Virginia Byers Kraus | Scholars@Duke

Virginia Byers Kraus
Professor of Medicine

My special area of expertise is as a clinician scientist investigating osteoarthritis. Osteoarthritis is the most common form of joint disease in man and its incidence increases with age. It is a problem of increasing concern to the medical community due to the increasing longevity of the population. Trained as a molecular biologist and a Rheumatologist, I endeavor to study this disease from bedside to bench.

The work in this laboratory focuses on osteoarthritis and deals with the mechanisms of joint damage, and the discovery, validation and qualification of novel biochemical and genetic biomarkers for minimally invasive means of diagnosing disease, for predicting progression of disease, and for monitoring disease progression and response to therapy.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2010
Mary Bernheim Distinguished Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2021
Professor of Pathology, Pathology, Clinical Science Departments 2010
Professor in Orthopaedic Surgery, Orthopaedics, Orthopaedics 2015
Member of Duke Molecular Physiology Institute, Duke Molecular Physiology Institute, Duke Molecular Physiology Institute 2013
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047
Duke Box 104775, Durham, NC 27701
kraus004@duke.edu (919) 681-6652

Background
Education, Training, & Certifications
- Ph.D., Duke University 1993
- Fellow in Rheumatology, Medicine, Duke University 1986 - 1989
- Medical Resident, Medicine, Duke University 1983 - 1986
- M.D., Duke University 1982
Previous Appointments & Affiliations
- Associate Professor in Surgery, Surgery, Section of Surgical Disciplines 2010 - 2015
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 1996 - 2010
- Assistant Professor in Surgery, Surgery, Section of Surgical Disciplines 2000 - 2010
- Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2004 - 2010
- Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2003 - 2004
- Assistant Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 1995 - 2003
- Assistant Clinical Professor of Medicine, Medicine, Clinical Science Departments 1991 - 1995
Recognition
In the News
- JUN 28, 2021
  
  Duke Awards 22 Distinguished Professorships
- OCT 9, 2019 Duke Health News
  
  Humans Can't Replace Limbs, But We Can Regenerate Cartilage. Here's Why That Matters
Awards & Honors
Research
Selected Grants
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2027
- Extracellular Vesicle Analyses to Develop Aging and Resilience Biomarkers awarded by National Institutes of Health 2021 - 2025
- Behavior and Physiology in Aging awarded by National Institutes of Health 2015 - 2025
- Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health awarded by National Institutes of Health 2021 - 2025
- Mechanical Biomarkers of Chronic Low Back Pain awarded by National Institutes of Health 2019 - 2024
- Weight loss, in vivo cartilage mechanics, and joint health awarded by National Institutes of Health 2019 - 2023
- Exercise Induced Muscle Secreted Factors That Modify Osteoarthritis (OA) Severity awarded by National Institutes of Health 2021 - 2023
- Epigenetic Mechanisms Promoting Longevity awarded by National Institutes of Health 2018 - 2023
- Development of an Early Osteoarthritis Diagnostic Panel via a Proteomic Approach awarded by Zimmer Biomet Company 2018 - 2022
- Physical Resiliencies: Indicators and Mechanisms in the Elderly Collaborative (PRIME Collaborative) awarded by National Institutes of Health 2017 - 2022
- Biomarkers to Advance Clinical Phenotypes of Low Back Pain (BACk) awarded by National Institutes of Health 2017 - 2022
- Genomic Analysis of the CALERIE Trial to Generate New Knowledge for Geroscience awarded by Columbia University 2019 - 2022
- Qualification of Prognostic and Diagnostic Biomarkers of Knee Osteoarthritis awarded by National Institutes of Health 2017 - 2021
- Extracellular Vesicles and Their Role in Hallmarks of Aging awarded by National Institutes of Health 2018 - 2020
- Age-related alterations in the in vivo mechanical function of the spine awarded by National Institutes of Health 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Evaluation of Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial cells awarded by Bayer Corporation 2017 - 2019
- Epigenetic Mechanisms Promoting Longevity awarded by National Institutes of Health 2017 - 2018
- Behavioral Weight and Symptom Management for Breast Cancer Survivors and Partners awarded by National Institutes of Health 2015 - 2018
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- Subcontract NYU to Duke Amendment 1 - Leukocyte Gene Expresssion and Genetic Biomarkers of OA Incidence and Progression. awarded by New York University School of Medicine 2012 - 2017
- Macrophage Model System awarded by Bioiberica, S.A. 2016 - 2017
- Obesity, Biomechanics, and Inflammation in Osteoarthritis awarded by National Institutes of Health 2013 - 2016
- Bioiberica "Pre-Pilot Mobile App for OA" awarded by Bioiberica, S.A. 2014 - 2015
- Behavior And Physiology In Aging awarded by National Institutes of Health 1999 - 2015
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- Development of Methods to Quantify Biological and Pathological Aging of Cartilage awarded by National Institutes of Health 2011 - 2013
- Function and Behavior Phenotype of Inflammatory Arthritis in the Rat Knee and TMJ awarded by National Institutes of Health 2009 - 2011
- Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health 2003 - 2009
- Determination of OA Pathology by Biomarker Dating awarded by National Institutes of Health 2003 - 2009
- STRATEGIES TO PREDICT OSTEOARTHRITIS PROGRESSION awarded by National Institutes of Health 2002 - 2009
- Biomarkers Network Sample Repository awarded by National Institutes of Health 2003 - 2008
- Chondrocyte deformation and mechanical transduction. awarded by National Institutes of Health 1997 - 2003
- Metalloproteinases In Aging And Osteoarthritis awarded by National Institutes of Health 1998 - 2003
- same awarded by National Institutes of Health 1998 - 2003
- Cartilage Function and Micro-MRI After Meniscal Repair awarded by National Institutes of Health 1997 - 2000
- Intravenous Doxycycline For Rheumatoid Arthritis awarded by National Institutes of Health 1994 - 1998
- Cellular Genes Mediating E1a-Like Transcription Control awarded by National Institutes of Health 1992 - 1993
- Cellular Genes Mediating Ela-Like Transcription Control awarded by National Institutes of Health 1989 - 1993
External Relationships
- 23andMe
- GlaxoSmithKline
- Nordic Bioscience Clinical Development
- Novartis
- Paradigm Biopharma
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Alexander, Louie C., Janet L. Huebner, Greg Cicconetti, Joanne M. Jordan, Jordan B. Renner, Michael Doherty, Anthony G. Wilson, Marc C. Hochberg, Richard Loeser, and Virginia Byers Kraus. “Tibiofemoral knee osteoarthritis progresses symmetrically by knee compartment in the GOGO cohort (Accepted).” Osteoarthritis and Cartilage Open 4, no. 3 (September 2022): 100288–100288. https://doi.org/10.1016/j.ocarto.2022.100288.
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  - Goode, Adam P., David Hu, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Rebecca J. Cleveland, Kenneth A. Taylor, Joanne M. Jordan, and Yvonne M. Golightly. “Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project (Accepted).” Osteoarthritis and Cartilage Open 4, no. 3 (September 2022): 100270–100270. https://doi.org/10.1016/j.ocarto.2022.100270.
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  - Hunter, David J., Leticia A. Deveza, Jamie E. Collins, Elena Losina, Jeffrey N. Katz, Michael C. Nevitt, John A. Lynch, et al. “Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.” Arthritis Care Res (Hoboken) 74, no. 7 (July 2022): 1142–53. https://doi.org/10.1002/acr.24557.
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  - Zhang, Xin, Gurpreet Singh Baht, Rong Huang, Yu-Hsiu Chen, Kristin Happ Molitoris, Sara E. Miller, and Virginia Byers Kraus. “Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.” Aging Cell, June 3, 2022, e13651. https://doi.org/10.1111/acel.13651.
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  - Orenduff, Melissa C., Michael F. Coleman, Elaine M. Glenny, Kim M. Huffman, Erika T. Rezeli, Akshay Bareja, Carl F. Pieper, Virginia B. Kraus, and Stephen D. Hursting. “Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.” Exp Gerontol, May 24, 2022, 111841. https://doi.org/10.1016/j.exger.2022.111841.
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  - Lv, Y., C. Mao, X. Gao, J. S. Ji, V. B. Kraus, Z. Yin, J. Yuan, et al. “The obesity paradox is mostly driven by decreased noncardiovascular disease mortality in the oldest old in China: a 20-year prospective cohort study.” Nature Aging 2, no. 5 (May 1, 2022): 389–96. https://doi.org/10.1038/s43587-022-00201-3.
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  - Cen, Han, Qingran Yan, Weiyu Han, Tao Meng, Zhongshan Chen, Guangfeng Ruan, Tian Wang, et al. “Longitudinal Association of Infrapatellar Fat Pad Signal Intensity Alteration with Biochemical Biomarkers in Knee Osteoarthritis.” Rheumatology (Oxford), April 6, 2022. https://doi.org/10.1093/rheumatology/keac214.
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  - Zhang, X., S. Ma, A. Reed, T. Ho, G. Waitt, E. J. Soderblom, C. Aliferis, and V. B. Kraus. “PROTEOMIC SIGNATURES OF EXTRACELLULAR VESICLES DERIVED FROM SYNOVIAL FLUID AND PLASMA OF PARTICIPANTS WITH KNEE OSTEOARTHRITIS.” Osteoarthritis and Cartilage 30 (April 2022): S121–S121. https://doi.org/10.1016/j.joca.2022.02.154.
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  - Allen, Nicholas B., Bijan Abar, Richard M. Danilkowicz, Virginia B. Kraus, Steven A. Olson, and Samuel B. Adams. “Intra-Articular Synovial Fluid With Hematoma After Ankle Fracture Promotes Cartilage Damage In Vitro Partially Attenuated by Anti-Inflammatory Agents.” Foot Ankle Int 43, no. 3 (March 2022): 426–38. https://doi.org/10.1177/10711007211046952.
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  - Huang, Z. Y., Z. Y. Luo, Y. R. Cai, C. -. H. Chou, M. L. Yao, F. X. Pei, V. B. Kraus, and Z. K. Zhou. “Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing.” Osteoarthritis Cartilage 30, no. 3 (March 2022): 475–80. https://doi.org/10.1016/j.joca.2021.12.007.
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  - Jacobs, Cale A., Caitlin E. W. Conley, Virginia Byers Kraus, Drew A. Lansdown, Brian C. Lau, Xiaojuan Li, Sharmila Majumdar, Kurt P. Spindler, Nicole G. Lemaster, and Austin V. Stone. “MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial.” Trials 23, no. 1 (January 31, 2022): 98. https://doi.org/10.1186/s13063-021-05982-3.
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  - Bay-Jensen, Anne C., Ali Mobasheri, Christian S. Thudium, Virginia B. Kraus, and Morten A. Karsdal. “Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers.” Curr Opin Rheumatol 34, no. 1 (January 1, 2022): 54–60. https://doi.org/10.1097/BOR.0000000000000845.
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  - Chen, Yu-Hsiu, Xin Zhang, Kuei-Yueh Ko, Ming-Feng Hsueh, and Virginia Byers Kraus. “CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.” Oxid Med Cell Longev 2022 (2022): 5503575. https://doi.org/10.1155/2022/5503575.
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  - Huffman, Kim M., Daniel C. Parker, Manjushri Bhapkar, Susan B. Racette, Corby K. Martin, Leanne M. Redman, Sai Krupa Das, et al. “Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.” Eclinicalmedicine 43 (January 2022): 101261. https://doi.org/10.1016/j.eclinm.2021.101261.
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  - Han, Ashley J., Louie C. Alexander, Janet L. Huebner, Alexander B. Reed, and Virginia B. Kraus. “Increase in Free and Total Plasma TGF-β1 Following Physical Activity.” Cartilage 13, no. 1_suppl (December 2021): 1741S-1748S. https://doi.org/10.1177/1947603520916523.
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  - Wu, Bing, Yue Bin Lyu, Zhao Jin Cao, Yuan Wei, Wan Ying Shi, Xiang Gao, Jin Hui Zhou, et al. “Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.” Biomed Environ Sci 34, no. 11 (November 20, 2021): 859–70. https://doi.org/10.3967/bes2021.119.
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  - Zhou, Jinhui, Yuebin Lv, Feng Zhao, Yuan Wei, Xiang Gao, Chen Chen, Feng Lu, et al. “Albumin-corrected fructosamine predicts all-cause and non-CVD mortality among the very elderly aged ≥ 80 years without diabetes.” J Gerontol a Biol Sci Med Sci, November 10, 2021. https://doi.org/10.1093/gerona/glab339.
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  - Whitson, Heather E., Donna Crabtree, Carl F. Pieper, Christine Ha, Sandra Au, Miles Berger, Harvey J. Cohen, et al. “A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.” J Am Geriatr Soc 69, no. 11 (November 2021): 3232–41. https://doi.org/10.1111/jgs.17384.
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  - Li, Zhi-Hao, Pei-Dong Zhang, Qing Chen, Xiang Gao, Vincent C. H. Chung, Dong Shen, Xi-Ru Zhang, et al. “Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study.” Eur J Endocrinol 185, no. 5 (October 19, 2021): 765–74. https://doi.org/10.1530/EJE-21-0314.
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  - Kraus, V. B., and M. A. Karsdal. “Foundations of osteoarthritis section 3: clinical monitoring in OA chapter 15: biomarkers.” Osteoarthritis Cartilage, September 16, 2021. https://doi.org/10.1016/j.joca.2021.04.019.
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  - Zhang, Xi-Ru, Pei-Dong Zhang, Zhi-Hao Li, Pei Yang, Xiao-Meng Wang, Hua-Min Liu, Fen Liang, et al. “Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study.” Br J Nutr, September 16, 2021, 1–12. https://doi.org/10.1017/S000711452100372X.
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  - Kraus, Virginia Byers, and Morten A. Karsdal. “Osteoarthritis: Current Molecular Biomarkers and the Way Forward.” Calcif Tissue Int 109, no. 3 (September 2021): 329–38. https://doi.org/10.1007/s00223-020-00701-7.
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  - Alexander, Louie C., Grant McHorse, Janet L. Huebner, Anne-Christine Bay-Jensen, Morten A. Karsdal, and Virginia B. Kraus. “A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.” Arthritis Res Ther 23, no. 1 (August 31, 2021): 226. https://doi.org/10.1186/s13075-021-02610-y.
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  - Zhang, Xin, Janet L. Huebner, and Virginia Byers Kraus. “Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis.” Int J Mol Sci 22, no. 15 (August 3, 2021). https://doi.org/10.3390/ijms22158351.
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  - Buchanan, Michael W., Bridgette D. Furman, Jacob H. Zeitlin, Janet L. Huebner, Virginia B. Kraus, John S. Yi, and Steven A. Olson. “Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.” J Orthop Res 39, no. 8 (August 2021): 1710–21. https://doi.org/10.1002/jor.24899.
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  - Furman, B. D., J. H. Zeitlin, M. W. Buchanan, J. L. Huebner, V. B. Kraus, J. S. Yi, S. B. Adams, and S. A. Olson. “Immune cell profiling in the joint following human and murine articular fracture.” Osteoarthritis Cartilage 29, no. 6 (June 2021): 915–23. https://doi.org/10.1016/j.joca.2021.02.565.
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  - Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Todd A. Schwartz, Virginia B. Kraus, Jordan B. Renner, Richard H. Gracely, et al. “Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.” Arthritis Care Res (Hoboken), May 10, 2021. https://doi.org/10.1002/acr.24643.
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  - Luo, Yunyun, Jonathan Samuels, Svetlana Krasnokutsky, Inger Byrjalsen, Virginia B. Kraus, Yi He, Morten A. Karsdal, Steven B. Abramson, Mukundan Attur, and Anne C. Bay-Jensen. “A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.” J Orthop Traumatol 22, no. 1 (March 9, 2021): 10. https://doi.org/10.1186/s10195-021-00572-0.
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  - Hsueh, Ming-Feng, Xin Zhang, Samuel S. Wellman, Michael P. Bolognesi, and Virginia B. Kraus. “Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.” Arthritis Rheumatol 73, no. 1 (January 2021): 89–99. https://doi.org/10.1002/art.41486.
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  - Li, Zhi-Hao, Qing-Mei Huang, Xiang Gao, Vincent C. H. Chung, Pei-Dong Zhang, Dong Shen, Xi-Ru Zhang, et al. “Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study.” Front Cardiovasc Med 8 (2021): 769130. https://doi.org/10.3389/fcvm.2021.769130.
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  - Ramalingam, Sendhilnathan, Sharareh Siamakpour-Reihani, Lauren Bohannan, Yi Ren, Alexander Sibley, Jeff Sheng, Li Ma, et al. “A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant.” Plos One 16, no. 6 (2021): e0252995. https://doi.org/10.1371/journal.pone.0252995.
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  - Ross, Leanna M., Cris A. Slentz, Alyssa M. Zidek, Kim M. Huffman, Irina Shalaurova, James D. Otvos, Margery A. Connelly, et al. “Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.” Front Physiol 12 (2021): 626142. https://doi.org/10.3389/fphys.2021.626142.
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  - Zhang, Xin, Ming-Feng Hsueh, Janet L. Huebner, and Virginia B. Kraus. “TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression.” Front Immunol 12 (2021): 758386. https://doi.org/10.3389/fimmu.2021.758386.
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  - Li, Zhi-Hao, Yue-Bin Lv, Virginia Byers Kraus, Zhao-Xue Yin, Si-Min Liu, Xiao-Chang Zhang, Xiang Gao, et al. “Trends in the Incidence of Activities of Daily Living Disability Among Chinese Older Adults From 2002 to 2014.” J Gerontol a Biol Sci Med Sci 75, no. 11 (October 15, 2020): 2113–18. https://doi.org/10.1093/gerona/glz221.
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  - Parker, Daniel C., Cathleen Colόn-Emeric, Janet L. Huebner, Ching-Heng Chou, Virginia Byers Kraus, Carl F. Pieper, Richard Sloane, et al. “Biomarkers Associated with Physical Resilience After Hip Fracture.” J Gerontol a Biol Sci Med Sci 75, no. 10 (September 25, 2020): e166–72. https://doi.org/10.1093/gerona/glaa119.
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  - Attur, Mukundan, Svetlana Krasnokutsky, Hua Zhou, Jonathan Samuels, Gregory Chang, Jenny Bencardino, Pamela Rosenthal, et al. “The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis.” Arthritis Res Ther 22, no. 1 (September 10, 2020): 208. https://doi.org/10.1186/s13075-020-02298-6.
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  - Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nature Metabolism 2, no. 8 (August 2020): 794. https://doi.org/10.1038/s42255-020-0257-y.
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  - Chou, Ching-Heng, Vaibhav Jain, Jason Gibson, David E. Attarian, Collin A. Haraden, Christopher B. Yohn, Remi-Martin Laberge, Simon Gregory, and Virginia B. Kraus. “Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis.” Sci Rep 10, no. 1 (July 2, 2020): 10868. https://doi.org/10.1038/s41598-020-67730-y.
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  - King, John D., Grant Rowland, Alejandro G. Villasante Tezanos, James Warwick, Virginia B. Kraus, Christian Lattermann, and Cale A. Jacobs. “Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State.” Cartilage 11, no. 3 (July 2020): 329–37. https://doi.org/10.1177/1947603518790009.
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  - Lv, Yuebin, Virginia Byers Kraus, Xiang Gao, Zhaoxue Yin, Jinhui Zhou, Chen Mao, Jun Duan, et al. “Higher dietary diversity scores and protein-rich food consumption were associated with lower risk of all-cause mortality in the oldest old.” Clin Nutr 39, no. 7 (July 2020): 2246–54. https://doi.org/10.1016/j.clnu.2019.10.012.
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  - Li, Zhi-Hao, Qing Chen, Virginia Byers Kraus, Dong Shen, Xi-Ru Zhang, Pei-Dong Zhang, Wen-Fang Zhong, et al. “Leisure activities and disability in activities of daily living among the oldest-old Chinese population: evidence from the Chinese Longitudinal Healthy Longevity Study.” Aging (Albany Ny) 12, no. 11 (June 12, 2020): 10687–703. https://doi.org/10.18632/aging.103287.
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  - Wang, Jiaonan, Tiantian Li, Yuebin Lv, Virginia Byers Kraus, Yi Zhang, Chen Mao, Zhaoxue Yin, et al. “Fine Particulate Matter and Poor Cognitive Function among Chinese Older Adults: Evidence from a Community-Based, 12-Year Prospective Cohort Study.” Environ Health Perspect 128, no. 6 (June 2020): 67013. https://doi.org/10.1289/EHP5304.
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  - Zhou, Jinhui, Yuebin Lv, Chen Mao, Jun Duan, Xiang Gao, Jiaonan Wang, Zhaoxue Yin, et al. “Development and Validation of a Nomogram for Predicting the 6-Year Risk of Cognitive Impairment Among Chinese Older Adults.” J Am Med Dir Assoc 21, no. 6 (June 2020): 864-871.e6. https://doi.org/10.1016/j.jamda.2020.03.032.
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  - Li, Zhi-Hao, Xiang Gao, Vincent Ch Chung, Wen-Fang Zhong, Qi Fu, Yue-Bin Lv, Zheng-He Wang, et al. “Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.” Ann Rheum Dis 79, no. 6 (June 2020): 829–36. https://doi.org/10.1136/annrheumdis-2020-217176.
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  - Shiue, Kristin Y., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Marian T. Hannan, Howard J. Hillstrom, et al. “Is the Association between Knee Injury and Knee Osteoarthritis Modified by the Presence of General Joint Hypermobility.” Osteoarthr Cartil Open 2, no. 2 (June 2020). https://doi.org/10.1016/j.ocarto.2020.100045.
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  - Zhang, Yi, Tiantian Li, Runmei Ma, Zhaoxue Yin, Jiaonan Wang, Mike Z. He, Dandan Xu, et al. “Long-term exposure to ambient fine particulate matter and fasting blood glucose level in a Chinese elderly cohort.” Sci Total Environ 717 (May 15, 2020): 137191. https://doi.org/10.1016/j.scitotenv.2020.137191.
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  - Goode, Adam P., Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Steven Z. George, Rebecca J. Cleveland, Richard Gracely, et al. “Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project.” J Orthop Res 38, no. 5 (May 2020): 1027–37. https://doi.org/10.1002/jor.24534.
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  - Hsueh, M. -. F., M. P. Bolognesi, S. S. Wellman, and V. B. Kraus. “Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells.” Osteoarthritis Cartilage 28, no. 5 (May 2020): 639–45. https://doi.org/10.1016/j.joca.2020.01.013.
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  - Huang, ZeYu, Jing Chen, BoLei Li, Benhua Zeng, Ching-Heng Chou, Xin Zheng, JingWei Xie, et al. “Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.” Ann Rheum Dis 79, no. 5 (May 2020): 646–56. https://doi.org/10.1136/annrheumdis-2019-216471.
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  - Kimmerling, Kelly A., Sara J. Oswald, Janet L. Huebner, Dianne Little, Virginia B. Kraus, Jing X. Kang, Chia-Lung Wu, and Farshid Guilak. “Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis.” Arthritis Res Ther 22, no. 1 (April 15, 2020): 83. https://doi.org/10.1186/s13075-020-02170-7.
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  - Yuan, Jin-Qiu, Yue-Bin Lv, Virginia Byers Kraus, Xiang Gao, Zhao-Xue Yin, Hua-Shuai Chen, Jie-Si Luo, Yi Zeng, Chen Mao, and Xiao-Ming Shi. “Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study.” Bmc Oral Health 20, no. 1 (April 10, 2020): 100. https://doi.org/10.1186/s12903-020-01084-9.
