Andrew Paul Landstrom | Scholars@Duke

Andrew Paul Landstrom
Assistant Professor of Pediatrics

I am interested in the genetic and molecular mechanisms of sudden cardiac arrest in children. I am a physician-scientist trained at the confluence of pediatric cardiology, clinical electrophysiology, human genetics, and molecular biology which I apply towards the care for children with heritable arrhythmic disease of the heart. I run a basic science research lab exploring the genetic and molecular causes of sudden cardiac death in children and young adults. These include cardiomyopathies (hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular dysplasia/cardiomyopathy) and channelopathies (long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome). In our lab, we utilize human induced pluripotent stem cells, mouse models, and in vitro cellular models of disease. Further, I have an active translational research interest in the interpretation of cardiovascular genetic testing and clarifying “variants of unknown significance”. Overall, I hope to 1) utilize human genetics and functional genomics to more accurately diagnosis, risk stratify, and treat children and young adults at risk for these diseases and 2) determine the underlying molecular mechanisms of these complex and deadly diseases to identify novel patient-specific therapies.

Current Appointments & Affiliations

Assistant Professor of Pediatrics, Pediatrics, Cardiology, Pediatrics 2018
Assistant Professor in Cell Biology, Cell Biology, Basic Science Departments 2019

Contact Information

Duke University Medical Center, Box 2652, Durham, NC 27710
Duke University Medical Center, Box 2652, Durham, NC 27710
andrew.landstrom@duke.edu (919) 684-3028
Landstrom Lab Website
ORCiD Profile

Background
Education, Training, & Certifications
- Pediatric Cardiology Certification, American Board of Pediatrics 2018 - 2099
- General Pediatrics Certification, American Board of Pediatrics 2015 - 2099
- Advanced Clinical Fellowship, Pediatrics/Electrophysiology, Baylor College of Medicine 2017 - 2018
- Post-Doctoral Research Fellowship, Molecular Physiology And Biophysics, Baylor College of Medicine 2013 - 2018
- Clinical Fellowship, Pediatrics/Cardiology, Baylor College of Medicine 2014 - 2017
- Residency, Pediatrics, Baylor College of Medicine 2013 - 2014
- Internship, Pediatrics, Baylor College of Medicine 2012 - 2013
- M.D., Mayo School of Health Sciences 2012
- Ph.D., Mayo School of Health Sciences 2012
Recognition
In the News
- JAN 31, 2019 Duke Dept of Pediatrics
  
  Faculty Spotlight: Andrew Landstrom, MD, PhD
- JAN 23, 2019 Duke Research Blog
  
  Using Genetic Clues to Reform Cardiac Care
- NOV 15, 2018 Duke Dept of Pediatrics
  
  Landstrom wins AHA Early Career Investigator Award
- NOV 9, 2018 Duke Dept of Pediatrics
  
