Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.


Journal Article (Review)

In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia became the first gene therapy to be approved in the USA. This innovative form of cellular immunotherapy has been associated with remarkable response rates but is also associated with unique and often severe toxicities, which can lead to rapid cardiorespiratory and/or neurological deterioration. Multidisciplinary medical vigilance and the requisite health-care infrastructure are imperative to ensuring optimal patient outcomes, especially as these therapies transition from research protocols to standard care. Herein, authors representing the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Hematopoietic Stem Cell Transplantation (HSCT) Subgroup and the MD Anderson Cancer Center CAR T Cell Therapy-Associated Toxicity (CARTOX) Program have collaborated to provide comprehensive consensus guidelines on the care of children receiving CAR T cell therapy.

Full Text

Duke Authors

Cited Authors

  • Mahadeo, KM; Khazal, SJ; Abdel-Azim, H; Fitzgerald, JC; Taraseviciute, A; Bollard, CM; Tewari, P; Duncan, C; Traube, C; McCall, D; Steiner, ME; Cheifetz, IM; Lehmann, LE; Mejia, R; Slopis, JM; Bajwa, R; Kebriaei, P; Martin, PL; Moffet, J; McArthur, J; Petropoulos, D; O'Hanlon Curry, J; Featherston, S; Foglesong, J; Shoberu, B; Gulbis, A; Mireles, ME; Hafemeister, L; Nguyen, C; Kapoor, N; Rezvani, K; Neelapu, SS; Shpall, EJ; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network,

Published Date

  • January 2019

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 45 - 63

PubMed ID

  • 30082906

Pubmed Central ID

  • 30082906

Electronic International Standard Serial Number (EISSN)

  • 1759-4782

Digital Object Identifier (DOI)

  • 10.1038/s41571-018-0075-2


  • eng

Conference Location

  • England