Magnesium deficiency prolongs myocardial stunning in an open-chest swine model.
Published
Journal Article
The effect of magnesium deficiency on postischemic myocardial dysfunction (myocardial stunning) in an open-chest swine model was studied. Twelve swine were assigned either to low magnesium diet or control diet. Myocardial stunning was assessed by measuring regional wall thickening by epicardial Doppler before and after brief occlusion (8 min) of the left anterior descending coronary artery. Serum magnesium levels decreased significantly in the experimental group only. Glutathione levels were 42.6% lower in the magnesium deficient swine than in controls. Stunning time was significantly prolonged from 32.8 +/- 3.1 min in the control group to 43.8 +/- 4.6 min in the hypomagnesemic swine. In conclusion, magnesium deficiency is associated with prolonged recovery from myocardial stunning.
Full Text
Duke Authors
Cited Authors
- Herzog, WR; Atar, D; Mak, IT; Alyono, D; MacCord, C; Weglicki, WB
Published Date
- December 1994
Published In
Volume / Issue
- 47 / 2
Start / End Page
- 105 - 115
PubMed ID
- 7721477
Pubmed Central ID
- 7721477
International Standard Serial Number (ISSN)
- 0167-5273
Digital Object Identifier (DOI)
- 10.1016/0167-5273(94)90176-7
Language
- eng
Conference Location
- Netherlands