Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship in Interventional Cardiology, The George Washington University, School of Medicine and Health Sciences 1989 - 1990
  • Fellowship in Cardiovascular Disease, The George Washington University, School of Medicine and Health Sciences 1987 - 1989
  • Chief Resident in Internal Medicine, Medicine, Duke University School of Medicine 1986 - 1987
  • Internal Medicine Internship and Residency, Medicine, Duke University School of Medicine 1983 - 1986
  • Internship in General Surgery, University of Rochester, School of Medicine and Dentistry 1982 - 1983
  • M.D., Duke University School of Medicine 1982
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2018 - 2020
• Research
• 

  Selected Grants

  • Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity awarded by Novo Nordisk, Inc. 2019 - 2025
  • A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects with Acute Coronary Syndrome awarded by CSL Behring LLC 2019 - 2024
  • A Phase 3, Multicenter, Open-Label, Single-Arm Study of PB2452 in Ticagrelor-Treated Patients with Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure awarded by PhaseBio Pharmaceuticals, Inc. 2020 - 2023
  • A Phase 2 Randomized, Double-blind, Placebo-controlled, Proof of Concept Study to Evaluate the Safety and Efficacy of Antroquinonol in Hospitalized Patients with Mild to Moderate Pneumonia due to COVID-19 awarded by Golden Biotechnologies Corporation 2021 - 2023
  • HEART-FID awarded by American Regent 2020 - 2023
  • DIAMOND awarded by Relypsa, Inc. 2020 - 2022
  • A Phase III Study to Evaluate the Efficacy and Safety of Proxalutamide (GT0918) in Hospitalized Subjects with COVID-19 awarded by Suzhou Kintor Pharmaceuticals, Inc. 2022
  • cvMOBIUS awarded by Amgen, Inc. 2020 - 2021
  • Care OptimizatioN through PatieNt and hospital Engagement Clinical Trial for Heart Failure awarded by Novartis Pharmaceuticals Corporation 2018 - 2021
  • CHAMP-HF awarded by Novartis Pharmaceuticals Corporation 2016 - 2020
  • TACT2 awarded by Mount Sinai Medical Center 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • McEvoy, John W., Khalil Ibrahim, Thomas S. Kickler, William A. Clarke, Rani K. Hasan, Matthew J. Czarny, Ali R. Keramati, et al. “Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl).” Circulation 137, no. 3 (January 16, 2018): 307–9. https://doi.org/10.1161/CIRCULATIONAHA.117.031678.
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    • Ridker, Paul M., Brendan M. Everett, Tom Thuren, Jean G. MacFadyen, William H. Chang, Christie Ballantyne, Francisco Fonseca, et al. “Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.” N Engl J Med 377, no. 12 (September 21, 2017): 1119–31. https://doi.org/10.1056/NEJMoa1707914.
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    • Galiatsatos, Panagis, Theingi Tiffany Win, Jennifer Monti, Peter V. Johnston, William Herzog, Jeffrey C. Trost, Chao-Wei Hwang, Gene Y. Fridman, Nae-Yuh Wang, and Harry A. Silber. “Usefulness of a Noninvasive Device to Identify Elevated Left Ventricular Filling Pressure Using Finger Photoplethysmography During a Valsalva Maneuver.” Am J Cardiol 119, no. 7 (April 1, 2017): 1053–60. https://doi.org/10.1016/j.amjcard.2016.11.063.
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    • Bozzi, Laura M., Braxton D. Mitchell, Joshua P. Lewis, Kathy A. Ryan, William R. Herzog, Jeffrey R. O’Connell, Richard B. Horenstein, Alan R. Shuldiner, and Laura M. Yerges-Armstrong. “The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.” Curr Vasc Pharmacol 14, no. 1 (2016): 116–24. https://doi.org/10.2174/1570161113666150916094829.