  Two from Pediatrics win 2018 MEDx pilot project grants
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- The Role of Junctophilin Type 2 in Cardiac Node Automaticity awarded by National Institutes of Health 2018 - 2022
Fellowships, Supported Research, & Other Grants
- In vivo evaluation of novel anti-arrhythmic compounds to terminate potentially fatal tachyarrhythmia awarded by Mike Hogg Fund 2018
- The role of junctophilin-2 in the development of youthful sinus and atrioventricular nodal disease awarded by Pediatric and Congenital Electrophysiology Society 2016 - 2017
- The role of RyR2-Asn4643del in CPVT with emotionally-triggered sudden death awarded by National Institutes of Health 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Jones, Edward G., Neda Mazaheri, Reza Maroofian, Mina Zamani, Tahereh Seifi, Alireza Sedaghat, Gholamreza Shariati, et al. “Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy..” Sci Rep 9, no. 1 (June 21, 2019). https://doi.org/10.1038/s41598-019-44987-6.
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  - Headrick, Andrew T., Jill A. Rosenfeld, Yaping Yang, Hari Tunuguntla, Hugh D. Allen, Daniel J. Penny, Jeffrey J. Kim, and Andrew P. Landstrom. “Incidentally identified genetic variants in arrhythmogenic right ventricular cardiomyopathy-associated genes among children undergoing exome sequencing reflect healthy population variation..” Mol Genet Genomic Med 7, no. 6 (June 2019). https://doi.org/10.1002/mgg3.593.
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  - Jones, Edward G., and Andrew P. Landstrom. “Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation..” J Vis Exp, no. 143 (January 16, 2019). https://doi.org/10.3791/58907.
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  - Connell, Patrick S., Aamir Jeewa, Debra L. Kearney, Hari Tunuguntla, Susan W. Denfield, Hugh D. Allen, and Andrew P. Landstrom. “A 14-year-old in heart failure with multiple cardiomyopathy variants illustrates a role for signal-to-noise analysis in gene test re-interpretation..” Clinical Case Reports 7, no. 1 (January 2019): 211–17. https://doi.org/10.1002/ccr3.1920.
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  - Valdés, Santiago O., Christina Y. Miyake, Mary C. Niu, Caridad M. de la Uz, S Yukiko Asaki, Andrew P. Landstrom, Andrew E. Schneider, et al. “Early experience with intravenous sotalol in children with and without congenital heart disease..” Heart Rhythm 15, no. 12 (December 2018): 1862–69. https://doi.org/10.1016/j.hrthm.2018.07.010.
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  - Dailey-Schwartz, Andrew L., Hanna J. Tadros, Mahshid Sababi Azamian, Seema R. Lalani, Shaine A. Morris, Hugh D. Allen, Jeffrey J. Kim, and Andrew P. Landstrom. “Copy Number Variants of Undetermined Significance Are Not Associated with Worse Clinical Outcomes in Hypoplastic Left Heart Syndrome..” J Pediatr 202 (November 2018): 206-211.e2. https://doi.org/10.1016/j.jpeds.2018.07.022.
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  - Valdés, Santiago O., Andrew P. Landstrom, Andrew E. Schneider, Christina Y. Miyake, Caridad M. de la Uz, and Jeffrey J. Kim. “Intravenous sotalol for the management of postoperative junctional ectopic tachycardia..” Heartrhythm Case Rep 4, no. 8 (August 2018): 375–77. https://doi.org/10.1016/j.hrcr.2018.05.007.
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  - Landstrom, Andrew P., Ernesto Fernandez, Jill A. Rosenfeld, Yaping Yang, Andrew L. Dailey-Schwartz, Christina Y. Miyake, Hugh D. Allen, Daniel J. Penny, and Jeffrey J. Kim. “Amino acid-level signal-to-noise analysis of incidentally identified variants in genes associated with long QT syndrome during pediatric whole exome sequencing reflects background genetic noise..” Heart Rhythm 15, no. 7 (July 2018): 1042–50. https://doi.org/10.1016/j.hrthm.2018.02.031.
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  - Hildebrandt, Michelle A. T., Monica Reyes, Xifeng Wu, Xia Pu, Kara A. Thompson, Jianzhong Ma, Andrew P. Landstrom, Alanna C. Morrison, and Joann L. Ater. “Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors..” Sci Rep 7, no. 1 (August 29, 2017). https://doi.org/10.1038/s41598-017-09517-2.
