Magnesium deficiency prolongs myocardial stunning in an open-chest swine model.

Journal Article (Journal Article)

The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 +/- 3.1 min in the control group to 43.8 +/- 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.

Full Text

Duke Authors

Cited Authors

  • Herzog, WR; Atar, D; Mak, IT; Alyono, D; MacCord, C; Weglicki, WB

Published Date

  • December 1994

Published In

Volume / Issue

  • 47 / 2

Start / End Page

  • 105 - 115

PubMed ID

  • 7721477

International Standard Serial Number (ISSN)

  • 0167-5273

Digital Object Identifier (DOI)

  • 10.1016/0167-5273(94)90176-7


  • eng

Conference Location

  • Netherlands