Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.
Duke Scholars
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- Risk Factors
- Prostatic Neoplasms
- Polymorphism, Single Nucleotide
- Oligonucleotide Array Sequence Analysis
- Meta-Analysis as Topic
- Male
- Humans
- Genotype
- Genome-Wide Association Study
- Genetic Predisposition to Disease
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Risk Factors
- Prostatic Neoplasms
- Polymorphism, Single Nucleotide
- Oligonucleotide Array Sequence Analysis
- Meta-Analysis as Topic
- Male
- Humans
- Genotype
- Genome-Wide Association Study
- Genetic Predisposition to Disease