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  - Lv, Yuebin, Jinhui Zhou, Virginia Byers Kraus, Tiantian Li, Jeremy A. Sarnat, Jiaonan Wang, Yang Liu, et al. “Long-term exposure to PM2.5 and incidence of disability in activities of daily living among oldest old.” Environ Pollut 259 (April 2020): 113910. https://doi.org/10.1016/j.envpol.2020.113910.
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  - Hsueh, M. -. F., S. Wellman, M. Bolognesi, and V. B. Kraus. “Folate receptor positive macrophages of osteoarthritic synovial fluid are high producers of IL-1β.” Osteoarthritis and Cartilage 28 (April 2020): S108–9. https://doi.org/10.1016/j.joca.2020.02.176.
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  - Zhang, X., M. -. F. Hsueh, and V. B. Kraus. “Evaluation of CD34+ hematopoietic stem cell-associated extracellular vesicles as a potential personalized therapy for osteoarthritis.” Osteoarthritis and Cartilage 28 (April 2020): S331–32. https://doi.org/10.1016/j.joca.2020.02.512.
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  - Spil, W. E. van, S. M. A. Bierma-Zeinstra, L. A. Deveza, N. K. Arden, A. -. C. Bay-Jensen, V Byers Kraus, L. Carlesso, et al. “A consensus-based framework for conducting and reporting osteoarthritis phenotype research.” Arthritis Res Ther 22, no. 1 (March 20, 2020): 54. https://doi.org/10.1186/s13075-020-2143-0.
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  - Mao, Chen, Zhi-Hao Li, Yue-Bin Lv, Xiang Gao, Virginia Byers Kraus, Jin-Hui Zhou, Xian-Bo Wu, et al. “Specific Leisure Activities and Cognitive Functions Among the Oldest-Old: The Chinese Longitudinal Healthy Longevity Survey.” J Gerontol a Biol Sci Med Sci 75, no. 4 (March 9, 2020): 739–46. https://doi.org/10.1093/gerona/glz086.
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  - Li, Zhi-Hao, Wen-Fang Zhong, Simin Liu, Virginia Byers Kraus, Yu-Jie Zhang, Xiang Gao, Yue-Bin Lv, et al. “Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study.” Bmj 368 (March 4, 2020): m456. https://doi.org/10.1136/bmj.m456.
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  - Jacobs, Cale A., Emily R. Hunt, Caitlin E-W Conley, Darren L. Johnson, Austin V. Stone, Janet L. Huebner, Virginia B. Kraus, and Christian Lattermann. “Dysregulated Inflammatory Response Related to Cartilage Degradation after ACL Injury.” Med Sci Sports Exerc 52, no. 3 (March 2020): 535–41. https://doi.org/10.1249/MSS.0000000000002161.
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  - Baht, Gurpreet S., Akshay Bareja, David E. Lee, Rajesh R. Rao, Rong Huang, Janet L. Huebner, David B. Bartlett, et al. “Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.” Nat Metab 2, no. 3 (March 2020): 278–89. https://doi.org/10.1038/s42255-020-0184-y.
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  - Duan, Jun, Yue-Bin Lv, Xiang Gao, Jin-Hui Zhou, Virginia Byers Kraus, Yi Zeng, Hong Su, and Xiao-Ming Shi. “Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.” Bmc Geriatr 20, no. 1 (January 28, 2020): 29. https://doi.org/10.1186/s12877-020-1424-4.
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  - Attur, M., H. Zhou, J. Samuels, S. Krasnokutsky, M. Yau, J. U. Scher, M. Doherty, et al. “Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.” Annals of the Rheumatic Diseases 79, no. 3 (January 1, 2020). https://doi.org/10.15767/FEMINISTSTUDIES.45.2-3.0574.
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  - Bartlett, David B., Cris A. Slentz, Leslie H. Willis, Andrew Hoselton, Janet L. Huebner, Virginia B. Kraus, Jennifer Moss, et al. “Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.” Front Immunol 11 (2020): 729. https://doi.org/10.3389/fimmu.2020.00729.
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  - Zhang, Xin, Monica Jeanne Hubal, and Virginia Byers Kraus. “Immune cell extracellular vesicles and their mitochondrial content decline with ageing.” Immun Ageing 17 (2020): 1. https://doi.org/10.1186/s12979-019-0172-9.
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  - Bannuru, R. R., M. C. Osani, E. E. Vaysbrot, N. K. Arden, K. Bennell, S. M. A. Bierma-Zeinstra, V. B. Kraus, et al. “OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis.” Osteoarthritis Cartilage 27, no. 11 (November 2019): 1578–89. https://doi.org/10.1016/j.joca.2019.06.011.
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  - Hsueh, Ming-Feng, Patrik Önnerfjord, Michael P. Bolognesi, Mark E. Easley, and Virginia B. Kraus. “Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.” Sci Adv 5, no. 10 (October 2019): eaax3203. https://doi.org/10.1126/sciadv.aax3203.
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  - Huang, Rong, Xiaohua Zong, Puviindran Nadesan, Janet L. Huebner, Virginia B. Kraus, James P. White, Phillip J. White, and Gurpreet S. Baht. “Lowering circulating apolipoprotein E levels improves aged bone fracture healing.” Jci Insight 4, no. 18 (September 19, 2019). https://doi.org/10.1172/jci.insight.129144.
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  - Li, Fu-Rong, Xi-Ru Zhang, Wen-Fang Zhong, Zhi-Hao Li, Xiang Gao, Virginia Byers Kraus, Yue-Bin Lv, et al. “Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes.” J Clin Endocrinol Metab 104, no. 8 (August 1, 2019): 3345–54. https://doi.org/10.1210/jc.2018-02536.
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  - Huang, ZeYu, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen, and Virginia Byers Kraus. “Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials.” Arthritis Res Ther 21, no. 1 (July 15, 2019): 173. https://doi.org/10.1186/s13075-019-1951-6.
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  - Emery, Carolyn A., Jackie L. Whittaker, Armaghan Mahmoudian, L Stefan Lohmander, Ewa M. Roos, Kim L. Bennell, Clodagh M. Toomey, et al. “Establishing outcome measures in early knee osteoarthritis.” Nat Rev Rheumatol 15, no. 7 (July 2019): 438–48. https://doi.org/10.1038/s41584-019-0237-3.
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  - Haraden, Collin A., Janet L. Huebner, Ming-Feng Hsueh, Yi-Ju Li, and Virginia Byers Kraus. “Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.” Arthritis Res Ther 21, no. 1 (June 13, 2019): 146. https://doi.org/10.1186/s13075-019-1923-x.
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  - Gullo, Terese R., Yvonne M. Golightly, Rebecca J. Cleveland, Jordan B. Renner, Leigh F. Callahan, Joanne M. Jordan, Virginia B. Kraus, and Amanda E. Nelson. “Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.” Semin Arthritis Rheum 48, no. 6 (June 2019): 950–57. https://doi.org/10.1016/j.semarthrit.2018.10.001.
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  - Kraus, Virginia B., Kyle Sprow, Kenneth E. Powell, David Buchner, Bonny Bloodgood, Katrina Piercy, Stephanie M. George, William E. Kraus, and William E. 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*. “Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.” Med Sci Sports Exerc 51, no. 6 (June 2019): 1324–39. https://doi.org/10.1249/MSS.0000000000001944.
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  - Mao, Chen, Fu-Rong Li, Zhao-Xue Yin, Yue-Bin Lv, Jie-Si Luo, Jin-Qiu Yuan, Florence Mhungu, et al. “Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.” J Nutr 149, no. 6 (June 1, 2019): 1056–64. https://doi.org/10.1093/jn/nxz041.
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  - Mao, Chen, Jin-Qiu Yuan, Yue-Bin Lv, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jie-Si Luo, et al. “Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.” Bmc Geriatr 19, no. 1 (April 15, 2019): 104. https://doi.org/10.1186/s12877-019-1109-z.
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  - Gullo, Terese R., Yvonne M. Golightly, Portia Flowers, Joanne M. Jordan, Jordan B. Renner, Todd A. Schwartz, Virginia B. Kraus, Marian T. Hannan, Rebecca J. Cleveland, and Amanda E. Nelson. “Joint hypermobility is not positively associated with prevalent multiple joint osteoarthritis: a cross-sectional study of older adults.” Bmc Musculoskelet Disord 20, no. 1 (April 11, 2019): 165. https://doi.org/10.1186/s12891-019-2550-z.
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  - Goode, Adam P., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Marian T. Hannan, et al. “Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.” Bmc Musculoskelet Disord 20, no. 1 (April 9, 2019): 158. https://doi.org/10.1186/s12891-019-2523-2.
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  - Golightly, Yvonne M., Marian T. Hannan, Amanda E. Nelson, Howard J. Hillstrom, Rebecca J. Cleveland, Virginia B. Kraus, Todd A. Schwartz, et al. “Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort.” Arthritis Care Res (Hoboken) 71, no. 4 (April 2019): 538–44. https://doi.org/10.1002/acr.23686.
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  - Kraus, V. B., L. S. Simon, J. N. Katz, T. Neogi, D. Hunter, A. Guermazi, and M. A. Karsdal. “Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs.” Osteoarthritis Cartilage 27, no. 4 (April 2019): 571–79. https://doi.org/10.1016/j.joca.2018.11.002.
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  - Lv, Yue-Bin, Chen Mao, Xiang Gao, Zhao-Xue Yin, Virginia Byers Kraus, Jin-Qiu Yuan, Juan Zhang, Jie-Si Luo, Yi Zeng, and Xiao-Ming Shi. “Triglycerides Paradox Among the Oldest Old: "The Lower the Better?".” J Am Geriatr Soc 67, no. 4 (April 2019): 741–48. https://doi.org/10.1111/jgs.15733.
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  - Yin, Zhaoxue, Melanie Sereny Brasher, Virginia B. Kraus, Yuebin Lv, Xiaoming Shi, and Yi Zeng. “Dietary Diversity Was Positively Associated with Psychological Resilience among Elders: A Population-Based Study.” Nutrients 11, no. 3 (March 18, 2019). https://doi.org/10.3390/nu11030650.
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  - Spitzer, Andrew I., John C. Richmond, Virginia B. Kraus, Andreas Gomoll, Deryk G. Jones, Kim M. Huffman, Charles Peterfy, Amy Cinar, Joelle Lufkin, and Scott D. Kelley. “Safety and Efficacy of Repeat Administration of Triamcinolone Acetonide Extended-release in Osteoarthritis of the Knee: A Phase 3b, Open-label Study.” Rheumatol Ther 6, no. 1 (March 2019): 109–24. https://doi.org/10.1007/s40744-019-0140-z.
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  - Parker, Daniel, Richard Sloane, Carl F. Pieper, Katherine S. Hall, Virginia B. Kraus, William E. Kraus, Janet L. Huebner, et al. “Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.” J Gerontol a Biol Sci Med Sci 74, no. 3 (February 15, 2019): 283–89. https://doi.org/10.1093/gerona/gly121.
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  - Yuan, Jin-Qiu, Yue-Bin Lv, Hua-Shuai Chen, Xiang Gao, Zhao-Xue Yin, Wen-Tao Wang, Virginia Byers Kraus, et al. “Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study.” J Am Med Dir Assoc 20, no. 2 (February 2019): 177-182.e2. https://doi.org/10.1016/j.jamda.2018.05.029.
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  - Andonian, Brian J., Ching-Heng Chou, Olga R. Ilkayeva, Timothy R. Koves, Margery A. Connelly, William E. Kraus, Virginia B. Kraus, and Kim M. Huffman. “Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles.” Front Immunol 10 (2019): 1475. https://doi.org/10.3389/fimmu.2019.01475.
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  - Li, Zhi-Hao, Wen-Fang Zhong, Yue-Bin Lv, Virginia Byers Kraus, Xiang Gao, Pei-Liang Chen, Qing-Mei Huang, et al. “Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals.” Immun Ageing 16 (2019): 28. https://doi.org/10.1186/s12979-019-0168-5.
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  - Watt, F. E., N. Corp, S. R. Kingsbury, R. Frobell, M. Englund, D. T. Felson, M. Levesque, et al. “Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.” Osteoarthritis Cartilage 27, no. 1 (January 2019): 23–33. https://doi.org/10.1016/j.joca.2018.08.001.
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  - Andonian, Brian J., David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus, and Kim M. Huffman. “Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.” Arthritis Res Ther 20, no. 1 (December 27, 2018): 283. https://doi.org/10.1186/s13075-018-1786-6.
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  - Huang, Z. Y., E. Perry, J. L. Huebner, B. Katz, Y. -. J. Li, and V. B. Kraus. “Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial.” Osteoarthritis Cartilage 26, no. 12 (December 2018): 1658–65. https://doi.org/10.1016/j.joca.2018.08.005.
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  - Yuan, Jin-Qiu, Yue-Bin Lv, Virginia Byers Kraus, Xiang Gao, Zhao-Xue Yin, Hua-Shuai Chen, Jie-Si Luo, Yi Zeng, Chen Mao, and Xiaoming Shi. “Denture Use Protects Against All-Cause Mortality Associated with Tooth Loss in Older Adults,” September 29, 2018.
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  - Longobardi, L., J. M. Jordan, X. A. Shi, J. B. Renner, T. A. Schwartz, A. E. Nelson, D. A. Barrow, V. B. Kraus, and A. Spagnoli. “Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project.” Osteoarthritis Cartilage 26, no. 9 (September 2018): 1257–61. https://doi.org/10.1016/j.joca.2018.04.012.
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  - Huang, ZeYu, Cheng Huang, JinWei Xie, Jun Ma, GuoRui Cao, Qiang Huang, Bin Shen, Virginia Byers Kraus, and FuXing Pei. “Analysis of a large data set to identify predictors of blood transfusion in primary total hip and knee arthroplasty.” Transfusion 58, no. 8 (August 2018): 1855–62. https://doi.org/10.1111/trf.14783.
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  - Lv, Yue-Bin, Simin Liu, Zhao-Xue Yin, Xiang Gao, Virginia Byers Kraus, Chen Mao, Jin-Qiu Yuan, et al. “Associations of Body Mass Index and Waist Circumference with 3-Year All-Cause Mortality Among the Oldest Old: Evidence from a Chinese Community-Based Prospective Cohort Study.” J Am Med Dir Assoc 19, no. 8 (August 2018): 672-678.e4. https://doi.org/10.1016/j.jamda.2018.03.015.
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  - Zuo, Xintong, Alison Luciano, Carl F. Pieper, James R. Bain, Virginia B. Kraus, William E. Kraus, Miriam C. Morey, and Harvey J. Cohen. “Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.” J Am Geriatr Soc 66, no. 7 (July 2018): 1353–59. https://doi.org/10.1111/jgs.15393.
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  - Bartlett, David B., Leslie H. Willis, Cris A. Slentz, Andrew Hoselton, Leslie Kelly, Janet L. Huebner, Virginia B. Kraus, et al. “Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.” Arthritis Res Ther 20, no. 1 (June 14, 2018): 127. https://doi.org/10.1186/s13075-018-1624-x.
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  - Lv, Yue-Bin, Xiang Gao, Zhao-Xue Yin, Hua-Shuai Chen, Jie-Si Luo, Melanie Sereny Brasher, Virginia Byers Kraus, Tian-Tian Li, Yi Zeng, and Xiao-Ming Shi. “Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study.” Bmj 361 (June 5, 2018): k2158. https://doi.org/10.1136/bmj.k2158.
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  - Kraus, Virginia B. “Biomarkers as drug development tools: discovery, validation, qualification and use.” Nat Rev Rheumatol 14, no. 6 (June 2018): 354–62. https://doi.org/10.1038/s41584-018-0005-9.
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  - Deveza, L. A., V. B. Kraus, J. E. Collins, A. Guermazi, F. W. Roemer, M. C. Nevitt, and D. J. Hunter. “Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative.” Scand J Rheumatol 47, no. 3 (May 2018): 235–42. https://doi.org/10.1080/03009742.2017.1340511.
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  - Leung, Y. Y., B. Haaland, J. L. Huebner, S. B. S. Wong, M. Tjai, C. Wang, B. Chowbay, et al. “Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial.” Osteoarthritis Cartilage 26, no. 5 (May 2018): 631–40. https://doi.org/10.1016/j.joca.2018.01.026.
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  - Conaghan, Philip G., David J. Hunter, Stanley B. Cohen, Virginia B. Kraus, Francis Berenbaum, Jay R. Lieberman, Deryk G. Jones, et al. “Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study.” J Bone Joint Surg Am 100, no. 8 (April 18, 2018): 666–77. https://doi.org/10.2106/JBJS.17.00154.
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  - Flowers, Portia P. E., Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Adam P. Goode, et al. “Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.” Arthritis Res Ther 20, no. 1 (April 18, 2018): 76. https://doi.org/10.1186/s13075-018-1570-7.
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  - Nie, Yong, Jun Ma, ZeYu Huang, Bin Xu, Shuo Tang, Bin Shen, Virginia Byers Kraus, and FuXing Pei. “Upper partial fibulectomy improves knee biomechanics and function and decreases knee pain of osteoarthritis: A pilot and biomechanical study.” J Biomech 71 (April 11, 2018): 22–29. https://doi.org/10.1016/j.jbiomech.2017.12.004.
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  - Yin, Zhaoxue, Jing Chen, Jian Zhang, Zeping Ren, Kui Dong, Virginia B. Kraus, Zhuoqun Wang, et al. “Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study.” Nutrients 10, no. 4 (April 9, 2018). https://doi.org/10.3390/nu10040464.
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  - Goode, A., V. B. Kraus, Y. Golightly, J. Huebner, S. George, J. Martin, L. DeFrate, and J. M. Jordan. “ASSOCIATION BETWEEN N-CADHERIN, KERATIN-19 AND LUMICAN WITH DISC SPACE NARROWING: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT.” Osteoarthritis and Cartilage 26 (April 1, 2018): S421–S421.
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  - Furman, Bridgette D., Collin L. Kent, Janet L. Huebner, Virginia B. Kraus, Amy L. McNulty, Farshid Guilak, and Steven A. Olson. “CXCL10 is upregulated in synovium and cartilage following articular fracture.” J Orthop Res 36, no. 4 (April 2018): 1220–27. https://doi.org/10.1002/jor.23735.
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  - McIlwraith, C Wayne, Christopher E. Kawcak, David D. Frisbie, Christopher B. Little, Peter D. Clegg, Mandy J. Peffers, Morten A. Karsdal, et al. “Biomarkers for equine joint injury and osteoarthritis.” J Orthop Res 36, no. 3 (March 2018): 823–31. https://doi.org/10.1002/jor.23738.
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  - Amano, Keiko, Janet L. Huebner, Thomas V. Stabler, Matthew Tanaka, Charles E. McCulloch, Iryna Lobach, Nancy E. Lane, Virginia B. Kraus, C Benjamin Ma, and Xiaojuan Li. “Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery.” Am J Sports Med 46, no. 4 (March 2018): 890–99. https://doi.org/10.1177/0363546517749834.
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  - ZeYu Huang, Yong Nie, Bin Xu, Bin Shen, Virginia B. Kraus, and FuXing Pei. “Evidence and mechanism by which upper partial fibulectomy improves knee biomechanics and decreases knee pain of osteoarthritis.” J Orthop Res, February 9, 2018. https://doi.org/10.1002/jor.23867.
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  - Luyten, F. P., S. Bierma-Zeinstra, F. Dell’Accio, V. B. Kraus, K. Nakata, I. Sekiya, N. K. Arden, and L. S. Lohmander. “Toward classification criteria for early osteoarthritis of the knee.” Semin Arthritis Rheum 47, no. 4 (February 2018): 457–63. https://doi.org/10.1016/j.semarthrit.2017.08.006.
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  - Nie, Yong, HaoYang Wang, ZeYu Huang, Bin Shen, Virginia Byers Kraus, and Zongke Zhou. “Radiographic Underestimation of In Vivo Cup Coverage Provided by Total Hip Arthroplasty for Dysplasia.” Orthopedics 41, no. 1 (January 1, 2018): e46–51. https://doi.org/10.3928/01477447-20171114-01.
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  - Kraus, Virginia Byers, Jamie E. Collins, H Cecil Charles, Carl F. Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, et al. “Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.” Arthritis Rheumatol 70, no. 1 (January 2018): 80–87. https://doi.org/10.1002/art.40348.
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  - Lattermann, Christian, Caitlin E-W Conley, Darren L. Johnson, Emily K. Reinke, Laura J. Huston, Janet L. Huebner, Ching-Heng Chou, Virginia B. Kraus, Kurt P. Spindler, and Cale A. Jacobs. “Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.” Biomed Res Int 2018 (2018): 9387809. https://doi.org/10.1155/2018/9387809.
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  - Huang, ZeYu, XiaoWei Xie, LingLi Li, Qiang Huang, Jun Ma, Bin Shen, Virginia Byers Kraus, and FuXing Pei. “Intravenous and Topical Tranexamic Acid Alone Are Superior to Tourniquet Use for Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial.” J Bone Joint Surg Am 99, no. 24 (December 20, 2017): 2053–61. https://doi.org/10.2106/JBJS.16.01525.
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  - Adams, Samuel B., Rachel M. Reilly, Janet L. Huebner, Virginia B. Kraus, and Dana L. Nettles. “Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.” Foot Ankle Int 38, no. 10 (October 2017): 1055–63. https://doi.org/10.1177/1071100717728234.
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  - Wu, Chia-Lung, Jenna McNeill, Kelsey Goon, Dianne Little, Kelly Kimmerling, Janet Huebner, Virginia Kraus, and Farshid Guilak. “Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.” Arthritis Rheumatol 69, no. 9 (September 2017): 1772–83. https://doi.org/10.1002/art.40161.
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  - Leung, Y. Y., J. L. Huebner, B. Haaland, S. B. S. Wong, and V. B. Kraus. “Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain.” Osteoarthritis Cartilage 25, no. 9 (September 2017): 1420–27. https://doi.org/10.1016/j.joca.2017.04.001.
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  - Hsueh, M. -. F., V. B. Kraus, and P. Önnerfjord. “Cartilage matrix remodelling differs by disease state and joint type.” Eur Cell Mater 34 (August 24, 2017): 70–82. https://doi.org/10.22203/eCM.v034a05.
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  - Deveza, Leticia A., Virginia B. Kraus, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Michael Bowes, Michael C. Nevitt, Christoph Ladel, and David J. Hunter. “Association Between Biochemical Markers of Bone Turnover and Bone Changes on Imaging: Data From the Osteoarthritis Initiative.” Arthritis Care Res (Hoboken) 69, no. 8 (August 2017): 1179–91. https://doi.org/10.1002/acr.23121.
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  - Nwosu, L. N., M. Allen, L. Wyatt, J. L. Huebner, V. Chapman, D. A. Walsh, and V. B. Kraus. “Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.” Osteoarthritis Cartilage 25, no. 6 (June 2017): 858–65. https://doi.org/10.1016/j.joca.2017.01.002.
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  - Liu, Betty, Adam P. Goode, Teralyn E. Carter, Gangadhar M. Utturkar, Janet L. Huebner, Dean C. Taylor, Claude T. Moorman, et al. “Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.” Connect Tissue Res 58, no. 3–4 (May 2017): 305–16. https://doi.org/10.1080/03008207.2016.1256391.
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  - Adams, Samuel B., Elizabeth M. Leimer, Lori A. Setton, Richard D. Bell, Mark E. Easley, Janet L. Huebner, Thomas V. Stabler, Virginia B. Kraus, Steven A. Olson, and Dana L. Nettles. “Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures.” Foot Ankle Int 38, no. 5 (May 2017): 479–84. https://doi.org/10.1177/1071100717690427.
