.2020.12.004.
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  - Reinoso, Tyler R., Maicon Landim-Vieira, Yun Shi, Jamie R. Johnston, P Bryant Chase, Michelle S. Parvatiyar, Andrew P. Landstrom, Jose R. Pinto, and Hanna J. Tadros. “A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C.” J Muscle Res Cell Motil, November 11, 2020. https://doi.org/10.1007/s10974-020-09592-5.
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  - Moore, Jeremy P., Roberto G. Gallotti, Kevin M. Shannon, J Martijn Bos, Elham Sadeghi, Janette F. Strasburger, Ronald T. Wakai, et al. “Genotype Predicts Outcomes in Fetuses and Neonates With Severe Congenital Long QT Syndrome.” Jacc Clin Electrophysiol 6, no. 12 (November 2020): 1561–70. https://doi.org/10.1016/j.jacep.2020.06.001.
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  - Musunuru, Kiran, Ray E. Hershberger, Sharlene M. Day, N Jennifer Klinedinst, Andrew P. Landstrom, Victoria N. Parikh, Siddharth Prakash, Christopher Semsarian, Amy C. Sturm, and Amy C. American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. “Genetic Testing for Inherited Cardiovascular Diseases: A Scientific Statement From the American Heart Association.” Circ Genom Precis Med 13, no. 4 (August 2020): e000067. https://doi.org/10.1161/HCG.0000000000000067.
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  - Landstrom, Andrew P., and Svati H. Shah. “Rare Things Being Common: Implications for Common Genetic Variants in Rare Diseases Like Long-QT Syndrome.” Circulation 142, no. 4 (July 28, 2020): 339–41. https://doi.org/10.1161/CIRCULATIONAHA.120.048339.
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  - Tadros, Hanna J., Chelsea S. Life, Gustavo Garcia, Elisa Pirozzi, Edward G. Jones, Susmita Datta, Michelle S. Parvatiyar, et al. “Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes.” J Mol Cell Cardiol 142 (May 2020): 118–25. https://doi.org/10.1016/j.yjmcc.2020.04.005.
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  - Levine, Amber T., Heather A. Born, Andrew P. Landstrom, Samuel Larson, Wai Ling Lee, An T. Dao, Xander H. Wehrens, Yi-Chen Lai, and Anne E. Anderson. “Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus.” Sci Rep 10, no. 1 (March 4, 2020): 4043. https://doi.org/10.1038/s41598-020-60324-8.
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  - Ezekian, Jordan E., Sarah R. Clippinger, Jaquelin M. Garcia, Qixin Yang, Susan Denfield, Aamir Jeewa, William J. Dreyer, et al. “Variant R94C in TNNT2-Encoded Troponin T Predisposes to Pediatric Restrictive Cardiomyopathy and Sudden Death Through Impaired Thin Filament Relaxation Resulting in Myocardial Diastolic Dysfunction.” J Am Heart Assoc 9, no. 5 (March 3, 2020): e015111. https://doi.org/10.1161/JAHA.119.015111.
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  - Roberts, Jason D., S Yukiko Asaki, Andrea Mazzanti, J Martijn Bos, Izabela Tuleta, Alison R. Muir, Lia Crotti, et al. “An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.” Circulation 141, no. 6 (February 11, 2020): 429–39. https://doi.org/10.1161/CIRCULATIONAHA.119.043114.
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  - Howard, Taylor S., Santiago O. Valdes, Kyle D. Hope, Shaine A. Morris, Andrew P. Landstrom, Andrew E. Schneider, Christina Y. Miyake, et al. “Association of Wolff-Parkinson-White With Left Ventricular Noncompaction Cardiomyopathy in Children.” J Card Fail 25, no. 12 (December 2019): 1004–8. https://doi.org/10.1016/j.cardfail.2019.09.014.
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  - Jones, Edward G., Neda Mazaheri, Reza Maroofian, Mina Zamani, Tahereh Seifi, Alireza Sedaghat, Gholamreza Shariati, et al. “Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy.” Sci Rep 9, no. 1 (June 21, 2019): 9038. https://doi.org/10.1038/s41598-019-44987-6.
