Scholars@Duke
Virginia Byers Kraus

Virginia Byers Kraus

Professor of Medicine
Medicine, Rheumatology and Immunology
kraus004@duke.edu
Duke Box 104775, Durham, NC 27701
300 N Duke St, Carmichael Building Room 15-205, Durham, NC 27701-2047

Selected Publications

The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial

Journal Article Osteoarthritis and Cartilage Open · March 1, 2025 Objective: Given the high burden and increasing prevalence of post-traumatic osteoarthritis (PTOA), identifying clinically beneficial strategies to prevent or delay its onset could improve the quality of life of those at high risk of developing the disease ... Full text Cite

Plasma extracellular vesicles carry immune system-related peptides that predict human longevity.

Journal Article Geroscience · December 18, 2024 Extracellular vesicles (EVs) play crucial roles in aging. In this National Institutes on Aging-funded study, we sought to identify circulating extracellular vesicle (EV) biomarkers indicative of longevity. The plasma EV proteome of 48 older adults (mean ag ... Full text Link to item Cite

The CALERIE Genomic Data Resource.

Journal Article Nat Aging · December 13, 2024 Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from the CALERIE randomized, controlled trial of long-term CR in healthy, nonobese humans broadly supports a similar pattern of effects in humans. To ... Full text Link to item Cite

A 2-year calorie restriction intervention reduces glycomic biological age biomarkers.

Journal Article medRxiv · December 5, 2024 BACKGROUND/OBJECTIVE: In a subset of participants from the CALERIE™ Phase 2 study we evaluated the effects of 2y of ~25% Calorie Restriction (CR) diet on IgG N-glycosylation (GlycAge), plasma and complement C3 N-glycome as markers of aging and inflammaging ... Full text Link to item Cite

Mode of injury and level of synovitis alter inflammatory chondrocyte gene expression and associated pathways.

Journal Article Sci Rep · November 21, 2024 Although various joint injuries result in post-traumatic osteoarthritis (PTOA), differences in chondrocyte response to specific injuries, such as blunt compression or fracture, are unclear. Furthermore, the role of underlying joint inflammation, or synovit ... Full text Link to item Cite

Immune System-Related Plasma Pathogenic Extracellular Vesicle Subpopulations Predict Osteoarthritis Progression.

Journal Article Int J Mol Sci · November 21, 2024 Certain molecules found on the surface or within the cargo of extracellular vesicles (EVs) are linked to osteoarthritis (OA) severity and progression. We aimed to identify plasma pathogenic EV subpopulations that can predict knee radiographic OA (rOA) prog ... Full text Link to item Cite

Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change.

Journal Article medRxiv · September 8, 2024 BACKGROUND: Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle ge ... Full text Link to item Cite

The CALERIE™ Genomic Data Resource.

Journal Article bioRxiv · August 22, 2024 Caloric restriction (CR) slows biological aging and prolongs healthy lifespan in model organisms. Findings from CALERIE-2™ - the first ever randomized, controlled trial of long-term CR in healthy, non-obese humans - broadly supports a similar pattern of ef ... Full text Link to item Cite

Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study.

Journal Article Eur Heart J · June 28, 2024 BACKGROUND AND AIMS: Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an inverse relationship of BMI with mortality was reported. This study was to invest ... Full text Link to item Cite

Association of insomnia symptoms and trajectories with the risk of functional disability: a prospective cohort study.

Journal Article BMC Geriatr · June 5, 2024 BACKGROUND: There is limited understanding regarding prospective associations of insomnia symptoms and trajectories with functional disability. We aimed to investigate the associations of insomnia symptoms and trajectories with functional disability. METHO ... Full text Link to item Cite

IL-1ra gene therapy in equine osteoarthritis improves physiological, anatomical, and biological outcomes of joint degeneration.

Journal Article J Am Vet Med Assoc · June 1, 2024 OBJECTIVE: To evaluate the effects of a gene transfer approach to IL-1β inhibition in an equine osteochondral chip fragment model of joint injury using a self-complementary adeno-associated virus with interleukin receptor antagonist transgene cassette (scA ... Full text Link to item Cite

Molecular biomarker approaches to prevention of post-traumatic osteoarthritis.

Journal Article Nat Rev Rheumatol · May 2024 Up to 50% of individuals develop post-traumatic osteoarthritis (PTOA) within 10 years following knee-joint injuries such as anterior cruciate ligament rupture or acute meniscal tear. Lower-extremity PTOA prevalence is estimated to account for ≥12% of all s ... Full text Link to item Cite

An osteoarthritis pathophysiological continuum revealed by molecular biomarkers.

Journal Article Sci Adv · April 26, 2024 We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding to six proteins, reached AUC 77% probability to distinguis ... Full text Link to item Cite

Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT.

Journal Article Cell Rep · March 26, 2024 An intriguing effect of short-term caloric restriction (CR) is the expansion of certain stem cell populations, including muscle stem cells (satellite cells), which facilitate an accelerated regenerative program after injury. Here, we utilized the MetRSL274 ... Full text Link to item Cite

Serum proteomic biomarkers diagnostic of knee osteoarthritis.

Conference Osteoarthritis Cartilage · March 2024 OBJECTIVE: To better understand the pathogenesis of knee osteoarthritis (OA) through identification of serum diagnostics. DESIGN: We conducted multiple reaction monitoring mass spectrometry analysis of 107 peptides in baseline sera of two cohorts: the Foun ... Full text Link to item Cite

Serum proteomic panel validated for prediction of knee osteoarthritis progression.

Journal Article Osteoarthr Cartil Open · March 2024 OBJECTIVE: To further validate a serum proteomics panel for predicting radiographic (structural) knee OA progression. DESIGN: Serum peptides were targeted by multiple-reaction-monitoring mass spectrometry in the New York University cohort (n ​= ​104). Knee ... Full text Link to item Cite

Links between three chronic and age-related diseases, osteoarthritis, periodontitis, and osteoporosis, in a wild mammal (moose) population.

Journal Article Osteoarthritis Cartilage · March 2024 OBJECTIVE: Osteoarthritis, periodontitis and osteoporosis are chronic, age-related diseases which adversely impact millions of people worldwide. Because these diseases pose a major global public health challenge, there is an urgent need to better understan ... Full text Link to item Cite

Targeted Analysis of the Size Distribution of Heavy Chain-Modified Hyaluronan with Solid-State Nanopores.

Journal Article Anal Chem · January 30, 2024 The glycosaminoglycan hyaluronan (HA) plays important roles in diverse physiological functions where the distribution of its molecular weight (MW) can influence its behavior and is known to change in response to disease conditions. During inflammation, HA ... Full text Link to item Cite

Association of biochemical markers with bone marrow lesion changes on imaging-data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Res Ther · January 18, 2024 BACKGROUND: To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relationship between biochemical markers in ... Full text Link to item Cite

Association between regular proton pump inhibitors use and cardiovascular outcomes: A large prospective cohort study.

Journal Article Int J Cardiol · January 15, 2024 BACKGROUND: Proton pump inhibitors (PPIs) are widely prescribed for gastroesophageal reflux disease and peptic ulcer disease. However, the association between the regular PPIs use and the risk of cardiovascular disease (CVD) outcomes remains unclear. We ai ... Full text Link to item Cite

Ultra-rare genetic variation in relapsing polychondritis: a whole-exome sequencing study.

Journal Article Ann Rheum Dis · January 11, 2024 OBJECTIVE: Relapsing polychondritis (RP) is a systemic inflammatory disease of unknown aetiology. The objective of this study was to examine the contribution of rare genetic variations to RP. METHODS: We performed a case-control exome-wide rare variant ass ... Full text Link to item Cite

Anti-CMV IgG Seropositivity is Associated with Plasma Biomarker Evidence of Amyloid-β Accumulation.

Journal Article J Alzheimers Dis · 2024 BACKGROUND: Some human studies have identified infection with cytomegalovirus (CMV), a member of the alpha herpesvirus family, as a risk factor for Alzheimer's disease and related dementias (ADRD). To our knowledge, no studies have evaluated associations o ... Full text Link to item Cite

Immune system-related plasma extracellular vesicles in healthy aging.

Journal Article Front Immunol · 2024 OBJECTIVES: To identify age-related plasma extracellular vehicle (EVs) phenotypes in healthy adults. METHODS: EV proteomics by high-resolution mass spectrometry to evaluate EV protein stability and discover age-associated EV proteins (n=4 with 4 serial fre ... Full text Link to item Cite

Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.

Journal Article Aging Cell · December 2023 The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, preservation of function, and increased stress resistance. Whether CR elicits the same physiological and molecular responses in humans rema ... Full text Link to item Cite

Comprehensive characterization of pathogenic synovial fluid extracellular vesicles from knee osteoarthritis.

Journal Article Clin Immunol · December 2023 Synovial fluid (SF) extracellular vesicles (EVs) play a pathogenic role in osteoarthritis (OA). However, the surface markers, cell and tissue origins, and effectors of these EVs are largely unknown. We found that SF EVs contained 692 peptides that were pos ... Full text Link to item Cite

Biomarkers in osteoarthritis: current status and outlook - the FNIH Biomarkers Consortium PROGRESS OA study.

Journal Article Skeletal Radiol · November 2023 Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints' limited validity and responsiveness. To overcome this impasse, the Foundation for the NIH OA Bi ... Full text Link to item Cite

Arthritis Foundation/HSS Workshop on Hip Osteoarthritis, Part 2: Detecting Hips at Risk: Early Biomechanical and Structural Mechanisms.

Journal Article HSS J · November 2023 Far more publications are available for osteoarthritis of the knee than of the hip. Recognizing this research gap, the Arthritis Foundation (AF), in partnership with the Hospital for Special Surgery (HSS), convened an in-person meeting of thought leaders t ... Full text Link to item Cite

Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes.

Journal Article Arthritis Res Ther · October 12, 2023 BACKGROUND: Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence. Add ... Full text Open Access Link to item Cite

Reflections from the OARSI 2022 clinical trials symposium: The pain of OA-Deconstruction of pain and patient-reported outcome measures for the benefit of patients and clinical trial design.

Journal Article Osteoarthritis Cartilage · October 2023 OBJECTIVE: Osteoarthritis (OA) drug development is hampered by a number of challenges. One of the main challenges is the apparent discordance between pain and structure, which has had a significant impact on drug development programs and has led to hesitan ... Full text Link to item Cite

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Journal Article Arthritis Rheumatol · September 2023 Full text Link to item Cite

Dietary Diversity Changes and Cognitive Frailty in Chinese Older Adults: A Prospective Community-Based Cohort Study.

Journal Article Nutrients · August 30, 2023 Evidence for the effects of dietary diversity changes and cognitive frailty (CF) in the older adults is not clear. This study aimed to investigate the relationship between dietary diversity changes and CF in older adults Chinese. A total of 14,382 particip ... Full text Link to item Cite

Association of Traumatic Knee Injury With Radiographic Evidence of Knee Osteoarthritis in Military Officers.

Journal Article Arthritis Care Res (Hoboken) · August 2023 OBJECTIVE: The association between knee injury and knee osteoarthritis (OA) is understudied relative to its importance, particularly in younger populations. This study was undertaken to examine the association of knee injury with radiographic features of k ... Full text Link to item Cite

Association of Dipeptidylpeptidase 4 (CD26) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis.

Journal Article Arthritis Rheumatol · July 2023 OBJECTIVE: To evaluate the association of dipeptidylpeptidase 4 (DPP-4; also known as CD26) with cellular senescence of human cartilage and progression of knee osteoarthritis (OA). METHODS: Articular cartilage sections and chondrocytes were acquired from 3 ... Full text Link to item Cite

Development and Validation of a Lifespan Prediction Model in Chinese Adults Aged 65 Years or Older.

Journal Article J Am Med Dir Assoc · July 2023 OBJECTIVES: Previous studies investigated factors associated with mortality. Nevertheless, evidence is limited regarding the determinants of lifespan. We aimed to develop and validate a lifespan prediction model based on the most important predictors. DESI ... Full text Link to item Cite

Effects of Leptin and Body Weight on Inflammation and Knee Osteoarthritis Phenotypes in Female Rats.