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  - Huang, Z. Y., and V. B. Kraus. “Reply to Stausholm et al.'s letter to the editor regarding our published study entitled, "Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis".” Osteoarthritis Cartilage 25, no. 4 (April 2017): e11–14. https://doi.org/10.1016/j.joca.2016.10.015.
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  - Lattermann, Christian, Cale A. Jacobs, Mary Proffitt Bunnell, Kate N. Jochimsen, John P. Abt, Emily K. Reinke, Lee G. Gammon, Janet L. Huebner, Virginia B. Kraus, and Kurt P. Spindler. “Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis.” J Orthop Res 35, no. 3 (March 2017): 641–50. https://doi.org/10.1002/jor.23329.
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  - AbouAssi, Hiba, Margery A. Connelly, Lori A. Bateman, K Noelle Tune, Janet L. Huebner, Virginia B. Kraus, Deborah A. Winegar, James D. Otvos, William E. Kraus, and Kim M. Huffman. “Does a lack of physical activity explain the rheumatoid arthritis lipid profile?” Lipids Health Dis 16, no. 1 (February 10, 2017): 39. https://doi.org/10.1186/s12944-017-0427-4.
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  - Lattermann, Christian, Cale A. Jacobs, Mary Proffitt Bunnell, Laura J. Huston, Lee G. Gammon, Darren L. Johnson, Emily K. Reinke, Janet L. Huebner, Virginia B. Kraus, and Kurt P. Spindler. “A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear.” Am J Sports Med 45, no. 2 (February 2017): 325–33. https://doi.org/10.1177/0363546516666818.
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  - Lv, Yue-Bin, Peng-Fei Zhu, Zhao-Xue Yin, Virginia Byers Kraus, Diane Threapleton, Choy-Lye Chei, Melanie Sereny Brasher, et al. “A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly.” J Am Med Dir Assoc 18, no. 2 (February 1, 2017): 193.e7-193.e13. https://doi.org/10.1016/j.jamda.2016.11.011.
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  - Huffman, Kim M., Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, et al. “Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.” Arthritis Res Ther 19, no. 1 (January 23, 2017): 12. https://doi.org/10.1186/s13075-016-1215-7.
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  - Gupta, Divakar, Joanne C. Wen, Janet L. Huebner, Sandra Stinnett, Virginia B. Kraus, Henry C. Tseng, and Molly Walsh. “Cytokine biomarkers in tear film for primary open-angle glaucoma.” Clin Ophthalmol 11 (2017): 411–16. https://doi.org/10.2147/OPTH.S125364.
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  - Stabler, Thomas V., Eulàlia Montell, Josep Vergés, Janet L. Huebner, and Virginia Byers Kraus. “Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?” Biomark Insights 12 (2017): 1177271917726964. https://doi.org/10.1177/1177271917726964.
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  - Yin, Z., Z. Fei, C. Qiu, M. S. Brasher, V. B. Kraus, W. Zhao, X. Shi, and Y. Zeng. “Dietary Diversity and Cognitive Function among Elderly People: A Population-Based Study.” J Nutr Health Aging 21, no. 10 (2017): 1089–94. https://doi.org/10.1007/s12603-017-0912-5.
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  - Daghestani, Hikmat N., Joanne M. Jordan, Jordan B. Renner, Michael Doherty, A Gerry Wilson, and Virginia B. Kraus. “Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.” Plos One 12, no. 12 (2017): e0190251. https://doi.org/10.1371/journal.pone.0190251.
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  - Kraus, Virginia Byers, Jamie E. Collins, David Hargrove, Elena Losina, Michael Nevitt, Jeffrey N. Katz, Susanne X. Wang, et al. “Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium.” Ann Rheum Dis 76, no. 1 (January 2017): 186–95. https://doi.org/10.1136/annrheumdis-2016-209252.
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  - Stabler, T. V., Z. Huang, E. Montell, J. Vergés, and V. B. Kraus. “Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules.” Osteoarthritis and Cartilage 25, no. 1 (January 2017): 166–74. https://doi.org/10.1016/j.joca.2016.08.012.
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  - Taylor, Adam M., Ming-Feng Hsueh, Lakshminarayan R. Ranganath, James A. Gallagher, Jane P. Dillon, Janet L. Huebner, Jon B. Catterall, and Virginia B. Kraus. “Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.” Rheumatology (Oxford) 56, no. 1 (January 2017): 156–64. https://doi.org/10.1093/rheumatology/kew355.
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  - Karsdal, M. A., M. Michaelis, C. Ladel, A. S. Siebuhr, A. R. Bihlet, J. R. Andersen, H. Guehring, C. Christiansen, A. C. Bay-Jensen, and V. B. Kraus. “Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future.” Osteoarthritis Cartilage 24, no. 12 (December 2016): 2013–21. https://doi.org/10.1016/j.joca.2016.07.017.
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  - Roemer, Frank W., Ali Guermazi, Jamie E. Collins, Elena Losina, Michael C. Nevitt, John A. Lynch, Jeffrey N. Katz, C Kent Kwoh, Virginia B. Kraus, and David J. Hunter. “Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change.” Bmc Musculoskelet Disord 17, no. 1 (November 10, 2016): 466. https://doi.org/10.1186/s12891-016-1310-6.
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  - Kraus, William E., Carl F. Pieper, Kim M. Huffman, Dana K. Thompson, Virginia B. Kraus, Miriam C. Morey, Harvey J. Cohen, et al. “Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.” J Gerontol a Biol Sci Med Sci 71, no. 11 (November 2016): 1507–13. https://doi.org/10.1093/gerona/glw031.
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  - Collins, Jamie E., Elena Losina, Michael C. Nevitt, Frank W. Roemer, Ali Guermazi, John A. Lynch, Jeffrey N. Katz, C. Kent Kwoh, Virginia B. Kraus, and David J. Hunter. “Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.” Arthritis Rheumatol 68, no. 10 (October 2016): 2422–31. https://doi.org/10.1002/art.39731.
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  - Castaño-Betancourt, Martha C., Dan S. Evans, Yolande F. M. Ramos, Cindy G. Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, et al. “Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.” Plos Genet 12, no. 10 (October 2016): e1006260. https://doi.org/10.1371/journal.pgen.1006260.
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  - Huang, Z. Y., T. Stabler, F. X. Pei, and V. B. Kraus. “Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation.” Osteoarthritis Cartilage 24, no. 10 (October 2016): 1769–75. https://doi.org/10.1016/j.joca.2016.05.008.
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  - Huebner, J. L., L. R. Landerman, T. J. Somers, F. J. Keefe, F. Guilak, J. A. Blumenthal, D. S. Caldwell, and V. B. Kraus. “Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation.” Osteoarthritis Cartilage 24, no. 9 (September 2016): 1528–34. https://doi.org/10.1016/j.joca.2016.04.002.
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  - Hunter, David, Michael Nevitt, John Lynch, Virginia Byers Kraus, Jeffrey N. Katz, Jamie E. Collins, Mike Bowes, et al. “Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium.” Ann Rheum Dis 75, no. 9 (September 2016): 1607–14. https://doi.org/10.1136/annrheumdis-2015-207602.
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  - Fu, Yao, Janet L. Huebner, Virginia B. Kraus, and Timothy M. Griffin. “Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats.” J Gerontol a Biol Sci Med Sci 71, no. 9 (September 2016): 1131–40. https://doi.org/10.1093/gerona/glv151.
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  - Coudeyre, Emmanuel, Virginia Byers Kraus, and François Rannou. “Osteoarthritis in physical medicine and rehabilitation.” Ann Phys Rehabil Med 59, no. 3 (June 2016): 133. https://doi.org/10.1016/j.rehab.2016.05.002.
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  - Leung, Ying-Ying, and Virginia B. Kraus. “Impact of glomerular filtration rate in colchicine toxicity.” Semin Arthritis Rheum 45, no. 6 (June 2016): e25. https://doi.org/10.1016/j.semarthrit.2016.02.007.
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  - Bartlett, David B., Margery A. Connelly, Hiba AbouAssi, Lori A. Bateman, K Noelle Tune, Janet L. Huebner, Virginia B. Kraus, et al. “A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.” Arthritis Res Ther 18 (April 12, 2016): 86. https://doi.org/10.1186/s13075-016-0982-5.
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  - Huebner, J. L., B. D. Furman, M. J. Manson, K. A. Kimmerling, S. A. Olson, F. Guilak, L. E. DeFrate, R. D. Zura, R. M. Reilly, and V. B. Kraus. “Acute inflammatory response after severe joint injury potentially involved in the development of post-traumatic arthritis.” Osteoarthritis and Cartilage 24 (April 2016): S79–80. https://doi.org/10.1016/j.joca.2016.01.169.
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  - Lv, Y. B., Z. X. Yin, C. L. Chei, M. S. Brasher, J. Zhang, V. B. Kraus, F. Qian, X. Shi, D. B. Matchar, and Y. Zeng. “Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly.” Journal of Nutrition, Health and Aging 20, no. 3 (March 1, 2016): 280–87. https://doi.org/10.1007/s12603-016-0701-6.
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  - Bowles, R. D., I. O. Karikari, D. N. VanDerwerken, M. S. Sinclair, R. D. Bell, K. J. Riebe, J. L. Huebner, V. B. Kraus, G. D. Sempowski, and L. A. Setton. “In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.” Eur J Pain 20, no. 3 (March 2016): 365–76. https://doi.org/10.1002/ejp.732.
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  - Lv, Y. -. B., Z. X. Yin, C. -. L. Chei, M. S. Brasher, J. Zhang, V. B. Kraus, F. Qian, X. -. M. Shi, D. B. Matchar, and Y. Zeng. “Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly.” J Nutr Health Aging 20, no. 3 (March 2016): 280–87. https://doi.org/10.1007/s12603-016-0701-6.
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  - Hsueh, Ming-Feng, Areej Khabut, Sven Kjellström, Patrik Önnerfjord, and Virginia Byers Kraus. “Elucidating the Molecular Composition of Cartilage by Proteomics.” J Proteome Res 15, no. 2 (February 5, 2016): 374–88. https://doi.org/10.1021/acs.jproteome.5b00946.
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  - Catterall, J. B., R. D. Zura, M. P. Bolognesi, and V. B. Kraus. “Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage.” Osteoarthritis Cartilage 24, no. 2 (February 2016): 374–81. https://doi.org/10.1016/j.joca.2015.09.003.
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  - Huang, Zeyu, and Virginia Byers Kraus. “Does lipopolysaccharide-mediated inflammation have a role in OA?” Nat Rev Rheumatol 12, no. 2 (February 2016): 123–29. https://doi.org/10.1038/nrrheum.2015.158.
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  - Peterson, Matthew J., Dana K. Thompson, Carl F. Pieper, Miriam C. Morey, Virginia B. Kraus, William E. Kraus, Patrick Sullivan, Gerda Fillenbaum, and Harvey J. Cohen. “A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.” J Gerontol a Biol Sci Med Sci 71, no. 2 (February 2016): 196–202. https://doi.org/10.1093/gerona/glv007.
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  - Olson, Steven A., Bridgette D. Furman, Virginia B. Kraus, Janet L. Huebner, and Farshid Guilak. “Reply to "Does progranulin account for the opposite effects of etanercept and infliximab/adalimumab in osteoarthritis?" by Wei et al.” J Orthop Res 34, no. 1 (January 2016): 15–16. https://doi.org/10.1002/jor.23095.
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  - Siebuhr, A. S., A. C. Bay-Jensen, J. M. Jordan, C. F. Kjelgaard-Petersen, C. Christiansen, S. B. Abramson, M. Attur, F. Berenbaum, V. Kraus, and M. A. Karsdal. “Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?” Scand J Rheumatol 45, no. 2 (2016): 87–98. https://doi.org/10.3109/03009742.2015.1060259.
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  - Huang, ZeYu, Jun Ma, Jing Chen, Bin Shen, FuXing Pei, and Virginia Byers Kraus. “The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis.” Arthritis Res Ther 17 (December 15, 2015): 360. https://doi.org/10.1186/s13075-015-0882-0.
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  - Stabler, Thomas, Robert D. Zura, Ming-Feng Hsueh, and Virginia B. Kraus. “Xanthine oxidase injurious response in acute joint injury.” Clin Chim Acta 451, no. Pt B (December 7, 2015): 170–74. https://doi.org/10.1016/j.cca.2015.09.025.
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  - Kraus, V. B., T. M. Kilfoil, T. W. Hash, G. McDaniel, J. B. Renner, J. A. Carrino, and S. Adams. “Atlas of radiographic features of osteoarthritis of the ankle and hindfoot.” Osteoarthritis Cartilage 23, no. 12 (December 2015): 2059–85. https://doi.org/10.1016/j.joca.2015.08.008.
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  - Montell, E., T. Stabler, J. Verges Milano, and V. B. Kraus. “ATTENTUATION OF HYALURONAN FRAGMENT INDUCED INFLAMMATORY RESPONSE IN MACROPHAGES BY CHONDROITIN SULPHATE.” Basic & Clinical Pharmacology & Toxicology 117 (December 1, 2015): 11–11.
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  - Eckstein, F., J. E. Collins, M. C. Nevitt, J. A. Lynch, V. B. Kraus, J. N. Katz, E. Losina, et al. “Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.” Arthritis Rheumatol 67, no. 12 (December 2015): 3184–89. https://doi.org/10.1002/art.39324.
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  - Leung, Ying Ying, Laura Li Yao Hui, and Virginia B. Kraus. “Colchicine--Update on mechanisms of action and therapeutic uses.” Semin Arthritis Rheum 45, no. 3 (December 2015): 341–50. https://doi.org/10.1016/j.semarthrit.2015.06.013.
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  - Attur, Mukundan, Svetlana Krasnokutsky, Alexander Statnikov, Jonathan Samuels, Zhiguo Li, Olga Friese, Marie-Pierre Hellio Le Graverand-Gastineau, et al. “Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers.” Arthritis Rheumatol 67, no. 11 (November 2015): 2905–15. https://doi.org/10.1002/art.39279.
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  - Wu, Chia-Lung, Deeptee Jain, Jenna N. McNeill, Dianne Little, John A. Anderson, Janet L. Huebner, Virginia B. Kraus, Ramona M. Rodriguiz, William C. Wetsel, and Farshid Guilak. “Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.” Ann Rheum Dis 74, no. 11 (November 2015): 2076–83. https://doi.org/10.1136/annrheumdis-2014-205601.
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  - Adams, Samuel B., Lori A. Setton, Richard D. Bell, Mark E. Easley, Janet L. Huebner, Thomas Stabler, Virginia B. Kraus, Elizabeth M. Leimer, Steven A. Olson, and Dana L. Nettles. “Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.” Foot Ankle Int 36, no. 11 (November 2015): 1264–71. https://doi.org/10.1177/1071100715611176.
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  - Attur, M., A. Statnikov, J. Samuels, Z. Li, A. V. Alekseyenko, J. D. Greenberg, S. Krasnokutsky, et al. “Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis.” Osteoarthritis Cartilage 23, no. 11 (November 2015): 1915–24. https://doi.org/10.1016/j.joca.2015.08.006.
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  - Daghestani, H. N., and V. B. Kraus. “Inflammatory biomarkers in osteoarthritis.” Osteoarthritis Cartilage 23, no. 11 (November 2015): 1890–96. https://doi.org/10.1016/j.joca.2015.02.009.
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  - Hsu, Yi-Hsiang, Youfang Liu, Marian T. Hannan, William Maixner, Shad B. Smith, Luda Diatchenko, Yvonne M. Golightly, et al. “Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.” J Med Genet 52, no. 11 (November 2015): 762–69. https://doi.org/10.1136/jmedgenet-2015-103142.
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  - Huang, Z., J. Chen, J. Ma, B. Shen, F. Pei, and V. B. Kraus. “Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis.” Osteoarthritis Cartilage 23, no. 9 (September 2015): 1437–44. https://doi.org/10.1016/j.joca.2015.04.005.
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  - Olson, Steven A., Bridgette D. Furman, Virginia B. Kraus, Janet L. Huebner, and Farshid Guilak. “Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture.” J Orthop Res 33, no. 9 (September 2015): 1266–77. https://doi.org/10.1002/jor.22940.
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  - Kraus, V. B., F. J. Blanco, M. Englund, M. A. Karsdal, and L. S. Lohmander. “Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.” Osteoarthritis Cartilage 23, no. 8 (August 2015): 1233–41. https://doi.org/10.1016/j.joca.2015.03.036.
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  - Fu, Q., J. Cao, J. B. Renner, J. M. Jordan, B. Caterson, V. Duance, M. Luo, and V. B. Kraus. “Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study.” Osteoarthritis Cartilage 23, no. 6 (June 2015): 868–73. https://doi.org/10.1016/j.joca.2015.01.009.
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  - Kloppenburg, M., E. Maheu, V. B. Kraus, F. Cicuttini, M. Doherty, R. -. L. Dreiser, Y. Henrotin, et al. “OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis.” Osteoarthritis Cartilage 23, no. 5 (May 2015): 772–86. https://doi.org/10.1016/j.joca.2015.03.007.
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  - Kraus, V. B., F. J. Blanco, M. Englund, Y. Henrotin, L. S. Lohmander, E. Losina, P. Önnerfjord, and S. Persiani. “OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.” Osteoarthritis Cartilage 23, no. 5 (May 2015): 686–97. https://doi.org/10.1016/j.joca.2015.03.002.
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  - Furman, Bridgette D., Kelly A. Kimmerling, Robert D. Zura, Rachel M. Reilly, Michal P. Zlowodzki, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines.” Arthritis Rheumatol 67, no. 5 (May 2015): 1234–39. https://doi.org/10.1002/art.39064.
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  - Leung, Ying-Ying, Julian Thumboo, Bak Siew Wong, Ben Haaland, Balram Chowbay, Bibhas Chakraborty, Mann Hong Tan, and Virginia B. Kraus. “Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.” Trials 16 (April 30, 2015): 200. https://doi.org/10.1186/s13063-015-0726-x.
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  - Chou, C. -. H., M. T. M. Lee, I. -. W. Song, L. -. S. Lu, H. -. C. Shen, C. -. H. Lee, J. -. Y. Wu, Y. -. T. Chen, V. B. Kraus, and C. -. C. Wu. “Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.” Osteoarthritis Cartilage 23, no. 4 (April 2015): 571–80. https://doi.org/10.1016/j.joca.2014.12.020.
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  - Karsdal, M. A., A. Bihlet, I. Byrjalsen, P. Alexandersen, C. Ladel, M. Michaels, J. R. Andersen, et al. “OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA.” Osteoarthritis Cartilage 23, no. 4 (April 2015): 550–58. https://doi.org/10.1016/j.joca.2014.12.024.
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  - Daghestani, Hikmat N., Carl F. Pieper, and Virginia B. Kraus. “Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis.” Arthritis Rheumatol 67, no. 4 (April 2015): 956–65. https://doi.org/10.1002/art.39006.
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  - Vovos, T. J., B. D. Furman, J. L. Huebner, K. A. Kimmerling, G. M. Utturkar, L. E. DeFrate, V. B. Kraus, F. Guilak, and S. A. Olson. “Joint incongruity and biomarkers of bone metabolism as predictors of post-traumatic arthritis in mice.” Osteoarthritis and Cartilage 23 (April 2015): A242–43. https://doi.org/10.1016/j.joca.2015.02.449.
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  - Lv, Yue-Bin, Zhao-Xue Yin, Choy-Lye Chei, Han-Zhu Qian, Virginia Byers Kraus, Juan Zhang, Melanie Sereny Brasher, Xiao-Ming Shi, David Bruce Matchar, and Yi Zeng. “Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.” Atherosclerosis 239, no. 1 (March 2015): 137–42. https://doi.org/10.1016/j.atherosclerosis.2015.01.002.
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  - Orlowsky, Eric W., and Virginia Byers Kraus. “The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive.” J Rheumatol 42, no. 3 (March 2015): 363–71. https://doi.org/10.3899/jrheum.140382.
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  - Kimmerling, K. A., B. D. Furman, D. S. Mangiapani, M. A. Moverman, S. M. Sinclair, J. L. Huebner, A. Chilkoti, et al. “Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.” Eur Cell Mater 29 (January 31, 2015): 124–39. https://doi.org/10.22203/ecm.v029a10.
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  - Band, P. A., J. Heeter, H. -. G. Wisniewski, V. Liublinska, C. W. Pattanayak, R. J. Karia, T. Stabler, E. A. Balazs, and V. B. Kraus. “Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression.” Osteoarthritis Cartilage 23, no. 1 (January 2015): 70–76. https://doi.org/10.1016/j.joca.2014.09.017.
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  - Leung, Y. -. Y., J. Thumboo, S. B. Wong, B. Haaland, B. Chowbay, B. Chakraborty, M. H. Tan, and V. B. Kraus. “Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): Study protocol for a randomized controlled trial.” Trials 16, no. 1 (2015). https://doi.org/10.1186/s13063-015-0726-x.
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  - Attur, Mukundan, Alexander Statnikov, Svetlana Krasnokutsky Samuels, Virginia B. Kraus, Joanne Jordan, Braxton D. Mitchell, Michelle Yau, et al. “Elevated Peripheral Blood Leukocyte Inflammatory Gene Expression in Radiographic Progressors with Symptomatic Knee Osteoarthritis: NYU and OAI Cohorts.” Arthritis & Rheumatology 66 (October 1, 2014): S34–S34.
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  - Hunter, David J., Jamie E. Collins, Michael C. Nevitt, John A. Lynch, Virginia B. Kraus, Jeffrey N. Katz, Elena Losina, et al. “Preliminary Assessment of Predictive Validity of Cartilage Thickness MRI Biomarkers in Knee OA - the Fnih OA Biomarkers Consortium.” Arthritis & Rheumatology 66 (October 1, 2014): S87–88.
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  - Montell, E., J. Verges, E. W. Orlowsky, T. Stabler, and Byers Kraus. “MONOSODIUM URATE CRYSTAL INDUCED MACROPHAGE INFLAMMATION IS ATTENUATED BY CHONDROITIN SULFATE: PRE-CLINICAL MODEL FOR GOUT PROPHYLAXIS?” Basic & Clinical Pharmacology & Toxicology 115 (October 1, 2014): 21–21.
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  - AbouAssi, Hiba, K Noelle Tune, Brian Gilmore, Lori A. Bateman, Gary McDaniel, Michael Muehlbauer, Janet L. Huebner, et al. “Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis.” J Rheumatol 41, no. 10 (October 2014): 1974–79. https://doi.org/10.3899/jrheum.140224.
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  - Orlowsky, Eric W., Thomas V. Stabler, Eulàlia Montell, Josep Vergés, and Virginia Byers Kraus. “Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?” Bmc Musculoskelet Disord 15 (September 27, 2014): 318. https://doi.org/10.1186/1471-2474-15-318.
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  - Huebner, Janet L., Anne C. Bay-Jensen, Kim M. Huffman, Yi He, Diana J. Leeming, Gary E. McDaniel, Morten A. Karsdal, and Virginia B. Kraus. “Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis.” Arthritis Rheumatol 66, no. 9 (September 2014): 2440–49. https://doi.org/10.1002/art.38739.
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  - Montell, E., J. Verges, E. W. Orlowsky, T. Stabler, and Byers Kraus. “MONOSODIUM URATE CRYSTAL INDUCED MACROPHAGE INFLAMMATION IS ATTENUATED BY CHONDROITIN SULFATE: PRE-CLINICAL MODEL FOR GOUT PROPHYLAXIS?” Basic & Clinical Pharmacology & Toxicology 115 (September 1, 2014): 34–34.
