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Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression.

Publication ,  Journal Article
Serebruany, VL; Ordonez, JV; Herzog, WR; Rohde, M; Mortensen, SA; Folkers, K; Gurbel, PA
Published in: J Cardiovasc Pharmacol
January 1997

Improved cardiovascular morbidity and mortality have been observed in several clinical studies of dietary supplementation with coenzyme Q10 (CoQ10, ubiquinone). Several mechanisms have been proposed to explain the effects of CoQ10, but a comprehensive explanation of its cardioprotective properties is still lacking. One attractive theory links ubiquinone with the inhibition of platelets. The effect of CoQ10 intake on platelet size and surface antigens was examined in human volunteers. Study participants received 100 mg of CoQ10 twice daily in addition to their usual diet for 20 days. Receptor expression was measured by flow cytometry with monoclonal murine anti-human antibodies CD9 (p24), CD42B (Ib), CD41b (IIb), CD61 (IIIa), CD41a (IIb/IIIa), CD49b (VLA-2), CD62p (P selectin), CD31 (PECAM-1), and CD51/CD61 (vitronectin). An increase of total serum CoQ10 level (from 0.6 +/- 0.1 to 1.8 +/- 0.3 micrograms/ml; p < 0.001) was found at protocol termination. Fluorescence intensity was higher for the large platelets when compared with the whole platelet population. Significant inhibition of vitronectin-receptor expression was observed consistently throughout ubiquinone treatment. Reduction of platelet size was observed at the end of CoQ10 supplementation. Inhibition of the platelet vitronectin receptor and a reduction of the platelet size are direct evidence of a link between dietary CoQ10 intake and platelets. These findings may not be fully explained by the known antioxidant and bioenergetic properties of CoQ10. Diminished vitronectin-receptor expression and reduced platelet size resulting from CoQ10 therapy may contribute to the observed clinical benefits in patients with cardiovascular diseases.

Duke Scholars

Published In

J Cardiovasc Pharmacol

DOI

ISSN

0160-2446

Publication Date

January 1997

Volume

29

Issue

1

Start / End Page

16 / 22

Location

United States

Related Subject Headings

  • Ubiquinone
  • Receptors, Vitronectin
  • Platelet Membrane Glycoproteins
  • Particle Size
  • Male
  • Integrin beta3
  • Integrin alphaV
  • Humans
  • Food, Fortified
  • Flow Cytometry
 

Citation

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Serebruany, V. L., Ordonez, J. V., Herzog, W. R., Rohde, M., Mortensen, S. A., Folkers, K., & Gurbel, P. A. (1997). Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. J Cardiovasc Pharmacol, 29(1), 16–22. https://doi.org/10.1097/00005344-199701000-00003
Serebruany, V. L., J. V. Ordonez, W. R. Herzog, M. Rohde, S. A. Mortensen, K. Folkers, and P. A. Gurbel. “Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression.J Cardiovasc Pharmacol 29, no. 1 (January 1997): 16–22. https://doi.org/10.1097/00005344-199701000-00003.
Serebruany VL, Ordonez JV, Herzog WR, Rohde M, Mortensen SA, Folkers K, et al. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. J Cardiovasc Pharmacol. 1997 Jan;29(1):16–22.
Serebruany, V. L., et al. “Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression.J Cardiovasc Pharmacol, vol. 29, no. 1, Jan. 1997, pp. 16–22. Pubmed, doi:10.1097/00005344-199701000-00003.
Serebruany VL, Ordonez JV, Herzog WR, Rohde M, Mortensen SA, Folkers K, Gurbel PA. Dietary coenzyme Q10 supplementation alters platelet size and inhibits human vitronectin (CD51/CD61) receptor expression. J Cardiovasc Pharmacol. 1997 Jan;29(1):16–22.

Published In

J Cardiovasc Pharmacol

DOI

ISSN

0160-2446

Publication Date

January 1997

Volume

29

Issue

1

Start / End Page

16 / 22

Location

United States

Related Subject Headings

  • Ubiquinone
  • Receptors, Vitronectin
  • Platelet Membrane Glycoproteins
  • Particle Size
  • Male
  • Integrin beta3
  • Integrin alphaV
  • Humans
  • Food, Fortified
  • Flow Cytometry