Scholars@Duke
William Raymond Herzog

William Raymond Herzog

Clinical Associate in the Department of Medicine
Medicine, Cardiology

Selected Publications

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.

Journal Article N Engl J Med · September 21, 2017 BACKGROUND: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. METHODS: We conducted a ... Full text Link to item Cite

Usefulness of a Noninvasive Device to Identify Elevated Left Ventricular Filling Pressure Using Finger Photoplethysmography During a Valsalva Maneuver.

Journal Article Am J Cardiol · April 1, 2017 The high rate of re-hospitalization for heart failure might be reduced by improving noninvasive techniques for identifying elevated left ventricular (LV) filling pressure. We previously showed that changes in a finger photoplethysmography (PPG) waveform du ... Full text Link to item Cite

The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.

Journal Article Curr Vasc Pharmacol · 2016 Clopidogrel and aspirin are commonly prescribed anti-platelet medications indicated for patients who have experienced, or are at risk for, ischemic cardiovascular events. The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study was designed to chara ... Full text Link to item Cite

Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.

Journal Article PLoS One · 2015 Platelet Endothelial Aggregation Receptor 1 (PEAR1) is a newly identified membrane protein reported to be involved in multiple vascular and thrombotic processes. While most studies to date have focused on the effects of this receptor in platelets, PEAR1 is ... Full text Link to item Cite

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.

Journal Article Circ Cardiovasc Genet · April 2013 BACKGROUND- Aspirin or dual antiplatelet therapy with aspirin and clopidogrel is a standard therapy for patients who are at increased risk for cardiovascular events. However, the genetic determinants of variable response to aspirin (alone and in combinatio ... Full text Link to item Cite

Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.

Journal Article Circ Cardiovasc Genet · October 2010 BACKGROUND: Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, w ... Full text Link to item Cite

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

Journal Article JAMA · August 26, 2009 CONTEXT: Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous coronary intervention by inhibiting adenosine diphosphate (ADP)-dependent platelet activation. However, nonresponsiveness is ... Full text Link to item Cite

Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).

Journal Article Am J Cardiol · August 15, 2009 This study was designed to determine the factors that contribute to interindividual variation in the antiplatelet effects of aspirin. We measured platelet response to aspirin in 745 (400 men and 345 women) drug-naive asymptomatic subjects of the Heredity a ... Full text Link to item Cite

Severe coronary artery disease: is there a place for percutaneous coronary intervention?

Journal Article Pol Arch Med Wewn · June 2009 Management of severe coronary artery disease (CAD), defined as multivessel disease with or without significant left main artery disease remains a topic for considerable discussion. Although coronary artery bypass graft (CABG) surgery has been the mainstay ... Link to item Cite

Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Arrest the Reactivity of Platelets) study.

Journal Article J Am Coll Cardiol · February 24, 2009 OBJECTIVES: The primary objective of this study was to compare the effect of therapy with bivalirudin alone versus bivalirudin plus eptifibatide on platelet reactivity measured by turbidometric aggregometry and thrombin-induced platelet-fibrin clot strengt ... Full text Link to item Cite

The genetic response to short-term interventions affecting cardiovascular function: rationale and design of the Heredity and Phenotype Intervention (HAPI) Heart Study.

Journal Article Am Heart J · May 2008 BACKGROUND: The etiology of cardiovascular disease (CVD) is multifactorial. Efforts to identify genes influencing CVD risk have met with limited success to date, likely because of the small effect sizes of common CVD risk alleles and the presence of gene b ... Full text Link to item Cite

The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting.

Journal Article J Am Coll Cardiol · May 3, 2005 OBJECTIVES: We determined the effect of clopidogrel dosing on the incidence of nonresponsiveness (NR) and high post-treatment platelet aggregation (post-PA). BACKGROUND: We have reported NR after a 300-mg loading dose. Limited information is available on t ... Full text Link to item Cite

Assessment of contemporary stent deployment using intravascular ultrasound.

Journal Article Catheter Cardiovasc Interv · October 2002 Four second- and third-generation coronary stents were evaluated using QCA and intravascular ultrasound for adequacy of stent expansion, the influence of disease burden on adequacy of deployment, and postdeployment structural effects on the artery. Despite ... Full text Link to item Cite

Beating-heart mitral valve surgery: preliminary model and methodology.

