A canine model of acute coronary artery thrombosis for the evaluation of reperfusion strategies.
A model of coronary artery thrombosis which: (1) provides a stable thrombus; (2) incorporates intimal injury; (3) has a low mortality rate; (4) responds predictably to thrombolytic therapy, and (5) is technically simple, was developed. Intimal injury was produced proximal to a critical stenosis and followed by the infusion of a blood and thrombin mixture into the injured segment. After thrombus formation flow remained absent in all control animals (n = 7). Microscopy showed intimal injury and coronary thrombosis with platelets adherent to the subendothelium. In animals treated with tissue plasminogen activator (n = 7) flow returned to > 60% of baseline at 20.2 +/- 7.7 min and was cyclical. Mortality and complications were infrequent. This model is useful in investigations of reperfusion therapy.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tissue Plasminogen Activator
- Thrombolytic Therapy
- Microscopy, Electron
- Male
- Endothelium, Vascular
- Dogs
- Disease Models, Animal
- Coronary Vessels
- Coronary Thrombosis
- Cardiovascular System & Hematology
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tissue Plasminogen Activator
- Thrombolytic Therapy
- Microscopy, Electron
- Male
- Endothelium, Vascular
- Dogs
- Disease Models, Animal
- Coronary Vessels
- Coronary Thrombosis
- Cardiovascular System & Hematology