Journal Article JBMR Plus · July 2023 Leptin is a proinflammatory adipokine that contributes to obesity-associated osteoarthritis (OA), especially in women. However, the extent to which leptin causes knee OA separate from the effect of increased body weight is not clear. We hypothesized that l ... Full text Link to item Cite

Biomarkers and longitudinal changes in lumbar spine degeneration and low back pain: the Johnston County Osteoarthritis Project.

Journal Article Osteoarthritis Cartilage · June 2023 OBJECTIVE: To determine if baseline biomarkers are associated with longitudinal changes in the worsening of disc space narrowing (DSN), vertebral osteophytes (OST), and low back pain (LBP). DESIGN: Paired baseline (2003-2004) and follow-up (2006-2010) lumb ... Full text Link to item Cite

Ultra-Rare Genetic Variation in Relapsing Polychondritis: A Whole-Exome Sequencing Study.

Conference medRxiv · April 17, 2023 OBJECTIVE: Relapsing polychondritis (RP) is a systemic inflammatory disease of unknown etiology. The study objective was to examine the contribution of rare genetic variations in RP. METHODS: We performed a case-control exome-wide rare variant association ... Full text Link to item Cite

A Novel Movement-Evoked Pain Provocation Test for Older Adults With Persistent Low Back Pain: Safety, Feasibility, and Associations With Self-reported Physical Function and Usual Gait Speed.

Journal Article Clin J Pain · April 1, 2023 OBJECTIVES: Low back pain (LBP) is highly prevalent and disabling for older adults. Movement-evoked pain is an emerging measure that may help to predict disability; but is not currently a part of geriatric LBP clinical care. This study tested the safety an ... Full text Link to item Cite

Increased Effusion Synovitis for Those With a Dysregulated Inflammatory Response After an Anterior Cruciate Ligament Injury.

Journal Article Cureus · April 2023 Introduction The progression to posttraumatic osteoarthritis (PTOA) after an anterior cruciate ligament (ACL) injury is likely multifactorial, involving biological, mechanical, and psychosocial factors. Following acute joint trauma, there appears to be a s ... Full text Link to item Cite

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.

Journal Article Nat Aging · March 2023 The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan1-3. Caloric restriction (CR), defined as lessening caloric intake without ... Full text Link to item Cite

Dietary diversity and frailty among older Chinese people: evidence from the Chinese Longitudinal Healthy Longevity Study.

Journal Article Am J Clin Nutr · February 2023 BACKGROUND: Dietary diversity is widely advocated as a means to promote health, but little is known regarding whether the beneficial effects still apply in older adults. OBJECTIVE: To examine the association between the dietary diversity score (DDS) and fr ... Full text Link to item Cite

A "best-in-class" systemic biomarker predictor of clinically relevant knee osteoarthritis structural and pain progression.

Journal Article Sci Adv · January 25, 2023 We aimed to identify markers in blood (serum) to predict clinically relevant knee osteoarthritis (OA) progression defined as the combination of both joint structure and pain worsening over 48 months. A set of 15 serum proteomic markers corresponding to 13 ... Full text Link to item Cite

Population Attributable Fractions for Modifiable Factors of Longevity and Healthy Longevity Among the Late-Elderly Aged 75 Years or Older - China, 1998-2018.

Journal Article China CDC Wkly · January 13, 2023 WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Limited evidence on healthy longevity was provided in the world, and no studies investigated the fractions of healthy longevity attributed to modifiable factors. WHAT IS ADDED BY THIS REPORT?: Incidences of longevit ... Full text Link to item Cite

Chondroprotection of leptin deficiency demystified?

Journal Article Osteoarthritis Cartilage · January 2023 Full text Link to item Cite

The Inflamma-type: a patient phenotype characterized by a dysregulated inflammatory response after lower extremity articular fracture.

Journal Article Inflamm Res · January 2023 Synovial fluid was collected from 113 patients who had suffered tibial plateau (n = 48), tibial plafond (n = 29), or rotational ankle fractures (n = 36). Concentrations of IL-1β, IL-1RA, IL-6, IL-8, IL-10, and MMP-1, -3, and -13 were quantified using multi ... Full text Link to item Cite

Tryptophan Metabolism and Neurodegeneration: Longitudinal Associations of Kynurenine Pathway Metabolites with Cognitive Performance and Plasma Alzheimer's Disease and Related Dementias Biomarkers in the Duke Physical Performance Across the LifeSpan Study.

Journal Article J Alzheimers Dis · 2023 BACKGROUND: The kynurenine pathway (KP) comprises a family of tryptophan-derived metabolites that some studies have reported are associated with poorer cognitive performance and an increased risk of Alzheimer's disease and related dementias (ADRD). OBJECTI ... Full text Open Access Link to item Cite

RELATIONSHIP BETWEEN REPRODUCTIVE AND BONE BIOMARKERS AND OSTEOARTHRITIS IN ZOO ASIAN (ELEPHAS MAXIMUS) AND AFRICAN (LOXODONTA AFRICANA) ELEPHANTS.

Journal Article J Zoo Wildl Med · January 2023 Osteoarthritis (OA) is common in zoo Asian (Elephas maximus) and African (Loxodonta africana) elephants. This study investigated the relationship between confirmed or suspected OA with ovarian cyclicity, gonadotropins, progestagens, luteinizing hormone (LH ... Full text Link to item Cite

MEASURES OF LEMUR PHYSIOLOGICAL AGING

Conference AMERICAN JOURNAL OF PRIMATOLOGY · 2023 Cite

Leisure Activities, Genetic Risk, and Frailty: Evidence from the Chinese Adults Aged 80 Years or Older.

Journal Article Gerontology · 2023 INTRODUCTION: About half of adults aged ≥80 years suffer from frailty. Exercise is considered effective in preventing frailty but may be inapplicable to adults aged ≥80 years due to physical limitations. As an alternative, we aimed to explore the associati ... Full text Link to item Cite

Exercise Intensity Is A Key Driver Of Differential Smrna Expression In Skeletal Muscle

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2023 Cite

Preclinical and Early Osteoarthritis

Chapter · 2023 The term early osteoarthritis (OA) is often used to refer to mild or moderately severe radiographic OA. More recently, the term early OA has been used to refer to preradiographic or even earlier phases of disease. Diagnosis of OA in its early preradiograph ... Open Access Link to item Cite

Epigenome-wide Association Study Analysis of Calorie Restriction in Humans, CALERIETM Trial Analysis.

Journal Article J Gerontol A Biol Sci Med Sci · December 29, 2022 Calorie restriction (CR) increases healthy life span and is accompanied by slowing or reversal of aging-associated DNA methylation (DNAm) changes in animal models. In the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIETM ... Full text Link to item Cite

Longitudinal association of infrapatellar fat pad signal intensity alteration with biochemical biomarkers in knee osteoarthritis.

Journal Article Rheumatology (Oxford) · December 23, 2022 OBJECTIVE: To explore the longitudinal association of quantitative infrapatellar fat pad (IPFP) signal intensity alteration with OA-related biomarkers. METHODS: Eighteen OA-related biochemical biomarkers of 600 knee OA participants in the Foundation for th ... Full text Link to item Cite

The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes.

Journal Article Clin Epigenetics · December 3, 2022 BACKGROUND: Epigenetic age is a DNA methylation-based biomarker of aging that is accurate across the lifespan and a range of cell types. The difference between epigenetic age and chronological age, termed age acceleration (AA), is a strong predictor of lif ... Full text Open Access Link to item Cite

Association of physical activity and air pollution exposure with the risk of type 2 diabetes: a large population-based prospective cohort study.

Journal Article Environ Health · November 6, 2022 BACKGROUND: The interplay between physical activity (PA) and air pollution in relation to type 2 diabetes (T2D) remains largely unknown. Based on a large population-based cohort study, this study aimed to examine whether the benefits of PA with respect to ... Full text Link to item Cite

Causal analysis identifies small HDL particles and physical activity as key determinants of longevity of older adults.

Journal Article EBioMedicine · November 2022 BACKGROUND: The hard endpoint of death is one of the most significant outcomes in both clinical practice and research settings. Our goal was to discover direct causes of longevity from medically accessible data. METHODS: Using a framework that combines loc ... Full text Link to item Cite

Predictors of Lumbar Spine Degeneration and Low Back Pain in the Community: The Johnston County Osteoarthritis Project.

Journal Article Arthritis Care Res (Hoboken) · October 2022 OBJECTIVE: To determine the incidence and worsening of lumbar spine structure and low back pain (LBP) and whether they are predicted by demographic characteristics or clinical characteristics or appendicular joint osteoarthritis (OA). METHODS: Paired basel ... Full text Link to item Cite

FDA/Arthritis Foundation osteoarthritis drug development workshop recap: Assessment of long-term benefit.

Journal Article Semin Arthritis Rheum · October 2022 OBJECTIVE: To summarize proceedings of a workshop convened to discuss the current state of science in the disease of osteoarthritis (OA), identify the knowledge gaps, and examine the developmental and regulatory challenges in bringing these products to mar ... Full text Link to item Cite

Clinical monitoring in osteoarthritis: Biomarkers.

Journal Article Osteoarthritis Cartilage · September 2022 OBJECTIVE: The purpose of this overview of osteoarthritis (OA) biomarkers is to provide the non-specialist with a toolbox, based on experience acquired by biomarker researchers over many years, to understand biomarkers in general and their use in the OA fi ... Full text Link to item Cite

Biomarker clusters differentiate phenotypes of lumbar spine degeneration and low back pain: The Johnston County Osteoarthritis Project.

Journal Article Osteoarthr Cartil Open · September 2022 OBJECTIVE: Describe the association between biomarkers and lumbar spine degeneration (vertebral osteophytes [OST], facet joint osteoarthritis [FOA], and disc space narrowing [DSN]), for persons with and without low back pain (LBP) and determine whether clu ... Full text Link to item Cite

Tibiofemoral knee osteoarthritis progresses symmetrically by knee compartment in the GOGO cohort.

Journal Article Osteoarthr Cartil Open · September 2022 OBJECTIVE: To evaluate the degree of symmetry of knee osteoarthritis (OA) structural severity and progression of participants with a mean follow-up time of 3.8 years. DESIGN: Participants from the Genetics of Generalized Osteoarthritis (GOGO) study (n = 70 ... Full text Link to item Cite

Reflections from the 2021 OARSI clinical trial symposium: Considerations for understanding biomarker assessments in osteoarthritis drug development - Should future studies focus on disease activity, rather than status?

Journal Article Osteoarthritis and cartilage open · September 2022 ObjectiveOsteoarthritis (OA) is heterogeneous disease, for which drug development has proven to be challenging, both facilitated and hampered by changing guidelines. This is evident by the current lack of approved treatments, which improve joint f ... Full text Cite

Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study.

Journal Article Br J Nutr · August 28, 2022 Chronic inflammation exerts pleiotropic effects in the aetiology and progression of chronic obstructive pulmonary disease (COPD). Glucosamine is widely used in many countries and may have anti-inflammatory properties. We aimed to prospectively evaluate the ... Full text Link to item Cite

Osteoarthritis

Chapter · August 19, 2022 Full text Cite

Albumin-Corrected Fructosamine Predicts All-Cause and Non-CVD Mortality Among the Very Elderly Aged 80 Years or Older Without Diabetes.

Journal Article J Gerontol A Biol Sci Med Sci · August 12, 2022 BACKGROUND: Several guidelines have suggested alternative glycemic markers for hemoglobin A1c among older adults with limited life expectancy or multiple coexisting chronic illnesses. We evaluated associations between fructosamine, albumin-corrected fructo ... Full text Link to item Cite

Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.

Journal Article Exp Gerontol · August 2022 Aging is a multifactorial process associated with progressive degradation of physiological integrity and function. One of the greatest factors contributing to the deleterious effects of aging is the decline of functional ability due to loss of muscle mass, ... Full text Link to item Cite

Multivariable Modeling of Biomarker Data From the Phase I Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Care Res (Hoboken) · July 2022 OBJECTIVE: To determine the optimal combination of imaging and biochemical biomarkers for use in the prediction of knee osteoarthritis (OA) progression. METHODS: The present study was a nested case-control trial from the Foundation of the National Institut ... Full text Link to item Cite

Rejuvenation of neutrophils and their extracellular vesicles is associated with enhanced aged fracture healing.