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  - Yin, Zhaoxue, Xiaoming Shi, Virginia B. Kraus, Melanie Sereny Brasher, Huashuai Chen, Yuzhi Liu, Yuebin Lv, and Yi Zeng. “Gender-dependent association of body mass index and waist circumference with disability in the Chinese oldest old.” Obesity (Silver Spring) 22, no. 8 (August 2014): 1918–25. https://doi.org/10.1002/oby.20775.
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  - Furman, Bridgette D., Daniel S. Mangiapani, Evan Zeitler, Karsyn N. Bailey, Phillip H. Horne, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.” Arthritis Res Ther 16, no. 3 (June 25, 2014): R134. https://doi.org/10.1186/ar4591.
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  - Aslam, Imran, Irina Perjar, Xiaoyan A. Shi, Jordan B. Renner, Virginia B. Kraus, Yvonne M. Golightly, Joanne M. Jordan, and Amanda E. Nelson. “Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.” J Rheumatol 41, no. 5 (May 2014): 938–44. https://doi.org/10.3899/jrheum.130904.
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  - Kraus, Virginia Byers. “Osteoarthritis: The zinc link.” Nature 507, no. 7493 (March 27, 2014): 441–42. https://doi.org/10.1038/507441a.
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  - Bowles, Robby D., Brian A. Mata, Richard D. Bell, Timothy K. Mwangi, Janet L. Huebner, Virginia B. Kraus, and Lori A. Setton. “In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.” Arthritis Rheumatol 66, no. 3 (March 2014): 637–46. https://doi.org/10.1002/art.38279.
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  - Lotz, M., J. Martel-Pelletier, C. Christiansen, M. L. Brandi, O. Bruyère, R. Chapurlat, J. Collette, et al. “Value of biomarkers in osteoarthritis: Current status and perspectives.” Postgraduate Medical Journal 90, no. 1061 (March 1, 2014): 171–78. https://doi.org/10.1136/postgradmedj-2013-203726rep.
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  - Hunter, David J., Michael Nevitt, Elena Losina, and Virginia Kraus. “Biomarkers for osteoarthritis: current position and steps towards further validation.” Best Pract Res Clin Rheumatol 28, no. 1 (February 2014): 61–71. https://doi.org/10.1016/j.berh.2014.01.007.
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  - Karsdal, M. A., A. C. Bay-Jensen, R. J. Lories, S. Abramson, T. Spector, P. Pastoureau, C. Christiansen, et al. “The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?” Ann Rheum Dis 73, no. 2 (February 2014): 336–48. https://doi.org/10.1136/annrheumdis-2013-204111.
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  - Wisniewski, H. -. G., E. Colón, V. Liublinska, R. J. Karia, T. V. Stabler, M. Attur, S. B. Abramson, P. A. Band, and V. B. Kraus. “TSG-6 activity as a novel biomarker of progression in knee osteoarthritis.” Osteoarthritis Cartilage 22, no. 2 (February 2014): 235–41. https://doi.org/10.1016/j.joca.2013.12.004.
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  - Karsdal, M. A., C. Christiansen, C. Ladel, K. Henriksen, V. B. Kraus, and A. C. Bay-Jensen. “Osteoarthritis--a case for personalized health care?” Osteoarthritis Cartilage 22, no. 1 (January 2014): 7–16. https://doi.org/10.1016/j.joca.2013.10.018.
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  - Nelson, Amanda E., Emily Elstad, Robert F. DeVellis, Todd A. Schwartz, Yvonne M. Golightly, Jordan B. Renner, Philip G. Conaghan, Virginia B. Kraus, and Joanne M. Jordan. “Composite measures of multi-joint symptoms, but not of radiographic osteoarthritis, are associated with functional outcomes: the Johnston County Osteoarthritis Project.” Disabil Rehabil 36, no. 4 (2014): 300–306. https://doi.org/10.3109/09638288.2013.790490.
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  - Orlowsky, E. W., T. V. Stabler, E. Montell, J. Vergés, and V. B. Kraus. “Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: Pre-clinical model for gout prophylaxis?” Bmc Musculoskeletal Disorders 15, no. 1 (January 1, 2014). https://doi.org/10.1186/1471-2474-15-318.
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  - Evans, Christopher H., Virginia B. Kraus, and Lori A. Setton. “Progress in intra-articular therapy.” Nat Rev Rheumatol 10, no. 1 (January 2014): 11–22. https://doi.org/10.1038/nrrheum.2013.159.
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  - Olson, Steven A., Phillip Horne, Bridgette Furman, Janet Huebner, Mamun Al-Rashid, Virginia Byers Kraus, and Farshid Guilak. “The role of cytokines in posttraumatic arthritis.” J Am Acad Orthop Surg 22, no. 1 (January 2014): 29–37. https://doi.org/10.5435/JAAOS-22-01-29.
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  - Song, I-Wen, Wei-Ru Li, Li-Ying Chen, Li-Fen Shen, Kai-Ming Liu, Jeffrey J. Y. Yen, Yi-Ju Chen, et al. “Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.” Plos One 9, no. 3 (2014): e92194. https://doi.org/10.1371/journal.pone.0092194.
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  - Benjamin, Ashlee M., J Will Thompson, Erik J. Soderblom, Scott J. Geromanos, Ricardo Henao, Virginia B. Kraus, M Arthur Moseley, and Joseph E. Lucas. “A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.” Bmc Bioinformatics 14 (December 16, 2013): 364. https://doi.org/10.1186/1471-2105-14-364.
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  - Lotz, M., J. Martel-Pelletier, C. Christiansen, M. -. L. Brandi, O. Bruyère, R. Chapurlat, J. Collette, et al. “Value of biomarkers in osteoarthritis: current status and perspectives.” Ann Rheum Dis 72, no. 11 (November 2013): 1756–63. https://doi.org/10.1136/annrheumdis-2013-203726.
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  - Kraus, V. B., T. W. Worrell, J. B. Renner, R. E. Coleman, and C. F. Pieper. “High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment.” Osteoarthritis Cartilage 21, no. 11 (November 2013): 1693–99. https://doi.org/10.1016/j.joca.2013.07.008.
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  - Verges, J., E. Orlowsky, T. Stabler, E. Montell, and V. B. Kraus. “THE EFFECTS OF CHONDROITIN SULFATE ON INFLAMMASOME ACTIVATION.” Basic & Clinical Pharmacology & Toxicology 113 (September 1, 2013): 39–39.
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  - Kraus, V. B. “Osteoarthritis” 2 (August 29, 2013): 983–89. https://doi.org/10.1016/B978-0-12-382227-7.00081-1.
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  - Hunter, D. J., F. Eckstein, V. B. Kraus, E. Losina, L. Sandell, and A. Guermazi. “Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop.” Osteoarthritis Cartilage 21, no. 7 (July 2013): 939–42. https://doi.org/10.1016/j.joca.2013.04.014.
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  - Kraus, Virginia Byers, Sheng Feng, ShengChu Wang, Scott White, Maureen Ainslie, Marie-Pierre Hellio Le Graverand, Alan Brett, et al. “Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression.” Arthritis Rheum 65, no. 7 (July 2013): 1812–21. https://doi.org/10.1002/art.37970.
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  - Orlowsky, E., T. V. Stabler, E. Montell, J. Verges, and V. B. Kraus. “THE EFFECTS OF CHONDROITIN SULPHATE ON INFLAMMASOME ACTIVATION.” Annals of the Rheumatic Diseases 72 (June 1, 2013): 794–95.
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  - Kimmerling, K. A., B. D. Furman, D. S. Mangiapani, M. A. Moverman, S. M. Sinclair, J. L. Huebner, V. B. Kraus, L. A. Setton, F. Guilak, and S. A. Olson. “Prolonged local delivery of IL-1Ra prevents post-traumatic arthritis in mice.” Osteoarthritis and Cartilage 21 (April 2013): S30–31. https://doi.org/10.1016/j.joca.2013.02.082.
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  - Hunt, Michael A., Courtney L. Pollock, Virginia Byers Kraus, Tore Saxne, Sue Peters, Janet L. Huebner, Eric C. Sayre, and Jolanda Cibere. “Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study.” Bmc Musculoskelet Disord 14 (March 27, 2013): 115. https://doi.org/10.1186/1471-2474-14-115.
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  - Chou, C. -. H., C. -. H. Lee, L. -. S. Lu, I. -. W. Song, H. -. P. Chuang, S. -. Y. Kuo, J. -. Y. Wu, et al. “Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees.” Osteoarthritis Cartilage 21, no. 3 (March 2013): 450–61. https://doi.org/10.1016/j.joca.2012.11.016.
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  - Lewis, John S., Bridgette D. Furman, Evan Zeitler, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice.” Arthritis Rheum 65, no. 3 (March 2013): 660–70. https://doi.org/10.1002/art.37796.
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  - Nelson, Amanda E., Yvonne M. Golightly, Jordan B. Renner, Todd A. Schwartz, Virginia B. Kraus, Charles G. Helmick, and Joanne M. Jordan. “Brief report: differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: the Johnston County Osteoarthritis Project.” Arthritis Rheum 65, no. 2 (February 2013): 373–77. https://doi.org/10.1002/art.37775.
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  - Lotz, M., J. Martel-Pelletier, C. Christiansen, M. L. Brandi, O. Bruyère, R. Chapurlat, J. Collette, et al. “Value of biomarkers in osteoarthritis: Current status and perspectives.” Annals of the Rheumatic Diseases 72, no. 11 (2013): 1756–63. https://doi.org/10.1136/annrheumdis-2013-203726.
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  - Chou, Ching-Heng, Chia-Chun Wu, I-Wen Song, Hui-Ping Chuang, Liang-Suei Lu, Jen-Huei Chang, San-Yuan Kuo, et al. “Genome-wide expression profiles of subchondral bone in osteoarthritis.” Arthritis Res Ther 15, no. 6 (2013): R190. https://doi.org/10.1186/ar4380.
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  - Diekman, Brian O., Chia-Lung Wu, Craig R. Louer, Bridgette D. Furman, Janet L. Huebner, Virginia B. Kraus, Steven A. Olson, and Farshid Guilak. “Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.” Cell Transplant 22, no. 8 (2013): 1395–1408. https://doi.org/10.3727/096368912X653264.
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  - Nolan, Daniel, William E. Kraus, Elizabeth Hauser, Yi-Ju Li, Dana K. Thompson, Jessica Johnson, Hsiang-Cheng Chen, et al. “Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.” Plos One 8, no. 8 (2013): e71779. https://doi.org/10.1371/journal.pone.0071779.
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  - Goode, A. P., S. W. Marshall, V. B. Kraus, J. B. Renner, T. Stürmer, T. S. Carey, D. E. Irwin, and J. M. Jordan. “Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project.” Osteoarthritis Cartilage 20, no. 11 (November 2012): 1286–93. https://doi.org/10.1016/j.joca.2012.08.003.
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  - Hoch, J. M., C. G. Mattacola, V. B. Kraus, and C. Lattermann. “The role of cartilage degradation biomarkers in understanding the development of post-traumatic osteoarthritis following acute articular cartilage damage - A review.” European Musculoskeletal Review 7, no. 3 (October 3, 2012): 147–50.
  - Goode, Adam P., Stephen W. Marshall, Jordan B. Renner, Timothy S. Carey, Virginia B. Kraus, Debra E. Irwin, Til Stürmer, and Joanne M. Jordan. “Lumbar spine radiographic features and demographic, clinical, and radiographic knee, hip, and hand osteoarthritis.” Arthritis Care Res (Hoboken) 64, no. 10 (October 2012): 1536–44. https://doi.org/10.1002/acr.21720.
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  - Louer, Craig R., Bridgette D. Furman, Janet L. Huebner, Virginia B. Kraus, Steven A. Olson, and Farshid Guilak. “Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice.” Arthritis Rheum 64, no. 10 (October 2012): 3220–30. https://doi.org/10.1002/art.34533.
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  - Yin, Zhao-Xue, Xiao-Ming Shi, Virginia B. Kraus, Simon M. Fitzgerald, Han-Zhu Qian, Jian-Wei Xu, Yi Zhai, Melanie D. Sereny, and Yi Zeng. “High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.” Age Ageing 41, no. 5 (September 2012): 600–606. https://doi.org/10.1093/ageing/afs033.
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  - Thompson, Dana K., Richard Sloane, James R. Bain, Robert D. Stevens, Christopher B. Newgard, Carl F. Pieper, and Virginia B. Kraus. “Daily Variation of Serum Acylcarnitines and Amino Acids.” Metabolomics 8, no. 4 (August 2012): 556–65. https://doi.org/10.1007/s11306-011-0345-9.
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  - Somers, Tamara J., James A. Blumenthal, Farshid Guilak, Virginia B. Kraus, Daniel O. Schmitt, Michael A. Babyak, Linda W. Craighead, et al. “Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study.” Pain 153, no. 6 (June 2012): 1199–1209. https://doi.org/10.1016/j.pain.2012.02.023.
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  - Zhai, Yi, Xiao Ming Shi, Simon Michael Fitzgerald, Han Zhu Qian, Virginia B. Kraus, Melanie Sereny, Perry Hu, Zhao Xue Yin, Jian Wei Xu, and Yi Zeng. “High sensitivity C-reactive protein associated with different health predictors in middle-aged and oldest old Chinese.” Biomed Environ Sci 25, no. 3 (June 2012): 257–66. https://doi.org/10.3967/0895-3988.2012.03.002.
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  - Cheng, A. W. M., M. Bolognesi, and V. B. Kraus. “DIO2 modifies inflammatory responses in chondrocytes.” Osteoarthritis Cartilage 20, no. 5 (May 2012): 440–45. https://doi.org/10.1016/j.joca.2012.02.006.
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  - Allen, Kyle D., Brian A. Mata, Mostafa A. Gabr, Janet L. Huebner, Samuel B. Adams, Virginia B. Kraus, Daniel O. Schmitt, and Lori A. Setton. “Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.” Arthritis Res Ther 14, no. 2 (April 17, 2012): R78. https://doi.org/10.1186/ar3801.
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  - Kemta Lekpa, Fernando, Virginia B. Kraus, and Xavier Chevalier. “Biologics in relapsing polychondritis: a literature review.” Semin Arthritis Rheum 41, no. 5 (April 2012): 712–19. https://doi.org/10.1016/j.semarthrit.2011.08.006.
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  - Kraus, V. B., J. Birmingham, T. V. Stabler, S. Feng, D. C. Taylor, C. T. Moorman, W. E. Garrett, and A. P. Toth. “Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254).” Osteoarthritis Cartilage 20, no. 4 (April 2012): 271–78. https://doi.org/10.1016/j.joca.2011.12.009.
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  - Catterall, Jonathan B., Ming F. Hsueh, Thomas V. Stabler, Christopher R. McCudden, Michael Bolognesi, Robert Zura, Joanne M. Jordan, Jordan B. Renner, Sheng Feng, and Virginia B. Kraus. “Protein modification by deamidation indicates variations in joint extracellular matrix turnover.” J Biol Chem 287, no. 7 (February 10, 2012): 4640–51. https://doi.org/10.1074/jbc.M111.249649.
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  - Griffin, Timothy M., Janet L. Huebner, Virginia B. Kraus, Zhen Yan, and Farshid Guilak. “Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise.” Arthritis Rheum 64, no. 2 (February 2012): 443–53. https://doi.org/10.1002/art.33332.
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  - Kraus, Virginia Byers. “Patient Evaluation and OA Study Design: OARSI/Biomarker Qualification.” Hss J 8, no. 1 (February 2012): 64–65. https://doi.org/10.1007/s11420-011-9234-z.
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  - Hwang, Priscilla Y., Kyle D. Allen, Mohammed F. Shamji, Liufang Jing, Brian A. Mata, Mostafa A. Gabr, Janet L. Huebner, Virginia B. Kraus, William J. Richardson, and Lori A. Setton. “Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.” Open Orthop J 6 (2012): 383–91. https://doi.org/10.2174/1874325001206010383.
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  - Huffman, Kim M., Leanne M. Redman, Lawrence R. Landerman, Carl F. Pieper, Robert D. Stevens, Michael J. Muehlbauer, Brett R. Wenner, et al. “Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.” Plos One 7, no. 4 (2012): e28190. https://doi.org/10.1371/journal.pone.0028190.
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  - Seifer, D. R., B. D. Furman, F. Guilak, S. A. Olson, S. C. Brooks, and V. B. Kraus. “Corrigendum to "Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice" [Osteoarthritis and Cartilage 2008;16(12): 1532-1538.” Osteoarthritis and Cartilage 20, no. 1 (January 1, 2012): 68. https://doi.org/10.1016/j.joca.2011.11.001.
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  - Tenenbaum, Jessica D., Victoria Christian, Melissa A. Cornish, Rowena J. Dolor, Ashley A. Dunham, Geoffrey S. Ginsburg, Virginia B. Kraus, et al. “The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records.” Am J Transl Res 4, no. 3 (2012): 291–301.
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  - Thompson, Dana K., Kim M. Huffman, William E. Kraus, and Virginia Byers Kraus. “Critical appraisal of four IL-6 immunoassays.” Plos One 7, no. 2 (2012): e30659. https://doi.org/10.1371/journal.pone.0030659.
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  - Huffman, Kim M., Carl F. Pieper, Virginia B. Kraus, William E. Kraus, Gerda G. Fillenbaum, and Harvey J. Cohen. “Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.” J Gerontol a Biol Sci Med Sci 66, no. 12 (December 2011): 1369–75. https://doi.org/10.1093/gerona/glr121.
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  - Nelson, Amanda E., Jordan B. Renner, Todd A. Schwartz, Virginia B. Kraus, Charles G. Helmick, and Joanne M. Jordan. “Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: the Johnston County Osteoarthritis project.” Arthritis Rheum 63, no. 12 (December 2011): 3843–52. https://doi.org/10.1002/art.30610.
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  - Nelson, Amanda E., Sanjay Chaudhary, Virginia B. Kraus, Fang Fang, Jiu-Chiuan Chen, Todd A. Schwartz, Xiaoyan A. Shi, et al. “Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: the Johnston County Osteoarthritis Project.” Environ Res 111, no. 8 (November 2011): 1208–14. https://doi.org/10.1016/j.envres.2011.08.002.
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  - Allen, K. P., B. A. Mata, M. A. Gabr, J. L. Huebner, V. B. Kraus, and L. A. Setton. “177 GAIT COMPENSATIONS IN A RAT MEDIAL MENISCUS TRANSECTION MODEL OF OSTEOARTHRITIS.” Osteoarthritis and Cartilage 19 (September 2011): S88–89. https://doi.org/10.1016/s1063-4584(11)60204-5.
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  - Meulenbelt, I., V. B. Kraus, L. J. Sandell, and J. Loughlin. “Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA.” Osteoarthritis Cartilage 19, no. 9 (September 2011): 1091–94. https://doi.org/10.1016/j.joca.2011.06.002.
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  - Catterall, J., M. -. F. Hsueh, T. V. Stabler, J. M. Renner, J. M. Jordan, and V. B. Kraus. “142 A UNIQUE DEAMIDATED CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) BIOMARKER PREFERENTIALLY IDENTIFIES HIP OSTEOARTHRITIS.” Osteoarthritis and Cartilage 19 (September 2011): S72–S72. https://doi.org/10.1016/s1063-4584(11)60169-6.
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  - Diekman, B. O., C. -. L. Wu, C. S. Louer, B. D. Furman, J. L. Huebner, V. B. Kraus, S. A. Olson, and F. Guilak. “1-17 INTRA-ARTICULAR INJECTION OF PURIFIED MESENCHYMAL STEM CELLS FROM C57BL/6 OR MRL/MPJ “SUPERHEALER” MICE PREVENTS POSTTRAUMATIC ARTHRITIS.” Osteoarthritis and Cartilage 19 (September 2011): S5–S5. https://doi.org/10.1016/s1063-4584(11)60023-x.
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  - Taylor, A. M., M. -. F. Hsueh, L. R. Ranganath, J. A. Gallagher, J. B. Catterall, and V. B. Kraus. “159 ANALYSIS OF CARTILAGE BIOMARKERS OF TURNOVER AND AGING IN THE OSTEOARTHROPATHY OF ALKAPTONURIA.” Osteoarthritis and Cartilage 19 (September 2011): S80–S80. https://doi.org/10.1016/s1063-4584(11)60186-6.
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  - Golightly, Yvonne M., Stephen W. Marshall, Virginia B. Kraus, Jordan B. Renner, Andrés Villaveces, Carri Casteel, and Joanne M. Jordan. “Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms?” Arthritis Rheum 63, no. 8 (August 2011): 2276–83. https://doi.org/10.1002/art.30412.
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  - Eckstein, F., MP Hellio Le Graverand, H. C. Charles, D. J. Hunter, V. B. Kraus, T. Sunyer, O. Nemirovskyi, B. T. Wyman, R. Buck, and R. A9001140, investigators. “Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis.” Ann Rheum Dis 70, no. 7 (July 2011): 1223–30. https://doi.org/10.1136/ard.2010.141382.
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  - Attur, Mukundan, Ilana Belitskaya-Lévy, Cheongeun Oh, Svetlana Krasnokutsky, Jeffrey Greenberg, Jonathan Samuels, Stephen Smiles, et al. “Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis.” Arthritis Rheum 63, no. 7 (July 2011): 1908–17. https://doi.org/10.1002/art.30360.
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  - Lewis, J. S., W. C. Hembree, B. D. Furman, L. Tippets, D. Cattel, J. L. Huebner, D. Little, et al. “Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee.” Osteoarthritis Cartilage 19, no. 7 (July 2011): 864–73. https://doi.org/10.1016/j.joca.2011.04.011.
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  - McDaniel, G., J. B. Renner, R. Sloane, and V. B. Kraus. “Association of knee and ankle osteoarthritis with physical performance.” Osteoarthritis Cartilage 19, no. 6 (June 2011): 634–38. https://doi.org/10.1016/j.joca.2011.01.016.
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  - Kraus, V. B., B. Burnett, J. Coindreau, S. Cottrell, D. Eyre, M. Gendreau, J. Gardiner, et al. “Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis.” Osteoarthritis Cartilage 19, no. 5 (May 2011): 515–42. https://doi.org/10.1016/j.joca.2010.08.019.
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  - Lum, Helen, Richard Sloane, Kim M. Huffman, Virginia B. Kraus, Dana K. Thompson, William E. Kraus, James R. Bain, et al. “Plasma acylcarnitines are associated with physical performance in elderly men.” J Gerontol a Biol Sci Med Sci 66, no. 5 (May 2011): 548–53. https://doi.org/10.1093/gerona/glr006.
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  - Kraus, V. B. “Osteoarthritis year 2010 in review: biochemical markers.” Osteoarthritis Cartilage 19, no. 4 (April 2011): 346–53. https://doi.org/10.1016/j.joca.2011.02.002.
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  - Allen, Kelli D., Joanne M. Jordan, Michael Doherty, Jordan B. Renner, and Virginia B. Kraus. “Performance of global assessments of hip, knee, and back symptom change.” Clin Rheumatol 30, no. 3 (March 2011): 331–38. https://doi.org/10.1007/s10067-010-1536-x.
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  - Schmitz, N., S. Laverty, V. B. Kraus, and T. Aigner. “Response to Letter to the Editor: 'India ink and cartilage'.” Osteoarthritis and Cartilage 19, no. 3 (March 1, 2011): 333–35. https://doi.org/10.1016/j.joca.2010.12.009.
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  - Denoble, Anna E., Kim M. Huffman, Thomas V. Stabler, Susan J. Kelly, Michael S. Hershfield, Gary E. McDaniel, R Edward Coleman, and Virginia B. Kraus. “Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.” Proc Natl Acad Sci U S A 108, no. 5 (February 1, 2011): 2088–93. https://doi.org/10.1073/pnas.1012743108.
