MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.

Journal Article (Journal Article)

PURPOSE: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Eight patients (6 men and 2 women; mean age, 56.6 ± 5.5 years) with 9 ablated HCCs constituted our study population. Three readers interpreted the studies to determine the presence or absence of residual malignancy. Two readers independently assessed the fused MR-PET images to compare registration accuracy of two types of T2-weighted (triggered T2 half-Fourier acquisition single-shot turbo spin-echo and turbo spin-echo) and T1-weighted [Cartesian and radial 3D gradient echo (GRE)]. Image quality evaluation of both 3D-GRE T1-weighted sequences was evaluated. Kappa statistics were used to measure inter-observer agreement. Non-parametric Kruskal-Wallis and Wilcoxon signed-rank tests were used for qualitative data analysis. RESULTS: Definite residual tumor was observed in 3/9 ablations; two were PET positive. All residual tumors were isovascular on MRI. Radial 3D-GRE demonstrated significantly superior MR-PET subjective co-registration in comparison with the remaining sequences and showed a non-significant trend toward higher image quality scores than Cartesian GRE. CONCLUSION: Whole-body hybrid MR-PET is feasible as a part of 1-month follow-up post-locoregional thermoablative treatment for HCC. Radial 3D-GRE offers improved co-registration with PET data, with overall good image quality.

Full Text

Duke Authors

Cited Authors

  • Ramalho, M; AlObaidy, M; Burke, LM; Dale, BM; Gerber, DA; Wong, TZ; Semelka, RC

Published Date

  • August 2015

Published In

Volume / Issue

  • 40 / 6

Start / End Page

  • 1405 - 1414

PubMed ID

  • 25906343

Electronic International Standard Serial Number (EISSN)

  • 1432-0509

Digital Object Identifier (DOI)

  • 10.1007/s00261-015-0436-6


  • eng

Conference Location

  • United States