The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.

Journal Article (Journal Article;Review)

Originally identified as a cell surface receptor that triggered the death of lymphocytes and tumor cells, it is now recognized that Fas (also known as CD95 or Apo-I) has distinct functions in the life and death of different cell types in the immune system. Fas signaling may also be involved in T cell costimulation and proliferation. Although Fas deficiency in humans and mice predisposes them towards systemic autoimmunity, Fas-FasL interactions can also facilitate organ-specific immunopathology. Proximal signaling by Fas and related receptors depends on subunit preassembly, which accounts for the dominant-negative effect of pathogenic receptor mutants and natural splice variants.

Full Text

Duke Authors

Cited Authors

  • Siegel, RM; Chan, FK; Chun, HJ; Lenardo, MJ

Published Date

  • December 2000

Published In

Volume / Issue

  • 1 / 6

Start / End Page

  • 469 - 474

PubMed ID

  • 11101867

International Standard Serial Number (ISSN)

  • 1529-2908

Digital Object Identifier (DOI)

  • 10.1038/82712


  • eng

Conference Location

  • United States