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  - Redman, Leanne M., Kim M. Huffman, Lawrence R. Landerman, Carl F. Pieper, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, et al. “Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.” J Clin Endocrinol Metab 96, no. 2 (February 2011): E312–21. https://doi.org/10.1210/jc.2010-1971.
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  - Cheng, A. W. M., T. V. Stabler, M. Bolognesi, and V. B. Kraus. “Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes.” Osteoarthritis Cartilage 19, no. 1 (January 2011): 118–25. https://doi.org/10.1016/j.joca.2010.10.019.
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  - Nelson, Amanda E., Robert F. DeVellis, Jordan B. Renner, Todd A. Schwartz, Philip G. Conaghan, Virginia B. Kraus, and Joanne M. Jordan. “Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis.” Arthritis Res Ther 13, no. 5 (2011): R176. https://doi.org/10.1186/ar3501.
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  - Huffman, Kim M., Cris A. Slentz, Lori A. Bateman, Dana Thompson, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, et al. “Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.” Diabetes Care 34, no. 1 (January 2011): 174–76. https://doi.org/10.2337/dc10-0709.
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  - Redman, Leanne M., Kim M. Huffman, Lawrence R. Landerman, Carl F. Pieper, James R. Bain, Michael J. Muehlbauer, Robert D. Stevens, et al. “Effect of Caloric Restriction with and without Exercise on Metabolic Intermediates in Nonobese Men and Women.” Endocrinology 152, no. 1 (January 1, 2011): 332–33. https://doi.org/10.1210/endo.152.1.9992.
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  - Lotz, M. K., and V. B. Kraus. “Erratum: Posttraumatic osteoarthritis: Pathogenesis and pharmacological treatment options (Arthritis Research & Therapy (2010) 12: 211 DOI: 10.1186/ar3046).” Arthritis Research and Therapy 12, no. 6 (November 9, 2010). https://doi.org/10.1186/ar3177.
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  - Denoble, Anna E., Norine Hall, Carl F. Pieper, and Virginia B. Kraus. “Patellar skin surface temperature by thermography reflects knee osteoarthritis severity.” Clin Med Insights Arthritis Musculoskelet Disord 3 (October 15, 2010): 69–75. https://doi.org/10.4137/CMAMD.S5916.
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  - Aigner, T., J. L. Cook, N. Gerwin, S. S. Glasson, S. Laverty, C. B. Little, W. McIlwraith, and V. B. Kraus. “Histopathology atlas of animal model systems - overview of guiding principles.” Osteoarthritis Cartilage 18 Suppl 3 (October 2010): S2–6. https://doi.org/10.1016/j.joca.2010.07.013.
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  - Huffman, K. M., L. M. Redman, L. R. Landerman, C. F. Pieper, J. B. Bain, V. B. Kraus, C. B. Newgard, and E. Ravussin. “CALORIC RESTRICTION AND IMPROVEMENTS IN METABOLIC FLEXIBILITY.” Gerontologist 50 (October 1, 2010): 349–349.
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  - Kraus, V. B., J. L. Huebner, J. DeGroot, and A. Bendele. “The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig.” Osteoarthritis Cartilage 18 Suppl 3 (October 2010): S35–52. https://doi.org/10.1016/j.joca.2010.04.015.
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  - Landerman, L. R., C. F. Pieper, K. M. Huffman, M. C. Morey, W. E. Kraus, H. Cohen, and V. B. Kraus. “ASSESSMENT OF THE RELATIONSHIP OF CYTOKINES WITH AGE, BMI, GENDER AND RACE: A META-ANALYSIS OF THE DUKE PEPPER STUDIES.” Gerontologist 50 (October 1, 2010): 349–50.
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  - Schmitz, N., S. Laverty, V. B. Kraus, and T. Aigner. “Basic methods in histopathology of joint tissues.” Osteoarthritis Cartilage 18 Suppl 3 (October 2010): S113–16. https://doi.org/10.1016/j.joca.2010.05.026.
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  - Sloane, R., V. B. Kraus, and D. Thompson. “THE RELATIONSHIP BETWEEN ACYLCARNATINES AND PHYSICAL PERFORMANCE IN OSTEOARTHRITIS.” Gerontologist 50 (October 1, 2010): 349–349.
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  - Thompson, D., V. B. Kraus, and R. Sloane. “THE RELATIONSHIP OF CYTOKINES WITH PHYSICAL PERFORMANCE: THE POP STUDY.” Gerontologist 50 (October 1, 2010): 349–349.
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  - Chuckpaiwong, Bavornrit, Hal Cecil Charles, Virginia B. Kraus, Farshid Guilak, and James A. Nunley. “Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.” J Orthop Res 28, no. 9 (September 2010): 1149–54. https://doi.org/10.1002/jor.21125.
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  - Kempta Lekpa, F., J. C. Piette, S. Bastuji-Garin, V. B. Kraus, T. V. Stabler, A. R. Poole, A. Marini-Portugal, and X. Chevalier. “Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis.” Clin Exp Rheumatol 28, no. 4 (July 2010): 553–55.
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  - Kraus, V. B., M. Nevitt, and L. J. Sandell. “Summary of the OA biomarkers workshop 2009--biochemical biomarkers: biology, validation, and clinical studies.” Osteoarthritis Cartilage 18, no. 6 (June 2010): 742–45. https://doi.org/10.1016/j.joca.2010.02.014.
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  - Nelson, A. E., Y. M. Golightly, V. B. Kraus, T. Stabler, J. B. Renner, C. G. Helmick, and J. M. Jordan. “Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project.” Osteoarthritis Cartilage 18, no. 6 (June 2010): 825–29. https://doi.org/10.1016/j.joca.2010.02.013.
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  - Attur, Mukundan, Hwa-Ying Wang, Virginia Byers Kraus, Jack F. Bukowski, Nazneen Aziz, Svetlana Krasnokutsky, Jonathan Samuels, et al. “Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.” Ann Rheum Dis 69, no. 5 (May 2010): 856–61. https://doi.org/10.1136/ard.2009.113043.
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  - Hunter, David J., Elena Losina, Ali Guermazi, Deb Burstein, Marissa N. Lassere, and Virginia Kraus. “A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials.” Curr Drug Targets 11, no. 5 (May 2010): 536–45. https://doi.org/10.2174/138945010791011947.
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  - Kraus, Virginia Byers. “Waiting for action on the osteoarthritis front.” Curr Drug Targets 11, no. 5 (May 2010): 518–20. https://doi.org/10.2174/138945010791011974.
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  - Schmitz, N., V. B. Kraus, and T. Aigner. “Targets to tackle--the pathophysiology of the disease.” Curr Drug Targets 11, no. 5 (May 2010): 521–27. https://doi.org/10.2174/138945010791011875.
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  - Kraus, Virginia B., Thomas B. Kepler, Thomas Stabler, Jordan Renner, and Joanne Jordan. “First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.” Plos One 5, no. 3 (March 17, 2010): e9739. https://doi.org/10.1371/journal.pone.0009739.
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  - Huebner, J. L., J. M. Williams, M. Deberg, Y. Henrotin, and V. B. Kraus. “Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis.” Osteoarthritis Cartilage 18, no. 3 (March 2010): 397–405. https://doi.org/10.1016/j.joca.2009.09.011.
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  - Chen, Hsiang-Cheng, Virginia Byers Kraus, Yi-Ju Li, Sarah Nelson, Carol Haynes, Jessica Johnson, Thomas Stabler, et al. “Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.” Arthritis Rheum 62, no. 3 (March 2010): 781–90. https://doi.org/10.1002/art.27288.
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  - McDaniel, G., K. L. Mitchell, C. Charles, and V. B. Kraus. “A comparison of five approaches to measurement of anatomic knee alignment from radiographs.” Osteoarthritis Cartilage 18, no. 2 (February 2010): 273–77. https://doi.org/10.1016/j.joca.2009.10.005.
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  - Catterall, Jonathan B., Thomas V. Stabler, Carl R. Flannery, and Virginia B. Kraus. “Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).” Arthritis Res Ther 12, no. 6 (2010): R229. https://doi.org/10.1186/ar3216.
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  - Griffin, Timothy M., Beverley Fermor, Janet L. Huebner, Virginia B. Kraus, Ramona M. Rodriguiz, William C. Wetsel, Li Cao, Lori A. Setton, and Farshid Guilak. “Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.” Arthritis Res Ther 12, no. 4 (2010): R130. https://doi.org/10.1186/ar3068.
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  - Hudelmaier, M., W. Wirth, B. Wehr, V. Kraus, B. T. Wyman, M. -. P. Hellio Le Graverand, and F. Eckstein. “Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease.” Cells Tissues Organs 192, no. 5 (2010): 340–50. https://doi.org/10.1159/000318178.
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  - Le Graverand, M-P Hellio, R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, et al. “Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography.” Ann Rheum Dis 69, no. 1 (January 2010): 155–62. https://doi.org/10.1136/ard.2008.099762.
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  - Kraus, Virginia Byers, Sheng Feng, ShengChu Wang, Scott White, Maureen Ainslie, Alan Brett, Anthony Holmes, and H Cecil Charles. “Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression.” Arthritis Rheum 60, no. 12 (December 2009): 3711–22. https://doi.org/10.1002/art.25012.
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  - Sims, Ershela L., Francis J. Keefe, Virginia B. Kraus, Farshid Guilak, Robin M. Queen, and Daniel Schmitt. “Racial differences in gait mechanics associated with knee osteoarthritis.” Aging Clin Exp Res 21, no. 6 (December 2009): 463–69. https://doi.org/10.1007/BF03327442.
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  - Kraus, V. B., G. McDaniel, T. W. Worrell, S. Feng, T. P. Vail, G. Varju, and R. E. Coleman. “Association of bone scintigraphic abnormalities with knee malalignment and pain.” Ann Rheum Dis 68, no. 11 (November 2009): 1673–79. https://doi.org/10.1136/ard.2008.094722.
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  - Nebel, Mary Beth, Ershela L. Sims, Francis J. Keefe, Virginia B. Kraus, Farshid Guilak, David S. Caldwell, Jennifer J. Pells, Robin Queen, and Daniel Schmitt. “The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis.” Arch Phys Med Rehabil 90, no. 11 (November 2009): 1874–79. https://doi.org/10.1016/j.apmr.2009.07.010.
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  - Addison, Shelby, R Edward Coleman, Sheng Feng, Gary McDaniel, and Virginia Byers Kraus. “Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation.” Arthritis Rheum 60, no. 11 (November 2009): 3366–73. https://doi.org/10.1002/art.24856.
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  - Griffin, Timothy M., Janet L. Huebner, Virginia B. Kraus, and Farshid Guilak. “Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis.” Arthritis Rheum 60, no. 10 (October 2009): 2935–44. https://doi.org/10.1002/art.24854.
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  - Allen, Kyle D., Timothy M. Griffin, Ramona M. Rodriguiz, William C. Wetsel, Virginia B. Kraus, Janet L. Huebner, Lawrence M. Boyd, and Lori A. Setton. “Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.” Arthritis Rheum 60, no. 9 (September 2009): 2684–93. https://doi.org/10.1002/art.24783.
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  - Hellio Le Graverand, M. -. P., R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, et al. “Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis.” Osteoarthritis Cartilage 17, no. 9 (September 2009): 1177–85. https://doi.org/10.1016/j.joca.2009.03.008.
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  - Maksymowych, Walter P., Oliver Fitzgerald, George A. Wells, Dafna D. Gladman, Robert Landewé, Mikkel Ostergaard, William J. Taylor, et al. “Proposal for levels of evidence schema for validation of a soluble biomarker reflecting damage endpoints in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and recommendations for study design.” J Rheumatol 36, no. 8 (August 2009): 1792–99. https://doi.org/10.3899/jrheum090347.
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  - Maksymowych, Walter P., Robert Landewé, Paul-Peter Tak, Christopher J. Ritchlin, Mikkel Ostergaard, Philip J. Mease, Hani El-Gabalawy, et al. “Reappraisal of OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage endpoints in rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: the OMERACT 9 v2 criteria.” J Rheumatol 36, no. 8 (August 2009): 1785–91. https://doi.org/10.3899/jrheum.090346.
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  - Syversen, Silje W., Robert Landewe, Désirée van der Heijde, Joan M. Bathon, Maarten Boers, Vivian P. Bykerk, Oliver Fitzgerald, et al. “Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers.” J Rheumatol 36, no. 8 (August 2009): 1769–84. https://doi.org/10.3899/jrheum.090262.
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  - Huebner, J. L., K. A. Johnson, V. B. Kraus, and R. A. Terkeltaub. “Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.” Osteoarthritis Cartilage 17, no. 8 (August 2009): 1056–64. https://doi.org/10.1016/j.joca.2009.02.015.
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  - Nelson, A. E., F. Fang, X. A. Shi, V. B. Kraus, T. Stabler, J. B. Renner, T. A. Schwartz, C. G. Helmick, and J. M. Jordan. “Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project.” Osteoarthritis Cartilage 17, no. 6 (June 2009): 772–76. https://doi.org/10.1016/j.joca.2008.11.010.
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  - Cibere, Jolanda, Hongbin Zhang, Patrick Garnero, A Robin Poole, Tatiana Lobanok, Tore Saxne, Virginia B. Kraus, et al. “Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.” Arthritis Rheum 60, no. 5 (May 2009): 1372–80. https://doi.org/10.1002/art.24473.
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  - Somers, Tamara J., Francis J. Keefe, Jennifer J. Pells, Kim E. Dixon, Sandra J. Waters, Paul A. Riordan, James A. Blumenthal, et al. “Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability.” J Pain Symptom Manage 37, no. 5 (May 2009): 863–72. https://doi.org/10.1016/j.jpainsymman.2008.05.009.
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  - Shamji, Mohammed F., Kyle D. Allen, Stephen So, Liufang Jing, Samuel B. Adams, Reinhard Schuh, Janet Huebner, et al. “Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.” Spine (Phila Pa 1976) 34, no. 7 (April 1, 2009): 648–54. https://doi.org/10.1097/BRS.0b013e318197f013.
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  - Couchman, J., V. Kraus, A. Boyde, N. Baker, E. Barr, S. Lohmander, D. Salter, et al. “Past, present and future insights into the understanding and treatment of osteoarthritis: Molecular and mechanical approaches.” International Journal of Experimental Pathology 90, no. 1 (February 1, 2009). https://doi.org/10.1111/j.1365-2613.2008.00612.x.
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  - Kraus, Virginia Byers. “Biomarkers and biomarker patterns: new and emerging trends to distinguish osteoarthritis disease subsets and progression.” International Journal of Experimental Pathology 90, no. 1 (February 1, 2009): A45–46.
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  - Catterall, Jonathan B., Daniel Barr, Michael Bolognesi, Robert D. Zura, and Virginia B. Kraus. “Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate.” Arthritis Res Ther 11, no. 2 (2009): R55. https://doi.org/10.1186/ar2675.
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  - Sims, Ershela L., Julie M. Carland, Francis J. Keefe, Virginia B. Kraus, Farshid Guilak, and Daniel Schmitt. “Sex differences in biomechanics associated with knee osteoarthritis.” J Women Aging 21, no. 3 (2009): 159–70. https://doi.org/10.1080/08952840903054856.
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  - Stabler, Thomas V., Samuel S. Byers, Robert D. Zura, and Virginia Byers Kraus. “Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.” Arthritis Res Ther 11, no. 2 (2009): R34. https://doi.org/10.1186/ar2639.
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  - Chen, Hsiang-Cheng, Svati H. Shah, Yi-Ju Li, Thomas V. Stabler, Joanne M. Jordan, and Virginia Byers Kraus. “Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels.” Arthritis Rheum 58, no. 12 (December 2008): 3854–64. https://doi.org/10.1002/art.24319.
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  - Eckstein, F., R. J. Buck, D. Burstein, H. C. Charles, J. Crim, M. Hudelmaier, D. J. Hunter, et al. “Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial.” Ann Rheum Dis 67, no. 12 (December 2008): 1683–88. https://doi.org/10.1136/ard.2007.076919.
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  - Gordon, Craig D., Thomas V. Stabler, and Virginia B. Kraus. “Variation in osteoarthritis biomarkers from activity not food consumption.” Clin Chim Acta 398, no. 1–2 (December 2008): 21–26. https://doi.org/10.1016/j.cca.2008.07.031.
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  - Mazzuca, S. A., M. -. P. Hellio Le Graverand, E. Vignon, D. J. Hunter, C. G. Jackson, V. B. Kraus, T. M. Link, T. J. Schnitzer, A. Vaz, and H. C. Charles. “Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees.” Osteoarthritis Cartilage 16, no. 12 (December 2008): 1555–59. https://doi.org/10.1016/j.joca.2008.04.010.
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  - Seifer, D. R., B. D. Furman, F. Guilak, S. A. Olson, S Carroll Brooks, and V Byers Kraus. “Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice.” Osteoarthritis Cartilage 16, no. 12 (December 2008): 1532–38. https://doi.org/10.1016/j.joca.2008.04.013.
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  - Le Graverand, M-P Hellio, E. P. Vignon, K. D. Brandt, S. A. Mazzuca, M. Piperno, R. Buck, H. C. Charles, et al. “Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees.” Ann Rheum Dis 67, no. 11 (November 2008): 1562–66. https://doi.org/10.1136/ard.2007.077834.
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  - Quintana, D. J., P. Garnero, J. L. Huebner, N. Charni-Ben Tabassi, and V. B. Kraus. “PIIANP and HELIXII diurnal variation.” Osteoarthritis Cartilage 16, no. 10 (October 2008): 1192–95. https://doi.org/10.1016/j.joca.2008.03.006.
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  - Atif, U., A. Philip, J. Aponte, E. M. Woldu, S. Brady, V. B. Kraus, J. M. Jordan, et al. “Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians.” Osteoarthritis Cartilage 16, no. 10 (October 2008): 1174–77. https://doi.org/10.1016/j.joca.2008.03.007.
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  - Chen, H. -. C., S. Shah, T. V. Stabler, Y. -. J. Li, and V. B. Kraus. “Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.” Osteoarthritis Cartilage 16, no. 9 (September 2008): 1054–59. https://doi.org/10.1016/j.joca.2007.12.010.
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  - Pells, Jennifer J., Rebecca A. Shelby, Francis J. Keefe, Kim E. Dixon, James A. Blumenthal, Lara LaCaille, Jessica M. Tucker, Daniel Schmitt, David S. Caldwell, and Virginia B. Kraus. “Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain.” Pain 136, no. 3 (June 2008): 340–47. https://doi.org/10.1016/j.pain.2007.07.012.
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  - Ward, Benjamin D., Bridgette D. Furman, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse.” Arthritis Rheum 58, no. 3 (March 2008): 744–53. https://doi.org/10.1002/art.23288.
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  - Elliott, A. L., V. B. Kraus, F. Fang, J. B. Renner, T. A. Schwartz, A. Salazar, T. Huguenin, M. C. Hochberg, C. G. Helmick, and J. M. Jordan. “Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project.” Ann Rheum Dis 66, no. 12 (December 2007): 1622–26. https://doi.org/10.1136/ard.2006.057422.
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  - Charles, H. C., V. B. Kraus, M. Ainslie, and M. -. P. Hellio Le Graverand-Gastineau. “Optimization of the fixed-flexion knee radiograph.” Osteoarthritis Cartilage 15, no. 11 (November 2007): 1221–24. https://doi.org/10.1016/j.joca.2007.05.012.
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  - Shamji, Mohammed F., Helawe Betre, Virginia B. Kraus, Jun Chen, Ashutosh Chilkoti, Rajeswari Pichika, Koichi Masuda, and Lori A. Setton. “Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic.” Arthritis Rheum 56, no. 11 (November 2007): 3650–61. https://doi.org/10.1002/art.22952.
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  - Kraus, V. B., T. V. Stabler, S. Y. Kong, G. Varju, and G. McDaniel. “Measurement of synovial fluid volume using urea.” Osteoarthritis Cartilage 15, no. 10 (October 2007): 1217–20. https://doi.org/10.1016/j.joca.2007.03.017.
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  - Henrotin, Yves, Shelby Addison, Virginia Kraus, and Michelle Deberg. “Type II collagen markers in osteoarthritis: what do they indicate?” Curr Opin Rheumatol 19, no. 5 (September 2007): 444–50. https://doi.org/10.1097/BOR.0b013e32829fb3b5.
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  - Kraus, V. B., T. V. Stabler, G. Luta, J. B. Renner, A. D. Dragomir, and J. M. Jordan. “Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis.” Osteoarthritis Cartilage 15, no. 8 (August 2007): 966–71. https://doi.org/10.1016/j.joca.2007.02.014.
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  - Allen, K. D., R. F. DeVellis, J. B. Renner, V. B. Kraus, and J. M. Jordan. “Validity and factor structure of the AUSCAN Osteoarthritis Hand Index in a community-based sample.” Osteoarthritis Cartilage 15, no. 7 (July 2007): 830–36. https://doi.org/10.1016/j.joca.2007.01.012.
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  - Huebner, J. L., D. R. Seifer, and V. B. Kraus. “Erratum to "A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis" [Osteoarthritis Cartilage 15 (2007) 354-356] (DOI:10.1016/j.joca.2006.10.014).” Osteoarthritis and Cartilage 15, no. 7 (July 1, 2007): 848. https://doi.org/10.1016/j.joca.2007.04.009.
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  - Kraus, V. B. “Response to letter: Static knee alignment and its association with radiographic knee osteoarthritis.” Osteoarthritis and Cartilage 15, no. 7 (July 1, 2007): 846–47. https://doi.org/10.1016/j.joca.2007.02.018.
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  - Huebner, J. L., D. R. Seifer, and V. B. Kraus. “A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis.” Osteoarthritis Cartilage 15, no. 3 (March 2007): 354–56. https://doi.org/10.1016/j.joca.2006.10.014.
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  - Huffman, K. M., J. R. Bowers, Z. Dailiana, J. L. Huebner, J. R. Urbaniak, and V. B. Kraus. “Synovial fluid metabolites in osteonecrosis.” Rheumatology (Oxford) 46, no. 3 (March 2007): 523–28. https://doi.org/10.1093/rheumatology/kel302.
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  - Keeling, Stephanie O., Robert Landewe, Desiree van der Heijde, Joan Bathon, Maarten Boers, Patrick Garnero, Piet Geusens, et al. “Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C-reactive protein.” J Rheumatol 34, no. 3 (March 2007): 623–33.
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  - Maksymowych, Walter P., Robert Landewe, Maarten Boers, Patrick Garnero, Piet Geusens, Hani El-Gabalawy, Dick Heinegard, et al. “Development of draft validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting structural damage endpoints in rheumatoid arthritis and spondyloarthritis clinical trials.” J Rheumatol 34, no. 3 (March 2007): 634–40.
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  - Birmingham, James D., Vladimir Vilim, and Virginia B. Kraus. “Collagen biomarkers for arthritis applications.” Biomark Insights 1 (February 7, 2007): 61–76.
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  - Kraus, Virginia B., and Joanne M. Jordan. “Serum C-Reactive Protein (CRP), Target for Therapy or Trouble?” Biomark Insights 1 (February 7, 2007): 77–80.
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  - Kraus, V. B., J. M. Jordan, M. Doherty, A. G. Wilson, R. Moskowitz, M. Hochberg, R. Loeser, et al. “The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes.” Osteoarthritis Cartilage 15, no. 2 (February 2007): 120–27. https://doi.org/10.1016/j.joca.2006.10.002.