Journal Article Aging Cell · July 2022 Tissue repair is negatively affected by advanced age. Recent evidence indicates that hematopoietic cell-derived extracellular vesicles (EVs) are modulators of regenerative capacity. Here, we report that plasma EVs carrying specific surface markers indicate ... Full text Link to item Cite

The obesity paradox is mostly driven by decreased noncardiovascular disease mortality in the oldest old in China: a 20-year prospective cohort study.

Journal Article Nat Aging · May 2022 National and international recommendations of healthy body mass index (BMI) are primarily based on evidence in young and middle-aged populations, with an insufficient representation of the oldest old (aged ≥80 years). Here, we report associations between B ... Full text Link to item Cite

Intra-Articular Synovial Fluid With Hematoma After Ankle Fracture Promotes Cartilage Damage In Vitro Partially Attenuated by Anti-Inflammatory Agents.

Journal Article Foot Ankle Int · March 2022 BACKGROUND: Intra-articular ankle fracture (IAF) causes posttraumatic osteoarthritis (PTOA), but the exact mechanism is unknown. Proinflammatory mediators have been shown to be present in the synovial fluid fracture hematoma (SFFH) but have not been linked ... Full text Link to item Cite

Single cell transcriptomics in human osteoarthritis synovium and in silico deconvoluted bulk RNA sequencing.

Journal Article Osteoarthritis Cartilage · March 2022 OBJECTIVES: To reveal the heterogeneity of different cell types of osteoarthritis (OA) synovial tissues at a single-cell resolution, and determine by novel methodology whether bulk-RNA-seq data could be deconvoluted to create in silico scRNA-seq data for s ... Full text Link to item Cite

MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial.

Journal Article Trials · January 31, 2022 BACKGROUND: After anterior cruciate ligament (ACL) reconstruction, patient-reported outcomes are improved 10 years post-surgery; however, cytokine concentrations remain elevated years after surgery with over 80% of those with combined ACL and meniscus inju ... Full text Open Access Link to item Cite

Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial.

Journal Article EClinicalMedicine · January 2022 BACKGROUND: For many cardiovascular risk factors there is no lower limit to which further reduction will result in decreased disease risk; this includes values within ranges considered normal for healthy adults. This seems to be true for new emerging metab ... Full text Link to item Cite

Blood and urine biomarkers in osteoarthritis - an update on cartilage associated type II collagen and aggrecan markers.

Journal Article Curr Opin Rheumatol · January 1, 2022 PURPOSE OF REVIEW: Osteoarthritis (OA) is a painful disease for which drug development has proven difficult. One major reason for this is the heterogeneity of the disease and the current lack of operationalized means to distinguish various disease endotype ... Full text Link to item Cite

CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.

Journal Article Oxid Med Cell Longev · 2022 Cellular senescence is characterized by cell cycle arrest and senescence-associated secretory phenotypes. Cellular senescence can be caused by various stress stimuli such as DNA damage, oxidative stress, and telomere attrition and is related to several chr ... Full text Link to item Cite

Evaluating immune response and metabolic related biomarkers pre-allogenic hematopoietic stem cell transplant in acute myeloid leukemia.

Journal Article PLoS One · 2022 Although hematopoietic stem cell transplantation (HCT) is the only curative treatment for acute myeloid leukemia (AML), it is associated with significant treatment related morbidity and mortality. There is great need for predictive biomarkers associated wi ... Full text Link to item Cite

Association of Biomarkers with Individual and Multiple Body Sites of Pain: The Johnston County Osteoarthritis Project.

Journal Article J Pain Res · 2022 INTRODUCTION: Biochemical biomarkers may provide insight into musculoskeletal pain reported at individual or multiple body sites. The purpose of this study was to determine if biomarkers or pressure-pain threshold (PPT) were associated with individual or m ... Full text Open Access Link to item Cite

Differential microRNA profiles of intramuscular and secreted extracellular vesicles in human tissue-engineered muscle.

Journal Article Front Physiol · 2022 Exercise affects the expression of microRNAs (miR/s) and muscle-derived extracellular vesicles (EVs). To evaluate sarcoplasmic and secreted miR expression in human skeletal muscle in response to exercise-mimetic contractile activity, we utilized a three-di ... Full text Open Access Link to item Cite

Effects Of Six Months Of Aerobic Exercise On Mir Expression In Skeletal Muscle

Conference MEDICINE & SCIENCE IN SPORTS & EXERCISE · 2022 Cite

Increase in Free and Total Plasma TGF-β1 Following Physical Activity.

Journal Article Cartilage · December 2021 OBJECTIVE: To evaluate effects of physical activity and food consumption on plasma concentrations of free and total transforming growth factor beta-1 (TGF-β1), beta-2 (TGF-β2), and beta-3 (TGF-β3) in individuals with knee osteoarthritis (OA). METHODS: Part ... Full text Open Access Link to item Cite

Associations of Sarcopenia, Handgrip Strength and Calf Circumference with Cognitive Impairment among Chinese Older Adults.

Journal Article Biomed Environ Sci · November 20, 2021 OBJECTIVE: To evaluate the associations of sarcopenia, handgrip strength and calf circumference with cognitive impairment among Chinese older adults. METHODS: Totally 2,525 older adults were recruited from the Healthy Aging and Biomarkers Cohort Study. Cog ... Full text Link to item Cite

A template for physical resilience research in older adults: Methods of the PRIME-KNEE study.

Journal Article J Am Geriatr Soc · November 2021 BACKGROUND: Older adults with similar health conditions often experience widely divergent outcomes following health stressors. Variable recovery after a health stressor may be due in part to differences in biological mechanisms at the molecular, cellular, ... Full text Link to item Cite

Association of sleep and circadian patterns and genetic risk with incident type 2 diabetes: a large prospective population-based cohort study.

Journal Article Eur J Endocrinol · October 19, 2021 OBJECTIVE: To examine the association of incident type 2 diabetes (T2D) risk with sleep factors, genetic risk, and their combination effects. DESIGN: Large prospective population-based cohort study. METHODS: This population-based prospective cohort study i ... Full text Link to item Cite

Osteoarthritis: Current Molecular Biomarkers and the Way Forward.

Journal Article Calcif Tissue Int · September 2021 The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measu ... Full text Link to item Cite

Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.

Journal Article J Orthop Res · September 2021 Posttraumatic arthritis (PTA) occurs commonly after articular fracture and may arise, in part, from joint surface incongruity after injury. MRL/MpJ (MRL) "super-healer" mice are protected from PTA compared to C57BL/6 (B6) mice following articular fracture. ... Full text Open Access Link to item Cite

A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis.

Journal Article Arthritis Res Ther · August 31, 2021 OBJECTIVE: To compare C-reactive protein (CRP) and matrix metalloproteinase-generated neoepitope of CRP (CRPM) as biomarkers of inflammation and radiographic severity in patients with knee osteoarthritis. METHODS: Participants with symptomatic osteoarthrit ... Full text Link to item Cite

Extracellular Vesicles as Biological Indicators and Potential Sources of Autologous Therapeutics in Osteoarthritis.

Journal Article Int J Mol Sci · August 3, 2021 Along with cytokines, extracellular vesicles (EVs) released by immune cells in the joint contribute to osteoarthritis (OA) pathogenesis. By high-resolution flow cytometry, we characterized 18 surface markers and 4 proinflammatory cytokines carried by EVs o ... Full text Link to item Cite

Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency.

Journal Article J Orthop Res · August 2021 The inflammatory response to joint injury, specifically intra-articular fracture, has been implicated in posttraumatic arthritis development. However, the role of T cells in regulating the development of posttraumatic arthritis is unclear. We hypothesized ... Full text Link to item Cite

Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization.

Conference Osteoarthritis Cartilage · July 2021 OBJECTIVE: Macrophages play an important part in the pathogenesis of osteoarthritis (OA). Our objective was to determine the effects of α-defensin-1 on macrophage polarization and consequently OA. METHODS: OA synovial tissue and synovial fluid were assesse ... Full text Link to item Cite

Immune cell profiling in the joint following human and murine articular fracture.

Journal Article Osteoarthritis Cartilage · June 2021 OBJECTIVE: Human and in vivo animal research implicates inflammation following articular fracture as contributing to post-traumatic arthritis. However, relevant immune cell subsets present following injury are currently undefined. Immunophenotyping human a ... Full text Link to item Cite

Osteoarthritis Research Society International (OARSI): Past, present and future.

Journal Article Osteoarthr Cartil Open · June 2021 We provide a detailed account of the origin and establishment of the Osteoarthritis Research Society International (OARSI) and celebrate its history from inception to the current day. We discuss the mission, vision and strategic objectives of OARSI and how ... Full text Link to item Cite

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis.

Journal Article J Orthop Traumatol · March 9, 2021 BACKGROUND: Osteoarthritis (OA) is a disease with multiple endotypes. A hallmark of OA is loss of cartilage; however, it is evident that the rate of cartilage loss differs among patients, which may partly be attributed to differential capacity for cartilag ... Full text Link to item Cite

Knee osteoarthritis and time-to all-cause mortality in six community-based cohorts: an international meta-analysis of individual participant-level data.

Journal Article Aging Clin Exp Res · March 2021 BACKGROUND: Osteoarthritis (OA) is a chronic joint disease, with increasing global burden of disability and healthcare utilisation. Recent meta-analyses have shown a range of effects of OA on mortality, reflecting different OA definitions and study methods ... Full text Link to item Cite

Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.

Journal Article Arthritis Rheumatol · January 2021 OBJECTIVE: To evaluate the role of immune cells and their effector cytokines in the pathogenesis and progression of knee osteoarthritis (OA) in matched OA synovial fluid (SF) and synovial tissue samples. METHODS: Cells from matched samples of synovial tiss ... Full text Link to item Cite

Profiling and targeting connective tissue remodeling in autoimmunity - A novel paradigm for diagnosing and treating chronic diseases.

Journal Article Autoimmun Rev · January 2021 Connective tissue (ConT) remodeling is an essential process in tissue regeneration, where a balanced replacement of old tissue by new tissue occurs. This balance is disturbed in chronic diseases, often autoimmune diseases, usually resulting in the buld up ... Full text Link to item Cite

Effects of Amount, Intensity, and Mode of Exercise Training on Insulin Resistance and Type 2 Diabetes Risk in the STRRIDE Randomized Trials.

Journal Article Front Physiol · 2021 BACKGROUND: Lipoprotein Insulin Resistance Index (LP-IR) and Diabetes Risk Index are novel spectroscopic multimarkers of insulin resistance and type 2 diabetes risk. As the Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE ... Full text Link to item Cite

A phase 2 trial of the somatostatin analog pasireotide to prevent GI toxicity and acute GVHD in allogeneic hematopoietic stem cell transplant.

Journal Article PLoS One · 2021 BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HCT) is an often curative intent treatment, however it is associated with significant gastrointestinal (GI) toxicity and treatment related mortality. Graft-versus-host disease is a significant ... Full text Link to item Cite

TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression.

Journal Article Front Immunol · 2021 OBJECTIVES: To identify plasma extracellular vesicles (EVs) associated with radiographic knee osteoarthritis (OA) progression. METHODS: EVs of small (SEV), medium (MEV) and large (LEV) sizes from plasma of OA participants (n=30) and healthy controls (HCs, ... Full text Link to item Cite

Healthy Sleep Associated With Lower Risk of Hypertension Regardless of Genetic Risk: A Population-Based Cohort Study.

Journal Article Front Cardiovasc Med · 2021 Background: Hypertension is a leading contributor to the global burden of disease and to mortality. The combined effects of sleep factors on the risk of hypertension are unclear. We aimed to evaluate the effect of combined sleep factors on the risk of hype ... Full text Link to item Cite

Metabolic and physiological effects of high intensity interval training in patients with knee osteoarthritis: A pilot and feasibility study.

