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Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty.

Publication ,  Journal Article
Laskey, WK; Zawacki, K; Lim, R; Herzog, W
Published in: Catheter Cardiovasc Interv
September 1999

Simultaneously obtained blood samples from the coronary sinus and systemic arterial circulation were analyzed for antithrombin III (ATIII) activity and fibrinopeptide A (FpA) concentration in nine patients undergoing elective PTCA in order to determine the effects of locally delivered heparin. Samples were obtained at the following designated times: prior to the administration of systemic heparin (period I); 5 min following a loading dose of systemic heparin (period II); 5 min following the final balloon inflation but prior to local delivery (period III); and 5 min following the administration of 4,000 units of unfractionated heparin using a local delivery catheter system (period IV). We found consistent increases in both systemic arterial (P = 0.006) and coronary sinus (P = 0.0002) ATIII activity with systemic heparinization designed to prolong the activated clotting time to 300 sec. However, local delivery of heparin further increased coronary sinus ATIII activity (P = 0.003, period III vs. period IV). FpA concentration decreased in both systemic arterial (P < 0.0001) and coronary sinus (P < 0. 0001) samples following systemic heparinization. Moreover, local delivery of heparin further decreased coronary sinus FpA concentration (P = 0.04). Thus, on a background of intense anticoagulation during PTCA, the local delivery of 4,000 units of unfractionated heparin confers incremental antithrombotic activity. Cathet. Cardiovasc. Intervent. 48:84-88, 1999.

Duke Scholars

Published In

Catheter Cardiovasc Interv

DOI

ISSN

1522-1946

Publication Date

September 1999

Volume

48

Issue

1

Start / End Page

84 / 88

Location

United States

Related Subject Headings

  • Whole Blood Coagulation Time
  • Thrombin
  • Male
  • Humans
  • Heparin
  • Fibrinopeptide A
  • Female
  • Coronary Vessels
  • Cardiovascular System & Hematology
  • Antithrombin III
 

Citation

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Laskey, W. K., Zawacki, K., Lim, R., & Herzog, W. (1999). Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty. Catheter Cardiovasc Interv, 48(1), 84–88. https://doi.org/10.1002/(sici)1522-726x(199909)48:1<84::aid-ccd17>3.0.co;2-o
Laskey, W. K., K. Zawacki, R. Lim, and W. Herzog. “Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty.Catheter Cardiovasc Interv 48, no. 1 (September 1999): 84–88. https://doi.org/10.1002/(sici)1522-726x(199909)48:1<84::aid-ccd17>3.0.co;2-o.
Laskey WK, Zawacki K, Lim R, Herzog W. Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty. Catheter Cardiovasc Interv. 1999 Sep;48(1):84–8.
Laskey, W. K., et al. “Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty.Catheter Cardiovasc Interv, vol. 48, no. 1, Sept. 1999, pp. 84–88. Pubmed, doi:10.1002/(sici)1522-726x(199909)48:1<84::aid-ccd17>3.0.co;2-o.
Laskey WK, Zawacki K, Lim R, Herzog W. Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty. Catheter Cardiovasc Interv. 1999 Sep;48(1):84–88.
Journal cover image

Published In

Catheter Cardiovasc Interv

DOI

ISSN

1522-1946

Publication Date

September 1999

Volume

48

Issue

1

Start / End Page

84 / 88

Location

United States

Related Subject Headings

  • Whole Blood Coagulation Time
  • Thrombin
  • Male
  • Humans
  • Heparin
  • Fibrinopeptide A
  • Female
  • Coronary Vessels
  • Cardiovascular System & Hematology
  • Antithrombin III