Oligodendroglial and pan-neural crest expression of Cre recombinase directed by Sox10 enhancer.

Journal Article (Journal Article)

Utilizing a recently identified Sox10 distal enhancer directing Cre expression, we report S4F:Cre, a transgenic mouse line capable of inducing recombination in oligodendroglia and all examined neural crest derived tissues. Assayed using R26R:LacZ reporter mice expression was detected in neural crest derived tissues including the forming facial skeleton, dorsal root ganglia, sympathetic ganglia, enteric nervous system, aortae, and melanoblasts, consistent with Sox10 expression. LacZ reporter expression was also detected in non-neural crest derived tissues including the oligodendrocytes and the ventral neural tube. This line provides appreciable differences in Cre expression pattern from other transgenic mouse lines that mark neural crest populations, including additional populations defined by the expression of other SoxE proteins. The S4F:Cre transgenic line will thus serve as a powerful tool for lineage tracing, gene function characterization, and genome manipulation in these populations.

Full Text

Duke Authors

Cited Authors

  • Stine, ZE; Huynh, JL; Loftus, SK; Gorkin, DU; Salmasi, AH; Novak, T; Purves, T; Miller, RA; Antonellis, A; Gearhart, JP; Pavan, WJ; McCallion, AS

Published Date

  • November 2009

Published In

Volume / Issue

  • 47 / 11

Start / End Page

  • 765 - 770

PubMed ID

  • 19830815

Pubmed Central ID

  • PMC2835405

Electronic International Standard Serial Number (EISSN)

  • 1526-968X

Digital Object Identifier (DOI)

  • 10.1002/dvg.20559


  • eng

Conference Location

  • United States