Journal Article Osteoarthr Cartil Open · December 2020 OBJECTIVE: To examine the feasibility of a 6-week high intensity interval training (HIIT) program in patients with symptomatic knee osteoarthritis (OA). A secondary aim was to evaluate the change in whole-body metabolism. DESIGN: In a single-arm interventi ... Full text Link to item Cite

Trends in the Incidence of Activities of Daily Living Disability Among Chinese Older Adults From 2002 to 2014.

Journal Article J Gerontol A Biol Sci Med Sci · October 15, 2020 BACKGROUND: Evidence of the trend of the incidence of activities of daily living (ADL) disability among Chinese older people is limited. We aimed to investigate the time trends and potential risk factors for the incidence of ADL disability among Chinese ol ... Full text Link to item Cite

Biomarkers Associated with Physical Resilience After Hip Fracture.

Journal Article J Gerontol A Biol Sci Med Sci · September 25, 2020 BACKGROUND: Clinically similar older adults demonstrate variable responses to health stressors, heterogeneity attributable to differences in physical resilience. However, molecular mechanisms underlying physical resilience are unknown. We previously derive ... Full text Link to item Cite

Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults.

Journal Article J Gerontol A Biol Sci Med Sci · September 16, 2020 Quantification of biological aging has been proposed for population surveillance of age-related decline in system integrity and evaluation of geroprotective therapies. However, methods of quantifying biological aging have been little studied in geriatric p ... Full text Link to item Cite

The combination of an inflammatory peripheral blood gene expression and imaging biomarkers enhance prediction of radiographic progression in knee osteoarthritis.

Journal Article Arthritis Res Ther · September 10, 2020 OBJECTIVE: Predictive biomarkers of progression in knee osteoarthritis are sought to enable clinical trials of structure-modifying drugs. A peripheral blood leukocyte (PBL) inflammatory gene signature, MRI-based bone marrow lesions (BML) and meniscus extru ... Full text Link to item Cite

Author Correction: Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Journal Article Nature metabolism · August 2020 An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Full text Cite

Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis.

Journal Article Sci Rep · July 2, 2020 We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the most widespread arthritis in the world, using the powerful tool of single-cell RNA-sequencing. Multiple cell types were identified based on profiling of 10,640 syn ... Full text Link to item Cite

Joint Fluid Proteome after Anterior Cruciate Ligament Rupture Reflects an Acute Posttraumatic Inflammatory and Chondrodegenerative State.

Journal Article Cartilage · July 2020 OBJECTIVE: The purpose of this study was to evaluate changes in the synovial fluid proteome following acute anterior cruciate ligament (ACL) injury. DESIGN: This study represents a secondary analysis of synovial fluid samples collected from the placebo gro ... Full text Link to item Cite

Different Phenotypes of Osteoarthritis in the Lumbar Spine Reflected by Demographic and Clinical Characteristics: The Johnston County Osteoarthritis Project.

Conference Arthritis Care Res (Hoboken) · July 2020 OBJECTIVE: To determine if associations between demographic and clinical characteristics and appendicular joint osteoarthritis (OA) reflect different phenotypes of OA in the lumbar spine. METHODS: Participants were from the Johnston County OA Project. Demo ... Full text Link to item Cite

Higher dietary diversity scores and protein-rich food consumption were associated with lower risk of all-cause mortality in the oldest old.

Journal Article Clin Nutr · July 2020 BACKGROUND & AIMS: Dietary diversity is widely advocated in national and international recommendations although whether the beneficial effects on survival or longevity still apply in the final phase of the lifespan remains understudied. We aimed to prospec ... Full text Link to item Cite

Leisure activities and disability in activities of daily living among the oldest-old Chinese population: evidence from the Chinese Longitudinal Healthy Longevity Study.

Journal Article Aging (Albany NY) · June 12, 2020 INTRODUCTION: To investigate the independent and joint effects of leisure activities on disability in activities of daily living (ADL) among the oldest-old Chinese population (aged ≥ 80 years). RESULTS: A total of 3696 participants with ADL disability were ... Full text Link to item Cite

Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.

Journal Article Ann Rheum Dis · June 2020 OBJECTIVES: To evaluate the associations of regular glucosamine use with all-cause and cause-specific mortality in a large prospective cohort. METHODS: This population-based prospective cohort study included 495 077 women and men (mean (SD) age, 56.6 (8.1) ... Full text Link to item Cite

Development and Validation of a Nomogram for Predicting the 6-Year Risk of Cognitive Impairment Among Chinese Older Adults.

Journal Article J Am Med Dir Assoc · June 2020 OBJECTIVE: Although some people with mild cognitive impairment may not suffer from dementia lifelong, about 5% of them will progress to dementia within 1 year in community settings. However, a general tool for predicting the risk of cognitive impairment wa ... Full text Link to item Cite

Fine Particulate Matter and Poor Cognitive Function among Chinese Older Adults: Evidence from a Community-Based, 12-Year Prospective Cohort Study.

Journal Article Environ Health Perspect · June 2020 BACKGROUND: Research on the relationship between long-term exposure to particulate matter with aerodynamic diameter ≤2.5μm (PM2.5) and poor cognitive function is lacking in developing countries, especially in highly polluted areas. OBJECTIVES: We evaluated ... Full text Link to item Cite

Is the Association between Knee Injury and Knee Osteoarthritis Modified by the Presence of General Joint Hypermobility.

Journal Article Osteoarthr Cartil Open · June 2020 OBJECTIVE: To evaluate whether joint hypermobility modifies the association between knee joint injury and knee osteoarthritis (OA) among adults. METHODS: Data were from three studies: Genetics of Generalized Osteoarthritis (GOGO; N=2,341), Genetics of Oste ... Full text Link to item Cite

Disease modification in osteoarthritis; pathways to drug approval.

Journal Article Osteoarthr Cartil Open · June 2020 OBJECTIVE: To summarize proceedings of a workshop convened to discuss advances in disease modifying osteoarthritis (OA) drugs and regulatory challenges in bringing these drugs to market. DESIGN: Summary of a one day workshop held in Washington, DC in May 2 ... Full text Link to item Cite

Long-term exposure to ambient fine particulate matter and fasting blood glucose level in a Chinese elderly cohort.

Journal Article Sci Total Environ · May 15, 2020 Fasting blood glucose level is the primary indicator for the diagnosis of diabetes. We aim to conduct a longitudinal study on the association between long-term fine particulate matter (PM2.5) exposure and fasting blood glucose concentrations. We recruited ... Full text Link to item Cite

Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project.

Journal Article J Orthop Res · May 2020 The purpose of this work is to determine the relationship between biomarkers of inflammation, structure, and pain with radiographic disc space narrowing (DSN) in community-based participants. A total of 74 participants (37 cases and 37 controls) enrolled i ... Full text Link to item Cite

Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells.

Journal Article Osteoarthritis Cartilage · May 2020 OBJECTIVE: To evaluate the anti-inflammatory effects of clinically relevant naproxen sodium (Nx) concentrations on human monocyte-derived macrophages in a controlled in vitro system and human primary synovial fluid (SF) cells. DESIGN: Using phorbol 12-myri ... Full text Link to item Cite

Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.

Journal Article Ann Rheum Dis · May 2020 OBJECTIVES: Emerging evidence suggests that the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which one 'hit' is provided by an adverse gut microbiom ... Full text Link to item Cite

Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis.

Journal Article Arthritis Res Ther · April 15, 2020 BACKGROUND: Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic mouse to examine the hypothesis that endogenous reduction of ω-6 to ω-3 FA ratio, under ... Full text Link to item Cite

Number of natural teeth, denture use and mortality in Chinese elderly: a population-based prospective cohort study.

Journal Article BMC Oral Health · April 10, 2020 BACKGROUND: The associations between the number of natural teeth/denture use and all-cause mortality remain unclear due to lake of investigation for the potential interaction between tooth loss and denture use and for the potential changes in these exposur ... Full text Link to item Cite

Long-term exposure to PM2.5 and incidence of disability in activities of daily living among oldest old.

Journal Article Environ Pollut · April 2020 Currently the Chinese government has adopted World Health Organization interim target-1 values as the national ambient air quality standards values. However, the population-based evidence was insufficient, especially for the oldest old (aged 80+). We evalu ... Full text Link to item Cite

A consensus-based framework for conducting and reporting osteoarthritis phenotype research.

Journal Article Arthritis Res Ther · March 20, 2020 BACKGROUND: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition in research design and different approaches to ... Full text Link to item Cite

Specific Leisure Activities and Cognitive Functions Among the Oldest-Old: The Chinese Longitudinal Healthy Longevity Survey.

Journal Article J Gerontol A Biol Sci Med Sci · March 9, 2020 BACKGROUND: Little is known about the role of specific leisure activities in affecting cognitive functions. We aim to examine the associations of specific leisure activities with the risk of cognitive impairment among oldest-old people in China. METHODS: T ... Full text Link to item Cite

Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study.

Journal Article BMJ · March 4, 2020 OBJECTIVES: To evaluate the associations of habitual fish oil supplementation with cardiovascular disease (CVD) and mortality in a large prospective cohort. DESIGN: Population based, prospective cohort study. SETTING: UK Biobank. PARTICIPANTS: A total of 4 ... Full text Link to item Cite

Dysregulated Inflammatory Response Related to Cartilage Degradation after ACL Injury.

Journal Article Med Sci Sports Exerc · March 2020 PURPOSE: Elevated synovial fluid (SF) concentrations of proinflammatory cytokines, degradative enzymes, and cartilage breakdown markers at the time of anterior cruciate ligament (ACL) reconstruction are associated with worse postoperative patient-reported ... Full text Link to item Cite

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.

Journal Article Ann Rheum Dis · March 2020 OBJECTIVE: In these studies, we examined the association of single nucleotide polymorphisms (SNPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis (SKOA) and the risk of incident OA. We also explored these genetic polymorphi ... Full text Link to item Cite

Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism.

Journal Article Nat Metab · March 2020 The immune system plays a multifunctional role throughout the regenerative process, regulating both pro-/anti-inflammatory phases and progenitor cell function. In the present study, we identify the myokine/cytokine Meteorin-like (Metrnl) as a critical regu ... Full text Link to item Cite

Association of cognitive impairment and elderly mortality: differences between two cohorts ascertained 6-years apart in China.

Journal Article BMC Geriatr · January 28, 2020 BACKGROUND: Cognitive impairment is a major contributor to mortality among the elderly. However, the relationship between cognitive impairment evaluated by educational levels and mortality and the trend between cognitive impairment and mortality with time ... Full text Link to item Cite

Infrapatellar fat pad abnormalities are associated with a higher inflammatory synovial fluid cytokine profile in young adults following ACL tear.

Journal Article Osteoarthritis Cartilage · January 2020 OBJECTIVE: To evaluate the degree of knee fat pad abnormalities after acute anterior cruciate ligament (ACL) tear via magnetic resonance fat pad scoring and to assess cross-sectionally its association with synovial fluid biomarkers and with early cartilage ... Full text Link to item Cite

Immune cell extracellular vesicles and their mitochondrial content decline with ageing.

Journal Article Immun Ageing · 2020 BACKGROUND: Although the mechanisms of action are not fully understood, extracellular vesicles (EVs) have emerged as key indicators and effectors of immune function. Characterizing circulating EVs associated with stem and immune cells across the lifespan o ... Full text Link to item Cite

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease

Journal Article Annals of the Rheumatic Diseases · January 1, 2020 Objective in these studies, we examined the association of single nucleotide polymorphisms (snPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis (sKoa) and the risk of incident oa. We also explored these genetic polymorphis ... Full text Cite

Rejuvenation of Neutrophil Functions in Association With Reduced Diabetes Risk Following Ten Weeks of Low-Volume High Intensity Interval Walking in Older Adults With Prediabetes - A Pilot Study.

Journal Article Front Immunol · 2020 Neutrophil dysfunction is a common feature of aging, and is associated with the pathogenesis of many age-related diseases, including type 2 diabetes mellitus (T2DM). Although exercise training improves metabolic health, decreases risk of T2DM, and is assoc ... Full text Link to item Cite

OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis.

Journal Article Osteoarthritis Cartilage · November 2019 OBJECTIVE: To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from ... Full text Link to item Cite

Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.