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    • Fisch, Adam S., Laura M. Yerges-Armstrong, Joshua D. Backman, Hong Wang, Patrick Donnelly, Kathleen A. Ryan, Ankita Parihar, et al. “Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.” Plos One 10, no. 9 (2015): e0138795. https://doi.org/10.1371/journal.pone.0138795.
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    • Lewis, Joshua P., Kathleen Ryan, Jeffrey R. O’Connell, Richard B. Horenstein, Coleen M. Damcott, Quince Gibson, Toni I. Pollin, et al. “Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.” Circ Cardiovasc Genet 6, no. 2 (April 2013): 184–92. https://doi.org/10.1161/CIRCGENETICS.111.964627.
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    • Gurbel, Paul A., Kevin P. Bliden, Mark J. Antonino, Tania Gesheff, Charles C. Cummings, Benjamin V. Dubois, William R. Herzog, and Udaya S. Tantry. “Time dependence of clopidogrel loading effect: platelet activation versus platelet aggregation.” Thromb Res 129, no. 1 (January 2012): 1–2. https://doi.org/10.1016/j.thromres.2011.07.048.
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    • Musunuru, Kiran, Wendy S. Post, William Herzog, Haiqing Shen, Jeffrey R. O’Connell, Patrick F. McArdle, Kathleen A. Ryan, et al. “Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.” Circ Cardiovasc Genet 3, no. 5 (October 2010): 445–53. https://doi.org/10.1161/CIRCGENETICS.109.923508.
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    • Shuldiner, Alan R., Jeffrey R. O’Connell, Kevin P. Bliden, Amish Gandhi, Kathleen Ryan, Richard B. Horenstein, Coleen M. Damcott, et al. “Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.” Jama 302, no. 8 (August 26, 2009): 849–57. https://doi.org/10.1001/jama.2009.1232.
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    • Shen, Haiqing, William Herzog, MaryAnn Drolet, Ruth Pakyz, Sylvia Newcomer, Paul Sack, Heidi Karon, et al. “Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).” Am J Cardiol 104, no. 4 (August 15, 2009): 606–12. https://doi.org/10.1016/j.amjcard.2009.04.027.
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    • Herzog, William R., and Andrew Farb. “Severe coronary artery disease: is there a place for percutaneous coronary intervention?” Pol Arch Med Wewn 119, no. 6 (June 2009): 397–402.
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    • Gurbel, Paul A., Kevin P. Bliden, Jorge F. Saucedo, Thomas A. Suarez, Joseph DiChiara, Mark J. Antonino, Elisabeth Mahla, et al. “Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Arrest the Reactivity of Platelets) study.” J Am Coll Cardiol 53, no. 8 (February 24, 2009): 648–57. https://doi.org/10.1016/j.jacc.2008.10.045.
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    • Mitchell, Braxton D., Patrick F. McArdle, Haiqing Shen, Evadnie Rampersaud, Toni I. Pollin, Lawrence F. Bielak, Cashell Jaquish, et al. “The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study.” Am Heart J 155, no. 5 (May 2008): 823–28. https://doi.org/10.1016/j.ahj.2008.01.019.
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    • Gurbel, Paul A., Kevin P. Bliden, Kevin M. Hayes, Jason A. Yoho, William R. Herzog, and Udaya S. Tantry. “The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting.” J Am Coll Cardiol 45, no. 9 (May 3, 2005): 1392–96. https://doi.org/10.1016/j.jacc.2005.01.030.
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    • Yoon, Samuel C., Warren K. Laskey, Assadour Assadourian, Debra Kelly, Joel Gellman, William Herzog, and J Lawrence Stafford. “Assessment of contemporary stent deployment using intravascular ultrasound.” Catheter Cardiovasc Interv 57, no. 2 (October 2002): 150–54. https://doi.org/10.1002/ccd.10311.
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    • Downing, Stephen W., William A. Herzog, Joseph S. McLaughlin, and Timothy P. Gilbert. “Beating-heart mitral valve surgery: preliminary model and methodology.” J Thorac Cardiovasc Surg 123, no. 6 (June 2002): 1141–46. https://doi.org/10.1067/mtc.2002.121680.