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  - Allen, K. D., J. M. Jordan, J. B. Renner, and V. B. Kraus. “Relationship of global assessment of change to AUSCAN and pinch and grip strength among individuals with hand osteoarthritis.” Osteoarthritis Cartilage 14, no. 12 (December 2006): 1281–87. https://doi.org/10.1016/j.joca.2006.06.004.
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  - Birmingham, James D., Virginia B. Kraus, and Alison P. Toth. “Clinical benefits of intra-articular anakinra (Kineret) for knee signs and symptoms of injury, arthritis, and arthrofibrosis.” Arthritis and Rheumatism 54, no. 12 (December 1, 2006): 4114–4114.
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  - McCudden, Christopher R., and Virginia B. Kraus. “Biochemistry of amino acid racemization and clinical application to musculoskeletal disease.” Clin Biochem 39, no. 12 (December 2006): 1112–30. https://doi.org/10.1016/j.clinbiochem.2006.07.009.
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  - Betre, Helawe, Wenge Liu, Michael R. Zalutsky, Ashutosh Chilkoti, Virginia B. Kraus, and Lori A. Setton. “A thermally responsive biopolymer for intra-articular drug delivery.” J Control Release 115, no. 2 (October 10, 2006): 175–82. https://doi.org/10.1016/j.jconrel.2006.07.022.
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  - Huebner, J. L., and V. B. Kraus. “Assessment of the utility of biomarkers of osteoarthritis in the guinea pig.” Osteoarthritis Cartilage 14, no. 9 (September 2006): 923–30. https://doi.org/10.1016/j.joca.2006.03.007.
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  - Bauer, D. C., D. J. Hunter, S. B. Abramson, M. Attur, M. Corr, D. Felson, D. Heinegård, et al. “Classification of osteoarthritis biomarkers: a proposed approach.” Osteoarthritis Cartilage 14, no. 8 (August 2006): 723–27. https://doi.org/10.1016/j.joca.2006.04.001.
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  - Kong, S. Y., T. V. Stabler, L. G. Criscione, A. L. Elliott, J. M. Jordan, and V. B. Kraus. “Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis.” Arthritis Rheum 54, no. 8 (August 2006): 2496–2504. https://doi.org/10.1002/art.21977.
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  - Allen, Kelli D., Joanne M. Jordan, Jordan B. Renner, and Virginia B. Kraus. “Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index.” Arthritis Rheum 54, no. 2 (February 2006): 551–56. https://doi.org/10.1002/art.21615.
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  - Kraus, Virginia B. “Do biochemical markers have a role in osteoarthritis diagnosis and treatment?” Best Pract Res Clin Rheumatol 20, no. 1 (February 2006): 69–80. https://doi.org/10.1016/j.berh.2005.09.001.
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  - Piscoya, J. L., B. Fermor, V. B. Kraus, T. V. Stabler, and F. Guilak. “The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants.” Osteoarthritis Cartilage 13, no. 12 (December 2005): 1092–99. https://doi.org/10.1016/j.joca.2005.07.003.
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  - Eckstein, Felix, H Cecil Charles, Robert J. Buck, Virginia B. Kraus, Ann E. Remmers, Martin Hudelmaier, Wolfgang Wirth, and Jeffrey L. Evelhoch. “Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.” Arthritis Rheum 52, no. 10 (October 2005): 3132–36. https://doi.org/10.1002/art.21348.
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  - Kraus, Virginia Byers. “Biomarkers in osteoarthritis.” Curr Opin Rheumatol 17, no. 5 (September 2005): 641–46. https://doi.org/10.1097/01.bor.0000174195.15421.17.
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  - Lamers, R. J. A. N., J. H. J. van Nesselrooij, V. B. Kraus, J. M. Jordan, J. B. Renner, A. D. Dragomir, G. Luta, J. van der Greef, and J. DeGroot. “Identification of an urinary metabolite profile associated with osteoarthritis.” Osteoarthritis Cartilage 13, no. 9 (September 2005): 762–68. https://doi.org/10.1016/j.joca.2005.04.005.
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  - McNulty, Amy L., Thomas V. Stabler, Thomas P. Vail, Gary E. McDaniel, and Virginia B. Kraus. “Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint.” Arthritis Rheum 52, no. 9 (September 2005): 2676–85. https://doi.org/10.1002/art.21254.
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  - Criscione, Lisa G., Alan L. Elliott, Thomas Stabler, Joanne M. Jordan, Carl F. Pieper, and Virginia B. Kraus. “Variation of serum hyaluronan with activity in individuals with knee osteoarthritis.” Osteoarthritis Cartilage 13, no. 9 (September 2005): 837–40. https://doi.org/10.1016/j.joca.2005.05.004.
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  - Chang, Jane, Teresa L. Kauf, Shibani Mahajan, Joanne M. Jordan, Virginia B. Kraus, T Parker Vail, Shelby D. Reed, Mohamed A. Omar, Kristijan H. Kahler, and Kevin A. Schulman. “Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis.” Arthritis Rheum 52, no. 8 (August 2005): 2366–75. https://doi.org/10.1002/art.21227.
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  - Boyd, Lawrence M., William J. Richardson, Jun Chen, Virginia B. Kraus, Alok Tewari, and Lori A. Setton. “Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR.” Ann Biomed Eng 33, no. 8 (August 2005): 1071–77. https://doi.org/10.1007/s10439-005-5775-y.
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  - McNulty, Amy L., Thomas P. Vail, and Virginia B. Kraus. “Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.” Biochim Biophys Acta 1712, no. 2 (June 30, 2005): 212–21. https://doi.org/10.1016/j.bbamem.2005.04.009.
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  - Kraus, Virginia B., T Parker Vail, Ted Worrell, and Gary McDaniel. “A comparative assessment of alignment angle of the knee by radiographic and physical examination methods.” Arthritis Rheum 52, no. 6 (June 2005): 1730–35. https://doi.org/10.1002/art.21100.
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  - Dominick, Kelli L., Joanne M. Jordan, Jordan B. Renner, and Virginia B. Kraus. “Relationship of radiographic and clinical variables to pinch and grip strength among individuals with osteoarthritis.” Arthritis Rheum 52, no. 5 (May 2005): 1424–30. https://doi.org/10.1002/art.21035.
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  - Elliott, Alan L., Virginia B. Kraus, Gheorghe Luta, Thomas Stabler, Jordan B. Renner, Janice Woodard, Anca D. Dragomir, Charles G. Helmick, Marc C. Hochberg, and Joanne M. Jordan. “Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project.” Arthritis Rheum 52, no. 1 (January 2005): 105–11. https://doi.org/10.1002/art.20724.
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  - Stabler, Thomas, Jean-Charles Piette, Xavier Chevalier, Andre Marini-Portugal, and Virginia B. Kraus. “Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation.” Arthritis Rheum 50, no. 11 (November 2004): 3663–67. https://doi.org/10.1002/art.20613.
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  - Boyd, Lawrence M., Jun Chen, Virginia B. Kraus, and Lori A. Setton. “Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc.” Spine (Phila Pa 1976) 29, no. 20 (October 15, 2004): 2217–22. https://doi.org/10.1097/01.brs.0000142747.90488.1d.
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  - Kraus, V. B., Y. -. J. Li, E. R. Martin, J. M. Jordan, J. B. Renner, M. Doherty, A. G. Wilson, et al. “Articular hypermobility is a protective factor for hand osteoarthritis.” Arthritis Rheum 50, no. 7 (July 2004): 2178–83. https://doi.org/10.1002/art.20354.
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  - Varjú, G., C. F. Pieper, J. B. Renner, and V. B. Kraus. “Assessment of hand osteoarthritis: correlation between thermographic and radiographic methods.” Rheumatology (Oxford) 43, no. 7 (July 2004): 915–19. https://doi.org/10.1093/rheumatology/keh204.
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  - Kraus, Virginia B., Janet L. Huebner, Thomas Stabler, Charlene M. Flahiff, Lori A. Setton, Christian Fink, Vladimir Vilim, and Amy G. Clark. “Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model.” Arthritis Rheum 50, no. 6 (June 2004): 1822–31. https://doi.org/10.1002/art.20291.
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  - Guilak, Farshid, Beverley Fermor, Francis J. Keefe, Virginia B. Kraus, Steven A. Olson, David S. Pisetsky, Lori A. Setton, and J Brice Weinberg. “The role of biomechanics and inflammation in cartilage injury and repair.” Clin Orthop Relat Res, no. 423 (June 2004): 17–26. https://doi.org/10.1097/01.blo.0000131233.83640.91.
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  - Flahiff, Charlene M., Virginia B. Kraus, Janet L. Huebner, and Lori A. Setton. “Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.” Osteoarthritis Cartilage 12, no. 5 (May 2004): 383–88. https://doi.org/10.1016/j.joca.2004.01.007.
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  - Jordan, Joanne M., Virginia B. Kraus, and Marc C. Hochberg. “Genetics of osteoarthritis.” Curr Rheumatol Rep 6, no. 1 (February 2004): 7–13. https://doi.org/10.1007/s11926-004-0078-0.
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  - Kraus, Virginia B., Thomas Stabler, Elizabeth T. Le, Mary Saltarelli, and Nancy B. Allen. “Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis.” Arthritis Rheum 48, no. 10 (October 2003): 2942–48. https://doi.org/10.1002/art.11281.
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  - Stabler, Thomas V., and Virginia B. Kraus. “Ascorbic acid accumulates in cartilage in vivo.” Clin Chim Acta 334, no. 1–2 (August 2003): 157–62. https://doi.org/10.1016/s0009-8981(03)00225-0.
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  - Kraus, Virginia Byers. “Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis.” Foot Ankle Clin 8, no. 2 (June 2003): 187–vii. https://doi.org/10.1016/s1083-7515(03)00035-4.
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  - Lamers, Robert-Jan A. N., Jeroen DeGroot, Elly J. Spies-Faber, Renger H. Jellema, Virginia B. Kraus, Nicole Verzijl, Johan M. TeKoppele, et al. “Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic Guinea pigs.” J Nutr 133, no. 6 (June 2003): 1776–80. https://doi.org/10.1093/jn/133.6.1776.
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  - Jordan, Joanne M., Gheorghe Luta, Thomas Stabler, Jordan B. Renner, Anca D. Dragomir, Vladimir Vilim, Marc C. Hochberg, Charles G. Helmick, and Virginia B. Kraus. “Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project.” Arthritis Rheum 48, no. 3 (March 2003): 675–81. https://doi.org/10.1002/art.10822.
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  - Vilím, Vladimír, Zdenek Vobůrka, Richard Vytásek, Ladislav Senolt, Ilja Tchetverikov, Virginia B. Kraus, and Karel Pavelka. “Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA.” Clin Chim Acta 328, no. 1–2 (February 2003): 59–69. https://doi.org/10.1016/s0009-8981(02)00375-3.
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  - Huebner, J. L., M. A. Hanes, B. Beekman, J. M. TeKoppele, and V. B. Kraus. “A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis.” Osteoarthritis Cartilage 10, no. 10 (October 2002): 758–67. https://doi.org/10.1053/joca.2002.0821.
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  - Dragomir, A. D., V. B. Kraus, J. B. Renner, G. Luta, A. Clark, V. Vilim, M. C. Hochberg, C. G. Helmick, and J. M. Jordan. “Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology.” Osteoarthritis Cartilage 10, no. 9 (September 2002): 687–91. https://doi.org/10.1053/joca.2002.0816.
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  - Flahiff, Charlene M., Daria A. Narmoneva, Janet L. Huebner, Virginia B. Kraus, Farshid Guilak, and Lori A. Setton. “Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage.” J Biomech 35, no. 9 (September 2002): 1285–90. https://doi.org/10.1016/s0021-9290(02)00079-9.
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  - Vilím, V., M. Olejárová, S. Machácek, J. Gatterová, V. B. Kraus, and K. Pavelka. “Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.” Osteoarthritis Cartilage 10, no. 9 (September 2002): 707–13. https://doi.org/10.1053/joca.2002.0819.
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  - Clark, Amy G., Amy L. Rohrbaugh, Ivan Otterness, and Virginia B. Kraus. “The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants.” Matrix Biol 21, no. 2 (March 2002): 175–84. https://doi.org/10.1016/s0945-053x(01)00193-7.
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  - Fink, C., H. J. Cooper, J. L. Huebner, F. Guilak, and V. B. Kraus. “Precision and accuracy of a transportable dual-energy X-ray absorptiometry unit for bone mineral measurements in guinea pigs.” Calcif Tissue Int 70, no. 3 (March 2002): 164–69. https://doi.org/10.1007/s00223-001-1063-5.
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  - Kraus, Virginia B., Janet L. Huebner, Christian Fink, Jeffrey B. King, Spencer Brown, T Parker Vail, and Farshid Guilak. “Urea as a passive transport marker for arthritis biomarker studies.” Arthritis Rheum 46, no. 2 (February 2002): 420–27. https://doi.org/10.1002/art.10124.
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  - Carlson, Cathy S., Farshid Guilak, Thomas P. Vail, Jean F. Gardin, and Virginia B. Kraus. “Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee.” J Orthop Res 20, no. 1 (January 2002): 92–100. https://doi.org/10.1016/S0736-0266(01)00066-3.
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  - Vilím, V., R. Vytásek, M. Olejárová, S. Machácek, J. Gatterová, B. Procházka, V. B. Kraus, and K. Pavelka. “Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis.” Osteoarthritis Cartilage 9, no. 7 (October 2001): 612–18. https://doi.org/10.1053/joca.2001.0434.
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  - Wang, J. Y., A. E. Baer, V. B. Kraus, and L. A. Setton. “Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture.” Spine (Phila Pa 1976) 26, no. 16 (August 15, 2001): 1747–51. https://doi.org/10.1097/00007632-200108150-00003.
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  - Hale, L. P., A. G. Clark, J. Li, P. K. Greer, and V. Byers Kraus. “Age-related thymic atrophy in the guinea pig.” Dev Comp Immunol 25, no. 5–6 (June 2001): 509–18. https://doi.org/10.1016/s0145-305x(00)00071-9.
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  - St Clair, E. W., W. E. Wilkinson, D. S. Pisetsky, D. J. Sexton, R. Drew, V. B. Kraus, and R. A. Greenwald. “The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial.” Arthritis Rheum 44, no. 5 (May 2001): 1043–47. https://doi.org/10.1002/1529-0131(200105)44:5<1043::AID-ANR183>3.0.CO;2-C.
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  - Baer, A. E., J. Y. Wang, V. B. Kraus, and L. A. Setton. “Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures.” J Orthop Res 19, no. 1 (January 2001): 2–10. https://doi.org/10.1016/S0736-0266(00)00003-6.
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  - Månsson, B., D. Heinegård, and T. Saxne. “Diagnosis of osteoarthritis in relation to molecular processes in cartilage: comment on the article by Clark et al.” Arthritis Rheum 43, no. 6 (June 2000): 1425–27. https://doi.org/10.1002/1529-0131(200006)43:6<1425::AID-ANR33>3.0.CO;2-X.
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  - Kraus, Virginia B., Amy G. Clark, Joanne M. Jordan, Anca D. Dragomir, Gheorghe Luta, and Vladimir Vilim. “Reply.” Arthritis &Amp; Rheumatism 43, no. 6 (June 2000): 1426–27. https://doi.org/10.1002/1529-0131(200006)43:6<1426::aid-anr34>3.0.co;2-t.
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  - Lindhorst, E., T. P. Vail, F. Guilak, H. Wang, L. A. Setton, V. Vilim, and V. B. Kraus. “Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis.” J Orthop Res 18, no. 2 (March 2000): 269–80. https://doi.org/10.1002/jor.1100180216.
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  - Setton, L. A., A. E. Baer, J. Y. Wang, and V. B. Kraus. “Biosynthesis of intervertebral disc matrix in vitro.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 2 (December 1, 1999): 1325.
  - Clark, A. G., J. M. Jordan, V. Vilim, J. B. Renner, A. D. Dragomir, G. Luta, and V. B. Kraus. “Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.” Arthritis Rheum 42, no. 11 (November 1999): 2356–64. https://doi.org/10.1002/1529-0131(199911)42:11<2356::AID-ANR14>3.0.CO;2-R.
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  - Selman, M., and A. Pardo. “Expression of matrix metalloproteinase 1 in rodents: comment on the article by Huebner et al.” Arthritis Rheum 42, no. 3 (March 1999): 590. https://doi.org/10.1002/1529-0131(199904)42:3<590::AID-ANR35>3.0.CO;2-F.
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  - Huebner, Janet L., and Virginia B. Kraus. “Reply.” Arthritis &Amp; Rheumatism 42, no. 3 (March 1999): 590–590. https://doi.org/10.1002/1529-0131(199904)42:3<590::aid-anr36>3.0.co;2-c.
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  - Huebner, J. L., I. G. Otterness, E. M. Freund, B. Caterson, and V. B. Kraus. “Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.” Arthritis Rheum 41, no. 5 (May 1998): 877–90. https://doi.org/10.1002/1529-0131(199805)41:5<877::AID-ART16>3.0.CO;2-#.
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  - Bello, A. E., W. E. Garrett, H. Wang, J. Lohnes, E. DeLong, B. Caterson, and V. B. Kraus. “Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury.” Osteoarthritis Cartilage 5, no. 6 (November 1997): 419–26. https://doi.org/10.1016/s1063-4584(97)80046-5.
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  - Kraus, V. B. “Pathogenesis and treatment of osteoarthritis.” Med Clin North Am 81, no. 1 (January 1997): 85–112. https://doi.org/10.1016/s0025-7125(05)70506-x.
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  - Kraus, V. B., E. M. N. Freund, J. L. Huebner, and B. Caterson. “Collagenase in a guinea PK3 model of natural osteoarthrftis.” Journal of Investigative Medicine 44, no. 3 (January 1, 1996).
  - Kraus, V. B., J. A. Inostroza, K. Yeung, D. Reinberg, and J. R. Nevins. “Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.” Proc Natl Acad Sci U S A 91, no. 14 (July 5, 1994): 6279–82. https://doi.org/10.1073/pnas.91.14.6279.
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  - Taylor, D. A., V. B. Kraus, J. J. Schwarz, E. N. Olson, and W. E. Kraus. “E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.” Mol Cell Biol 13, no. 8 (August 1993): 4714–27. https://doi.org/10.1128/mcb.13.8.4714-4727.1993.
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  - TAYLOR, D. A., V. B. KRAUS, J. J. SCHWARZ, E. N. OLSON, and W. E. KRAUS. “E1A-MEDIATED INHIBITION OF MYOGENESIS - A DIRECT PHYSICAL INTERACTION OF E1A(12S) AND BHLH PROTEINS.” Journal of Cellular Biochemistry, March 13, 1993, 225–225.
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  - KRAUS, V. B., J. A. INOSTROZA, D. REINBERG, E. MORAN, and J. R. NEVINS. “THE ACTIVATION OF THE HSP70-PROMOTER BY E1A COINCIDES WITH A RELEASE OF TBP FROM AN INTERACTION WITH THE INHIBITORY FACTOR DR1.” Journal of Cellular Biochemistry, January 9, 1993, 226–226.
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  - KRAUS, V. B., J. A. INOSTROZA, D. REINBERG, E. MORAN, and J. R. NEVINS. “THE ACTIVATION OF THE HSP70 PROMOTER BY E1A COINCIDES WITH A RELEASE OF TBP FROM AN INTERACTION WITH THE INHIBITORY FACTOR-DR1.” Journal of Cellular Biochemistry, January 9, 1993, 60–60.
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  - Kraus, V. B., E. Moran, and J. R. Nevins. “Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.” Mol Cell Biol 12, no. 10 (October 1992): 4391–99. https://doi.org/10.1128/mcb.12.10.4391-4399.1992.
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  - TAYLOR, D. A., V. B. KRAUS, and W. E. KRAUS. “E1A-MEDIATED INHIBITION OF MYOGENESIS - A DIRECT PHYSICAL INTERACTION OF E1A(12S) AND BHLH PROTEINS.” Circulation 86, no. 4 (October 1, 1992): 347–347.
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  - Chellappan, S., V. B. Kraus, B. Kroger, K. Munger, P. M. Howley, W. C. Phelps, and J. R. Nevins. “Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.” Proc Natl Acad Sci U S A 89, no. 10 (May 15, 1992): 4549–53. https://doi.org/10.1073/pnas.89.10.4549.
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  - Phelps, W. C., S. Bagchi, J. A. Barnes, P. Raychaudhuri, V. Kraus, K. Münger, P. M. Howley, and J. R. Nevins. “Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.” J Virol 65, no. 12 (December 1991): 6922–30. https://doi.org/10.1128/JVI.65.12.6922-6930.1991.
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  - Raychaudhuri, P., S. Bagchi, S. H. Devoto, V. B. Kraus, E. Moran, and J. R. Nevins. “Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.” Genes Dev 5, no. 7 (July 1991): 1200–1211. https://doi.org/10.1101/gad.5.7.1200.
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  - Manzi, S., V. B. Kraus, and E. W. St Clair. “An unusual photoactivated skin eruption. Quinidine-induced livedo reticularis.” Arch Dermatol 125, no. 3 (March 1989): 417–22. https://doi.org/10.1001/archderm.1989.01670150109020.
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  - Kraus, V. B., E. A. Harden, B. Wittels, J. O. Moore, and B. F. Haynes. “Demonstration of phenotypic abnormalities of thymic epithelium in thymoma including two cases with abundant Langerhans cells.” Am J Pathol 132, no. 3 (September 1988): 552–62.
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  - Kraus, V. B., J. N. Baraniuk, G. B. Hill, and N. B. Allen. “Ureaplasma urealyticum septic arthritis in hypogammaglobulinemia.” J Rheumatol 15, no. 2 (February 1988): 369–71.
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  - Kraus, V. B., W. J. Fulkerson, M. A. Gowen, and W. M. Samuelson. “Straw lung.” N Engl J Med 312, no. 14 (April 4, 1985): 924. https://doi.org/10.1056/nejm198504043121419.
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  - Kraus, V. M., R. M. Dasheiff, R. J. Fanelli, and J. O. McNamara. “Benzodiazepine receptor declines in hippocampal formation following limbic seizures.” Brain Res 277, no. 2 (October 31, 1983): 305–9. https://doi.org/10.1016/0006-8993(83)90938-1.
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- Book Sections
  - Hsueh, Ming-Feng, and Virginia Byers Kraus. “Biomarkers and osteoarthritis.” In Genomic and Precision Medicine Inflammatory and Metabolic Disease. Academic Press, 2019.
  - Golightly, Y. M., S. B. Adams, and V. B. Kraus. “Biomarkers of PTA.” In Post-Traumatic Arthritis: Pathogenesis, Diagnosis and Management, 317–30, 2015. https://doi.org/10.1007/978-1-4899-7606-2_25.
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  - Kraus, V. B. “Rare osteoarthritis: Ochronosis and Kashin-Beck disease.” In Rheumatology: Sixth Edition, 2–2:1536–47, 2015. https://doi.org/10.1016/B978-0-323-09138-1.00185-6.
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  - Kraus, V. B. “Preclinical osteoarthritis.” In Rheumatology: Sixth Edition, 2–2:1498–1502, 2015. https://doi.org/10.1016/B978-0-323-09138-1.00179-0.
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  - Kraus, V. B. “Preclinical Osteoarthritis,” n.d.
- Book Reviews
  - Hsueh, Ming-Feng, Patrik Önnerfjord, and Virginia Byers Kraus. “Biomarkers and proteomic analysis of osteoarthritis.” Matrix Biol, October 2014. https://doi.org/10.1016/j.matbio.2014.08.012.
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  - Kraus, V. B. “Rare Osteoarthritis: Ochronosis and Kashin-Beck Disease.” Rheumatology, 6th Edition, Ed. Mc Hochberg, Aj Silman, Js Smolen, Me Weinblatt, Mh Weisman (Mosby Elsevier, Philadelphia). 2014;Chapter 185:1536 1540., n.d.
