Francis Ka-Ming Chan | Scholars@Duke

Francis Ka-Ming Chan
Professor of Immunology

Our lab is interested in how cell death impacts innate inflammation and immune responses. We have a long-standing interest in the biology and signaling mechanism of tumor necrosis factor (TNF), a key cytokine that regulates many inflammatory diseases (e.g. rheumatoid arthritis, inflammatory bowel diseases etc), pathogen infections, and cancer. Several key discoveries made by the PI during his graduate school and postdoctoral training include identification of one of the first cell cycle inhibitors, INK4d-p19 (Mol Cell Biol. 1995, cited over 300 times), and the discovery of the "pre-ligand assembly domain (PLAD)" that mediates TNF receptors signal transduction (Science 2000, cited over 800 times).

In recent years, we have focused our effort on elucidating the signaling mechanism of a novel form of inflammatory cell death termed necroptosis. In 2009, our group identified Receptor Interacting Protein kinase 3 (RIPK3) as a central mediator of necroptosis (Cell, 2009, cited over 1000 times). Current projects include (1) deciphering the signaling mechanisms of necroptosis, (2) interrogation of the biology of RIPK3 and related necroptosis signaling molecules in intestinal wound healing and inflammation, (3) elucidation of the role of necroptosis in pathogen infections, and many others.

We aim to take the knowledge we gain from basic pathway discovery to better understand the principles of immune regulation. We believe our endeavor will pave the way for more efficacious therapeutic intervention in auto-inflammatory diseases, cancers and pathogen infections.

Current research projects in the lab include the following broad areas. Interested students and postdoctoral candidates are encouraged to contact Dr. Chan for more information on rotation projects and research opportunities.

1. The role of necroptosis signal adaptors in inflammatory diseases
We are interested in how the kinases RIPK1 and RIPK3, both of which have critical functions in cell death, contribute to injury-induced inflammation and tissue repair. Currently, we are using mouse models of intestinal injury and inflammation to study the function of these signal adaptors in intestinal homeostasis.

2. The role of cell death in anti-viral immune responses
We have discovered that necroptosis is an important innate immune defense mechanism against certain viruses. We are interested in how host cell death during pathogen infections can alter the course of the host immune response. On the other hand, we are also interested in exploring the mechanisms employed by different viral pathogens in combating the host cell death machinery.

3. Signaling mechanism of RIP kinases in cell death and inflammation
We found that the RIP kinases can promote inflammation through cell death-dependent and independent mechanisms. What are the molecular events that regulate the diverse functions of the RIP kinases? We are using biochemical, cell biological, and genetic tools to dissect the molecular regulation of these important immune signaling molecules.

Current Research Interests

Current research projects in the lab include the following broad areas. Interested students and postdoctoral candidates are encouraged to contact Dr. Chan for more information on rotation projects and research opportunities.

1. The role of necroptosis signal adaptors in inflammatory diseases
We are interested in how the kinases RIPK1 and RIPK3, both of which have critical functions in cell death, contribute to injury-induced inflammation and tissue repair. Currently, we are using mouse models of intestinal injury and inflammation to study the function of these signal adaptors in intestinal homeostasis.

2. The role of cell death in anti-viral immune responses
We have discovered that necroptosis is an important innate immune defense mechanism against certain viruses. We are interested in how host cell death during pathogen infections can alter the course of the host immune response. On the other hand, we are also interested in exploring the mechanisms employed by different viral pathogens in combating the host cell death machinery.

3. Signaling mechanism of RIP kinases in cell death and inflammation
We found that the RIP kinases can promote inflammation through cell death-dependent and independent mechanisms. What are the molecular events that regulate the diverse functions of the RIP kinases? We are using biochemical, cell biological, and genetic tools to dissect the molecular regulation of these important immune signaling molecules.