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  - Headrick, Andrew T., Jill A. Rosenfeld, Yaping Yang, Hari Tunuguntla, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim, and Andrew P. Landstrom. “Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation.” Mol Genet Genomic Med 7, no. 6 (June 2019): e593. https://doi.org/10.1002/mgg3.593.
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  - Jones, Edward G., and Andrew P. Landstrom. “Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation.” J Vis Exp, no. 143 (January 16, 2019). https://doi.org/10.3791/58907.
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  - Connell, Patrick S., Aamir Jeewa, Debra L. Kearney, Hari Tunuguntla, Susan W. Denfield, Hugh D. Allen, and Andrew P. Landstrom. “A 14-year-old in heart failure with multiple cardiomyopathy variants illustrates a role for signal-to-noise analysis in gene test re-interpretation.” Clin Case Rep 7, no. 1 (January 2019): 211–17. https://doi.org/10.1002/ccr3.1920.
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  - Valdés, Santiago O., Christina Y. Miyake, Mary C. Niu, Caridad M. de la Uz, S Yukiko Asaki, Andrew P. Landstrom, Andrew E. Schneider, et al. “Early experience with intravenous sotalol in children with and without congenital heart disease.” Heart Rhythm 15, no. 12 (December 2018): 1862–69. https://doi.org/10.1016/j.hrthm.2018.07.010.
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  - Dailey-Schwartz, Andrew L., Hanna J. Tadros, Mahshid Sababi Azamian, Seema R. Lalani, Shaine A. Morris, Hugh D. Allen, Jeffrey J. Kim, and Andrew P. Landstrom. “Copy Number Variants of Undetermined Significance Are Not Associated with Worse Clinical Outcomes in Hypoplastic Left Heart Syndrome.” J Pediatr 202 (November 2018): 206-211.e2. https://doi.org/10.1016/j.jpeds.2018.07.022.
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  - Valdés, Santiago O., Andrew P. Landstrom, Andrew E. Schneider, Christina Y. Miyake, Caridad M. de la Uz, and Jeffrey J. Kim. “Intravenous sotalol for the management of postoperative junctional ectopic tachycardia.” Heartrhythm Case Rep 4, no. 8 (August 2018): 375–77. https://doi.org/10.1016/j.hrcr.2018.05.007.
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  - Landstrom, Andrew P., Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, and Jeffrey J. Kim. “Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise.” Heart Rhythm 15, no. 7 (July 2018): 1042–50. https://doi.org/10.1016/j.hrthm.2018.02.031.
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  - Hildebrandt, Michelle A. T., Monica Reyes, Xifeng Wu, Xia Pu, Kara A. Thompson, Jianzhong Ma, Andrew P. Landstrom, Alanna C. Morrison, and Joann L. Ater. “Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors.” Sci Rep 7, no. 1 (August 29, 2017): 9698. https://doi.org/10.1038/s41598-017-09517-2.
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  - Landstrom, Andrew P., Dobromir Dobrev, and Xander H. T. Wehrens. “Calcium Signaling and Cardiac Arrhythmias.” Circ Res 120, no. 12 (June 9, 2017): 1969–93. https://doi.org/10.1161/CIRCRESAHA.117.310083.
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  - Landstrom, Andrew P., Andrew L. Dailey-Schwartz, Jill A. Rosenfeld, Yaping Yang, Margaret J. McLean, Christina Y. Miyake, Santiago O. Valdes, et al. “Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals.” Circ Arrhythm Electrophysiol 10, no. 4 (April 2017). https://doi.org/10.1161/CIRCEP.116.004742.
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  - Quick, Ann P., Andrew P. Landstrom, Qiongling Wang, David L. Beavers, Julia O. Reynolds, Giselle Barreto-Torres, Viet Tran, et al. “Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction.” Jacc Basic Transl Sci 2, no. 1 (February 2017): 56–67. https://doi.org/10.1016/j.jacbts.2016.11.004.
