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Human granulocyte collagenase.

Publication ,  Journal Article
Lazarus, GS; Brown, RS; Daniels, JR; Fullmer, HM
Published in: Science
March 29, 1968

A collagenase, operative at neutral and alkaline pH, has been extracted from the granule fraction of human granulocytic leukocytes. It digests reconstituted collagen fibrils and reduces the viscosity of collagen solutions. Cleavage of collagen in solution with purified enzyme produces the discrete products characteristic of other animal collagenases.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

March 29, 1968

Volume

159

Issue

3822

Start / End Page

1483 / 1485

Location

United States

Related Subject Headings

  • Viscosity
  • Neutrophils
  • Microbial Collagenase
  • Lymphocytes
  • Leukocytes
  • Inflammation
  • Hydrogen-Ion Concentration
  • Humans
  • General Science & Technology
  • Gels
 

Citation

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Lazarus, G. S., Brown, R. S., Daniels, J. R., & Fullmer, H. M. (1968). Human granulocyte collagenase. Science, 159(3822), 1483–1485. https://doi.org/10.1126/science.159.3822.1483
Lazarus, G. S., R. S. Brown, J. R. Daniels, and H. M. Fullmer. “Human granulocyte collagenase.Science 159, no. 3822 (March 29, 1968): 1483–85. https://doi.org/10.1126/science.159.3822.1483.
Lazarus GS, Brown RS, Daniels JR, Fullmer HM. Human granulocyte collagenase. Science. 1968 Mar 29;159(3822):1483–5.
Lazarus, G. S., et al. “Human granulocyte collagenase.Science, vol. 159, no. 3822, Mar. 1968, pp. 1483–85. Pubmed, doi:10.1126/science.159.3822.1483.
Lazarus GS, Brown RS, Daniels JR, Fullmer HM. Human granulocyte collagenase. Science. 1968 Mar 29;159(3822):1483–1485.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

March 29, 1968

Volume

159

Issue

3822

Start / End Page

1483 / 1485

Location

United States

Related Subject Headings

  • Viscosity
  • Neutrophils
  • Microbial Collagenase
  • Lymphocytes
  • Leukocytes
  • Inflammation
  • Hydrogen-Ion Concentration
  • Humans
  • General Science & Technology
  • Gels