Current Appointments & Affiliations

Professor of Immunology, Immunology, Basic Science Departments 2019
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2018

Contact Information

312 Jones Building, DUMC 3010, Durham, NC 27710
Jones 312, DUMC 3010, Durham, NC 27710
franciskaming.chan@duke.edu (919) 613-3892

Background
Education, Training, & Certifications
- Ph.D., University of California at Berkeley 1996
Duke Appointment History
- Instructor in the Department of Immunology, Immunology, Basic Science Departments 2018 - 2019
Academic Positions Outside Duke
- Professor of Pathology, University of Massachusetts Medical School. 2016 - 2018
- Associate Professor, University of Massachusetts Medical School. 2011 - 2016
- Assistant Professor, University of Massachusetts Medical School. 2002 - 2011
Recognition
Awards & Honors
Research
Selected Grants
- Investigating the PD-L1:NLRP3 signaling axis as a tumor intrinsic mechanism of adaptive resistance to anti-PD-1 antibody immunotherapy awarded by National Institutes of Health 2020 - 2025
- Necroptosis signaling adaptors in inflammatory diseases awarded by National Institutes of Health 2018 - 2021
- Viral mechanisms of necroptosis evasion awarded by National Institutes of Health 2018 - 2019
Publications & Artistic Works
Selected Publications
- Books
  - Galluzzi, Lorenzo, Oliver Kepp, Francis Ka-Ming Chan, and Guido Kroemer. Necroptosis: Mechanisms and Relevance to Disease. Vol. 12, 2017. https://doi.org/10.1146/annurev-pathol-052016-100247.
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- Academic Articles
  - Moriwaki, Kenta, Sakthi Balaji, and Francis Ka-Ming Chan. “The death-inducing activity of RIPK1 is regulated by the pH environment.” Sci Signal 13, no. 631 (May 12, 2020). https://doi.org/10.1126/scisignal.aay7066.
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  - Nailwal, Himani, and Francis Ka-Ming Chan. “Necroptosis in anti-viral inflammation.” Cell Death Differ 26, no. 1 (January 2019): 4–13. https://doi.org/10.1038/s41418-018-0172-x.
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  - Galluzzi, Lorenzo, Ilio Vitale, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Patrizia Agostinis, Emad S. Alnemri, et al. “Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.” Cell Death Differ 25, no. 3 (March 2018): 486–541. https://doi.org/10.1038/s41418-017-0012-4.
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  - Rathinam, Vijay A. K., and Francis Ka-Ming Chan. “Inflammasome, Inflammation, and Tissue Homeostasis.” Trends Mol Med 24, no. 3 (March 2018): 304–18. https://doi.org/10.1016/j.molmed.2018.01.004.
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  - Luz, Nivea F., Ricardo Khouri, Johan Van Weyenbergh, Dalila L. Zanette, Paloma P. Fiuza, Almerio Noronha, Aldina Barral, et al. “Leishmania braziliensis Subverts Necroptosis by Modulating RIPK3 Expression.” Front Microbiol 9 (2018): 2283. https://doi.org/10.3389/fmicb.2018.02283.
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  - Moquin, David Mark, and Francis Ka-Ming Chan. “Loss-of-Function RNAi Screen to Identify Necrosis-Signaling Molecules.” Methods Mol Biol 1857 (2018): 11–18. https://doi.org/10.1007/978-1-4939-8754-2_2.
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  - Kleino, Anni, Nancy F. Ramia, Gunes Bozkurt, Yanfang Shen, Himani Nailwal, Jing Huang, Johanna Napetschnig, et al. “Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signaling.” Immunity 47, no. 4 (October 17, 2017): 635-647.e6. https://doi.org/10.1016/j.immuni.2017.09.011.
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  - Orlowski, Gregory M., Shruti Sharma, Jeff D. Colbert, Matthew Bogyo, Stephanie A. Robertson, Hiroshi Kataoka, Francis K. Chan, and Kenneth L. Rock. “Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation.” J Leukoc Biol 102, no. 1 (July 2017): 7–17. https://doi.org/10.1189/jlb.3HI0316-152R.
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  - DeSouza-Vieira, Thiago, and Francis Ka-Ming Chan. “Bacterial pathogenesis: Pathogenic bacteria attack RHIM.” Nat Microbiol 2 (March 28, 2017): 17042. https://doi.org/10.1038/nmicrobiol.2017.42.
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  - Moriwaki, Kenta, Sakthi Balaji, John Bertin, Peter J. Gough, and Francis Ka-Ming Chan. “Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.” Cell Rep 18, no. 10 (March 7, 2017): 2441–51. https://doi.org/10.1016/j.celrep.2017.02.015.