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  - Landstrom, Andrew P., Dobromir Dobrev, and Xander H. T. Wehrens. “Calcium Signaling and Cardiac Arrhythmias..” Circ Res 120, no. 12 (June 9, 2017): 1969–93. https://doi.org/10.1161/CIRCRESAHA.117.310083.
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  - Landstrom, Andrew P., Andrew L. Dailey-Schwartz, Jill A. Rosenfeld, Yaping Yang, Margaret J. McLean, Christina Y. Miyake, Santiago O. Valdes, et al. “Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals..” Circ Arrhythm Electrophysiol 10, no. 4 (April 2017). https://doi.org/10.1161/CIRCEP.116.004742.
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  - Quick, Ann P., Andrew P. Landstrom, Qiongling Wang, David L. Beavers, Julia O. Reynolds, Giselle Barreto-Torres, Viet Tran, et al. “Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction..” Jacc Basic Transl Sci 2, no. 1 (February 2017): 56–67. https://doi.org/10.1016/j.jacbts.2016.11.004.
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  - Veltri, Tiago, Maicon Landim-Vieira, Michelle S. Parvatiyar, David Gonzalez-Martinez, Karissa M. Dieseldorff Jones, Clara A. Michell, David Dweck, Andrew P. Landstrom, P Bryant Chase, and Jose R. Pinto. “Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation..” Front Physiol 8 (2017). https://doi.org/10.3389/fphys.2017.00221.
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  - Landstrom, Andrew P., Nicole J. Boczek, Dan Ye, Christina Y. Miyake, Caridad M. De la Uz, Hugh D. Allen, Michael J. Ackerman, and Jeffrey J. Kim. “Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current..” Int J Cardiol 220 (October 1, 2016): 290–98. https://doi.org/10.1016/j.ijcard.2016.06.081.
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  - Quick, Ann P., Andrew P. Landstrom, and Xander H. T. Wehrens. “Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling..” Heart Rhythm 13, no. 3 (March 2016): 753–54. https://doi.org/10.1016/j.hrthm.2015.11.026.
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  - Landstrom, Andrew P., Jenny J. Sun, Russell S. Ray, and Xander H. T. Wehrens. “It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias..” Heart Rhythm 12, no. 11 (November 2015): 2294–95. https://doi.org/10.1016/j.hrthm.2015.07.008.
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  - Wang, Wei, Andrew P. Landstrom, Qiongling Wang, Michelle L. Munro, David Beavers, Michael J. Ackerman, Christian Soeller, and Xander H. T. Wehrens. “Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice..” Am J Physiol Heart Circ Physiol 307, no. 9 (November 1, 2014): H1317–26. https://doi.org/10.1152/ajpheart.00413.2014.
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  - Beavers, David L., Andrew P. Landstrom, David Y. Chiang, and Xander H. T. Wehrens. “Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases..” Cardiovasc Res 103, no. 2 (July 15, 2014): 198–205. https://doi.org/10.1093/cvr/cvu151.
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  - Landstrom, Andrew P., David L. Beavers, and Xander H. T. Wehrens. “The junctophilin family of proteins: from bench to bedside..” Trends Mol Med 20, no. 6 (June 2014): 353–62. https://doi.org/10.1016/j.molmed.2014.02.004.
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  - Kapplinger, Jamie D., Andrew P. Landstrom, J Martijn Bos, Benjamin A. Salisbury, Thomas E. Callis, and Michael J. Ackerman. “Distinguishing hypertrophic cardiomyopathy-associated mutations from background genetic noise..” J Cardiovasc Transl Res 7, no. 3 (April 2014): 347–61. https://doi.org/10.1007/s12265-014-9542-z.
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  - Beavers, David L., Wei Wang, Sameer Ather, Niels Voigt, Alejandro Garbino, Sayali S. Dixit, Andrew P. Landstrom, et al. “Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization..” J Am Coll Cardiol 62, no. 21 (November 19, 2013): 2010–19. https://doi.org/10.1016/j.jacc.2013.06.052.
