Human granulocyte collagenase.


Journal Article

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

Full Text

Duke Authors

Cited Authors

  • Lazarus, GS; Brown, RS; Daniels, JR; Fullmer, HM

Published Date

  • March 1, 1968

Published In

Volume / Issue

  • 159 / 3822

Start / End Page

  • 1483 - 1485

PubMed ID

  • 4307976

Pubmed Central ID

  • 4307976

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.159.3822.1483


  • eng