Journal Article J Thorac Cardiovasc Surg · June 2002 OBJECTIVE: It is our hypothesis that image-guided mitral valve repair can be performed on the beating heart without cardiopulmonary bypass. As a first phase, we tested the feasibility of suturing the anterior and posterior mitral valve leaflets under image ... Full text Link to item Cite

Feasibility of off-pump ASD closure using real-time 3-D echocardiography.

Conference Heart Surg Forum · 2002 BACKGROUND: If surgeons could "see " through blood and cardiac chamber walls, it would ultimately be unnecessary to open the heart or use cardiopulmonary bypass to perform procedures such as atrial septal defect (ASD) closure or mitral valve repair. Conven ... Link to item Cite

Effects of local heparin administration on coronary thrombin activity during percutaneous transluminal coronary angioplasty.

Journal Article Catheter Cardiovasc Interv · September 1999 Simultaneously obtained blood samples from the coronary sinus and systemic arterial circulation were analyzed for antithrombin III (ATIII) activity and fibrinopeptide A (FpA) concentration in nine patients undergoing elective PTCA in order to determine the ... Full text Link to item Cite

Serial changes of soluble endothelin-1 levels during myocardial ischaemia-reperfusion. Effects of magnesium, diltiazem and a novel MAC-1 inhibitor.

Journal Article Pharmacol Res · September 1998 The key role of endothelin-1 (ET-1) has been recognised in patients with ischaemic heart disease. However, the serial changes of ET-1 during both brief and prolonged ischaemia-reperfusion are poorly known. Serial changes of plasma ET-1 were measured during ... Full text Link to item Cite

Plasma fibronectin during myocardial ischemia-reperfusion: effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.

Journal Article Am J Hematol · April 1998 The important role of fibronectin (Fn) has been recognized in patients with ischemic heart disease. However, serial changes of Fn during both brief and prolonged ischemia-reperfusion are poorly known. Plasma Fn was measured during acute myocardial infarcti ... Full text Link to item Cite

Survival in Acute Myocardial Infarction Induced by Coronary Ligation: Prognostic Relevance of Certain Hemostatic Factors During the Occlusion Phase.

Journal Article J Thromb Thrombolysis · 1998 Alterations in various hemostatic factor have been identified as risk factors for survival after acute myocardial infarction (AMI). However, these clinical data are primarily limited to observations made during the postinfarct stage. We assessed the effect ... Full text Link to item Cite

Deployment of a previously embolized, unexpanded, and disarticulated Palmaz-Schatz stent.

Journal Article Cathet Cardiovasc Diagn · November 1997 Stent embolization is a rare but acknowledged complication of placement of disarticulated (half) Palmaz-Schatz stents. We report a case in which we diagnosed a previously unrecognized, embolized, undeployed half-stent in the distal LAD, causing slow flow, ... Full text Link to item Cite

Effects of intracoronary diltiazem on certain hemostatic parameters during acute myocardial infarction in swine.

Journal Article Int J Cardiol · August 29, 1997 Controversy currently exists regarding the use of diltiazem in the treatment of acute myocardial infarction (AMI). due to conflicting results from clinical trials and animal studies. The purpose of this project was to evaluate the changes in the hemostatic ... Full text Link to item Cite

Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors.

Journal Article Pharmacol Res · July 1997 UNLABELLED: The purpose of this study was an attempt to extrapolate favorable observations on the effects of magnesium on platelets and haemostasis from animal models to humans. Intravenous magnesium in the treatment of acute myocardial infarction has been ... Full text Link to item Cite

Short-term low dose intracoronary diltiazem administered at the onset of reperfusion reduces myocardial infarct size.

Journal Article Int J Cardiol · March 1997 BACKGROUND: Currently, controversy exists regarding the use of calcium-channel blockers in the treatment of acute myocardial infarction (AMI), due to apparent conflicting results from clinical trials and animal models. One hypothesis to explain such a disc ... Full text Link to item Cite

Serial changes of the plasma prostanoids during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.

Journal Article Prostaglandins Leukot Essent Fatty Acids · February 1997 The key role of prostanoids has been recognized in patients with ischemic heart disease. However, serial changes of thromboxane and prostacyclin during both brief and prolonged ischemia-reperfusion are poorly known. These plasma prostanoids were measured d ... Full text Link to item Cite

Could coenzyme Q10 affect hemostasis by inhibiting platelet vitronectin (CD51/CD61) receptor?

