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Andrew Paul Landstrom

Professor of Pediatrics
Pediatrics, Cardiology
Duke University Medical Center, Box 2652, Durham, NC 27710
Duke University Medical Center, Box 2652, Durham, NC 27710

Overview


Dr. Landstrom is a physician scientist who specializes in the care of children and young adults with arrhythmias, heritable cardiovascular diseases, and sudden unexplained death syndromes. As a clinician, he is trained in pediatric cardiology with a focus on arrhythmias and genetic diseases of the heart.  He specializes in caring for patients with heritable arrhythmia (channelopathies) such as long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome.  He also specializes in the evaluation of children following a cardiac arrest or after the sudden and unexplained death of a family member.  He has expertise in cardiovascular genetics and uses it to identify individuals in a family who may be at risk of a disease, even if all clinical testing is negative.  As a scientist, he is trained in genetics and cell biology.  He runs a research lab exploring the genetic and molecular causes of arrhythmias, sudden unexplained death syndromes, and heart muscle disease (cardiomyopathies).  He utilizes patient-derived induced pluripotent stem cells and genetic mouse models to identify the mechanisms of cardiovascular genetic disease with the goal of developing novel therapies.

Current Appointments & Affiliations


Professor of Pediatrics · 2025 - Present Pediatrics, Cardiology, Pediatrics
Director of the Duke Pediatric Research Scholars Program for Physician-Scientist Development · 2021 - Present Pediatrics, Clinical Science Departments
Associate Professor in Cell Biology · 2021 - Present Cell Biology, Basic Science Departments

In the News


Published June 24, 2019
The Heart of the Matter
Published January 31, 2019
Faculty Spotlight: Andrew Landstrom, MD, PhD
Published January 23, 2019
Using Genetic Clues to Reform Cardiac Care

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Recent Publications


Genetic and Genomic Testing in Cardiovascular Disease: A Policy Statement From the American Heart Association.

Journal Article Circulation · December 16, 2025 The rapid advancement of genomic and precision medicine has expanded the role of genetics and genomics in the diagnosis, risk stratification, and management of cardiovascular diseases. With the decreasing cost and increasing accessibility of genetic testin ... Full text Link to item Cite

A positive allosteric modulator of the β1AR with antagonist activity for catecholaminergic polymorphic ventricular tachycardia.

Journal Article J Clin Invest · December 15, 2025 Orthosteric beta blockers represent the leading pharmacological intervention for managing heart diseases owing to their ability to competitively antagonize β-adrenergic receptors (βARs). However, their use is often limited by adverse effects such as fatigu ... Full text Link to item Cite

Cardiac Channelopathies in the Pediatric Patient: Long QT Syndrome.

Journal Article Card Electrophysiol Clin · December 2025 Congenital long QT syndrome is the most common inherited arrhythmia syndrome and is characterized by prolongation of the QT interval in the absence of structural heart disease or external factors. Disease will often manifest during childhood resulting in l ... Full text Link to item Cite
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Recent Grants


iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030

2/3 CTSA K12 Program at Duke University

ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030

Unified Program for Therapeutics in Children

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030

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Education, Training & Certifications


Mayo School of Health Sciences · 2012 M.D.
Mayo School of Health Sciences · 2012 Ph.D.