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  - Chan, Francis Ka-Ming. “RIPK3 Slams the Brake on Leukemogenesis.” Cancer Cell 30, no. 1 (July 11, 2016): 7–9. https://doi.org/10.1016/j.ccell.2016.06.017.
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  - Farias Luz, Nivea, Sakthi Balaji, Kendi Okuda, Aline Silva Barreto, John Bertin, Peter J. Gough, Ricardo Gazzinelli, et al. “RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms.” J Immunol 196, no. 12 (June 15, 2016): 5056–63. https://doi.org/10.4049/jimmunol.1502492.
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  - Moriwaki, Kenta, and Francis Ka-Ming Chan. “Necroptosis-independent signaling by the RIP kinases in inflammation.” Cell Mol Life Sci 73, no. 11–12 (June 2016): 2325–34. https://doi.org/10.1007/s00018-016-2203-4.
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  - Moriwaki, Kenta, and Francis Ka-Ming Chan. “Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome.” J Biol Chem 291, no. 11 (March 11, 2016): 5948–59. https://doi.org/10.1074/jbc.M115.700997.
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  - Moriwaki, Kenta, Nivea Farias Luz, Sakthi Balaji, Maria Jose De Rosa, Carey L. O’Donnell, Peter J. Gough, John Bertin, Raymond M. Welsh, and Francis Ka-Ming Chan. “The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.” J Immunol 196, no. 1 (January 1, 2016): 407–15. https://doi.org/10.4049/jimmunol.1501662.
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  - Moriwaki, Kenta, Sakthi Balaji, and Francis Ka-Ming Chan. “Border Security: The Role of RIPK3 in Epithelium Homeostasis.” Front Cell Dev Biol 4 (2016): 70. https://doi.org/10.3389/fcell.2016.00070.
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  - Moriwaki, Kenta, John Bertin, Peter J. Gough, and Francis Ka-Ming Chan. “A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing.” J Immunol 194, no. 4 (February 15, 2015): 1938–44. https://doi.org/10.4049/jimmunol.1402167.
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  - Moriwaki, K., J. Bertin, P. J. Gough, G. M. Orlowski, and F. K. M. Chan. “Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death.” Cell Death Dis 6 (February 12, 2015): e1636. https://doi.org/10.1038/cddis.2015.16.
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  - Galluzzi, L., J. M. Bravo-San Pedro, I. Vitale, S. A. Aaronson, J. M. Abrams, D. Adam, E. S. Alnemri, et al. “Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.” Cell Death Differ 22, no. 1 (January 2015): 58–73. https://doi.org/10.1038/cdd.2014.137.
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  - Mandal, Pratyusha, Scott B. Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D. Lich, et al. “RIP3 induces apoptosis independent of pronecrotic kinase activity.” Mol Cell 56, no. 4 (November 20, 2014): 481–95. https://doi.org/10.1016/j.molcel.2014.10.021.
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  - Moriwaki, Kenta, Sakthi Balaji, Thomas McQuade, Nidhi Malhotra, Joonsoo Kang, and Francis Ka-Ming Chan. “The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.” Immunity 41, no. 4 (October 16, 2014): 567–78. https://doi.org/10.1016/j.immuni.2014.09.016.
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  - Chan, Francis Ka-Ming. “Cell biology: A guardian angel of cell integrity.” Nature 513, no. 7516 (September 4, 2014): 38–40. https://doi.org/10.1038/513038a.
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  - Polykratis, Apostolos, Nicole Hermance, Matija Zelic, Justine Roderick, Chun Kim, Trieu-My Van, Thomas H. Lee, Francis K. M. Chan, Manolis Pasparakis, and Michelle A. Kelliher. “Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.” J Immunol 193, no. 4 (August 15, 2014): 1539–43. https://doi.org/10.4049/jimmunol.1400590.
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  - Weng, Dan, Robyn Marty-Roix, Sandhya Ganesan, Megan K. Proulx, Gregory I. Vladimer, William J. Kaiser, Edward S. Mocarski, et al. “Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.” Proc Natl Acad Sci U S A 111, no. 20 (May 20, 2014): 7391–96. https://doi.org/10.1073/pnas.1403477111.
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  - Upton, Jason W., and Francis Ka-Ming Chan. “Staying alive: cell death in antiviral immunity.” Mol Cell 54, no. 2 (April 24, 2014): 273–80. https://doi.org/10.1016/j.molcel.2014.01.027.
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  - Zhang, Jianke, and Francis Ka-Ming Chan. “Cell biology. RIPK3 takes another deadly turn.” Science 343, no. 6177 (March 21, 2014): 1322–23. https://doi.org/10.1126/science.1252526.