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    • Herzog, W. R., and C. D. Bounds. “Intravascular ultrasound: Research tool or clinical workhorse?” Heartdrug 2, no. 1 (April 20, 2002): 1–3. https://doi.org/10.1159/000053051.
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    • Laskey, W. K., K. Zawacki, R. Lim, and W. Herzog. “Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty.” Catheter Cardiovasc Interv 48, no. 1 (September 1999): 84–88. https://doi.org/10.1002/(sici)1522-726x(199909)48:1<84::aid-ccd17>3.0.co;2-o.
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    • Serebruany, V. L., M. L. Schlossberg, L. R. Edenbaum, W. R. Herzog, and P. A. Gurbel. “Serial changes of soluble endothelin-1 levels during myocardial ischaemia-reperfusion. Effects of magnesium, diltiazem and a novel MAC-1 inhibitor.” Pharmacol Res 38, no. 3 (September 1998): 165–72. https://doi.org/10.1006/phrs.1998.0349.
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    • Serebruany, V. L., S. R. Solomon, W. R. Herzog, and P. A. Gurbel. “Plasma fibronectin during myocardial ischemia-reperfusion: effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.” Am J Hematol 57, no. 4 (April 1998): 309–14. https://doi.org/10.1002/(sici)1096-8652(199804)57:4<309::aid-ajh7>3.0.co;2-y.
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    • Serebruany, V. L., S. R. Solomon, A. R. Shustov, W. R. Herzog, and P. A. Gurbel. “Survival in Acute Myocardial Infarction Induced by Coronary Ligation: Prognostic Relevance of Certain Hemostatic Factors During the Occlusion Phase.” J Thromb Thrombolysis 5, no. 1 (1998): 29–35. https://doi.org/10.1023/A:1008815914024.
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    • Kirk, M. M., and W. R. Herzog. “Deployment of a previously embolized, unexpanded, and disarticulated Palmaz-Schatz stent.” Cathet Cardiovasc Diagn 42, no. 3 (November 1997): 331–34. https://doi.org/10.1002/(sici)1097-0304(199711)42:3<331::aid-ccd25>3.0.co;2-n.
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    • Serebruany, V. L., M. L. Schlossberg, L. R. Edenbaum, W. R. Herzog, and P. A. Gurbel. “Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.” Int J Cardiol 61, no. 1 (August 29, 1997): 21–29. https://doi.org/10.1016/s0167-5273(97)00111-3.
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    • Serebruany, V. L., W. R. Herzog, M. L. Schlossberg, and P. A. Gurbel. “Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors.” Pharmacol Res 36, no. 1 (July 1997): 17–22. https://doi.org/10.1006/phrs.1997.0212.
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    • Herzog, W. R., R. A. Vogel, M. L. Schlossberg, L. R. Edenbaum, H. J. Scott, and V. L. Serebruany. “Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size.” Int J Cardiol 59, no. 1 (March 1997): 21–27. https://doi.org/10.1016/s0167-5273(96)02883-5.
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    • Serebruany, V. L., W. R. Herzog, and P. A. Gurbel. “Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.” Prostaglandins Leukot Essent Fatty Acids 56, no. 2 (February 1997): 135–42. https://doi.org/10.1016/s0952-3278(97)90510-x.
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    • Serebruany, V. L., J. V. Ordonez, W. R. Herzog, M. Rohde, S. A. Mortensen, K. Folkers, and P. A. Gurbel. “Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression.” J Cardiovasc Pharmacol 29, no. 1 (January 1997): 16–22. https://doi.org/10.1097/00005344-199701000-00003.
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    • Serebruany, V. L., P. A. Gurbel, J. V. Ordoñez, W. R. Herzog, M. Rohde, S. A. Mortensen, and K. Folkers. “Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor?” Mol Aspects Med 18 Suppl (1997): S189–94. https://doi.org/10.1016/s0098-2997(97)00012-5.
