Demographic and clinical characteristics reflect different phenotypes of osteoarthritis in the lumbar spine: the Johnston County Osteoarthritis Project.

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Conference Paper

OBJECTIVE: Determine if associations between demographic, appendicular joint osteoarthritis (OA), clinical characteristics reflect different phenotypes of OA in the lumbar spine. METHODS: Participants were from the Johnston County OA Project. Demographics consisted of age, sex, and race (White and African American [AA]) and clinical characteristics consisted of body mass index (BMI), low back pain and injury, and knee, hip and hand osteoarthritis (OA). Participants were categorized as spine OA (SOA), facet joint OA (FOA), both SOA and FOA, or neither SOA nor FOA (referent group). Multinomial regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI). RESULTS: The average age (n=1,793) was 66.2 years (SD=10.1) and BMI was 30.7 (SD=6.2). A majority (63.8%) were women (n=1,144) and 31.8% (n=570) AA. Neither SOA nor FOA was present in 18.0%; 22.8% had FOA, 13.2% had SOA and 46.0% had both SOA and FOA. In adjusted analyses, AA were less likely to have FOA (OR=0.68 95% CI 0.49, 0.95) and both SOA and FOA (OR=0.51 95% CI 0.37, 0.70). Women were more likely to have FOA (OR=1.71 95% CI 1.24, 2.36). BMI ≥30 kg/m2 was associated with FOA (OR=1.76 95% CI 1.28, 2.42) and both SOA and FOA (OR=1.85 95% CI 1.37, 2.51). Knee OA was associated with all three groups while lower back injury was associated with only SOA. Participants with hip OA were less likely to have FOA. CONCLUSION: Race, sex, BMI, hip OA, and lower back injury may inform different OA phenotypes in the lumbar spine. This article is protected by copyright. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Goode, AP; Cleveland, RJ; George, SZ; Kraus, VB; Schwartz, TA; Gracely, RH; Jordan, JM; Golightly, YM

Published Date

  • May 6, 2019

Published In

PubMed ID

  • 31058435

Pubmed Central ID

  • 31058435

Electronic International Standard Serial Number (EISSN)

  • 2151-4658

Digital Object Identifier (DOI)

  • 10.1002/acr.23918

Conference Location

  • United States