Human granulocyte collagenase.

Journal Article (Journal Article)

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

Full Text

Duke Authors

Cited Authors

  • Lazarus, GS; Brown, RS; Daniels, JR; Fullmer, HM

Published Date

  • March 29, 1968

Published In

Volume / Issue

  • 159 / 3822

Start / End Page

  • 1483 - 1485

PubMed ID

  • 4307976

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.159.3822.1483


  • eng

Conference Location

  • United States