Journal Article Mol Aspects Med · 1997 Improved cardiovascular morbidity and mortality have been observed in several clinical studies of dietary supplementation with coenzyme Q10 (CoQ10, ubiquinone). Several mechanisms have been proposed to explain the effects of CoQ10. One attractive theory li ... Full text Link to item Cite

Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression.

Journal Article J Cardiovasc Pharmacol · January 1997 Improved cardiovascular morbidity and mortality have been observed in several clinical studies of dietary supplementation with coenzyme Q10 (CoQ10, ubiquinone). Several mechanisms have been proposed to explain the effects of CoQ10, but a comprehensive expl ... Full text Link to item Cite

Hemostatic changes after early versus late intracoronary magnesium during acute myocardial infarction in swine.

Journal Article J Cardiovasc Pharmacol · December 1996 There has been some debate regarding the benefit of magnesium (Mg) in the treatment of acute myocardial infarction (AMI) because of conflicting results from recent clinical trials. Several different hypotheses have been advanced to explain the cardioprotec ... Full text Link to item Cite

Mild myocardial stunning affects platelet aggregation and hemostasis in swine

Journal Article FASEB Journal · December 1, 1996 The key role of platelet activation and hemostatic disorders have been increasingly recognized in patients with unstable angina and acute myocardial infarction. However, the dynamics of the hemostatic profile during brief ischemia-reperfusion are poorly un ... Cite

Changes in the haemostatic profile during magnesium deficiency in swine.

Journal Article Magnes Res · October 1996 Epidemiological studies of populations living in areas of low magnesium (Mg) intake have consistently shown a higher cardiovascular morbidity. Several hypotheses have been advanced to explain the cardioprotective properties of magnesium. Few studies, howev ... Link to item Cite

Intracoronary magnesium and diltiazem affect to a similar extent certain hemostatic factors during acute myocardial infarction in swine.

Journal Article Pharmacology · October 1996 The use of calcium antagonists and magnesium (Mg) in the treatment of acute myocardial infarction is controversial. We compared changes in hemostasis during acute myocardial infarction after either low-dose intracoronary Mg or diltiazem infusion in 20 York ... Full text Link to item Cite

Serial changes of natural antithrombotics during myocardial ischemia-reperfusion in swine. Effects of magnesium, diltiazem, and a novel Mac-1 inhibitor.

Journal Article Blood Coagul Fibrinolysis · September 1996 Plasma antithrombin-III (AT-III), protein S, and protein C were measured during myocardial stunning (MS) and acute myocardial infarction (AMI). The effects of magnesium (Mg), diltiazem, and a Mac-1 inhibitor on their plasma levels were elucidated. Forty-ni ... Full text Link to item Cite

Mac-1 inhibitor affects certain hemostatic parameters during myocardial stunning in swine.

Journal Article Pharmacology · August 1996 Myocardial stunning (MS) is a transient contractile dysfunction occurring subsequent to an episode of ischemia followed by reperfusion. NPC 15669 is a leumedin, which inhibits leukocyte adhesion to the endothelium by blocking Mac-1 upregulation. The effect ... Full text Link to item Cite

Hemostatic changes after dietary coenzyme Q10 supplementation in swine.

Journal Article J Cardiovasc Pharmacol · August 1996 Improved cardiovascular morbidity and mortality have been observed in several clinical studies of dietary supplementation with coenzyme Q10 (CoQ10). We elucidated the effect of CoQ10 on certain hemostatic parameters that may influence the progression of he ... Full text Link to item Cite

Timing of magnesium therapy affects experimental infarct size.

Journal Article Circulation · November 1, 1995 BACKGROUND: Controversy exists regarding the use of magnesium in the treatment of acute myocardial infarction (AMI) because of apparent conflicting results from clinical trials. One hypothesis to explain the various clinical observations proposes that the ... Full text Link to item Cite

ISIS-4.

Journal Article Lancet · May 27, 1995 Link to item Cite

The influence of angiographically demonstrated coronary collaterals on the results of stress echocardiography.

Journal Article Clin Cardiol · April 1995 Previous studies using thallium-201 scintigraphy have suggested that angiographic coronary collaterals can protect against the development of stress-induced perfusion abnormalities, but the effect of collaterals on stress echocardiography (SECHO) has not b ... Full text Link to item Cite

Reactivity of coronary arteries in relation to serum magnesium levels in patients with ischaemic heart disease--a quantitative coronary angiographic study.