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  - Sosna, Justyna, Susann Voigt, Sabine Mathieu, Arne Lange, Lutz Thon, Parvin Davarnia, Thomas Herdegen, et al. “TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death.” Cell Mol Life Sci 71, no. 2 (January 2014): 331–48. https://doi.org/10.1007/s00018-013-1381-6.
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  - McQuade, Thomas, Youngsik Cho, and Francis Ka-Ming Chan. “Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis.” Biochem J 456, no. 3 (December 15, 2013): 409–15. https://doi.org/10.1042/BJ20130860.
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  - Moriwaki, Kenta, and Francis Ka-Ming Chan. “RIP3: a molecular switch for necrosis and inflammation.” Genes Dev 27, no. 15 (August 1, 2013): 1640–49. https://doi.org/10.1101/gad.223321.113.
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  - Moquin, David M., Thomas McQuade, and Francis Ka-Ming Chan. “CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis.” Plos One 8, no. 10 (2013): e76841. https://doi.org/10.1371/journal.pone.0076841.
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  - Chan, Francis Ka-Ming. “Fueling the flames: Mammalian programmed necrosis in inflammatory diseases.” Cold Spring Harb Perspect Biol 4, no. 11 (November 1, 2012). https://doi.org/10.1101/cshperspect.a008805.
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  - Li, Jixi, Thomas McQuade, Ansgar B. Siemer, Johanna Napetschnig, Kenta Moriwaki, Yu-Shan Hsiao, Ermelinda Damko, et al. “The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.” Cell 150, no. 2 (July 20, 2012): 339–50. https://doi.org/10.1016/j.cell.2012.06.019.
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  - Fortes, Guilherme B., Leticia S. Alves, Rosane de Oliveira, Fabianno F. Dutra, Danielle Rodrigues, Patricia L. Fernandez, Thais Souto-Padron, et al. “Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.” Blood 119, no. 10 (March 8, 2012): 2368–75. https://doi.org/10.1182/blood-2011-08-375303.
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  - Zhang, Haibing, Xiaohui Zhou, Thomas McQuade, Jinghe Li, Francis Ka-Ming Chan, and Jianke Zhang. “Erratum: Corrigendum: Functional complementation between FADD and RIP1 in embryos and lymphocytes.” Nature 483, no. 7390 (March 2012): 498–498. https://doi.org/10.1038/nature10976.
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  - Chan, Francis Ka-Ming, and Eric H. Baehrecke. “RIP3 finds partners in crime.” Cell 148, no. 1–2 (January 20, 2012): 17–18. https://doi.org/10.1016/j.cell.2011.12.020.
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  - Zhang, Haibing, Xiaohui Zhou, Thomas McQuade, Jinghe Li, Francis Ka-Ming Chan, and Jianke Zhang. “Functional complementation between FADD and RIP1 in embryos and lymphocytes.” Nature 471, no. 7338 (March 17, 2011): 373–76. https://doi.org/10.1038/nature09878.
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  - Cho, YoungSik, Thomas McQuade, Haibing Zhang, Jianke Zhang, and Francis Ka-Ming Chan. “RIP1-dependent and independent effects of necrostatin-1 in necrosis and T cell activation.” Plos One 6, no. 8 (2011): e23209. https://doi.org/10.1371/journal.pone.0023209.
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  - Challa, Sreerupa, Melissa Woelfel, Melissa Guildford, David Moquin, and Francis Ka-Ming Chan. “Viral cell death inhibitor MC159 enhances innate immunity against vaccinia virus infection.” J Virol 84, no. 20 (October 2010): 10467–76. https://doi.org/10.1128/JVI.00983-10.
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  - Challa, Sreerupa, and Francis Ka-Ming Chan. “Going up in flames: necrotic cell injury and inflammatory diseases.” Cell Mol Life Sci 67, no. 19 (October 2010): 3241–53. https://doi.org/10.1007/s00018-010-0413-8.
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  - Cho, Young S., Sreerupa Challa, Lauren Clancy, and Francis K-M Chan. “Lipopolysaccharide-induced expression of TRAIL promotes dendritic cell differentiation.” Immunology 130, no. 4 (August 2010): 504–15. https://doi.org/10.1111/j.1365-2567.2010.03266.x.
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  - Moquin, David, and Francis Ka-Ming Chan. “The molecular regulation of programmed necrotic cell injury.” Trends Biochem Sci 35, no. 8 (August 2010): 434–41. https://doi.org/10.1016/j.tibs.2010.03.001.