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  - Reynolds, Julia O., David Y. Chiang, Wei Wang, David L. Beavers, Sayali S. Dixit, Darlene G. Skapura, Andrew P. Landstrom, Long-Sheng Song, Michael J. Ackerman, and Xander H. T. Wehrens. “Junctophilin-2 is necessary for T-tubule maturation during mouse heart development..” Cardiovasc Res 100, no. 1 (October 1, 2013): 44–53. https://doi.org/10.1093/cvr/cvt133.
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  - Parvatiyar, Michelle S., Andrew P. Landstrom, Cicero Figueiredo-Freitas, James D. Potter, Michael J. Ackerman, and Jose Renato Pinto. “A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation..” J Biol Chem 287, no. 38 (September 14, 2012): 31845–55. https://doi.org/10.1074/jbc.M112.377713.
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  - Landstrom, A. P., and M. J. Ackerman. “Beyond the cardiac myofilament: hypertrophic cardiomyopathy- associated mutations in genes that encode calcium-handling proteins..” Curr Mol Med 12, no. 5 (June 2012): 507–18.
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  - Landstrom, A. P., D. J. Tester, and M. J. Ackerman. “Role of genetic testing for sudden death predisposing heart conditions in athletes,” December 1, 2011, 85–100. https://doi.org/10.1007/978-0-387-92775-6_5.
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  - Landstrom, A. P., and M. J. Ackerman. “The Achilles' heel of cardiovascular genetic testing: distinguishing pathogenic mutations from background genetic noise..” Clin Pharmacol Ther 90, no. 4 (October 2011): 496–99. https://doi.org/10.1038/clpt.2011.192.
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  - Kapplinger, Jamie D., Andrew P. Landstrom, Benjamin A. Salisbury, Thomas E. Callis, Guido D. Pollevick, David J. Tester, Moniek G. P. J. Cox, et al. “Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia-associated mutations from background genetic noise..” J Am Coll Cardiol 57, no. 23 (June 7, 2011): 2317–27. https://doi.org/10.1016/j.jacc.2010.12.036.
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  - Waddell, Leigh B., Frances A. Lemckert, Xi F. Zheng, Jenny Tran, Frances J. Evesson, Joanne M. Hawkes, Angela Lek, et al. “Dysferlin, annexin A1, and mitsugumin 53 are upregulated in muscular dystrophy and localize to longitudinal tubules of the T-system with stretch..” J Neuropathol Exp Neurol 70, no. 4 (April 2011): 302–13. https://doi.org/10.1097/NEN.0b013e31821350b0.
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  - Oort, Ralph J. van, Alejandro Garbino, Wei Wang, Sayali S. Dixit, Andrew P. Landstrom, Namit Gaur, Angela C. De Almeida, et al. “Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice..” Circulation 123, no. 9 (March 8, 2011): 979–88. https://doi.org/10.1161/CIRCULATIONAHA.110.006437.
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  - Landstrom, Andrew P., Cherisse A. Kellen, Sayali S. Dixit, Ralph J. van Oort, Alejandro Garbino, Noah Weisleder, Jianjie Ma, Xander H. T. Wehrens, and Michael J. Ackerman. “Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling..” Circ Heart Fail 4, no. 2 (March 2011): 214–23. https://doi.org/10.1161/CIRCHEARTFAILURE.110.958694.
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  - Landstrom, Andrew P., Babatunde A. Adekola, J Martijn Bos, Steve R. Ommen, and Michael J. Ackerman. “PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing..” Am Heart J 161, no. 1 (January 2011): 165–71. https://doi.org/10.1016/j.ahj.2010.08.001.
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  - Ho, Carolyn Y. “Genetics and clinical destiny: improving care in hypertrophic cardiomyopathy..” Circulation 122, no. 23 (December 7, 2010): 2430–40. https://doi.org/10.1161/CIRCULATIONAHA.110.978924.
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  - Landstrom, Andrew P., and Michael J. Ackerman. “Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy..” Circulation 122, no. 23 (December 7, 2010): 2441–49. https://doi.org/10.1161/CIRCULATIONAHA.110.954446.