Journal Article Magnes Res · March 1995 The aim of the present study was to evaluate the relationship between coronary vascular tone and serum magnesium concentration in patients with ischaemic heart disease. Thirty-seven patients were subjected to intracoronary injection of 200 micrograms nitro ... Link to item Cite

Regional and Systemic Platelet Function Is Altered by Myocardial Ischemia-Reperfusion.

Journal Article J Thromb Thrombolysis · 1995 Background: Myocardial reperfusion after short durations of ischemia causes prolonged contractile dysfunction (myocardial stunning). Recently it has also been suggested that ischemia-reperfusion results in impaired coronary endothelial function. Since plat ... Full text Link to item Cite

NPC 15669, an Antiinflammatory Leucine Derivative, Reduces In Vitro Platelet Aggregability in Both Swine and Human Plasma.

Journal Article J Thromb Thrombolysis · 1995 Background: Leumedins inhibit cell adhesion to endothelium via blockage of integrin binding. We tested a hypothesis that the novel leucine derivate NPC 15669 will affect in vitro platelet aggregability (PA) in both human and swine plasma. Methods and Resul ... Full text Link to item Cite

Effects of a Novel Leumedin NPC 15669 on Myocardial Stunning and Preconditioned Infarction Size in Swine.

Journal Article J Thromb Thrombolysis · 1995 Background: NPC is a member of the leumedins and is an inhibitor of leukocyte adhesion to endothelium via blockage of integrin binding. NPC 15669 also may have antiplatelet effects. We tested the efficacy of the novel leukocyte recruitment inhibitor NPC 15 ... Full text Link to item Cite

Magnesium deficiency prolongs myocardial stunning in an open-chest swine model.

Journal Article Int J Cardiol · December 1994 The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring ... Full text Link to item Cite

Accelerated intravenous dosing of recombinant tissue-type plasminogen activator causes rapid but unstable reperfusion in a canine model of acute myocardial infarction.

Journal Article Coron Artery Dis · November 1994 BACKGROUND: Accelerated intravenous dosing is currently the preferred regimen for administering recombinant tissue-type plasminogen activator (rt-PA) in acute myocardial infarction (AMI). This regimen is recommended on the basis of clinical angiographic st ... Link to item Cite

Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion.

Journal Article J Cardiovasc Pharmacol · October 1994 We tested the hypothesis that acute, intravenous (i.v.) magnesium (Mg2+) supplementation would protect against myocardial stunning in an in situ swine model of regional ischemia and reperfusion and that a concomitant inhibitory effect on platelet aggregati ... Full text Link to item Cite

Magnesium and myocardial infarction.

Journal Article Lancet · May 21, 1994 Link to item Cite

A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies.

Journal Article Cardiology · 1994 A model of coronary artery thrombosis which: (1) provides a stable thrombus; (2) incorporates intimal injury; (3) has a low mortality rate; (4) responds predictably to thrombolytic therapy, and (5) is technically simple, was developed. Intimal injury was p ... Full text Link to item Cite

Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.

Journal Article Magnes Res · December 1993 The effect of magnesium sulphate infusion on ex vivo platelet aggregation in 11 female Yorkshire swine was observed using platelet-rich plasma and different agonists (ADP 5 mM; ADP 10 mM and collagen 1 mg/ml). Infusion of 1 g MgSO4 over 1 h produced a sign ... Link to item Cite

Coenzyme Q10 protects ischemic myocardium in an open-chest swine model.

Journal Article Clin Investig · 1993 Myocardial stunning, defined as a reversible decrease in contractility after ischemia and reperfusion, may be a manifestation of reperfusion injury caused by free oxygen radical damage. The aim of this study was to test the hypothesis that pretreatment wit ... Full text Link to item Cite

Comparison of the effect of polymethylmethacrylate and silicone intraocular lenses on rabbit corneal endothelium in vitro.

Journal Article J Cataract Refract Surg · July 1987 An in vitro comparison of corneal endothelial damage caused by polymethylmethacrylate and by silicone intraocular lenses was made. Endothelial damage was assessed by vital staining of corneal endothelium immediately following direct contact with an intraoc ... Full text Link to item Cite