Journal Article Sci Adv · October 2019 Unlike highly regenerative animals, such as axolotls, humans are believed to be unable to counteract cumulative damage, such as repetitive joint use and injury that lead to the breakdown of cartilage and the development of osteoarthritis. Turnover of insol ... Full text Link to item Cite

Lowering circulating apolipoprotein E levels improves aged bone fracture healing.

Journal Article JCI Insight · September 19, 2019 Age is a well-established risk factor for impaired bone fracture healing. Here, we identify a role for apolipoprotein E (ApoE) in age-associated impairment of bone fracture healing and osteoblast differentiation, and we investigate the mechanism by which A ... Full text Link to item Cite

High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly.

Journal Article J Clin Endocrinol Metab · August 1, 2019 CONTEXT: The patterns of the association between high-density lipoprotein cholesterol (HDL-C) concentrations and mortality among the elderly are still unclear. OBJECTIVE: To examine the association of HDL-C concentrations with mortality and to identify the ... Full text Link to item Cite

Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes.

Journal Article J Clin Endocrinol Metab · August 1, 2019 CONTEXT: The patterns of associations between glycated Hb (HbA1c) and mortality are still unclear. OBJECTIVE: To explore the extent to which ranges of HbA1c levels are associated with the risk of mortality among participants with and without diabetes. DESI ... Full text Link to item Cite

Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials.

Journal Article Arthritis Res Ther · July 15, 2019 OBJECTIVE: To evaluate contextual effects in the form of placebo responses (PRs) for patient-reported pain and function and objectively measured function in osteoarthritis (OA) clinical trials. METHODS: Two authors independently searched major electronic d ... Full text Link to item Cite

Establishing outcome measures in early knee osteoarthritis.

Journal Article Nat Rev Rheumatol · July 2019 The classification and monitoring of individuals with early knee osteoarthritis (OA) are important considerations for the design and evaluation of therapeutic interventions and require the identification of appropriate outcome measures. Potential outcome d ... Full text Link to item Cite

Biomarkers and osteoarthritis

Chapter · June 15, 2019 Genomic and Precision Medicine: Inflammation and Metabolic Disorders. ... Cite

Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.

Journal Article Arthritis Res Ther · June 13, 2019 BACKGROUND: To identify a synovial fluid (SF) biomarker profile characteristic of individuals with an inflammatory osteoarthritis (OA) endotype. METHODS: A total of 48 knees (of 25 participants) were characterized for an extensive array of SF biomarkers qu ... Full text Link to item Cite

Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.

Journal Article Semin Arthritis Rheum · June 2019 BACKGROUND/PURPOSE: To update definitions of multiple joint osteoarthritis (MJOA), and to determine the frequency and impact of MJOA in a community-based cohort. METHODS: Following PRISMA guidelines and with the help of a professional research librarian, w ... Full text Link to item Cite

Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.

Journal Article J Nutr · June 1, 2019 BACKGROUND: High concentrations of plasma 25-hydroxyvitamin D [25(OH)D], a marker of circulating vitamin D, have been associated with a lower risk of mortality in epidemiologic studies of multiple populations, but the association for Chinese adults aged ≥8 ... Full text Link to item Cite

Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.

Journal Article Med Sci Sports Exerc · June 2019 INTRODUCTION: We conducted a systematic umbrella review to evaluate the literature relating to effects of physical activity on pain, physical function, health-related quality of life, comorbid conditions and osteoarthritis (OA) structural disease progressi ... Full text Link to item Cite

Associations between superoxide dismutase, malondialdehyde and all-cause mortality in older adults: a community-based cohort study.

Journal Article BMC Geriatr · April 15, 2019 BACKGROUND: Oxidative stress is an important theory of aging but population-based evidence has been lacking. This study aimed to evaluate the associations between biomarkers of oxidative stress, including plasma superoxide dismutase (SOD) activity and malo ... Full text Open Access Link to item Cite

Joint hypermobility is not positively associated with prevalent multiple joint osteoarthritis: a cross-sectional study of older adults.

Journal Article BMC Musculoskelet Disord · April 11, 2019 BACKGROUND: This cross-sectional study evaluated associations of joint hypermobility and multiple joint osteoarthritis (MJOA) in a community-based cohort of adults 45+ years of age. METHODS: MJOA and joint hypermobility data were from 1677 participants (me ... Full text Link to item Cite

Relationship of joint hypermobility with low Back pain and lumbar spine osteoarthritis.

Journal Article BMC Musculoskelet Disord · April 9, 2019 BACKGROUND: Chronic low back pain (cLBP) affects millions of Americans and costs billions. Studies suggest a link between cLBP and joint hypermobility. METHODS: We conducted cross-sectional primary analyses of joint hypermobility and cLBP, lumbar spine ost ... Full text Link to item Cite

Relationship of Joint Hypermobility with Ankle and Foot Radiographic Osteoarthritis and Symptoms in a Community-Based Cohort.

Journal Article Arthritis Care Res (Hoboken) · April 2019 OBJECTIVE: To explore associations of joint hypermobility (a condition where range of motion is greater than normal) with ankle and foot radiographic osteoarthritis (OA) and symptoms in a large community-based cohort of African American and white adults ag ... Full text Link to item Cite

Proposed study designs for approval based on a surrogate endpoint and a post-marketing confirmatory study under FDA's accelerated approval regulations for disease modifying osteoarthritis drugs.

Journal Article Osteoarthritis Cartilage · April 2019 In 1992, the Food and Drug Administration (FDA) instituted the accelerated approval regulations that allow drugs or biologics for serious conditions that fill an unmet medical need to be approved on the basis of a surrogate endpoint or an intermediate clin ... Full text Link to item Cite

Triglycerides Paradox Among the Oldest Old: "The Lower the Better?".

Journal Article J Am Geriatr Soc · April 2019 OBJECTIVES: Currently, most treatment guidelines suggest lowering hypertriglyceridemia of any severity, even in elderly individuals. However associations of serum triglycerides (TGs) with adverse health and mortality risk decrease with age, it remains uncl ... Full text Link to item Cite

Senescence in osteoarthritis

Conference Osteoarthritis and Cartilage · April 2019 Full text Cite

Dietary Diversity Was Positively Associated with Psychological Resilience among Elders: A Population-Based Study.

Journal Article Nutrients · March 18, 2019 The association between dietary diversity (DD) and psychological resilience among older people is an underdeveloped area of research. This cross-sectional study explored the associations of DD with psychological resilience among 8571 community-based elderl ... Full text Link to item Cite

Safety and Efficacy of Repeat Administration of Triamcinolone Acetonide Extended-release in Osteoarthritis of the Knee: A Phase 3b, Open-label Study.

Journal Article Rheumatol Ther · March 2019 INTRODUCTION: The aim of this work is to assess the safety and efficacy of repeat administration of triamcinolone acetonide extended-release (TA-ER) in patients with symptomatic knee osteoarthritis (OA), including those with advanced radiographic severity. ... Full text Link to item Cite

Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood.

Journal Article J Gerontol A Biol Sci Med Sci · February 15, 2019 Aging is characterized by deleterious immune and metabolic changes, but the onset of these changes is unknown. We measured immune and metabolic biomarkers in adults beginning at age 30. To our knowledge, this is the first study to evaluate these biomarkers ... Full text Open Access Link to item Cite

Association Between Late-Life Blood Pressure and the Incidence of Cognitive Impairment: A Community-Based Prospective Cohort Study.

Journal Article J Am Med Dir Assoc · February 2019 OBJECTIVES: To investigate the association between late-life blood pressure and the incidence of cognitive impairment in older adults. DESIGN: Prospective cohort study. SETTING: Community-living older adults from 22 provinces in China. PARTICIPANTS: We inc ... Full text Link to item Cite

Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.

Journal Article Osteoarthritis Cartilage · January 2019 OBJECTIVE: There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generat ... Full text Open Access Link to item Cite

Plasma MicroRNAs in Established Rheumatoid Arthritis Relate to Adiposity and Altered Plasma and Skeletal Muscle Cytokine and Metabolic Profiles.

Journal Article Front Immunol · 2019 Background: MicroRNAs have been implicated in the pathogenesis of rheumatoid arthritis (RA), obesity, and altered metabolism. Although RA is associated with both obesity and altered metabolism, expression of RA-related microRNA in the setting of these card ... Full text Link to item Cite

Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals.

Journal Article Immun Ageing · 2019 BACKGROUND: The association of high-sensitivity C-reactive protein (hsCRP) with mortality is controversial. We aimed to investigate the associations of hsCRP concentrations with the risks of all-cause and cause-specific mortality and identify potential mod ... Full text Link to item Cite

Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study.

Journal Article Immun Ageing · 2019 BACKGROUND: Inflammatory markers, such as high sensitivity C-reactive protein (hs-CRP), and cognitive impairment (CI) are associated with mortality; CRP is related to the deterioration of CI. However, it is still unknown whether these two indices predict m ... Full text Link to item Cite

Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes.

Journal Article Arthritis Res Ther · December 27, 2018 BACKGROUND: Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise training could improve remodeling, we m ... Full text Open Access Link to item Cite

Biomarkers of inflammation - LBP and TLR- predict progression of knee osteoarthritis in the DOXY clinical trial.

Journal Article Osteoarthritis Cartilage · December 2018 OBJECTIVE: To evaluate systemic inflammatory biomarkers in symptomatic knee osteoarthritis (OA) and their association with radiographic and biochemical OA progression. METHODS: Lipopolysaccharide (LPS) binding protein (LBP), soluble Toll-like receptor 4 (s ... Full text Link to item Cite

Association of Body Mass Index With Disability in Activities of Daily Living Among Chinese Adults 80 Years of Age or Older.

Journal Article JAMA Netw Open · September 7, 2018 IMPORTANCE: Body mass index (BMI) shows a U-shaped association with impaired physical functioning among adults; the association is reduced or eliminated with aging. OBJECTIVE: To examine whether BMI is associated with subsequent disability in activities of ... Full text Link to item Cite

Associations between the chemokine biomarker CCL2 and knee osteoarthritis outcomes: the Johnston County Osteoarthritis Project.

Journal Article Osteoarthritis Cartilage · September 2018 OBJECTIVE: Our study analyzes the association between chemokine-ligand-2 (CCL2) serum concentrations at baseline and knee radiographic osteoarthritis (OA) (knee-rOA), knee-rOA progression, individual radiographic features and knee symptomatic OA at 5-year ... Full text Link to item Cite

Associations of Body Mass Index and Waist Circumference with 3-Year All-Cause Mortality Among the Oldest Old: Evidence from a Chinese Community-Based Prospective Cohort Study.

Journal Article J Am Med Dir Assoc · August 2018 OBJECTIVE: Current international and national guidelines for body mass index (BMI) and waist circumference (WC) have been recommended to all adults. However, whether recommendations applied to the oldest old (aged 80+) is poorly known. The study objective ... Full text Link to item Cite

Analysis of a large data set to identify predictors of blood transfusion in primary total hip and knee arthroplasty.

Journal Article Transfusion · August 2018 BACKGROUND: The aim of this study was to identify the predictors of need for allogenic blood transfusion (ALBT) in primary lower limb total joint arthroplasty (TJA). STUDY DESIGN AND METHODS: This study utilized a large dataset of 15,187 patients undergoin ... Full text Link to item Cite

Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.

Journal Article J Am Geriatr Soc · July 2018 OBJECTIVES: To determine whether combinations of inflammatory markers are related to physical function. DESIGN AND SUBJECTS: secondary analysis of baseline of three observational studies of community-dwelling older adults MEASUREMENTS: The baseline data fr ... Full text Open Access Link to item Cite

Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study.

Journal Article Arthritis Res Ther · June 14, 2018 BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infect ... Full text Open Access Link to item Cite

Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study.

Journal Article BMJ · June 5, 2018 OBJECTIVE: To examine the associations of blood pressure with all cause mortality and cause specific mortality at three years among oldest old people in China. DESIGN: Community based, longitudinal prospective study. SETTING: 2011 and 2014 waves of the Chi ... Full text Link to item Cite

Biomarkers as drug development tools: discovery, validation, qualification and use.