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    • Serebruany, V. L., W. R. Herzog, M. L. Schlossberg, L. R. Edenbaum, and P. A. Gurbel. “Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine.” J Cardiovasc Pharmacol 28, no. 6 (December 1996): 817–23. https://doi.org/10.1097/00005344-199612000-00012.
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    • Serebruany, V. L., W. R. Herzog, and P. A. Gurbel. “Mild myocardial stunning affects platelet aggregation and hemostasis in swine.” Faseb Journal 10, no. 3 (December 1, 1996).
    • Serebruany, V. L., M. L. Schlossberg, L. R. Edenbaum, W. R. Herzog, and P. A. Gurbel. “Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.” Pharmacology 53, no. 4 (October 1996): 224–33. https://doi.org/10.1159/000139434.
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    • Serebruany, V. L., W. R. Herzog, L. R. Edenbaum, A. R. Shustov, and P. A. Gurbel. “Changes in the haemostatic profile during magnesium deficiency in swine.” Magnes Res 9, no. 3 (October 1996): 155–63.
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    • Serebruany, V. L., W. R. Herzog, and P. A. Gurbel. “Serial changes of natural antithrombotics during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.” Blood Coagul Fibrinolysis 7, no. 6 (September 1996): 632–40. https://doi.org/10.1097/00001721-199609000-00009.
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    • Serebruany, V. L., S. R. Solomon, L. R. Edenbaum, W. R. Herzog, and P. A. Gurbel. “Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine.” Pharmacology 53, no. 2 (August 1996): 87–97. https://doi.org/10.1159/000139419.
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    • Serebruany, V. L., W. R. Herzog, S. P. Atamas, P. A. Gurbel, M. Rohde, S. A. Mortensen, and K. Folkers. “Hemostatic changes after dietary coenzyme Q10 supplementation in swine.” J Cardiovasc Pharmacol 28, no. 2 (August 1996): 175–81. https://doi.org/10.1097/00005344-199608000-00001.
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    • Herzog, W. R., and V. L. Serebruany. “How magnesium therapy may influence clinical outcome in acute myocardial infarction: review of potential mechanisms.” Coron Artery Dis 7, no. 5 (May 1996): 364–70. https://doi.org/10.1097/00019501-199605000-00006.
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    • Herzog, W. R. “The use of magnesium in the treatment of patients with acute myocardial infarction.” Coronary Artery Disease 7, no. 5 (January 1, 1996): 339–40. https://doi.org/10.1097/00019501-199605000-00001.
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    • Herzog, W. R., M. L. Schlossberg, K. S. MacMurdy, L. R. Edenbaum, M. J. Gerber, R. A. Vogel, and V. L. Serebruany. “Timing of magnesium therapy affects experimental infarct size.” Circulation 92, no. 9 (November 1, 1995): 2622–26. https://doi.org/10.1161/01.cir.92.9.2622.
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    • Cleland, J. G. “ISIS-4.” Lancet 345, no. 8961 (May 27, 1995): 1372–73.
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    • Stone, D. A., M. C. Corretti, M. W. Hawke, W. Herzog, S. Rodriguez, and G. D. Plotnick. “The influence of angiographically demonstrated coronary collaterals on the results of stress echocardiography.” Clin Cardiol 18, no. 4 (April 1995): 205–8. https://doi.org/10.1002/clc.4960180405.
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    • Herzog, W. R., F. J. Materese, and D. Atar. “Reactivity of coronary arteries in relation to serum magnesium levels in patients with ischaemic heart disease--a quantitative coronary angiographic study.” Magnes Res 8, no. 1 (March 1995): 57–63.
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    • Gurbel, P. A., V. L. Serebruany, S. F. Komjathy, M. E. Collins, D. C. Sane, H. I. Scott, M. L. Schlossberg, and W. R. Herzog. “Regional and Systemic Platelet Function Is Altered by Myocardial Ischemia-Reperfusion.” J Thromb Thrombolysis 1, no. 2 (1995): 187–94. https://doi.org/10.1007/BF01062577.
