Andrew Paul Landstrom
Assistant Professor of Pediatrics

I am interested in the genetic and molecular mechanisms of sudden cardiac arrest in children.  I am a physician-scientist trained at the confluence of pediatric cardiology, clinical electrophysiology, human genetics, and molecular biology which I apply towards the care for children with heritable arrhythmic disease of the heart.  I run a basic science research lab exploring the genetic and molecular causes of sudden cardiac death in children and young adults. These include cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy) and channelopathies (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome).  In our lab, we utilize human induced pluripotent stem cells, mouse models, and in vitro cellular models of disease.  Further, I have an active translational research interest in the interpretation of cardiovascular genetic testing and clarifying “variants of unknown significance”.   Overall, I hope to 1) utilize human genetics and functional genomics to more accurately diagnosis, risk stratify, and treat children and young adults at risk for these diseases and 2) determine the underlying molecular mechanisms of these complex and deadly diseases to identify novel patient-specific therapies.

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