Journal Article Nat Rev Rheumatol · June 2018 The 21st Century Cures Act, approved in the USA in December 2016, has encouraged the establishment of the national Precision Medicine Initiative and the augmentation of efforts to address disease prevention, diagnosis and treatment on the basis of a molecu ... Full text Link to item Cite

Is synovitis detected on non-contrast-enhanced magnetic resonance imaging associated with serum biomarkers and clinical signs of effusion? Data from the Osteoarthritis Initiative.

Journal Article Scand J Rheumatol · May 2018 OBJECTIVES: To determine the relationship between synovitis detected on non-contrast-enhanced (non-CE) magnetic resonance imaging (MRI), biochemical markers of inflammation, and clinical assessment of effusion in people with knee osteoarthritis (OA). METHO ... Full text Link to item Cite

Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial.

Journal Article Osteoarthritis Cartilage · May 2018 OBJECTIVES: Uric acid may activate an innate immune response in osteoarthritis (OA), contributing to disease pathology and progression. We evaluated the effectiveness of colchicine on pain and function in symptomatic knee OA (KOA) and the underlying mechan ... Full text Link to item Cite

Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study.

Journal Article Arthritis Res Ther · April 18, 2018 BACKGROUND: Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, an ... Full text Open Access Link to item Cite

Effects of a Single Intra-Articular Injection of a Microsphere Formulation of Triamcinolone Acetonide on Knee Osteoarthritis Pain: A Double-Blinded, Randomized, Placebo-Controlled, Multinational Study.

Journal Article J Bone Joint Surg Am · April 18, 2018 BACKGROUND: Intra-articular corticosteroids relieve osteoarthritis pain, but rapid systemic absorption limits efficacy. FX006, a novel, microsphere-based, extended-release triamcinolone acetonide (TA) formulation, prolongs TA joint residence and reduces sy ... Full text Open Access Link to item Cite

Upper partial fibulectomy improves knee biomechanics and function and decreases knee pain of osteoarthritis: A pilot and biomechanical study.

Journal Article J Biomech · April 11, 2018 To investigate the change in clinical outcomes and biomechanical properties of the knee in response to upper partial fibulectomy. Sixteen patients with medial compartment knee osteoarthritis (KOA) underwent upper partial fibulectomy. Visual analog scale (V ... Full text Link to item Cite

Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study.

Journal Article Nutrients · April 9, 2018 Although dietary patterns are crucial to cognitive function, associations of dietary patterns with cognitive function have not yet been fully understood. This cross-sectional study explored dietary patterns associated with cognitive function among the olde ... Full text Open Access Link to item Cite

CXCL10 is upregulated in synovium and cartilage following articular fracture.

Journal Article J Orthop Res · April 2018 The objective of this study was to investigate the expression of the chemokine CXCL10 and its role in joint tissues following articular fracture. We hypothesized that CXCL10 is upregulated following articular fracture and contributes to cartilage degradati ... Full text Open Access Link to item Cite

Biomarkers for equine joint injury and osteoarthritis.

Journal Article J Orthop Res · March 2018 We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fractur ... Full text Link to item Cite

Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery.

Journal Article Am J Sports Med · March 2018 BACKGROUND: Anterior cruciate ligament tears can lead to posttraumatic osteoarthritis. In addition to biomechanical factors, changes in biochemical profiles within the knee joint after injury and anterior cruciate ligament reconstruction (ACLR) may play a ... Full text Link to item Cite

Evidence and mechanism by which upper partial fibulectomy improves knee biomechanics and decreases knee pain of osteoarthritis.

Journal Article J Orthop Res · February 9, 2018 To investigate the change in short-term clinical outcomes and biomechanical properties of the knee in response to upper partial fibulectomy and to probe into the biomechanical mechanism underlying the clinical benefits of upper partial fibulectomy for medi ... Full text Link to item Cite

TSG-6 - a double-edged sword for osteoarthritis (OA).

Conference Osteoarthritis Cartilage · February 2018 PURPOSE: To explore mechanisms underlying the association of TSG-6 with osteoarthritis (OA) progression. METHODS: TSG-6-mediated heavy chain (HC) transfer (TSG-6 activity) and its association with inflammatory mediators were quantified in knee OA (n=25) sy ... Full text Link to item Cite

Toward classification criteria for early osteoarthritis of the knee.

Journal Article Semin Arthritis Rheum · February 2018 OBJECTIVE: To propose draft classification criteria for early stage osteoarthritis (OA) of the knee for use in a primary care setting. METHODS: A group of basic scientists, physician-scientists, rheumatologists, orthopedic surgeons, and physiotherapists in ... Full text Link to item Cite

Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA).

Conference Osteoarthritis Cartilage · January 2018 OBJECTIVE: Intra-articular (IA) corticosteroids relieve osteoarthritis (OA) pain, but rapid absorption into systemic circulation may limit efficacy and produce untoward effects. We compared the pharmacokinetics (PK) of IA triamcinolone acetonide (TA) deliv ... Full text Link to item Cite

Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Rheumatol · January 2018 OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structural worsening). METHODS: The Foundation for the National Institutes of He ... Full text Link to item Cite

Radiographic Underestimation of In Vivo Cup Coverage Provided by Total Hip Arthroplasty for Dysplasia.

Journal Article Orthopedics · January 1, 2018 The accuracy of using 2-dimensional anteroposterior pelvic radiography to assess acetabular cup coverage among patients with developmental dysplasia of the hip after total hip arthroplasty (THA) remains unclear in retrospective clinical studies. A group of ... Full text Link to item Cite

Select Biomarkers on the Day of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes at 2-Year Follow-Up: A Pilot Study.

Journal Article Biomed Res Int · 2018 BACKGROUND: The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and the progression of osteoarthritis; ... Full text Open Access Link to item Cite

Intravenous and Topical Tranexamic Acid Alone Are Superior to Tourniquet Use for Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial.

Journal Article J Bone Joint Surg Am · December 20, 2017 BACKGROUND: Tourniquet use during primary total knee arthroplasty is thought to reduce intraoperative blood loss and improve visibility. Our goal was to investigate whether tourniquet use is necessary for controlling intraoperative blood loss when alternat ... Full text Link to item Cite

Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: the Johnston County Osteoarthritis Project.

Conference Osteoarthritis Cartilage · October 2017 OBJECTIVE: To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA. DESIGN: A ... Full text Link to item Cite

Time-Dependent Effects on Synovial Fluid Composition During the Acute Phase of Human Intra-articular Ankle Fracture.

Journal Article Foot Ankle Int · October 2017 BACKGROUND: The study objective was to examine the effect of time and fracture severity on the undiluted synovial fluid (SF) microenvironment during the acute phase following intra-articular fracture (IAF) of the human ankle. METHODS: Ankle SF from 54 pati ... Full text Link to item Cite

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain.

Journal Article Osteoarthritis Cartilage · September 2017 OBJECTIVE: The role of inflammation and pain in osteoarthritis (OA) is not fully understood. We evaluated the association between pro-inflammatory biomarkers and pain. METHODS: We used baseline data and samples from a randomized controlled trial of colchic ... Full text Link to item Cite

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.

Journal Article Arthritis Rheumatol · September 2017 OBJECTIVE: To investigate whether short-term, systemic depletion of macrophages can mitigate osteoarthritis (OA) following injury in the setting of obesity. METHODS: CSF-1R-GFP+ macrophage Fas-induced apoptosis (MaFIA)-transgenic mice that allow conditiona ... Full text Link to item Cite

Cartilage matrix remodelling differs by disease state and joint type.

Journal Article Eur Cell Mater · August 24, 2017 Dramatic alterations in mechanical properties have been documented for osteoarthritic (OA) cartilage. However, the matrix composition underlying these changes has not been mapped and their aetiology is not entirely understood. We hypothesised that an under ... Full text Link to item Cite

Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?

Conference Biomarker Insights · August 22, 2017 Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and differentiated into adipocytes using an established protoco ... Full text Cite

Association Between Biochemical Markers of Bone Turnover and Bone Changes on Imaging: Data From the Osteoarthritis Initiative.

Journal Article Arthritis Care Res (Hoboken) · August 2017 OBJECTIVE: To determine the relationship between biochemical markers involved in bone turnover and bone features on imaging in knees with osteoarthritis (OA). METHODS: We analyzed data from the Foundation for the National Institutes of Health OA Biomarkers ... Full text Link to item Cite

Pain prediction by serum biomarkers of bone turnover in people with knee osteoarthritis: an observational study of TRAcP5b and cathepsin K in OA.

Journal Article Osteoarthritis Cartilage · June 2017 OBJECTIVES: To investigate serum biomarkers, tartrate resistant acid phosphatase 5b (TRAcP5b) and cathepsin K (cath-K), indicative of osteoclastic bone resorption, and their relationship to pain and pain change in knee osteoarthritis (OA). METHODS: Sera an ... Full text Link to item Cite

Inflammatory Microenvironment Persists After Bone Healing in Intra-articular Ankle Fractures.

Journal Article Foot Ankle Int · May 2017 BACKGROUND: Post-traumatic osteoarthritis (PTOA) is responsible for the majority of cases of ankle arthritis. While acute and end-stage intra-articular inflammation has previously been described, the state of the joint between fracture healing and end-stag ... Full text Link to item Cite

Quantitative assessment of cartilage remodeling in health and disease

Conference Osteoarthritis and Cartilage · April 2017 Full text Cite

Logistical challenges and design considerations for studies using acute anterior cruciate ligament injury as a potential model for early posttraumatic osteoarthritis.

Journal Article J Orthop Res · March 2017 Anterior cruciate ligament (ACL) injuries are common and lead to posttraumatic osteoarthritis (PTOA) in a high percentage of patients. Research has been ineffective in identifying successful treatment options for people suffering from symptomatic PTOA resu ... Full text Link to item Cite

Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

Journal Article Lipids Health Dis · February 10, 2017 BACKGROUND: In rheumatoid arthritis (RA), cardiovascular risk is associated with paradoxical reductions in total cholesterol, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C). Concentrations of small LDL (LDL-P) ... Full text Link to item Cite

A Multicenter Study of Early Anti-inflammatory Treatment in Patients With Acute Anterior Cruciate Ligament Tear.

Journal Article Am J Sports Med · February 2017 BACKGROUND: It is increasingly recognized that biochemical abnormalities of the joint precede radiographic abnormalities of posttraumatic osteoarthritis (PTOA) by as much as decades. A growing body of evidence strongly suggests that the progression from an ... Full text Link to item Cite

A U-shaped Association Between Blood Pressure and Cognitive Impairment in Chinese Elderly.

Journal Article J Am Med Dir Assoc · February 1, 2017 OBJECTIVES: Higher or lower blood pressure may relate to cognitive impairment, whereas the relationship between blood pressure and cognitive impairment among the elderly is not well-studied. The study objective was to determine whether blood pressure is as ... Full text Open Access Link to item Cite

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability.

Journal Article Arthritis Res Ther · January 23, 2017 BACKGROUND: To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. METHODS: Persons with seropositive or erosive RA (n = 51) and control subjects matched for age, gender, race, bod ... Full text Open Access Link to item Cite

Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium.

Conference Ann Rheum Dis · January 2017 OBJECTIVE: To establish reference intervals for osteoarthritis (OA)-related biomarkers used in the Foundation for the National Institutes of Health (FNIH) OA Biomarkers Consortium Project. METHODS: A total of 129 'multijoint controls' were selected from 27 ... Full text Link to item Cite

Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium.

Journal Article Ann Rheum Dis · January 2017 OBJECTIVE: To investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression. METHODS: Eighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases ( ... Full text Link to item Cite

Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules.

Journal Article Osteoarthritis Cartilage · January 2017 OBJECTIVE: To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate (CS). DESIGN: THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration deter ... Full text Link to item Cite

Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.

Journal Article Connect Tissue Res · 2017 PURPOSE: Meniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study is to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compar ... Full text Link to item Cite

Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.

Journal Article Rheumatology (Oxford) · January 2017 OBJECTIVE: Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes ... Full text Link to item Cite

Cytokine biomarkers in tear film for primary open-angle glaucoma.