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  - Landstrom, Andrew P., and Michael J. Ackerman. “Is genotype clinically useful in predicting prognosis in hypertrophic cardiomyopathy? Genetics and Clinical Destiny: Improving Care in Hypertrophic Cardiomyopathy Response.” Circulation 122, no. 23 (December 7, 2010): 2440–2440.
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  - Landstrom, Andrew P., and Michael J. Ackerman. “GWAS or Gee Whiz, PSAS or Pshaw: elucidating the biologic and clinical significance of genetic variation in cardiovascular disease..” Heart Rhythm 6, no. 12 (December 2009): 1751–53. https://doi.org/10.1016/j.hrthm.2009.09.016.
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  - Garbino, Alejandro, Ralph J. van Oort, Sayali S. Dixit, Andrew P. Landstrom, Michael J. Ackerman, and Xander H. T. Wehrens. “Molecular evolution of the junctophilin gene family..” Physiol Genomics 37, no. 3 (May 13, 2009): 175–86. https://doi.org/10.1152/physiolgenomics.00017.2009.
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  - Landstrom, Andrew P., Michelle S. Parvatiyar, Jose R. Pinto, Michelle L. Marquardt, J Martijn Bos, David J. Tester, Steve R. Ommen, James D. Potter, and Michael J. Ackerman. “Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C..” J Mol Cell Cardiol 45, no. 2 (August 2008): 281–88. https://doi.org/10.1016/j.yjmcc.2008.05.003.
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  - Ackerman, Michael J., and Andrew P. Landstrom. “Detection of subclinical fabry disease in patients presenting with hypertrophic cardiomyopathy..” J Am Coll Cardiol 50, no. 25 (December 18, 2007): 2404–5. https://doi.org/10.1016/j.jacc.2007.09.022.
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  - Landstrom, Andrew P., Ryan A. Knudson, Gordon W. Dewald, Rhett P. Ketterling, and Ayalew Tefferi. “Philadelphia chromosome mosaicism at diagnosis in chronic myeloid leukemia: clinical correlates and effect on imatinib mesylate treatment outcome..” Leuk Lymphoma 48, no. 11 (November 2007): 2137–40. https://doi.org/10.1080/10428190701618284.
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  - Pandit, Bhaswati, Anna Sarkozy, Len A. Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A. Pogna, et al. “Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy..” Nat Genet 39, no. 8 (August 2007): 1007–12. https://doi.org/10.1038/ng2073.
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  - Landstrom, Andrew P., Noah Weisleder, Karin B. Batalden, J Martijn Bos, David J. Tester, Steve R. Ommen, Xander H. T. Wehrens, et al. “Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans..” J Mol Cell Cardiol 42, no. 6 (June 2007): 1026–35. https://doi.org/10.1016/j.yjmcc.2007.04.006.
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  - Landstrom, Andrew P., Rhett P. Ketterling, Ryan A. Knudson, and Ayalew Tefferi. “Utility of peripheral blood dual color, double fusion fluorescent in situ hybridization for BCR/ABL fusion to assess cytogenetic remission status in chronic myeloid leukemia..” Leuk Lymphoma 47, no. 10 (October 2006): 2055–61. https://doi.org/10.1080/10428190600783551.
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  - Landstrom, Andrew P., and Ayalew Tefferi. “Fluorescent in situ hybridization in the diagnosis, prognosis, and treatment monitoring of chronic myeloid leukemia..” Leuk Lymphoma 47, no. 3 (March 2006): 397–402. https://doi.org/10.1080/10428190500353133.
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Teaching & Mentoring
Advising & Mentoring
- I always enjoy hearing from clinicians and scientists in training of all levels who are interested in our research directions. I have experience mentoring medical students, residents, and clinical fellows as well as graduate students and post-doctoral research fellows. Please take a look at our lab website for more information.

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Education, Training, & Certifications

In the News

Awards & Honors

Subject Headings

Selected Grants

Fellowships, Supported Research, & Other Grants

Selected Publications

Academic Articles

Advising & Mentoring