NKG2D-mediated activation of cytotoxic lymphocytes: unique signaling pathways and distinct functional outcomes.
Journal Article (Journal Article;Review)
NKG2D is an important immunosurveillance receptor that triggers a unique signal transduction pathway resulting in a variety of functional outcomes. NKG2D couples to the non-ITAM-containing DAP10 and initiates at least two signaling branches that are both required for cytotoxicity. Transformed, infected, or healthy cells can express NKG2D ligands, and NKG2D(+) lymphocytes can be unaffected, costimulated, or fully activated by the NKG2D-ligand interaction. The NKG2D-mediated response can be modulated by factors such as cytokine milieu and possibly the particular ligand expressed. Thus, this nontraditional NKG2D-DAP10 initiated signal pathway enables lymphocytes to differentially respond to ligands based on the cellular environment.
Full Text
Duke Authors
Cited Authors
- Upshaw, JL; Leibson, PJ
Published Date
- June 2006
Published In
Volume / Issue
- 18 / 3
Start / End Page
- 167 - 175
PubMed ID
- 16723257
International Standard Serial Number (ISSN)
- 1044-5323
Digital Object Identifier (DOI)
- 10.1016/j.smim.2006.03.001
Language
- eng
Conference Location
- England