Journal Article Clin Ophthalmol · 2017 PURPOSE: To determine the utility of tear film cytokines as biomarkers for early primary open-angle glaucoma (POAG). METHODS: Patients without POAG and eye drop-naïve patients with newly diagnosed POAG were recruited from an academic hospital-based glaucom ... Full text Open Access Link to item Cite

Dietary Diversity and Cognitive Function among Elderly People: A Population-Based Study.

Journal Article J Nutr Health Aging · 2017 OBJECTIVES: To explore associations of dietary diversity with cognitive function among Chinese elderly. DESIGN: This cross-sectional study was conducted in 2011-2012, data were analyzed using multiple linear regression and logistic regression models. SETTI ... Full text Link to item Cite

Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?

Journal Article Biomark Insights · 2017 Monocyte chemoattractant protein-1 (MCP-1) overproduction from inflamed adipose tissue is a major contributor to obesity-related metabolic syndromes. 3T3-L1 embryonic fibroblasts were cultured and differentiated into adipocytes using an established protoco ... Full text Open Access Link to item Cite

Serum N-propeptide of collagen IIA (PIIANP) as a marker of radiographic osteoarthritis burden.

Journal Article PLoS One · 2017 OBJECTIVE: Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomark ... Full text Open Access Link to item Cite

Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future.

Journal Article Osteoarthritis Cartilage · December 2016 Osteoarthritis (OA) is the biggest unmet medical need among the many musculoskeletal conditions and the most common form of arthritis. It is a major cause of disability and impaired quality of life in the elderly. We review several ambitious but failed att ... Full text Link to item Cite

Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change.

Journal Article BMC Musculoskelet Disord · November 10, 2016 BACKGROUND: To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month per ... Full text Open Access Link to item Cite

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

Journal Article J Gerontol A Biol Sci Med Sci · November 2016 BACKGROUND: Older age and obesity are associated with metabolic dysregulation; the mechanism by which these factors impact metabolism across the lifespan is important, but relatively unknown. We evaluated a panel of amino acids (AAs) and acylcarnitines (AC ... Full text Link to item Cite

Semiquantitative Imaging Biomarkers of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Rheumatol · October 2016 OBJECTIVE: To determine the association between changes in semiquantitative magnetic resonance imaging (MRI) biomarkers over 24 months and radiographic and pain progression over 48 months in knees with mild-to-moderate osteoarthritis (OA). METHODS: We unde ... Full text Link to item Cite

Both systemic and local lipopolysaccharide (LPS) burden are associated with knee OA severity and inflammation.

Journal Article Osteoarthritis Cartilage · October 2016 OBJECTIVE: The microbiome is recognized as a new frontier in medicine with connections to a variety of diseases. We aimed to evaluate the association of lipopolysaccharide (LPS), a key pro-inflammatory product of the microbiome, with severity of inflammati ... Full text Link to item Cite

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Journal Article PLoS Genet · October 2016 Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage t ... Full text Open Access Link to item Cite

Longitudinal validation of periarticular bone area and 3D shape as biomarkers for knee OA progression? Data from the FNIH OA Biomarkers Consortium.

Journal Article Ann Rheum Dis · September 2016 OBJECTIVE: To perform a longitudinal validation study of imaging bone biomarkers of knee osteoarthritis (OA) progression. METHODS: We undertook a nested case-control study within the Osteoarthritis Initiative in knees (one knee per subject) with a Kellgren ... Full text Link to item Cite

Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats.

Journal Article J Gerontol A Biol Sci Med Sci · September 2016 The infrapatellar fat pad (IFP) secretes inflammatory mediators in osteoarthritic knees, but the effect of aging on IFP inflammation is unknown. We tested the hypothesis that aging increases basal and interleukin-1β (IL-1β)-stimulated IFP inflammation in 1 ... Full text Link to item Cite

Exploratory secondary analyses of a cognitive-behavioral intervention for knee osteoarthritis demonstrate reduction in biomarkers of adipocyte inflammation.

Journal Article Osteoarthritis Cartilage · September 2016 OBJECTIVE: To investigate the effects of pain coping skills training (PCST) and a lifestyle behavioral weight management (BWM) program on inflammatory markers and biomarker associations with pain and function in the OA LIFE study. METHOD: Serum samples wer ... Full text Link to item Cite

Direct in vivo evidence of activated macrophages in human osteoarthritis.

Conference Osteoarthritis Cartilage · September 2016 OBJECTIVE: Through binding to folate receptor-β (FR-β), the new (99m)Tc-EC20 (Etarfolatide) imaging technique detects activated but not resting macrophages in vivo. The goal of this study was to investigate macrophage-related inflammation in osteoarthritis ... Full text Link to item Cite

Osteoarthritis in physical medicine and rehabilitation.

Journal Article Ann Phys Rehabil Med · June 2016 Full text Link to item Cite

A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls.

Journal Article Arthritis Res Ther · April 12, 2016 BACKGROUND: RA and CVD both have inflammation as part of the underlying biology. Our objective was to explore the relationships of GlycA, a measure of glycosylated acute phase proteins, with inflammation and cardiometabolic risk in RA, and explore whether ... Full text Open Access Link to item Cite

Association of synovial fluid inflammatory biomarkers and knee pain

Conference Osteoarthritis and Cartilage · April 2016 Full text Cite

A big data approach for selection of a large osteoarthritis cohort

Conference Osteoarthritis and Cartilage · April 2016 Full text Cite

In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy.

Journal Article Eur J Pain · March 2016 BACKGROUND: Methods for the detection of the temporal and spatial generation of painful symptoms are needed to improve the diagnosis and treatment of painful neuropathies and to aid preclinical screening of molecular therapeutics. METHODS: In this study, w ... Full text Link to item Cite

Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly.

Journal Article J Nutr Health Aging · March 2016 OBJECTIVES: The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance ... Full text Open Access Link to item Cite

Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly

Journal Article Journal of Nutrition, Health and Aging · March 1, 2016 Objectives: The association between cognitive function and cholesterol levels is poorly understood and inconsistent results exist among the elderly. The purpose of this study is to investigate the association of cholesterol level with cognitive performance ... Full text Open Access Cite

Elucidating the Molecular Composition of Cartilage by Proteomics.

Journal Article J Proteome Res · February 5, 2016 Articular cartilage consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. Most prior studies defining the zonal distribution of cartilage have extracted proteins with guanidine-HCl. However, an unex ... Full text Open Access Link to item Cite

A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.

Journal Article J Gerontol A Biol Sci Med Sci · February 2016 Understanding associations between circulating biomarkers and physical performance across the adult life span could aid in better describing mechanistic pathways leading to disability. We hypothesized that high concentrations of circulating biomarkers woul ... Full text Link to item Cite

Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage.

Journal Article Osteoarthritis Cartilage · February 2016 OBJECTIVE: We investigated tissue turnover in healthy and osteoarthritic cartilage. We challenge long held views that osteoarthritis (OA) is dominated by a similar turnover process in all joints and present evidence that hip and knee cartilage respond very ... Full text Link to item Cite

Does lipopolysaccharide-mediated inflammation have a role in OA?

Journal Article Nat Rev Rheumatol · February 2016 The nature of the gastrointestinal microbiome determines the reservoir of lipopolysaccharide, which can migrate from the gut into the circulation, where it contributes to low-grade inflammation. Osteoarthritis (OA) is a low-grade inflammatory condition, an ... Full text Link to item Cite

Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment?

Journal Article Scand J Rheumatol · 2016 The disabling and painful disease osteoarthritis (OA) is the most common form of arthritis. Strong evidence suggests that a subpopulation of OA patients has a form of OA driven by inflammation. Consequently, understanding when inflammation is the driver of ... Full text Link to item Cite

The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis.

Journal Article Arthritis Res Ther · December 15, 2015 BACKGROUND: In recent decades, low-level laser therapy (LLLT) has been widely used to relieve pain caused by different musculoskeletal disorders. Though widely used, its reported therapeutic outcomes are varied and conflicting. Results similarly conflict r ... Full text Open Access Link to item Cite

Xanthine oxidase injurious response in acute joint injury.

Journal Article Clin Chim Acta · December 7, 2015 BACKGROUND: While acute trauma is a major cause of osteoarthritis, its etiology is poorly understood. We sought to determine whether xanthine oxidase (XO), a major producer of reactive oxygen species, plays a role in the early events of acute joint injury. ... Full text Open Access Link to item Cite

Colchicine--Update on mechanisms of action and therapeutic uses.

Journal Article Semin Arthritis Rheum · December 2015 OBJECTIVES: To review the literature and provide an update on the mechanisms of action and therapeutic uses of oral colchicine in arthritis and inflammatory conditions. METHODS: We performed PubMed database searches through June 2014 for relevant studies i ... Full text Link to item Cite

Atlas of radiographic features of osteoarthritis of the ankle and hindfoot.

Journal Article Osteoarthritis Cartilage · December 2015 OBJECTIVE: To develop a radiographic atlas of osteoarthritis (OA) for use as a template and guide for standardized scoring of radiographic features of OA of the ankle and hindfoot joints. METHOD: Under Institutional Review Board approval, ankle and hindfoo ... Full text Link to item Cite

Brief Report: Cartilage Thickness Change as an Imaging Biomarker of Knee Osteoarthritis Progression: Data From the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Rheumatol · December 2015 OBJECTIVE: To investigate the association of cartilage thickness change over 24 months, as determined by magnetic resonance imaging (MRI), with knee osteoarthritis (OA) progression at 24-48 months. METHODS: This nested case-control study included 600 knees ... Full text Link to item Cite

ATTENTUATION OF HYALURONAN FRAGMENT INDUCED INFLAMMATORY RESPONSE IN MACROPHAGES BY CHONDROITIN SULPHATE

Journal Article BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY · December 1, 2015 Link to item Cite

Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.

Journal Article Ann Rheum Dis · November 2015 OBJECTIVE: The mechanisms linking obesity and osteoarthritis (OA) are not fully understood and have been generally attributed to increased weight, rather than metabolic or inflammatory factors. Here, we examined the influence of fatty acids, adipokines, an ... Full text Link to item Cite

Low-grade inflammation in symptomatic knee osteoarthritis: prognostic value of inflammatory plasma lipids and peripheral blood leukocyte biomarkers.

Journal Article Arthritis Rheumatol · November 2015 OBJECTIVE: Inflammatory mediators, such as prostaglandin E2 (PGE2 ) and interleukin-1β (IL-1β), are produced by osteoarthritic (OA) joint tissue, where they may contribute to disease pathogenesis. We undertook the present study to examine whether inflammat ... Full text Link to item Cite

Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans.

Journal Article J Med Genet · November 2015 OBJECTIVE: Hallux valgus (HV) affects ∼36% of Caucasian adults. Although considered highly heritable, the underlying genetic determinants are unclear. We conducted the first genome-wide association study (GWAS) aimed to identify genetic variants associated ... Full text Link to item Cite

Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture.

Journal Article Foot Ankle Int · November 2015 BACKGROUND: Posttraumatic osteoarthritis (PTOA) can occur after intra-articular fracture despite anatomic fracture reduction. It has been hypothesized that an early inflammatory response after intra-articular injury could lead to irreversible cartilage dam ... Full text Link to item Cite

Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · November 2015 OBJECTIVE: Pro- and anti-inflammatory mediators, such as IL-1β and IL1Ra, are produced by joint tissues in osteoarthritis (OA), where they may contribute to pathogenesis. We examined whether inflammatory events occurring within joints are reflected in plas ... Full text Link to item Cite

Inflammatory biomarkers in osteoarthritis.

Journal Article Osteoarthritis Cartilage · November 2015 Osteoarthritis (OA) is highly prevalent and a leading cause of disability worldwide. Despite the global burden of OA, diagnostic tests and treatments for the molecular or early subclinical stages are still not available for clinical use. In recent years, t ... Full text Link to item Cite

Effectiveness of low-level laser therapy in patients with knee osteoarthritis: a systematic review and meta-analysis.