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  - Cho, Young Sik, Seung Yeon Park, Hee Suk Shin, and Francis Ka-Ming Chan. “Physiological consequences of programmed necrosis, an alternative form of cell demise.” Mol Cells 29, no. 4 (April 2010): 327–32. https://doi.org/10.1007/s10059-010-0066-3.
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  - Cho, Young Sik, Sreerupa Challa, David Moquin, Ryan Genga, Tathagat Dutta Ray, Melissa Guildford, and Francis Ka-Ming Chan. “Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.” Cell 137, no. 6 (June 12, 2009): 1112–23. https://doi.org/10.1016/j.cell.2009.05.037.
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  - Chan, Francis Ka-Ming. “Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling.” Cytokine 37, no. 2 (February 2007): 101–7. https://doi.org/10.1016/j.cyto.2007.03.005.
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  - Woelfel, Melissa, Jacqueline Bixby, Michael A. Brehm, and Francis Ka-Ming Chan. “Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.” J Immunol 177, no. 6 (September 15, 2006): 3814–20. https://doi.org/10.4049/jimmunol.177.6.3814.
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  - Sedger, Lisa M., Sarah R. Osvath, Xiao-Ming Xu, Grace Li, Francis K-M Chan, John W. Barrett, and Grant McFadden. “Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death.” J Virol 80, no. 18 (September 2006): 9300–9309. https://doi.org/10.1128/JVI.02449-05.
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  - Zheng, Lixin, Nicolas Bidere, David Staudt, Alan Cubre, Jan Orenstein, Francis K. Chan, and Michael Lenardo. “Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.” Mol Cell Biol 26, no. 9 (May 2006): 3505–13. https://doi.org/10.1128/MCB.26.9.3505-3513.2006.
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  - Clancy, Lauren, Karen Mruk, Kristina Archer, Melissa Woelfel, Juthathip Mongkolsapaya, Gavin Screaton, Michael J. Lenardo, and Francis Ka-Ming Chan. “Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.” Proc Natl Acad Sci U S A 102, no. 50 (December 13, 2005): 18099–104. https://doi.org/10.1073/pnas.0507329102.
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  - Deng, Guo-Min, Lixin Zheng, Francis Ka-Ming Chan, and Michael Lenardo. “Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors.” Nat Med 11, no. 10 (October 2005): 1066–72. https://doi.org/10.1038/nm1304.
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  - Chan, Francis Ka-Ming, Joanna Shisler, Jacqueline G. Bixby, Martin Felices, Lixin Zheng, Michael Appel, Jan Orenstein, Bernard Moss, and Michael J. Lenardo. “A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.” J Biol Chem 278, no. 51 (December 19, 2003): 51613–21. https://doi.org/10.1074/jbc.M305633200.
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  - Chan, Francis Ka-Ming, and Michael J. Lenardo. “Tumor Necrosis Factor Family Ligands and Receptors in the Immune System: Targets for Future Pharmaceuticals.” Drug News Perspect 15, no. 8 (October 2002): 483–90. https://doi.org/10.1358/dnp.2002.15.8.840068.
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  - Chan, F. K., R. M. Siegel, D. Zacharias, R. Swofford, K. L. Holmes, R. Y. Tsien, and M. J. Lenardo. “Fluorescence resonance energy transfer analysis of cell surface receptor interactions and signaling using spectral variants of the green fluorescent protein.” Cytometry 44, no. 4 (August 1, 2001): 361–68. https://doi.org/10.1002/1097-0320(20010801)44:4<361::aid-cyto1128>3.0.co;2-3.
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  - Siegel, R. M., F. K. Chan, H. J. Chun, and M. J. Lenardo. “The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.” Nat Immunol 1, no. 6 (December 2000): 469–74. https://doi.org/10.1038/82712.
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  - Chan, F. K. “The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function.” Ann Rheum Dis 59 Suppl 1 (November 2000): i50–53. https://doi.org/10.1136/ard.59.suppl_1.i50.
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  - Chan, K. F., M. R. Siegel, and J. M. Lenardo. “Signaling by the TNF receptor superfamily and T cell homeostasis.” Immunity 13, no. 4 (October 2000): 419–22. https://doi.org/10.1016/s1074-7613(00)00041-8.
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  - Chan, F. K., H. J. Chun, L. Zheng, R. M. Siegel, K. L. Bui, and M. J. Lenardo. “A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.” Science 288, no. 5475 (June 30, 2000): 2351–54. https://doi.org/10.1126/science.288.5475.2351.