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  - Veltri, Tiago, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P Bryant Chase, and Jose R. Pinto. “Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation.” Front Physiol 8 (2017): 221. https://doi.org/10.3389/fphys.2017.00221.
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  - Landstrom, Andrew P., Nicole J. Boczek, Dan Ye, Christina Y. Miyake, Caridad M. De la Uz, Hugh D. Allen, Michael J. Ackerman, and Jeffrey J. Kim. “Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current.” Int J Cardiol 220 (October 1, 2016): 290–98. https://doi.org/10.1016/j.ijcard.2016.06.081.
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  - Quick, Ann P., Andrew P. Landstrom, and Xander H. T. Wehrens. “Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling.” Heart Rhythm 13, no. 3 (March 2016): 753–54. https://doi.org/10.1016/j.hrthm.2015.11.026.
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  - Landstrom, Andrew P., Jenny J. Sun, Russell S. Ray, and Xander H. T. Wehrens. “It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias.” Heart Rhythm 12, no. 11 (November 2015): 2294–95. https://doi.org/10.1016/j.hrthm.2015.07.008.
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  - Wang, Wei, Andrew P. Landstrom, Qiongling Wang, Michelle L. Munro, David Beavers, Michael J. Ackerman, Christian Soeller, and Xander H. T. Wehrens. “Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.” Am J Physiol Heart Circ Physiol 307, no. 9 (November 1, 2014): H1317–26. https://doi.org/10.1152/ajpheart.00413.2014.
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  - Beavers, David L., Andrew P. Landstrom, David Y. Chiang, and Xander H. T. Wehrens. “Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.” Cardiovasc Res 103, no. 2 (July 15, 2014): 198–205. https://doi.org/10.1093/cvr/cvu151.
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  - Landstrom, Andrew P., David L. Beavers, and Xander H. T. Wehrens. “The junctophilin family of proteins: from bench to bedside.” Trends Mol Med 20, no. 6 (June 2014): 353–62. https://doi.org/10.1016/j.molmed.2014.02.004.
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  - Kapplinger, Jamie D., Andrew P. Landstrom, J Martijn Bos, Benjamin A. Salisbury, Thomas E. Callis, and Michael J. Ackerman. “Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise.” J Cardiovasc Transl Res 7, no. 3 (April 2014): 347–61. https://doi.org/10.1007/s12265-014-9542-z.
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  - Beavers, David L., Wei Wang, Sameer Ather, Niels Voigt, Alejandro Garbino, Sayali S. Dixit, Andrew P. Landstrom, et al. “Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.” J Am Coll Cardiol 62, no. 21 (November 19, 2013): 2010–19. https://doi.org/10.1016/j.jacc.2013.06.052.
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  - Reynolds, Julia O., David Y. Chiang, Wei Wang, David L. Beavers, Sayali S. Dixit, Darlene G. Skapura, Andrew P. Landstrom, Long-Sheng Song, Michael J. Ackerman, and Xander H. T. Wehrens. “Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.” Cardiovasc Res 100, no. 1 (October 1, 2013): 44–53. https://doi.org/10.1093/cvr/cvt133.
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  - Parvatiyar, Michelle S., Andrew P. Landstrom, Cicero Figueiredo-Freitas, James D. Potter, Michael J. Ackerman, and Jose Renato Pinto. “A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation.” J Biol Chem 287, no. 38 (September 14, 2012): 31845–55. https://doi.org/10.1074/jbc.M112.377713.
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  - Landstrom, A. P., and M. J. Ackerman. “Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins.” Curr Mol Med 12, no. 5 (June 2012): 507–18. https://doi.org/10.2174/156652412800620020.
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  - Landstrom, A. P., D. J. Tester, and M. J. Ackerman. “Role of genetic testing for sudden death predisposing heart conditions in athletes,” December 1, 2011, 85–100. https://doi.org/10.1007/978-0-387-92775-6_5.
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  - Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise.” Clin Pharmacol Ther 90, no. 4 (October 2011): 496–99. https://doi.org/10.1038/clpt.2011.192.
