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MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.

Publication ,  Journal Article
Ramalho, M; AlObaidy, M; Burke, LM; Dale, BM; Gerber, DA; Wong, TZ; Semelka, RC
Published in: Abdom Imaging
August 2015

PURPOSE: The purpose of the study was to evaluate the feasibility and protocol optimization of whole-body hybrid MR-PET system performed 1-month after post-locoregional thermoablative procedures for hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: Eight patients (6 men and 2 women; mean age, 56.6 ± 5.5 years) with 9 ablated HCCs constituted our study population. Three readers interpreted the studies to determine the presence or absence of residual malignancy. Two readers independently assessed the fused MR-PET images to compare registration accuracy of two types of T2-weighted (triggered T2 half-Fourier acquisition single-shot turbo spin-echo and turbo spin-echo) and T1-weighted [Cartesian and radial 3D gradient echo (GRE)]. Image quality evaluation of both 3D-GRE T1-weighted sequences was evaluated. Kappa statistics were used to measure inter-observer agreement. Non-parametric Kruskal-Wallis and Wilcoxon signed-rank tests were used for qualitative data analysis. RESULTS: Definite residual tumor was observed in 3/9 ablations; two were PET positive. All residual tumors were isovascular on MRI. Radial 3D-GRE demonstrated significantly superior MR-PET subjective co-registration in comparison with the remaining sequences and showed a non-significant trend toward higher image quality scores than Cartesian GRE. CONCLUSION: Whole-body hybrid MR-PET is feasible as a part of 1-month follow-up post-locoregional thermoablative treatment for HCC. Radial 3D-GRE offers improved co-registration with PET data, with overall good image quality.

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Published In

Abdom Imaging

DOI

EISSN

1432-0509

Publication Date

August 2015

Volume

40

Issue

6

Start / End Page

1405 / 1414

Location

United States

Related Subject Headings

  • Whole Body Imaging
  • Treatment Outcome
  • Reproducibility of Results
  • Postoperative Period
  • Postoperative Complications
  • Positron-Emission Tomography
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Multimodal Imaging
  • Middle Aged
 

Citation

APA
Chicago
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MLA
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Ramalho, M., AlObaidy, M., Burke, L. M., Dale, B. M., Gerber, D. A., Wong, T. Z., & Semelka, R. C. (2015). MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations. Abdom Imaging, 40(6), 1405–1414. https://doi.org/10.1007/s00261-015-0436-6
Ramalho, Miguel, Mamdoh AlObaidy, Lauren M. Burke, Brian M. Dale, David A. Gerber, Terence Z. Wong, and Richard C. Semelka. “MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.Abdom Imaging 40, no. 6 (August 2015): 1405–14. https://doi.org/10.1007/s00261-015-0436-6.
Ramalho M, AlObaidy M, Burke LM, Dale BM, Gerber DA, Wong TZ, et al. MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations. Abdom Imaging. 2015 Aug;40(6):1405–14.
Ramalho, Miguel, et al. “MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations.Abdom Imaging, vol. 40, no. 6, Aug. 2015, pp. 1405–14. Pubmed, doi:10.1007/s00261-015-0436-6.
Ramalho M, AlObaidy M, Burke LM, Dale BM, Gerber DA, Wong TZ, Semelka RC. MR-PET evaluation of 1-month post-ablation therapy for hepatocellular carcinoma: preliminary observations. Abdom Imaging. 2015 Aug;40(6):1405–1414.

Published In

Abdom Imaging

DOI

EISSN

1432-0509

Publication Date

August 2015

Volume

40

Issue

6

Start / End Page

1405 / 1414

Location

United States

Related Subject Headings

  • Whole Body Imaging
  • Treatment Outcome
  • Reproducibility of Results
  • Postoperative Period
  • Postoperative Complications
  • Positron-Emission Tomography
  • Observer Variation
  • Nuclear Medicine & Medical Imaging
  • Multimodal Imaging
  • Middle Aged