Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
Eeles, RA; Olama, AAA; Benlloch, S; Saunders, EJ; Leongamornlert, DA; Tymrakiewicz, M; Ghoussaini, M; Luccarini, C; Dennis, J; Jugurnauth-Little, S; Dadaev, T; Neal, DE; Hamdy, FC; Donovan, JL; Muir, K; Giles, GG; Severi, G; Wiklund, F; Gronberg, H; Haiman, CA; Schumacher, F; Henderson, BE; Le Marchand, L; Lindstrom, S; Kraft, P; Hunter, DJ; Gapstur, S; Chanock, SJ; Berndt, SI; Albanes, D; Andriole, G; Schleutker, J; Weischer, M; Canzian, F; Riboli, E; Key, TJ; Travis, RC; Campa, D; Ingles, SA; John, EM; Hayes, RB; Pharoah, PDP; Pashayan, N; Khaw, K-T; Stanford, JL; Ostrander, EA; Signorello, LB; Thibodeau, SN; Schaid, D; Maier, C; Vogel, W; Kibel, AS; Cybulski, C; Lubinski, J; Cannon-Albright, L; Brenner, H; Park, JY; Kaneva, R; Batra, J; Spurdle, AB; Clements, JA; Teixeira, MR; Dicks, E; Lee, A; Dunning, AM; Baynes, C; Conroy, D; Maranian, MJ; Ahmed, S; Govindasami, K; Guy, M; Wilkinson, RA; Sawyer, EJ; Morgan, A; Dearnaley, DP; Horwich, A; Huddart, RA; Khoo, VS; Parker, CC; Van As, NJ; Woodhouse, CJ; Thompson, A; Dudderidge, T; Ogden, C; Cooper, CS; Lophatananon, A; Cox, A; Southey, MC; Hopper, JL; English, DR; Aly, M; Adolfsson, J; Xu, J; Zheng, SL; Yeager, M; Kaaks, R; Diver, WR; Gaudet, MM; Stern, MC; Corral, R; Joshi, AD; Shahabi, A; Wahlfors, T; Tammela, TLJ; Auvinen, A; Virtamo, J; Klarskov, P; Nordestgaard, BG; Røder, MA; Nielsen, SF; Bojesen, SE; Siddiq, A; Fitzgerald, LM; Kolb, S; Kwon, EM; Karyadi, DM; Blot, WJ; Zheng, W; Cai, Q; McDonnell, SK; Rinckleb, AE; Drake, B; Colditz, G; Wokolorczyk, D; Stephenson, RA; Teerlink, C; Muller, H; Rothenbacher, D; Sellers, TA; Lin, H-Y; Slavov, C; Mitev, V; Lose, F; Srinivasan, S; Maia, S; Paulo, P; Lange, E; Cooney, KA; Antoniou, AC; Vincent, D; Bacot, F; Tessier, DC; COGS–Cancer Research UK GWAS–ELLIPSE (part of GAME-ON) Initiative, ; Australian Prostate Cancer Bioresource, ; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, ; UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators, ; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, ; Kote-Jarai, Z; Easton, DF
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