Going up in flames: necrotic cell injury and inflammatory diseases.
Journal Article (Journal Article;Review)
Recent evidence indicates that cell death can be induced through multiple mechanisms. Strikingly, the same death signal can often induce apoptotic as well as non-apoptotic cell death. For instance, inhibition of caspases often converts an apoptotic stimulus to one that causes necrosis. Because a dedicated molecular circuitry distinct from that controlling apoptosis is required for necrotic cell injury, terms such as "programmed necrosis" or "necroptosis" have been used to distinguish stimulus-dependent necrosis from those induced by non-specific traumas (e.g., heat shock) or secondary necrosis induced as a consequence of apoptosis. In several experimental models, programmed necrosis/necroptosis has been shown to be a crucial control point for pathogen- or injury-induced inflammation. In this review, we will discuss the molecular mechanisms that regulate programmed necrosis/necroptosis and its biological significance in pathogen infections, drug-induced cell injury, and trauma-induced tissue damage.
Full Text
Duke Authors
Cited Authors
- Challa, S; Chan, FK-M
Published Date
- October 2010
Published In
Volume / Issue
- 67 / 19
Start / End Page
- 3241 - 3253
PubMed ID
- 20532807
Pubmed Central ID
- PMC3051829
Electronic International Standard Serial Number (EISSN)
- 1420-9071
Digital Object Identifier (DOI)
- 10.1007/s00018-010-0413-8
Language
- eng
Conference Location
- Switzerland