NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes.

Journal Article (Journal Article;Review)

NKG2D is an important immunosurveillance receptor that triggers a unique signal transduction pathway resulting in a variety of functional outcomes. NKG2D couples to the non-ITAM-containing DAP10 and initiates at least two signaling branches that are both required for cytotoxicity. Transformed, infected, or healthy cells can express NKG2D ligands, and NKG2D(+) lymphocytes can be unaffected, costimulated, or fully activated by the NKG2D-ligand interaction. The NKG2D-mediated response can be modulated by factors such as cytokine milieu and possibly the particular ligand expressed. Thus, this nontraditional NKG2D-DAP10 initiated signal pathway enables lymphocytes to differentially respond to ligands based on the cellular environment.

Full Text

Duke Authors

Cited Authors

  • Upshaw, JL; Leibson, PJ

Published Date

  • June 2006

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 167 - 175

PubMed ID

  • 16723257

International Standard Serial Number (ISSN)

  • 1044-5323

Digital Object Identifier (DOI)

  • 10.1016/j.smim.2006.03.001


  • eng

Conference Location

  • England