- Conference Papers
  - Hsueh, M. -. F., A. Reed, M. Orenduff, M. P. Bolognesi, M. E. Easley, P. Onnerfjord, and V. B. Kraus. “CARTILAGE ANABOLISM IS HIGHLY REGULATED BY MIRNAS IN RESPONSE TO OA STRESS.” In Osteoarthritis and Cartilage, 30:S356–57, 2022.
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  - Reed, A., M. -. F. Hsueh, J. L. Huebner, Y. -. J. Li, B. Ma, A. Krych, S. Rodeo, S. Majumdar, and V. B. Kraus. “SURGERY INDUCES SECOND CYTOKINE STORM IN INDIVIDUALS WHO EXPERIENCE AN ANTERIOR CRUCIATE LIGAMENT TEAR.” In Osteoarthritis and Cartilage, 30:S100–101, 2022.
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  - Reed, A., Y. -. J. Li, E. Soderblom, A. Moseley, S. Sun, K. Zhou, N. Arden, A. Nelson, and V. B. Kraus. “SERUM PROTEOMIC BIOMARKERS DIAGNOSTIC OF KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 29:S5–6, 2021.
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  - Sun, S., Y. -. J. Li, E. J. Soderblom, M. A. Moseley, K. Zhou, A. Reed, N. Arden, and V. B. Kraus. “SERUM PROGNOSTIC BIOMARKERS FOR INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 29:S8–9, 2021.
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  - Zhou, K., Y. -. J. Li, E. Soderblom, A. Reed, S. Sun, M. A. Moseley, and V. B. Kraus. “QUALIFICTION OF PROTEOMIC BIOMARKERS FOR KNEE OSTEOARTHRITIS PROGRESSION.” In Osteoarthritis and Cartilage, 29:S7–8, 2021.
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  - Xie, J. W., Y. Wang, K. Xiao, H. Xu, Z. Y. Luo, L. Li, F. X. Pei, V. B. Kraus, and Z. Y. Huang. “Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization.” In Osteoarthritis Cartilage, 29:1048–59, 2021. https://doi.org/10.1016/j.joca.2021.04.006.
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  - Hsueh, M. -. F., J. L. Huebner, C. A. Jacobs, C. Lattermann, K. P. Spindler, and V. B. Kraus. “ASSOCIATION OF MATRIX METALLOPEPTIDASE 9 WITH NEUTROPHIL ELASTASE IN JOINT INJURY AND OSTEOARTHRITIS PROGRESSION.” In Osteoarthritis and Cartilage, 29:S65–66, 2021.
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  - Goode, Adam P., Rebecca J. Cleveland, Steven Z. George, Virginia B. Kraus, Todd A. Schwartz, Richard H. Gracely, Joanne M. Jordan, and Yvonne M. Golightly. “Different Phenotypes of Osteoarthritis in the Lumbar Spine Reflected by Demographic and Clinical Characteristics: The Johnston County Osteoarthritis Project.” In Arthritis Care Res (Hoboken), 72:974–81, 2020. https://doi.org/10.1002/acr.23918.
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  - Huffman, Kim M., Andrew Concoff, Andrew Spitzer, John C. Richmond, Andreas Gomoll, Virginia B. Kraus, Deryk G. Jones, Amy Cinar, and Scott Kelley. “Fitbit Analysis Shows Enhanced Mobility Of Knee Osteoarthritis Patients Treated With Triamcinolone Acetonide Extended Release.” In Medicine and Science in Sports and Exercise, 52:1012–1012, 2020.
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  - Kelley, Scott, Kim Huffman, Philip Conaghan, Michael Bowes, Amy Cinar, Alan Kivitz, Virginia Byers Kraus, et al. “Effect Of Triamcinolone Acetonide Extended-release On Synovial Inflammation In Patients With Osteoarthritis Of The Knee.” In Medicine and Science in Sports and Exercise, 52:1010–1010, 2020.
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  - Ross, Leanna M., Roshan Tourani, Sisi Ma, Steven Shen, Daniel C. Parker, Kim M. Huffman, Virginia B. Kraus, Constantin F. Aliferis, and William E. Kraus. “Utilizing Causal Pathway Analysis To Predict Change In Cardiorespiratory Fitness In The STRRIDE Randomized Trials.” In Medicine and Science in Sports and Exercise, 52:503–503, 2020.
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  - Huffman, K. M., A. Spitzer, J. C. Richmond, A. Gomoll, V. B. Kraus, D. G. Jones, A. Concoff, A. Cinar, and S. Kelley. “FITBIT (R)-DERIVED EVIDENCE OF ENHANCED MOBILITY OF PATIENTS WITH KNEE OSTEOARTHRITIS TREATED WITH TRIAMCINOLONE ACETONIDE EXTENDED RELEASE: RESULTS FROM A PHASE 3B, SINGLE-ARM, OPEN-LABEL STUDY.” In Osteoarthritis and Cartilage, 28:S497–S497, 2020.
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  - Jr, Alexander L. C., A. J. Han, J. L. Huebner, and V. B. Kraus. “TRANSFORMING GROWTH FACTOR BETA VARIATION WITH PHYSICAL ACTIVITY IN KNEE OSTEOARTHRITIS.” In Osteoarthritis and Cartilage, 28:S332–S332, 2020.
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  - Goode, Adam, David Hu, Rebecca Cleveland, Steven George, Virginia Byers Kraus, Todd Schwartz, Richard Gracely, Joanne Jordan, and Yvonne Golightly. “Transitions in Lumbar Spine Osteoarthritis: The Johnston County Osteoarthritis Project.” In Arthritis & Rheumatology, Vol. 71. WILEY, 2019.
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  - Goode, Adam, Rebecca Cleveland, David Hu, Steven George, Virginia Byers Kraus, Todd Schwartz, Richard Gracely, Louis DeFrate, Joanne Jordan, and Yvonne Golightly. “Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project.” In Arthritis & Rheumatology, Vol. 71. WILEY, 2019.
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  - Huffman, Kim M., John Richmond, Andrew Spitzer, Andreas Gomoll, Deryk G. Jones, Virginia B. Kraus, Amy Cinar, Joelle Lufkin, and Scott Kelley. “Initial/Repeat Triamcinolone Acetonide Extended-Release (TA-ER) Reduces Osteoarthritis Knee Pain Regardless of Prior Intra-Articular Corticosteroids (IACS).” In Medicine &Amp; Science in Sports &Amp; Exercise, 51:876–876. Ovid Technologies (Wolters Kluwer Health), 2019. https://doi.org/10.1249/01.mss.0000563118.31561.b3.
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  - Chen, Y. -. H., C. -. H. Chou, C. Haraden, D. Attarian, and V. B. Kraus. “Senescence in osteoarthritis.” In Osteoarthritis and Cartilage, 27:S94–S94. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.135.
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  - Chou, C. -. H., J. Gibson, D. E. Attarian, C. Haraden, C. B. Yohn, R. -. M. Laberge, S. Gregory, and V. B. Kraus. “Profiling human chondrocytes and synoviocytes using single cell RNA sequencing identifies cell diversity in the pathogenesis of osteoarthritis in the joint organ.” In Osteoarthritis and Cartilage, 27:S27–S27. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.042.
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  - Gomoll, A., A. Spitzer, J. C. Richmond, V. B. Kraus, D. G. Jones, K. M. Huffman, A. Cinar, J. Lufkin, and S. Kelley. “Repeat administration of triamcinolone acetonide extended-release affords consistent, clinically relevant improvements in pain: results from a phase 3B, single-arm, open-label study.” In Osteoarthritis and Cartilage, 27:S505–6. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.570.
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  - Parker, D. C., D. W. Belsky, and V. B. Kraus. “Quantifications of biological aging predict disability and mortality in older adults in the Duke EPESE.” In Journal of the American Geriatrics Society, 67:S145–S145. WILEY, 2019.
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  - Zhang, X., and V. B. Kraus. “Multiparametric analysis of human plasma exosome phenotype by conventional flow cytometry.” In Osteoarthritis and Cartilage, 27:S95–96. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.138.
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  - Hsueh, M. -. F., P. Onnerfjord, M. P. Bolognesi, M. E. Easley, and V. B. Kraus. “microRNAs and cartilage matrix protein turnover responded collectively to the stress of osteoarthritis.” In Osteoarthritis and Cartilage, 27:S59–S59. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.084.
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  - Golightly, Yvonne M., Maryalice Nocera, Anthony I. Beutler, Jordan B. Renner, Ali Guermazi, John Cantrell, Darin A. Padua, et al. “Association of Knee Ligament and/or Meniscal Injury with Radiographic Knee Osteoarthritis in Military Officers.” In Arthritis & Rheumatology, Vol. 70. WILEY, 2018.
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  - Andonian, Brian J., Ching-Heng Chou, Virginia B. Kraus, William E. Kraus, and Kim M. Huffman. “Plasma Mir-146a-5p Associates with Beneficial Body Composition and Plasma Metabolic Profiles in Rheumatoid Arthritis.” In Arthritis & Rheumatology, Vol. 70. WILEY, 2018.
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  - Hsueh, M. -. F., E. Montell, and V. B. Kraus. “AB0071 Effects of chondroitin sulphate and glucosamine on inflammatory cytokines in macrophages.” In Cytokines and Inflammatory Mediators. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. https://doi.org/10.1136/annrheumdis-2018-eular.2954.
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  - Hsueh, M. -. F., and V. B. Kraus. “AB0072 Evaluation of anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial cells.” In Cytokines and Inflammatory Mediators. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. https://doi.org/10.1136/annrheumdis-2018-eular.3337.
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  - Huebner, J. L., C. Haraden, Y. -. J. Li, and V. B. Kraus. “BIOMARKERS OF MACROPHAGE-ASSOCIATED INFLAMMATORY PATHWAYS ARE ASSOCIATED WITH OA SYMPTOMS AND RADIOGRAPHIC DISEASE.” In Osteoarthritis and Cartilage, 26:S42–S42. ELSEVIER SCI LTD, 2018.
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  - Hunt, E. R., C. Jacobs, J. L. Huebner, V. B. Kraus, and C. Lattermann. “ARE SERUM CARTILAGE DEGENERATION BIOMARKER CONCENTRATIONS ACCURATE REPRESENTATIONS OF THE INTRA-ARTICULAR ENVIRONMENT OF THE KNEE?” In Osteoarthritis and Cartilage, 26:S197–98. ELSEVIER SCI LTD, 2018.
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  - Karsdal, M. A., A. -. C. Bay-Jensen, A. R. Bihlet, V. B. Kraus, I. Byrjalsen, and J. R. Andersen. “OSTEOARTHRITIS CLINICAL TRIAL DESIGN AND FOOD AND DRUG ADMINISTRATION ACCELERATED APPROVAL: LESSONS LEARNED FROM THE OSTEOPOROSIS AND LIVER FIBROSIS FIELDS.” In Osteoarthritis and Cartilage, 26:S271–S271. ELSEVIER SCI LTD, 2018.
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  - Peterson, R. O., S. R. Hoy, L. M. Vucetich, J. A. Vucetich, V. B. Kraus, and J. L. Huebner. “URINARY BIOMARKERS TO NON-INVASIVELY EVALUATE HEALTH IN WILD MOOSE (ALCES ALCES).” In Osteoarthritis and Cartilage, 26:S196–97. ELSEVIER SCI LTD, 2018.
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  - Chen, Y. -. H., C. -. H. Chou, A. Khodabukus, N. Bursac, G. Truskey, W. Kraus, and V. B. Kraus. “Effects of simulated muscle exercise on chondrocyte gene expression in a 3D-alginate bead model system.” In Osteoarthritis and Cartilage, 26:S139–40. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.303.
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  - Hsueh, M. -. F., P. Onnerfjord, M. P. Bolognesi, M. E. Easley, and V. B. Kraus. “Differential cartilage turnover along the human lower limb revealed by protein deamidation.” In Osteoarthritis and Cartilage, 26:S32–S32. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.080.
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  - Hsueh, M. -. F., Y. Lu, S. S. Wellman, M. P. Bolognesi, and V. B. Kraus. “Functional folate receptor cell-associated inflammatory cytokines predict the progression of knee osteoarthritis.” In Osteoarthritis and Cartilage, 26:S121–22. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.266.
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  - Katz, N. P., P. G. Conaghan, V. B. Kraus, J. Lufkin, J. R. Johnson, and S. Kelley. “Triamcinolone acetonide extended-release injectable suspension (TA-ER) provides clinically relevant improvements in pain and function of knee osteoarthritis: a pooled analysis of 3 randomized clinical trials employing composite assessments.” In Osteoarthritis and Cartilage, 26:S232–33. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.485.
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  - Spitzer, A., J. Richmond, A. Gomoll, D. G. Jones, V. B. Kraus, J. Lufkin, J. R. Johnson, and S. Kelley. “Assessment of the safety of repeat administration of triamcinolone acetonide extended-release injectable suspension in patients with knee osteoarthritis: trial design, methods and preliminary data.” In Osteoarthritis and Cartilage, 26:S251–52. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.515.
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  - Chou, C. -. H., D. E. Attarian, H. -. G. Wisniewski, P. A. Band, and V. B. Kraus. “TSG-6 - a double-edged sword for osteoarthritis (OA).” In Osteoarthritis Cartilage, 26:245–54, 2018. https://doi.org/10.1016/j.joca.2017.10.019.
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  - Kraus, V. B., P. G. Conaghan, H. A. Aazami, P. Mehra, A. J. Kivitz, J. Lufkin, J. Hauben, J. R. Johnson, and N. Bodick. “Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA).” In Osteoarthritis Cartilage, 26:34–42, 2018. https://doi.org/10.1016/j.joca.2017.10.003.
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  - Conaghan, Philip G., Francis Berenbaum, Virginia B. Kraus, James Johnson, and Scott Kelley. “Updating the Knee Osteoarthritis Intra-Articular Corticosteroid Meta-Analysis with Two Large Trials of Extended-Release Triamcinolone Acetonide (FX006) Versus Placebo.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.
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  - Feng, Sheng, Su Chen, Li Wang, Charles Peterfy, Virginia B. Kraus, Rajesh Kamath, Lanju Zhang, et al. “Biomarkers Predictive of Pain Improvement in Knee Osteoarthritis Subjects Treated with the Anti-IL-1 alpha/beta Dual Variable Domain Immunoglobulin ABT-981.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.
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  - Goode, A. P., A. E. Nelson, V. B. Kraus, J. B. Renner, and J. M. Jordan. “Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project.” In Osteoarthritis Cartilage, 25:1672–79, 2017. https://doi.org/10.1016/j.joca.2017.07.007.
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  - Andonian, Brian J., David Bartlett, Virginia B. Kraus, Janet Huebner, William E. Kraus, and Kim M. Huffman. “Skeletal Muscle Cytokine and Myostatin Responses to High-Intensity Interval Training in Rheumatoid Arthritis Contrasted with Prediabetes Mellitus.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.
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  - Andonian, Brian J., David Bartlett, Virginia B. Kraus, Janet Huebner, William E. Kraus, and Kim M. Huffman. “Serum Galectin-3 in Rheumatoid Arthritis Compared with Healthy Controls and Subjects with Prediabetes before and after High-Intensity Interval Training.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.
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  - Stabler, T. V., E. Montell, J. Vergés, J. L. Huebner, and V. B. Kraus. “Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?” In Biomarker Insights, Vol. 12, 2017. https://doi.org/10.1177/1177271917726964.
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  - Montell, E., T. V. Stabler, and V. B. Kraus. “THU0044 Chondroitin sulphate inhibits monocyte chemoattractant protein-1 release from 3T3L1 adipocytes: a new treatment opportunity for obesity-related metabolic syndromes?” In Poster Presentations. BMJ Publishing Group Ltd and European League Against Rheumatism, 2017. https://doi.org/10.1136/annrheumdis-2017-eular.2140.
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  - Attur, M., S. Ma, J. Samuels, S. Krasnokutsky Samuels, H. Zhou, J. T. Bencardino, M. C. Hochberg, et al. “Functional genetic polymorphism of IL-1rn encoding the IL-1 receptor antagonist predicts radiographic severity of symptomatic knee OA.” In Osteoarthritis and Cartilage, 25:S210–11. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.366.
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  - Conaghan, P., V. Strand, D. Hunter, V. B. Kraus, F. Berenbaum, N. P. Katz, J. Lufkin, J. R. Johnson, S. Kelley, and N. Bodick. “An intra-articular, extended release formulation of triamcinolone (FX006) affords clinically relevant improvements in pain and function of knee osteoarthritis: post-hoc pooled analyses of 3 randomized controlled trials.” In Osteoarthritis and Cartilage, 25:S432–33. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.747.
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  - Flowers, P., R. J. Cleveland, T. A. Schwartz, A. E. Nelson, V. B. Kraus, H. J. Hillstrom, A. P. Goode, et al. “Association of joint hypermobility and lower body osteoarthritis by race.” In Osteoarthritis and Cartilage, 25:S197–98. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.340.
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  - Goode, A. P., R. J. Cleveland, T. A. Schwartz, A. E. Nelson, V. B. Kraus, H. J. Hillstrom, M. T. Hannan, et al. “Relationship of joint hypermobility with low back pain and lumbar spine osteoarthritis: a pooled analysis of three cross-sectional studies.” In Osteoarthritis and Cartilage, 25:S190–91. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.326.
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  - Haraden, C., V Byers Kraus, D. Attarian, R. -. M. Laberge, and C. -. H. Chou. “Senescence Indicators are Positively Associated with Severity of Osteoarthritis.” In Osteoarthritis and Cartilage, 25:S311–S311. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.521.
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  - Montell, E., T. V. Stabler, J. Vergés, and V. B. Kraus. “Chondroitin Sulphate Inhibits Monocyte Chemoattractant Protein-1 Release from 3T3L1 Adipocytes: A New Treatment Opportunity for Obesity-related Metabolic Syndromes?” In Osteoarthritis and Cartilage, 25:S272–S272. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.460.
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  - Furman, B. D., K. A. Kimmerling, S. Ramamoorthy, Y. -. J. Li, Y. -. H. Wu, J. L. Huebner, F. Guilak, V. B. Kraus, and S. A. Olson. “Articular fracture upregulates lipid metabolites in human synovial fluid.” In Osteoarthritis and Cartilage, 25:S381–S381. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.652.
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  - Hsueh, M. -. F., V. B. Kraus, and P. Onnerfjord. “Quantitative assessment of cartilage remodeling in health and disease.” In Osteoarthritis and Cartilage, 25:S52–S52. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.097.
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  - Hsueh, M. -. F., Y. Lu, L. Wheeler, S. S. Wellman, M. P. Bolognesi, and V. B. Kraus. “Functional folate receptor cells within synovium and fluid as therapeutic targets for osteoarthritis.” In Osteoarthritis and Cartilage, 25:S42–43. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.082.
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  - Huebner, J. L., B. D. Furman, K. A. Kimmerling, S. A. Olson, F. Guilak, and V. B. Kraus. “Identification of biomarkers indicative of synovitis in the mouse articular fracture model of PTA.” In Osteoarthritis and Cartilage, 25:S104–S104. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.165.
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  - Kraus, Virginia B., David E. Hargrove, David J. Hunter, Jordan B. Renner, and Joanne M. Jordan. “Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium.” In Ann Rheum Dis, 76:179–85, 2017. https://doi.org/10.1136/annrheumdis-2016-209253.
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  - Attur, Mukundan, Sisi Ma, Jonathan Samuels, Svetlana Krasnokutsky Samuels, Hua Zhou, Jenny Bencardino, Marc C. Hochberg, et al. “Genetic Polymorphism of IL-1RN Encoding the IL-1 Receptor Antagonist Predicts Radiographic Severity of Symptomatic Knee OA.” In Arthritis & Rheumatology, Vol. 68. WILEY, 2016.
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  - Marshall, Stephen W., Yvonne M. Golightly, Maryalice Nocera, Ali Guermazi, L Stefan Lohmander, John Cantrell, Darin A. Padua, et al. “Association of Anterior Cruciate Ligament/Meniscal Injury with Knee Function, Knee Pain, and Knee Osteoarthritis in Military Officers.” In Arthritis & Rheumatology, Vol. 68. WILEY, 2016.
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  - Montell, E., T. Stabler, J. Verges, and V. B. Kraus. “CHONDROITIN SULPHATE INHIBITION OF NF-kappa B ACTIVITY: ATTENTUATION OF HYALURONAN FRAGMENT INDUCED INFLAMMATORY RESPONSE IN MACROPHAGES BY CHONDROITIN SULPHATE IS MEDIATED BY REDUCTION IN NF-kappa B ACTIVITY.” In Basic & Clinical Pharmacology & Toxicology, 119:30–30. WILEY-BLACKWELL, 2016.
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  - Kraus, V. B., G. McDaniel, J. L. Huebner, T. V. Stabler, C. F. Pieper, S. W. Shipes, N. A. Petry, et al. “Direct in vivo evidence of activated macrophages in human osteoarthritis.” In Osteoarthritis Cartilage, 24:1613–21, 2016. https://doi.org/10.1016/j.joca.2016.04.010.
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  - Golightly, Y. M., A. E. Nelson, M. T. Hannan, H. J. Hillstrom, V. B. Kraus, R. J. Cleveland, A. P. Goode, T. A. Schwartz, J. B. Renner, and J. M. Jordan. “SAT0614 Joint Hypermobility and Ankle Osteoarthritis in A Community-Based Cohort.” In Annals of the Rheumatic Diseases, 75:892.1-892. BMJ, 2016. https://doi.org/10.1136/annrheumdis-2016-eular.5041.
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  - Golightly, Y. M., A. P. Goode, R. J. Cleveland, A. E. Nelson, M. T. Hannan, H. J. Hillstrom, V. B. Kraus, T. A. Schwartz, J. B. Renner, and J. M. Jordan. “FRI0598 Relationship of Joint Hypermobility with Low Back Pain and Lumbar Spine Osteoarthritis: A Cohort Study.” In Annals of the Rheumatic Diseases, 75:659.1-659. BMJ, 2016. https://doi.org/10.1136/annrheumdis-2016-eular.4361.
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  - Stabler, T., E. Montell, J. Vergés, and V. B. Kraus. “FRI0037 Chondroitin Sulphate Inhibition of NF-κB Activity: Attentuation of Hyaluronan Fragment Induced Inflammatory Response in Macrophages by Chondroitin Sulphate Is Mediated by Reduction in NF-κB Activity.” In Annals of the Rheumatic Diseases, 75:439.1-439. BMJ, 2016. https://doi.org/10.1136/annrheumdis-2016-eular.2717.
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  - Chou, C. -. H., H. -. G. Wisniewski, P. Band, J. Huebner, T. Stabler, C. Lattermann, and V. B. Kraus. “TSG-6 Activity reflects severity of inflammation in knee osteoarthritis and acute joint injury.” In Osteoarthritis and Cartilage, 24:S81–82. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.174.
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  - Grasso, M. A., Y. Yesha, N. Rishe, V. B. Kraus, and A. Niskar. “A big data approach for selection of a large osteoarthritis cohort.” In Osteoarthritis and Cartilage, 24:S208–9. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.405.
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  - Kraus, V. B., H. Martinez, M. Herrero, and J. Verges. “A proteomic panel predicts drug response to the combination of glucosamine and chondroitin sulfate.” In Osteoarthritis and Cartilage, 24:S89–S89. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.187.
