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Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.

Publication ,  Journal Article
Herzog, WR; Atar, D; Gurbel, PA; Vogel, RA; Schlossberg, ML; Serebruany, VL
Published in: Magnes Res
December 1993

The effect of magnesium sulphate infusion on ex vivo platelet aggregation in 11 female Yorkshire swine was observed using platelet-rich plasma and different agonists (ADP 5 mM; ADP 10 mM and collagen 1 mg/ml). Infusion of 1 g MgSO4 over 1 h produced a significant decrease in platelet aggregability. A dose-dependent effect of different ADP concentrations on platelet aggregation was noticed. Platelet inhibition was most consistent when using ADP 5 mM. We estimate this concentration of agonist as optimal in swine. The swine model is a good choice for investigation of in vivo platelet activation, especially with regard to cardiovascular research. We conclude that there is an inhibitory effect of supplemental magnesium on ex vivo platelet aggregation in swine with initial normomagnesaemia.

Duke Scholars

Published In

Magnes Res

ISSN

0953-1424

Publication Date

December 1993

Volume

6

Issue

4

Start / End Page

349 / 353

Location

England

Related Subject Headings

  • Swine
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Nutrition & Dietetics
  • Magnesium Sulfate
  • Infusions, Intravenous
  • Female
  • Dose-Response Relationship, Drug
  • Collagen
  • Animals
 

Citation

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Herzog, W. R., Atar, D., Gurbel, P. A., Vogel, R. A., Schlossberg, M. L., & Serebruany, V. L. (1993). Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine. Magnes Res, 6(4), 349–353.
Herzog, W. R., D. Atar, P. A. Gurbel, R. A. Vogel, M. L. Schlossberg, and V. L. Serebruany. “Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.Magnes Res 6, no. 4 (December 1993): 349–53.
Herzog WR, Atar D, Gurbel PA, Vogel RA, Schlossberg ML, Serebruany VL. Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine. Magnes Res. 1993 Dec;6(4):349–53.
Herzog, W. R., et al. “Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine.Magnes Res, vol. 6, no. 4, Dec. 1993, pp. 349–53.
Herzog WR, Atar D, Gurbel PA, Vogel RA, Schlossberg ML, Serebruany VL. Effect of magnesium sulphate infusion on ex vivo platelet aggregation in swine. Magnes Res. 1993 Dec;6(4):349–353.

Published In

Magnes Res

ISSN

0953-1424

Publication Date

December 1993

Volume

6

Issue

4

Start / End Page

349 / 353

Location

England

Related Subject Headings

  • Swine
  • Platelet Aggregation Inhibitors
  • Platelet Aggregation
  • Nutrition & Dietetics
  • Magnesium Sulfate
  • Infusions, Intravenous
  • Female
  • Dose-Response Relationship, Drug
  • Collagen
  • Animals