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  - Siegel, R. M., J. K. Frederiksen, D. A. Zacharias, F. K. Chan, M. Johnson, D. Lynch, R. Y. Tsien, and M. J. Lenardo. “Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.” Science 288, no. 5475 (June 30, 2000): 2354–57. https://doi.org/10.1126/science.288.5475.2354.
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  - Chan, F. K., and M. J. Lenardo. “A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes.” Eur J Immunol 30, no. 2 (February 2000): 652–60. https://doi.org/10.1002/1521-4141(200002)30:2<652::AID-IMMU652>3.0.CO;2-L.
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  - Wang, J., L. Zheng, A. Lobito, F. K. Chan, J. Dale, M. Sneller, X. Yao, J. M. Puck, S. E. Straus, and M. J. Lenardo. “Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.” Cell 98, no. 1 (July 9, 1999): 47–58. https://doi.org/10.1016/S0092-8674(00)80605-4.
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  - Brunner, M. C., C. A. Chambers, F. K. Chan, J. Hanke, A. Winoto, and J. P. Allison. “CTLA-4-Mediated inhibition of early events of T cell proliferation.” J Immunol 162, no. 10 (May 15, 1999): 5813–20.
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  - Lenardo, M., K. M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. “Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.” Annu Rev Immunol 17 (1999): 221–53. https://doi.org/10.1146/annurev.immunol.17.1.221.
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  - Chan, F. K., A. Chen, and A. Winoto. “Thymic expression of the transcription factor Nur77 rescues the T cell but not the B cell abnormality of gld/gld mice.” J Immunol 161, no. 8 (October 15, 1998): 4252–56.
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  - Cheng, L. E., F. K. Chan, D. Cado, and A. Winoto. “Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis.” Embo J 16, no. 8 (April 15, 1997): 1865–75. https://doi.org/10.1093/emboj/16.8.1865.
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  - Kalus, W., R. Baumgartner, C. Renner, A. Noegel, F. K. Chan, A. Winoto, and T. A. Holak. “NMR structural characterization of the CDK inhibitor p19INK4d.” Febs Lett 401, no. 2–3 (January 20, 1997): 127–32. https://doi.org/10.1016/s0014-5793(96)01465-2.
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  - Calnan, B. J., S. Szychowski, F. K. Chan, D. Cado, and A. Winoto. “A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection.” Immunity 3, no. 3 (September 1995): 273–82. https://doi.org/10.1016/1074-7613(95)90113-2.
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  - Chan, F. K., J. Zhang, L. Cheng, D. N. Shapiro, and A. Winoto. “Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4.” Mol Cell Biol 15, no. 5 (May 1995): 2682–88. https://doi.org/10.1128/mcb.15.5.2682.
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  - Itano, A., D. Cado, F. K. Chan, and E. Robey. “A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection.” Immunity 1, no. 4 (July 1994): 287–90. https://doi.org/10.1016/1074-7613(94)90080-9.
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- Book Sections
  - Moriwaki, K., and F. K. -. M. Chan. “The Inflammatory Signal Adaptor RIPK3: Functions Beyond Necroptosis.,” 328:253–75, 2017. https://doi.org/10.1016/bs.ircmb.2016.08.007.
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  - Chan, Francis Ka-Ming, Nivea Farias Luz, and Kenta Moriwaki. “Programmed necrosis in the cross talk of cell death and inflammation.,” 33:79–106, 2015. https://doi.org/10.1146/annurev-immunol-032414-112248.
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  - Moriwaki, K., and F. K. M. Chan. “Programmed necrosis in immunity and inflammatory diseases.” In Necrotic Cell Death, 177–94, 2014. https://doi.org/10.1007/978-1-4614-8220-8_10.
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  - Moriwaki, Kenta, and Francis K. M. Chan. “Necrosis-dependent and independent signaling of the RIP kinases in inflammation.” In Cytokine Growth Factor Rev, 25:167–74, 2014. https://doi.org/10.1016/j.cytogfr.2013.12.013.
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  - Cho, Youngsik, Sreerupa Challa, and Francis Ka-Ming Chan. “A RNA interference screen identifies RIP3 as an essential inducer of TNF-induced programmed necrosis.” In Adv Exp Med Biol, 691:589–93, 2011. https://doi.org/10.1007/978-1-4419-6612-4_62.
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Teaching & Mentoring
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