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  - Kraus, V. B., J. Catterall, E. Soderblom, M. A. Moseley, and S. Suchindran. “Development of a serum biomarker panel highly predictive of knee osteoarthritis progression.” In Osteoarthritis and Cartilage, 24:S20–S20. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.065.
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  - Kraus, V. B., J. Catterall, E. Soderblom, M. A. Moseley, and S. Suchindran. “Development of a serum biomarker panel highly predictive of a knee osteoarthritis diagnosis.” In Osteoarthritis and Cartilage, 24:S72–S72. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.156.
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  - Leung, Y. Y., B. Wong, B. Haaland, and V. B. Kraus. “Association between radiographic severity and pain in knee osteoarthritis.” In Osteoarthritis and Cartilage, 24:S440–S440. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.798.
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  - Leung, Y. Y., J. L. Huebner, B. Wong, and V. B. Kraus. “Association of synovial fluid inflammatory biomarkers and knee pain.” In Osteoarthritis and Cartilage, 24:S73–S73. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.159.
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  - Nwosu, L. N., V. Chapman, D. A. Walsh, and V. B. Kraus. “Subchondral bone biomarkers as predictors of OA pain progression; linking structural pathology and pain.” In Osteoarthritis and Cartilage, 24:S51–S51. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.116.
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  - Stabler, T., E. Montell, J. Vergés, and V. B. Kraus. “Chondroitin sulphate inhibition of NF-κB activity: attentuation of hyaluronan fragment induced inflammatory response in macrophages by chondroitin sulphate is mediated by reduction in NF-κB activity.” In Osteoarthritis and Cartilage, 24:S331–32. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.592.
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  - Montell, E., T. Stabler, J. Verges, and V. B. Kraus. “ATTENTUATION OF HYALURONAN FRAGMENT INDUCED INFLAMMATORY RESPONSE IN MACROPHAGES BY CHONDROITIN SULPHATE.” In Clinical Therapeutics, 37:E120–E120. ELSEVIER, 2015.
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  - Stabler, T., E. Montell, J. Verges, and V. B. Kraus. “SAT0029 Attenuation of Hyaluronan Fragment Induced Inflammatory Response in Macrophages by Chondroitin Sulphate.” In Annals of the Rheumatic Diseases, 74:659.2-659. BMJ, 2015. https://doi.org/10.1136/annrheumdis-2015-eular.2760.
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  - Chou, C. -. H., M. Lee, I. -. W. Song, L. -. S. Lu, J. -. Y. Wu, Y. -. T. Chen, V. B. Kraus, and C. -. C. Wu. “Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.” In Osteoarthritis and Cartilage, 23:A73–A73. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.149.
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  - Daghestani, H. N., J. M. Jordan, M. Doherty, A. Wilson, and V. B. Kraus. “N-propeptide of collagen IIA (PIIANP) as a marker of osteoarthritis burden.” In Osteoarthritis and Cartilage, 23:A87–A87. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.791.
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  - Daghestani, H. N., Z. Huang, and V. B. Kraus. “Characterization of folate receptor beta expression on cells of bone origin.” In Osteoarthritis and Cartilage, 23:A131–A131. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.858.
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  - Stabler, T., E. Montell, J. Verges, and V. B. Kraus. “Attentuation of hyaluronan fragment induced inflammatory response in macrophages by chondroitin sulphate.” In Osteoarthritis and Cartilage, 23:A263–64. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.481.
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  - Hsueh, M. -. F., A. Khabut, S. Kjellström, P. Önnerfjord, and V. B. Kraus. “Cartilage permeability assessment based on proteomic analysis of plasma protein penetration.” In Osteoarthritis and Cartilage, 23:A132–33. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.863.
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  - Hsueh, M. -. F., V. B. Kraus, A. Khabut, and P. Önnerfjord. “Quantitative proteomics of articular cartilage using sequential extraction of transverse cryosections.” In Osteoarthritis and Cartilage, 23:A137–A137. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.871.
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  - Taylor, A. M., M. -. F. Hsueh, L. R. Ranganath, J. A. Gallagher, J. B. Catterall, and V. B. Kraus. “Analysis of cartilage biomarkers of aging and turnover in the osteoarthropathy of alkaptonuria.” In Osteoarthritis and Cartilage, 23:A135–A135. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.867.
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  - Daghestani, H. N., C. F. Pieper, and V. B. Kraus. “Released macrophage markers as predictors of knee OA progression.” In Osteoarthritis and Cartilage, 22:S67–S67. Elsevier BV, 2014. https://doi.org/10.1016/j.joca.2014.02.137.
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  - Kraus, V Byers, C. F. Pieper, A. Halaweish, E. Newman, C. Berasi, M. Bolognesi, C. Charles, R. Frobell, and L. S. Lohmander. “Radiographic subchondral bone trabecular integrity predicts osteoarthritis structural outcomes after anterior cruciate ligament rupture.” In Osteoarthritis and Cartilage, 22:S254–S254. Elsevier BV, 2014. https://doi.org/10.1016/j.joca.2014.02.484.
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  - Lattermann, C., M. Proffitt, V. B. Kraus, and K. P. Spindler. “MOON-AAA GCP clinical trial: early lessons from an early interventional trial in patients within 1 week after ACL tear.” In Osteoarthritis and Cartilage, 22:S199–S199. Elsevier BV, 2014. https://doi.org/10.1016/j.joca.2014.02.380.
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  - Goode, Adam, Amanda E. Nelson, Virginia B. Kraus, Jordan B. Renner, and Joanne M. Jordan. “Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project.” In Arthritis and Rheumatism, 65:S102–S102. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: Wiley, 2013.
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  - Karsdal, Morten Asser, Janet L. Huebner, Virginia Byers Kraus, Diana J. Leeming, Edward Coleman, Gary E. McDaniel, Kim M. Huffman, Kim Henriksen, and Anne C. Bay-jensen. “Subchondral Bone Turnover and Osteophyte Formation Are Key Aspects In The Progression Of Osteoarthritis and May Be Assessed and Predicted By a-CTX.” In Arthritis and Rheumatism, 65:S28–S28. WILEY-BLACKWELL, 2013.
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  - Orlowsky, Eric W., Thomas V. Stabler, Eulalia Montell, Josep Verges, and Virginia B. Kraus. “Monosodium Urate Crystal Induced Macrophage Inflammation Is Attenuated By Chondroitin Sulfate: Pre-Clinical Model For Gout Prophylaxis?” In Arthritis and Rheumatism, 65:S366–S366. WILEY-BLACKWELL, 2013.
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  - Chou, C. -. H., C. -. H. Lee, L. -. S. Lu, I. -. W. Song, H. -. P. Chuang, S. -. Y. Kuo, J. -. Y. Wu, et al. “Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees.” In Osteoarthritis and Cartilage, 21:S12–S12. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.047.
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  - Cibere, J., E. C. Sayre, J. M. Esdaile, A. Thorne, J. A. Kopec, J. Singer, S. Nicolaou, et al. “Associations of clinical and biomarker variables with cartilage damage in painful pre-radiographic knee osteoarthritis. results from a population-based study.” In Osteoarthritis and Cartilage, 21:S161–S161. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.343.
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  - Daghestani, H. N., G. McDaniel, J. L. Huebner, T. Stabler, C. Pieper, E. Coleman, and V. B. Kraus. “Soluble macrophage biomarkers are associated with osteoarthritis-related knee inflammation.” In Osteoarthritis and Cartilage, 21:S76–77. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.166.
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  - Orlowsky, E. W., T. V. Stabler, E. Montell, J. Vergas, and V. B. Kraus. “The effects of chondroitin sulphate on inflammasome activation.” In Osteoarthritis and Cartilage, 21:S205–6. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.429.
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  - Wu, C. -. L., D. Jain, D. Little, J. A. Anderson, J. L. Huebner, V. B. Kraus, R. M. Rodriguiz, W. C. Wetsel, and F. Guilak. “Dietary fatty acids differentially affect the development of injury-induced osteoarthritis with diet-induced obesity in mice.” In Osteoarthritis and Cartilage, 21:S224–25. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.464.
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  - Hsueh, M. -. F., E. J. Soderblom, R. D. Zura, M. P. Bolognesi, and V. B. Kraus. “Study of deamidation of cartilage extracellular matrix proteins to investigate cartilage turnover.” In Osteoarthritis and Cartilage, 21:S112–S112. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.237.
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  - Yin, Zhao-Xue, Xiao-Ming Shi, Virginia B. Kraus, Melanie D. Sereny, and Yi Zeng. “HS-CRP AND TRADITIONAL RISK FACTORS: WHO IS STILL SIGNIFICANTLY ASSOCIATED WITH DIABETES IN CHINESE OLDEST-OLD?” In Heart, 98:E155.1-E155. BMJ, 2012. https://doi.org/10.1136/heartjnl-2012-302920g.3.
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  - Ning, Tony, Carl Pieper, Virginia B. Kraus, William E. Kraus, and Kim M. Huffman. “Knee Osteoarthritis and Serum Uric Acid Concentration: The Third National Health and Examination Survey.” In Arthritis and Rheumatism, 64:S116–S116. WILEY-BLACKWELL, 2012.
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  - Aslam, I., X. Shi, J. B. Renner, V. B. Kraus, Y. M. Golightly, A. E. Nelson, and J. M. Jordan. “The Association between Australian/Canadian Hand Osteoarthritis Index (AUSCAN) and Biomarkers of Joint Metabolism.” In Journal of the American Geriatrics Society, 60:S79–80. WILEY-BLACKWELL, 2012.
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  - Golightly, Y. M., A. E. Nelson, V. B. Kraus, J. B. Renner, and J. M. Jordan. “General joint hypermobility and hip osteoarthritis: the Johnston County osteoarthritis project.” In Osteoarthritis and Cartilage, 20:S182–S182. Elsevier BV, 2012. https://doi.org/10.1016/j.joca.2012.02.280.
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  - Goode, A. P., V. B. Kraus, S. W. Marshall, J. B. Renner, T. S. Carey, and J. M. Jordan. “Associations between lumbar spine individual radiographic features and knee, hip and hand osteoarthritis: the Johnston County osteoarthritis project.” In Osteoarthritis and Cartilage, 20:S268–69. Elsevier BV, 2012. https://doi.org/10.1016/j.joca.2012.02.453.
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  - Huebner, J. L., L. R. Landerman, T. J. Somers, V. B. Kraus, F. Guilak, J. A. Blumenthal, D. S. Caldwell, J. R. Rice, and F. J. Keefe. “Inflammatory biomarkers of OA, IL-6 and leptin are modifiable in overweight/obese OA patients with a protocol that combines training in pain coping skills and weight management.” In Osteoarthritis and Cartilage, 20:S38–S38. Elsevier BV, 2012. https://doi.org/10.1016/j.joca.2012.02.570.
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  - Huebner, J. L., N. Ha, S. Bourdon, and V. B. Kraus. “Performance metrics of a newly formatted type ii collagen cleavage neo-epitope assay for human urine: C2C-HUSA.” In Osteoarthritis and Cartilage, 20:S86–S86. Elsevier BV, 2012. https://doi.org/10.1016/j.joca.2012.02.080.
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  - Hunt, M. A., C. L. Pollock, V. B. Kraus, T. Saxne, S. Peters, J. L. Huebner, E. C. Sayre, and J. Cibere. “Biomarkers of cartilage degradation and synthesis relevant to knee osteoarthritis: relationships with dynamic knee joint load and changes following exercise.” In Osteoarthritis and Cartilage, 20:S83–84. Elsevier BV, 2012. https://doi.org/10.1016/j.joca.2012.02.076.
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  - Nelson, A. E., J. B. Renner, Y. M. Golightly, T. A. Schwartz, V. B. Kraus, C. G. Helmick, and J. M. Jordan. “Differences in multi-joint symptomatic osteoarthritis phenotypes by race and gender: the Johnston County osteoarthritis project.” In Osteoarthritis and Cartilage, 20:S156–S156. Elsevier BV, 2012. https://doi.org/10.1016/j.joca.2012.02.230.
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  - Goode, Adam P., Virginia B. Kraus, Yvonne M. Golightly, Stephen W. Marshall, Debra E. Irwin, and Joanne M. Jordan. “Association of Lumbar Spine Individual Radiographic Features with Serum C-Propeptide (sCPII) and Serum Collagen Neoepitope (sC2C) of Type II Collagen: The Johnston County Osteoarthritis Project.” In Arthritis and Rheumatism, 63:S346–S346. WILEY-BLACKWELL, 2011.
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  - Lekpa, Fernando Kemta, Virginia Byers Kraus, and Xavier Chevalier. “Biologics In Relapsing Polychondritis: a Literature Review.” In Arthritis and Rheumatism, 63:S761–S761. WILEY-BLACKWELL, 2011.
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  - Yau, Michelle S., Laura Yerges-Armstrong, Michael Doherty, Marc Hochberg, Joanne M. Jordan, Virginia Byers Kraus, Braxton Mitchell, and A. G. Wilson. “Heritability and Linkage of Radiographic Progression of Hip and Knee Osteoarthritis: Results From the Longitudinal Component of the Genetics of Generalized Osteoarthritis Study.” In Arthritis and Rheumatism, 63:S324–25. WILEY-BLACKWELL, 2011.
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  - Ning, Tony, Carl Pieper, Virginia Byers Kraus, William E. Kraus, and Kim M. Huffman. “Serum Uric Acid Concentration and Physical Activity: the National Health and Nutrition Examination Survey 2003-2004.” In Arthritis and Rheumatism, 63:S79–S79. WILEY-BLACKWELL, 2011.
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  - Goode, Adam, V. B. Kraus, Y. G. Golightly, S. W. Marshall, and J. M. Jordan. “Association of Lumbar Spine Individual Radiographic Features with Urinary Cross-linked C- Telopeptide of Type II Collagen (CTX-II) and Serum Hyaluronan.” In The Johnston County Osteoarthritis Project. Osteoarthritis Cartilage., 19:S73–S73, 2011. https://doi.org/10.1016/S1063-4584(11)60172-6.
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  - Golightly, Y. M., S. W. Marshall, V. B. Kraus, J. B. Renner, A. Villaveces, C. Casteel, and J. M. Jordan. “124 SERUM CARTILAGE OLIGOMERIC MATRIX PROTEIN HYALURONAN HIGH-SENSITIVITY C-REACTIVE PROTEIN AND KERATAN SULFATE AS PREDICTORS OF INCIDENT RADIOGRAPHIC KNEE OSTEOARTHRITIS: DIFFERENCES BY CHRONIC KNEE SYMPTOMS.” In Osteoarthritis and Cartilage, 18:S62–63. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60151-3.
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  - Huebner, J. L., A. C. Bay Jensen, D. J. Leeming, R. E. Coleman, G. McDaniel, M. A. Karsdal, and V. B. Kraus. “048 URINARYMARKERS, ALPHA CTX AND CTXII, ARE INDICATIVE OF OA SEVERITY AND BONE TURNOVER.” In Osteoarthritis and Cartilage, 18:S29–30. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60075-1.
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  - Kraus, V Byers, J. Birmingham, T. Stabler, S. Feng, D. C. Taylor, C. T. Moorman, W. E. Garrett, and A. Toth. “INTRAARTICULAR IL1-RA AFTER ACUTE KNEE INJURY DECREASES BIOMARKERS OF INFLAMMATION AND IMPROVES PAIN AND FUNCTION.” In Osteoarthritis and Cartilage, 18:S11–12. W B SAUNDERS CO LTD, 2010.
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  - Nelson, A. E., R. F. DeVellis, J. B. Renner, P. G. Conaghan, V. B. Kraus, and J. M. Jordan. “014 A COMPOSITE SCORE OFMULTI-JOINT RADIOGRAPHIC OSTEOARTHRITIS: THE JOHNSTON COUNTY OSTEOARTHRITIS PROJECT.” In Osteoarthritis and Cartilage, 18:S15–S15. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60041-6.
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  - Stabler, T. V., A. E. Heinrichs, K. M. Huffman, G. E. McDaniel, and V. B. Kraus. “109 INFLAMMASOME ACTIVATION IN OSTEOARTHRITIS BY URIC ACID.” In Osteoarthritis and Cartilage, 18:S55–56. Elsevier BV, 2010. https://doi.org/10.1016/s1063-4584(10)60136-7.
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  - Chen, J. C., V. B. Kraus, L. F. Callahan, T. Stabler, J. B. Renner, and J. M. Jordan. “Higher educational level is associated with decreased serum cartilage oligomeric matrix protein (COMP).” In Arthritis and Rheumatism, 58:S492–S492. WILEY-LISS, 2008.
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  - Nelson, Amanda E., Fang Fang, Virginia B. Kraus, Thomas Stabler, Jordan B. Renner, Charles G. Helmick, and Joanne M. Jordan. “Is serum transforming growth factor-beta (TGF-beta) a biomarker of radiographic osteoarthritis (rOA) at the knee and hip?” In Arthritis and Rheumatism, 58:S492–S492. WILEY-LISS, 2008.
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  - Allen, Kelli D., Robert F. DeVellis, Jordan B. Renner, Virginia B. Kraus, and Joanne M. Jordan. “Validity and factor structure of the AUSCAN osteoarthritis hand index in an African American and white community sample.” In Arthritis and Rheumatism, 54:S150–S150. WILEY-LISS, 2006.
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  - McCudden, C. R., and V. B. Kraus. “Protein racemization as a biomarker of osteoarthritis.” In Clinical Chemistry, 52:A159–A159. AMER ASSOC CLINICAL CHEMISTRY, 2006.
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  - Elliott, A. L., F. Fang, V. B. Kraus, J. B. Renner, C. Helmick, M. C. Hochberg, and J. M. Jordan. “Association of symptoms and signs of hand osteoarthritis with hip and knee osteoarthritis in African-Americans and Caucasians.” In Arthritis and Rheumatism, 52:S515–S515. WILEY-BLACKWELL, 2005.
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  - Mazzuca, S. A., V. B. Kraus, J. M. Jordan, K. D. Brandt, B. P. Katz, K. A. Lane, and A. Elliott. “Relationship of baseline cartilage oligomeric matrix protein (COMP) levels to joint space narrowing (JSN) in patients with knee osteoarthritis (OA).” In Arthritis and Rheumatism, 52:S72–S72. WILEY-BLACKWELL, 2005.
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  - Dominick, K. L., J. M. Jordan, J. B. Renner, and V. B. Kraus. “Relationships of radiographic and clinical variables to pinch and grip strength among patients with osteoarthritis.” In Arthritis and Rheumatism, 50:S147–48. WILEY-LISS, 2004.
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  - Jordan, J. M., V. B. Kraus, J. B. Renner, G. Luta, A. D. Dragomir, M. Ionescu, T. Lobanok, L. King, and A. R. Poole. “Predictive ability of serum biomarkers of types I and II collagen cleavage and aggrecan turnover in incidence and progression of radiographic knee osteoarthritis in African Americans and Caucasians.” In Arthritis and Rheumatism, 50:S481–S481. WILEY-LISS, 2004.
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  - Jordan, J. M., V. B. Kraus, J. B. Renner, G. Luta, A. D. Dragomir, M. Ionescu, T. Lobanok, L. King, and A. R. Poole. “Ethnic and gender differences in serum biomarkers of types I and II collagen cleavage and aggrecan turnover in African Americans and Caucasians.” In Arthritis and Rheumatism, 50:S481–S481. WILEY-LISS, 2004.
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  - McDaniel, G. E., T. P. Vail, and V. B. Kraus. “Comparison of knee alignment angle by x-ray and goniometer.” In Arthritis and Rheumatism, 50:S343–S343. WILEY-LISS, 2004.
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  - Dragomir, A. D., J. M. Jordan, V. B. Kraus, G. Luta, J. B. Renner, and A. R. Poole. “Altered levels of serum cartilage markers in postmenopausal African-American and caucasian women on current hormone replacement therapy.” In Osteoarthritis and Cartilage, 12:S54–55. W B SAUNDERS CO LTD, 2004.
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  - Eckstein, F., R. J. Buck, H. C. Charles, M. Hudelmaier, W. Wirth, V. B. Kraus, and J. L. Evelhoch. “Improved precision of quantitative cartilage measurements with magnetic resonance imaging at 3 T.” In Osteoarthritis and Cartilage, 12:S119–S119. W B SAUNDERS CO LTD, 2004.
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  - Kraus, V. B. “Using epidemiologic studies to identify surrogates for radiographic outcome.” In Osteoarthritis and Cartilage, 12:S9–S9. W B SAUNDERS CO LTD, 2004.
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  - Dragomir, A. D., V. B. Kraus, G. Luta, T. Stabler, J. B. Renner, C. G. Helmick, M. C. Hochberg, and J. M. Jordan. “Lower levels of 2 putative biomarkers of osteoarthritis (OA) in postmenopausal African American and Caucasian women on current hormone replacement therapy.” In Arthritis and Rheumatism, 48:S211–S211. WILEY-LISS, 2003.
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  - Jordan, J. M., V. B. Kraus, J. B. Renner, G. Luta, A. D. Dragomir, T. Stabler, V. Vilim, M. C. Hochberg, and C. G. Helmick. “Associations between medical co-morbidities and putative biomarkers of osteoarthritis (OA).” In Arthritis and Rheumatism, 48:S213–S213. WILEY-LISS, 2003.
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  - Stabler, T. V., J. M. Jordan, V. B. Kraus, G. Luta, J. B. Renner, A. D. Dragomir, M. C. Hochberg, and C. G. Helmick. “Serum C-reactive protein (CRP) levels and osteoarthritis.” In Clinical Chemistry, 49:A53–A53. AMER ASSOC CLINICAL CHEMISTRY, 2003.
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  - Dragomir, A. D., V. B. Kraus, T. Stabler, G. Luta, J. B. Renner, L. Arab, M. C. Hochberg, C. G. Helmick, and J. M. Jordan. “Lower levels of serum cartilage oligomeric matrix protein (COMP) in postmenopausal African-American and caucasian women on current hormone replacement therapy (HRT).” In Arthritis and Rheumatism, 46:S373–S373. WILEY, 2002.
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  - Jordan, J. M., G. Luta, T. Stabler, J. B. Renner, A. D. Dragomir, M. C. Hochberg, C. G. Helmick, and V. B. Kraus. “Serum c-reactive protein (CRP) and osteoarthritis (OA).” In Arthritis and Rheumatism, 46:S373–S373. WILEY, 2002.
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  - Jordan, J. M., G. Luta, T. Stabler, J. B. Renner, A. D. Dragomir, M. C. Hochberg, C. G. Helmick, and V. B. Kraus. “Serum hyaluronic acid levels and radiographic knee Osteoarthritis in African-Americans and caucasians.” In Arthritis and Rheumatism, 46:S464–S464. WILEY, 2002.
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  - Little, D., C. L. Wu, D. Jain, J. McNeill, J. Anderson, J. Huebner, R. Rodriguiz, W. Wetsel, V. Kraus, and F. Guilak. “Omega-3 Fatty Acids Mitigate Obesity-induced Osteoarthritis And Accelerate Wound Repair.,” n.d.
  - Wu, C. -. L., J. McNeill, K. Goon, D. Little, K. Kimmerling, J. L. Huebner, V. B. Kraus, and F. Guilak. “The effect of conditional macrophage depletion on development of injury-induced knee OA in obese transgenic MAFIA mice.,” n.d.
- Preprints
  - Ramaker, Megan E., David L. Corcoran, Abner T. Apsley, Michael S. Kobor, Virginia B. Kraus, William E. Kraus, David T. S. Lin, et al. “Epigenome-wide association study analysis of calorie restriction in humans, CALERIE™ Trial analysis.” Cold Spring Harbor Laboratory, n.d. https://doi.org/10.1101/2022.06.03.494722.
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