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  - Kapplinger, Jamie D., Andrew P. Landstrom, Benjamin A. Salisbury, Thomas E. Callis, Guido D. Pollevick, David J. Tester, Moniek G. P. J. Cox, et al. “Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associated mutations from background genetic noise.” J Am Coll Cardiol 57, no. 23 (June 7, 2011): 2317–27. https://doi.org/10.1016/j.jacc.2010.12.036.
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  - Waddell, Leigh B., Frances A. Lemckert, Xi F. Zheng, Jenny Tran, Frances J. Evesson, Joanne M. Hawkes, Angela Lek, et al. “Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch.” J Neuropathol Exp Neurol 70, no. 4 (April 2011): 302–13. https://doi.org/10.1097/NEN.0b013e31821350b0.
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  - Oort, Ralph J. van, Alejandro Garbino, Wei Wang, Sayali S. Dixit, Andrew P. Landstrom, Namit Gaur, Angela C. De Almeida, et al. “Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.” Circulation 123, no. 9 (March 8, 2011): 979–88. https://doi.org/10.1161/CIRCULATIONAHA.110.006437.
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  - Landstrom, Andrew P., Cherisse A. Kellen, Sayali S. Dixit, Ralph J. van Oort, Alejandro Garbino, Noah Weisleder, Jianjie Ma, Xander H. T. Wehrens, and Michael J. Ackerman. “Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.” Circ Heart Fail 4, no. 2 (March 2011): 214–23. https://doi.org/10.1161/CIRCHEARTFAILURE.110.958694.
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  - Landstrom, Andrew P., Babatunde A. Adekola, J Martijn Bos, Steve R. Ommen, and Michael J. Ackerman. “PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing.” Am Heart J 161, no. 1 (January 2011): 165–71. https://doi.org/10.1016/j.ahj.2010.08.001.
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  - Landstrom, Andrew P., and Michael J. Ackerman. “Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy.” Circulation 122, no. 23 (December 7, 2010): 2441–49. https://doi.org/10.1161/CIRCULATIONAHA.110.954446.
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  - Landstrom, Andrew P., and Michael J. Ackerman. “Is genotype clinically useful in predicting prognosis in hypertrophic cardiomyopathy? Genetics and Clinical Destiny: Improving Care in Hypertrophic Cardiomyopathy Response.” Circulation 122, no. 23 (December 7, 2010): 2440–2440.
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  - Landstrom, Andrew P., and Michael J. Ackerman. “GWAS or Gee Whiz, PSAS or Pshaw: elucidating the biologic and clinical significance of genetic variation in cardiovascular disease.” Heart Rhythm 6, no. 12 (December 2009): 1751–53. https://doi.org/10.1016/j.hrthm.2009.09.016.
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  - Garbino, Alejandro, Ralph J. van Oort, Sayali S. Dixit, Andrew P. Landstrom, Michael J. Ackerman, and Xander H. T. Wehrens. “Molecular evolution of the junctophilin gene family.” Physiol Genomics 37, no. 3 (May 13, 2009): 175–86. https://doi.org/10.1152/physiolgenomics.00017.2009.
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  - Landstrom, Andrew P., Michelle S. Parvatiyar, Jose R. Pinto, Michelle L. Marquardt, J Martijn Bos, David J. Tester, Steve R. Ommen, James D. Potter, and Michael J. Ackerman. “Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C.” J Mol Cell Cardiol 45, no. 2 (August 2008): 281–88. https://doi.org/10.1016/j.yjmcc.2008.05.003.
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  - Ackerman, Michael J., and Andrew P. Landstrom. “Detection of subclinical fabry disease in patients presenting with hypertrophic cardiomyopathy.” J Am Coll Cardiol 50, no. 25 (December 18, 2007): 2404–5. https://doi.org/10.1016/j.jacc.2007.09.022.
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  - Landstrom, Andrew P., Ryan A. Knudson, Gordon W. Dewald, Rhett P. Ketterling, and Ayalew Tefferi. “Philadelphia chromosome mosaicism at diagnosis in chronic myeloid leukemia: clinical correlates and effect on imatinib mesylate treatment outcome.” Leuk Lymphoma 48, no. 11 (November 2007): 2137–40. https://doi.org/10.1080/10428190701618284.
