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Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling.

Publication ,  Journal Article
Chan, FK-M
Published in: Cytokine
February 2007

The tumor necrosis factor (TNF) family of cytokines and their receptors regulates many areas of metazoan biology. Specifically, this cytokine-receptor family plays crucial roles in regulating myriad aspects of immune development and functions. Disruption of ligand-receptor interaction or downstream signal transduction components in the TNF family often leads to pathological conditions. Historically, members of the TNF receptor family (TNFRs) were thought to exist as monomeric receptor chains prior to stimulation. Binding of the trimeric ligand then induces the trimerization of the receptors and activation of downstream signaling. However, recent evidence indicates that many TNFRs exist as pre-assembled oligomers on the cell surface. Pre-ligand assembly of TNFR oligomers is mediated by the pre-ligand assembly domain (PLAD), which resides within the membrane distal cysteine-rich domain of the receptors. Growing evidence indicates that PLAD-mediated receptor association regulates cellular responses to TNF-like cytokines, especially in cells of the immune system. Thus, targeting pre-ligand assembly may offer new possibilities for therapeutic intervention in different pathological conditions involving TNF-like cytokines.

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Published In

Cytokine

DOI

ISSN

1043-4666

Publication Date

February 2007

Volume

37

Issue

2

Start / End Page

101 / 107

Location

England

Related Subject Headings

  • fas Receptor
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Tumor Necrosis Factor
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Protein Structure, Quaternary
  • Ligands
  • Immunology
  • Humans
  • Animals
 

Citation

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MLA
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Chan, F.-M. (2007). Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling. Cytokine, 37(2), 101–107. https://doi.org/10.1016/j.cyto.2007.03.005
Chan, Francis Ka-Ming. “Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling.Cytokine 37, no. 2 (February 2007): 101–7. https://doi.org/10.1016/j.cyto.2007.03.005.
Chan, Francis Ka-Ming. “Three is better than one: pre-ligand receptor assembly in the regulation of TNF receptor signaling.Cytokine, vol. 37, no. 2, Feb. 2007, pp. 101–07. Pubmed, doi:10.1016/j.cyto.2007.03.005.
Journal cover image

Published In

Cytokine

DOI

ISSN

1043-4666

Publication Date

February 2007

Volume

37

Issue

2

Start / End Page

101 / 107

Location

England

Related Subject Headings

  • fas Receptor
  • T-Lymphocytes
  • Signal Transduction
  • Receptors, Tumor Necrosis Factor
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Protein Structure, Quaternary
  • Ligands
  • Immunology
  • Humans
  • Animals