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    • Herzog, W. R., P. A. Gurbel, R. A. Vogel, M. L. Schlossberg, A. I. Schneider, and V. L. Serebruany. “Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine.” J Thromb Thrombolysis 1, no. 2 (1995): 163–70. https://doi.org/10.1007/BF01062574.
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    • Serebruany, V. L., W. R. Herzog, P. A. Gurbel, M. L. Schlossberg, H. J. Scott, and R. A. Vogel. “NPC 15669, an Antiinflammatory Leucine Derivative, Reduces In Vitro Platelet Aggregability in Both Swine and Human Plasma.” J Thromb Thrombolysis 1, no. 2 (1995): 171–78. https://doi.org/10.1007/BF01062575.
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    • Herzog, W. R., D. Atar, I. T. Mak, D. Alyono, C. MacCord, and W. B. Weglicki. “Magnesium deficiency prolongs myocardial stunning in an open-chest swine model.” Int J Cardiol 47, no. 2 (December 1994): 105–15. https://doi.org/10.1016/0167-5273(94)90176-7.
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    • Gurbel, P. A., R. D. Anderson, C. S. MacCord, H. Scott, V. Serebruany, and W. R. Herzog. “Accelerated intravenous dosing of recombinant tissue-type plasminogen activator causes rapid but unstable reperfusion in a canine model of acute myocardial infarction.” Coron Artery Dis 5, no. 11 (November 1994): 929–36.
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    • Atar, D., V. Serebruany, J. Poulton, J. Godard, A. Schneider, and W. R. Herzog. “Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion.” J Cardiovasc Pharmacol 24, no. 4 (October 1994): 603–11. https://doi.org/10.1097/00005344-199410000-00011.
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    • Ziskind, A. A., J. Portelli, S. Rodriguez, J. L. Stafford, W. R. Herzog, J. G. Knox, and R. A. Vogel. “Successful use of education and cost-based feedback strategies to reduce physician utilization of low-osmolality contrast agents in the cardiac catheterization laboratory.” Am J Cardiol 73, no. 16 (June 15, 1994): 1219–21. https://doi.org/10.1016/0002-9149(94)90187-2.
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    • Egger, M., and G. D. Smith. “Magnesium and myocardial infarction.” Lancet 343, no. 8908 (May 21, 1994): 1285.
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    • Gurbel, P. A., C. S. MacCord, R. D. Anderson, H. Scott, D. Atar, W. Mergner, and W. R. Herzog. “A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies.” Cardiology 84, no. 1 (1994): 1–8. https://doi.org/10.1159/000176322.
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    • Herzog, W. R., D. Atar, P. A. Gurbel, R. A. Vogel, M. L. Schlossberg, and V. L. Serebruany. “Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.” Magnes Res 6, no. 4 (December 1993): 349–53.
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    • Atar, D., S. A. Mortensen, H. Flachs, and W. R. Herzog. “Coenzyme Q10 protects ischemic myocardium in an open-chest swine model.” Clin Investig 71, no. 8 Suppl (1993): S103–11. https://doi.org/10.1007/BF00226849.
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    • Herzog, W. R., and R. L. Peiffer. “Comparison of the effect of polymethylmethacrylate and silicone intraocular lenses on rabbit corneal endothelium in vitro.” J Cataract Refract Surg 13, no. 4 (July 1987): 397–400. https://doi.org/10.1016/s0886-3350(87)80038-x.
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  • Book Sections

    • Khan, Y., N. Faraday, W. Herzog, and A. R. Shuldiner. “Genetic Determinants of Arterial Thrombosis.” In Cardiovascular Genetics and Genomics, 193–210, 2009. https://doi.org/10.1002/9781444311785.ch13.
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  • Conference Papers

    • Downing, Stephen W., William R. Herzog, Michael C. McElroy, and Timothy B. Gilbert. “Feasibility of off-pump ASD closure using real-time 3-D echocardiography.” In Heart Surg Forum, 5:96–99, 2002.
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