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  - Pandit, Bhaswati, Anna Sarkozy, Len A. Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A. Pogna, et al. “Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.” Nat Genet 39, no. 8 (August 2007): 1007–12. https://doi.org/10.1038/ng2073.
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  - Landstrom, Andrew P., Noah Weisleder, Karin B. Batalden, J Martijn Bos, David J. Tester, Steve R. Ommen, Xander H. T. Wehrens, et al. “Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans.” J Mol Cell Cardiol 42, no. 6 (June 2007): 1026–35. https://doi.org/10.1016/j.yjmcc.2007.04.006.
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  - Landstrom, Andrew P., Rhett P. Ketterling, Ryan A. Knudson, and Ayalew Tefferi. “Utility of peripheral blood dual color, double fusion fluorescent in situ hybridization for BCR/ABL fusion to assess cytogenetic remission status in chronic myeloid leukemia.” Leuk Lymphoma 47, no. 10 (October 2006): 2055–61. https://doi.org/10.1080/10428190600783551.
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  - Landstrom, Andrew P., and Ayalew Tefferi. “Fluorescent in situ hybridization in the diagnosis, prognosis, and treatment monitoring of chronic myeloid leukemia.” Leuk Lymphoma 47, no. 3 (March 2006): 397–402. https://doi.org/10.1080/10428190500353133.
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- Conference Papers
  - Lei, Ienglam, Wei Huang, Francis D. Pagani, Eugene Chen, Zhong Wang, Jordan S. Pober, George Tellides, et al. “Differential Left and Right Ventricle Response to Cold Storage Followed by Reperfusion in Heart Transplantation.” In Circulation, Vol. 142, 2020.
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  - Word, Tarah A., Andrew Landstrom, Ann Quick, Mayra Shak, Christina Miyake, Hugh D. Allen, and Xander Wehrens. “Assessing the Efficacy of Novel RYR2 Inhibitor, EL20, in Induced Pluripotent Stem Cell Derived Cardiomyocytes from a Catecholaminergic Polymorphic Ventricular Tachycardia Patient.” In Circulation Research, Vol. 125. LIPPINCOTT WILLIAMS & WILKINS, 2019.
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  - Dailey-Schwartz, Andrew L., Mahshid Sababi, Seema Lalani, Shaine A. Morris, Hugh Allen, Jeffrey J. Kim, and Andrew P. Landstrom. “Characterization and Prognostic Value of Chromosomal Microarray Findings of Undetermined Significance in Hypoplastic Left Heart Syndrome.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Jones, Edward G., Hari Tunuguntla, Jill A. Rosenfeld, Yaping Yang, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim, and Andrew P. Landstrom. “Incidentally Identified Variants in Genes Associated With Hypertrophic Cardiomyopathy Are Rarely Associated With Pathologic Ventricular Hypertrophy.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Landstrom, Andrew P., Nicole J. Boczek, Dan Ye, Hugh D. Allen, Michael J. Ackerman, and Jeffrey J. Kim. “A Novel Mutation Identified in a Large Multi-Generational Family With Long QT Syndrome Reveals Distinct, Disease-Specific Mutation Hot Spots within the CACNA/C-Encoded L-type Calcium Channel.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Quick, Ann P., David L. Beavers, Jordan Showell, Leonne E. Philippen, Andrew P. Landstrom, Shaine A. Morris, Robia G. Pautler, and Xander H. Wehrens. “Pseudo-knockin Mice Expressing JPH2-A399S Develop Cardiac Hypertrophy by Magnetic Resonance Imaging.” In Circulation Research, Vol. 117. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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  - Valdivia, Carmen R., Andrew P. Landstrom, Michelle E. Capes, Jing Zhang, Francisco J. Alvarado, Patricia P. Powers, Michael A. Ackerman, and Hector H. Valdivia. “Common Polymorphism RYR2-Q2958R Increases Spontaneous Calcium Release Under Stress and May be Associated With Increased Risk of Sudden Cardiac Death.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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  - Parvatiyar, Michelle S., Andrew P. Landstrom, Jose Renato Pinto, Jingsheng Liang, Michael J. Ackerman, and James D. Potter. “A Novel Mutation in TNNC1-ENCODED Cardiac Troponin C Predisposes to Hypertrophic Cardiomyopathy and Recurrent Episodes of Aborted Sudden Cardiac Death.” In Biophysical Journal, 100:114–114. CELL PRESS, 2011.
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  - Kapplinger, Jamie, Andrew P. Landstrom, J. M. Bos, Benjamin A. Salisbury, Thomas E. Callis, and Michael J. Ackerman. “Spectrum and Prevalence of Genetic Variation in Hypertrophic Cardiomyopathy-Susceptibility Genes Among Ostensibly Healthy Adults.” In Circulation, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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  - Landstrom, Andrew P., Alejandro Garbino, Xander H. Wehrens, Noah Weisleder, Jianjie Ma, and Michael J. Ackerman. “Cardiac Junctophilin-2 Expression Silencing Results in Cellular Hypertrophy and Isoproterenol-Sensitive Derangements in Calcium-Handling.” In Circulation, 120:S569–S569. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Landstrom, Andrew P., Michelle S. Parvatiyar, Jose R. Pinto, Michelle L. Marquardt, J. M. Bos, Steve R. Ommen, James D. Potter, and Michael J. Ackerman. “Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C.” In Circulation, 116:95–96, 2007.
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  - Landstrom, Andrew P., Noah Weisleder, J. M. Bos, Jianjie Ma, Andrea Tjondrokoesoemo, Steve R. Ommen, Iacopo Olivotto, Franco Cecchi, Francesca Girolami, and Michael J. Ackerman. “Identification and characterization of a novel mutation in JPH2-encoded junctophilin-2 in an Italian hypertrophic cardiomyopathy cohort.” In Circulation, 116:153–153. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Will, Melissa L., Andrew P. Landstrom, J Martijn Bos, Bernard J. Gersh, Steve R. Ommen, and Michael J. Ackerman. “Prevalence and spectrum of thin filament mutations in 1025 patients with hypertrophic cardiomyopathy.” In Circulation, 116:57–58. LIPPINCOTT WILLIAMS & WILKINS, 2007.
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  - Landstrom, A., R. Ketterling, R. Knudson, G. Dewald, and A. Tefferi. “PHILADELPHIA CHROMOSOME MOSAICISM DUE TO ADDITIONAL CYTOGENETIC ABNORMALITIES IN CHRONIC MYELOID LEUKEMIA MIGHT ADVERSELY AFFECT PROGNOSIS AND RESPONSE TO IMATINIB.” In Journal of Investigative Medicine, 55:S349–S349. BMJ, 2007. https://doi.org/10.1097/00042871-200703010-00017.
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Teaching & Mentoring
Recent Courses
- CELLBIO 493: Research Independent Study 2021
- CELLBIO 493: Research Independent Study 2020
Advising & Mentoring
- I always enjoy hearing from clinicians and scientists in training of all levels who are interested in our research directions. I have experience mentoring medical students, residents, and clinical fellows as well as graduate students and post-doctoral research fellows. Please take a look at our lab website for more information.
Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Bass Connections Team Leader. Crowdsourced Health: Online Patient Communities Enabling Health Innovation. 2020 - 2021 2020 - 2021
Academic & Administrative Activities
- Research Mentor, Human Genetics and Genomics Study Program, Duke University School of Medicine
  
  Research Mentor, Cardiovascular Study Program, Duke University School of Medicine
  
  Curriculum Committee, Duke University School of Medicine Medical School
  
  Admissions Committee, Duke University Medical Scientist Training Program
  
  Admissions Committee, Duke University School of Medicine Medical School
  
  Research Mentor, Duke Pediatric Research Scholars Program for Physician-Scientist Development

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Advising & Mentoring

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