Journal Article Osteoarthritis Cartilage · September 2015 OBJECTIVE: To investigate the efficacy of low-level laser therapy (LLLT) treatment of knee osteoarthritis (KOA) by a systematic literature search with meta-analyses on selected studies. DESIGN: MEDLINE, EMBASE, ISI Web of Science and Cochrane Library were ... Full text Link to item Cite

Therapeutic opportunities to prevent post-traumatic arthritis: Lessons from the natural history of arthritis after articular fracture.

Journal Article J Orthop Res · September 2015 An estimated 12% of patients seeking surgical intervention for symptomatic arthritis have an etiology of post-traumatic arthritis (PTA). The onset of PTA is rapid in the setting of articular fracture (AF). The investigation began with development of a muri ... Full text Link to item Cite

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use.

Journal Article Osteoarthritis Cartilage · August 2015 Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for OA that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease co ... Full text Link to item Cite

Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study.

Journal Article Osteoarthritis Cartilage · June 2015 OBJECTIVE: Kashin-Beck Disease (KBD) is a rare and severe osteoarthropathy endemic to China. We evaluated the frequency and patterns of hand radiographic osteoarthritis (rOA) in adults with and without KBD. METHODS: Han Chinese (N = 438) from Yongshou Coun ... Full text Link to item Cite

Articular ankle fracture results in increased synovitis, synovial macrophage infiltration, and synovial fluid concentrations of inflammatory cytokines and chemokines.

Journal Article Arthritis Rheumatol · May 2015 OBJECTIVE: The inflammatory response following an articular fracture is thought to play a role in the development of posttraumatic arthritis (PTA) but has not been well characterized. The objective of this study was to characterize the acute inflammatory r ... Full text Link to item Cite

OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.

Journal Article Osteoarthritis Cartilage · May 2015 The objective of this work was to describe requirements for inclusion of soluble biomarkers in osteoarthritis (OA) clinical trials and progress toward OA-related biomarker qualification. The Guidelines for Biomarkers Working Group, representing experts in ... Full text Link to item Cite

OARSI Clinical Trials Recommendations: Design and conduct of clinical trials for hand osteoarthritis.

Journal Article Osteoarthritis Cartilage · May 2015 Hand osteoarthritis (OA) is a very frequent disease, but yet understudied. However, a lot of works have been published in the past 10 years, and much has been done to better understand its clinical course and structural progression. Despite this new knowle ... Full text Link to item Cite

Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.

Journal Article Trials · April 30, 2015 BACKGROUND: Despite the high prevalence and global impact of knee osteoarthritis (KOA), current treatments are palliative. No disease modifying anti-osteoarthritic drug (DMOAD) has been approved. We recently demonstrated significant involvement of uric aci ... Full text Open Access Link to item Cite

Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis.

Journal Article Arthritis Rheumatol · April 2015 OBJECTIVE: To evaluate the ability of the macrophage markers CD163 and CD14 to predict different osteoarthritis (OA) phenotypes defined by severity of joint inflammation, radiographic features and progression, and joint pain. METHODS: We evaluated 2 differ ... Full text Link to item Cite

Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.

Journal Article Osteoarthritis Cartilage · April 2015 OBJECTIVE: To identify disease relevant genes and pathways associated with knee Osteoarthritis (OA) progression in human subjects using medial and lateral compartment dominant OA knee tissue. DESIGN: Gene expression of knee cartilage was comprehensively as ... Full text Link to item Cite

OA phenotypes, rather than disease stage, drive structural progression--identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA.

Journal Article Osteoarthritis Cartilage · April 2015 BACKGROUND/PURPOSE: The aim of this study was to identify key characteristics of disease progression through investigation of the association of radiographic progression over two years with baseline Joint Space Width (JSW), Kellgren-Lawrence (KL) grade, We ... Full text Link to item Cite

Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.

Journal Article Atherosclerosis · March 2015 OBJECTIVE: Low-density lipoprotein cholesterol (LDL-C) is a risk factor for survival in middle-aged individuals, but conflicting evidence exists on the relationship between LDL-C and all-cause mortality among the elderly. The goal of this study was to asse ... Full text Open Access Link to item Cite

The role of innate immunity in osteoarthritis: when our first line of defense goes on the offensive.

Journal Article J Rheumatol · March 2015 Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis remains poorly understood. OA is no longer considered a "wear and tear" condition but rather one driven by proteases where chronic low-grade inflammation may play a role ... Full text Link to item Cite

Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.

Journal Article Eur Cell Mater · January 31, 2015 Post-traumatic arthritis (PTA) is a rapidly progressive form of arthritis that develops due to joint injury, including articular fracture. Current treatments are limited to surgical restoration and stabilization of the joint; however, evidence suggests tha ... Full text Link to item Cite

Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression.

Journal Article Osteoarthritis Cartilage · January 2015 OBJECTIVE: We investigated the relationship between the molecular weight (MW) distribution of hyaluronan (HA) in synovial fluid (SF) and risk of knee osteoarthritis (OA) progression. METHODS: HA MW was analyzed for 65 baseline knee SFs. At 3-year follow-up ... Full text Link to item Cite

Biomarkers of PTA

Chapter · January 1, 2015 Prognostic biomarkers may indicate the likelihood of disease development and speed of progression or may serve as predictive indicators of responsiveness to treatment. Joint injuries, particularly severe injuries, may result in post-traumatic osteoarthriti ... Full text Open Access Cite

Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): Study protocol for a randomized controlled trial

Journal Article Trials · 2015 © Leung et al.Background: Despite the high prevalence and global impact of knee osteoarthritis (KOA), current treatments are palliative. No disease modifying anti-osteoarthritic drug (DMOAD) has been approved. We recently demonstrated significant involveme ... Full text Cite

Adipose depots, not disease-related factors, account for skeletal muscle insulin sensitivity in established and treated rheumatoid arthritis.

Journal Article J Rheumatol · October 2014 OBJECTIVE: In prior reports, individuals with rheumatoid arthritis (RA) exhibited increased insulin resistance. However, those studies were limited by either suboptimal assessment methods for insulin sensitivity or a failure to account for important determ ... Full text Link to item Cite

Biomarkers and proteomic analysis of osteoarthritis.

Other Matrix Biol · October 2014 Our friend and colleague, Dr. Dick Heinegård, contributed greatly to the understanding of joint tissue biochemistry, the discovery and validation of arthritis-related biomarkers and the establishment of methodology for proteomic studies in osteoarthritis ( ... Full text Open Access Link to item Cite

Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?

Journal Article BMC Musculoskelet Disord · September 27, 2014 BACKGROUND: Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested in gout. In vitro, CS has anti-inflammatory and positive effects on osteoarthritic ... Full text Open Access Link to item Cite

Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis.

Journal Article Arthritis Rheumatol · September 2014 OBJECTIVE: To evaluate joint tissue remodeling using the urinary collagen biomarkers urinary α-C-telopeptide of type I collagen (α-CTX) and urinary C-telopeptide of type II collagen (CTX-II) and to determine the association of these biomarkers with osteoar ... Full text Link to item Cite

Gender-dependent association of body mass index and waist circumference with disability in the Chinese oldest old.

Journal Article Obesity (Silver Spring) · August 2014 OBJECTIVES: To explore associations of BMI and waist circumference (WC) with disability among the Chinese oldest old. METHODS: The 5,495 oldest old in the sixth wave of Chinese Longitudinal Healthy Longevity Study conducted in 2011 were included in this st ... Full text Open Access Link to item Cite

Targeting pro-inflammatory cytokines following joint injury: acute intra-articular inhibition of interleukin-1 following knee injury prevents post-traumatic arthritis.

Journal Article Arthritis Res Ther · June 25, 2014 INTRODUCTION: Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1(IL-1) and tumor necrosis factor alpha (TNF-α), are acutely elevated following jo ... Full text Open Access Link to item Cite

Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.

Journal Article J Rheumatol · May 2014 OBJECTIVE: To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade ≥ 2], symptoms, and function. METHODS: Cross-sectional data were available for 663 participants ... Full text Link to item Cite

Released macrophage markers as predictors of knee OA progression

Conference Osteoarthritis and Cartilage · April 2014 Full text Cite

Osteoarthritis: The zinc link.

Journal Article Nature · March 27, 2014 Full text Link to item Cite

In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis.

Journal Article Arthritis Rheumatol · March 2014 OBJECTIVE: To investigate the relationship between NF-κB activity, cytokine levels, and pain sensitivities in a rodent model of osteoarthritis (OA). METHODS: OA was induced in transgenic NF-κB-luciferase reporter mice via intraarticular injection of monoso ... Full text Open Access Link to item Cite

Value of biomarkers in osteoarthritis: Current status and perspectives

Journal Article Postgraduate Medical Journal · March 1, 2014 Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article w ... Full text Cite

TSG-6 activity as a novel biomarker of progression in knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · February 2014 OBJECTIVE: To establish whether there is an association between TSG-6 activity and osteoarthritis progression. DESIGN: TSG-6 activity was determined in 132 synovial fluids from patients with OA of the knee, using a novel quantitative TSG-6 activity assay. ... Full text Link to item Cite

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

Journal Article Ann Rheum Dis · February 2014 Osteoarthritis (OA) is the most common form of arthritic disease, and a major cause of disability and impaired quality of life in the elderly. OA is a complex disease of the entire joint, affecting bone, cartilage and synovium that thereby presents multipl ... Full text Link to item Cite

Biomarkers for osteoarthritis: current position and steps towards further validation.

Journal Article Best Pract Res Clin Rheumatol · February 2014 Historically disease knowledge development and treatment innovation in osteoarthritis (OA) has been considered to be slow. One of the many reasons purported as responsible for this slow pace has been the alleged lack of valid and responsive biomarkers to a ... Full text Link to item Cite

Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: Pre-clinical model for gout prophylaxis?

Journal Article BMC Musculoskeletal Disorders · January 1, 2014 Background: Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested in gout. In vitro, CS has anti-inflammatory and positive effects on osteoarthritic ... Full text Open Access Cite

Osteoarthritis--a case for personalized health care?

Journal Article Osteoarthritis Cartilage · January 2014 For both economic and ethical reasons, identification of the optimal treatment for each individual patient is a pressing concern, not only for the patients and their physician, but also health care payers and the pharmaceutical industry. In the field of os ... Full text Link to item Cite

The role of cytokines in posttraumatic arthritis.

Journal Article J Am Acad Orthop Surg · January 2014 The development of arthritis after joint injury is commonly known as posttraumatic arthritis (PTA). The inciting traumatic event may range from cartilage contusion and bone bruise combined with meniscus or ligament tear, to intra-articular fracture. End-st ... Full text Link to item Cite

Composite measures of multi-joint symptoms, but not of radiographic osteoarthritis, are associated with functional outcomes: the Johnston County Osteoarthritis Project.

Journal Article Disabil Rehabil · 2014 PURPOSE: To determine associations between multiple joint symptoms and radiographic osteoarthritis (rOA) and functional outcomes. METHOD: Complete cross-sectional data for multi-joint symptoms and radiographs, Health Assessment Questionnaire (HAQ) scores, ... Full text Link to item Cite

Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.

Journal Article PLoS One · 2014 ZDHHC13 is a member of DHHC-containing palmitoyl acyltransferases (PATs) family of enzymes. It functions by post-translationally adding 16-carbon palmitate to proteins through a thioester linkage. We have previously shown that mice carrying a recessive Zdh ... Full text Open Access Link to item Cite

Progress in intra-articular therapy.

Journal Article Nat Rev Rheumatol · January 2014 Diarthrodial joints are well suited to intra-articular injection, and the local delivery of therapeutics in this fashion brings several potential advantages to the treatment of a wide range of arthropathies. Possible benefits over systemic delivery include ... Full text Open Access Link to item Cite

A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information.

Journal Article BMC Bioinformatics · December 16, 2013 BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, specifically label-free LC-MS/MS, a ... Full text Open Access Link to item Cite

High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment.

Journal Article Osteoarthritis Cartilage · November 2013 OBJECTIVE: To evaluate ankle joint abnormalities in a knee osteoarthritis (OA) cohort. METHODS: Participants (n = 159) with symptomatic and radiographic OA in at least one knee underwent technetium-99m methylene diphosphonate bone scan (scored 0-3) of the ... Full text Link to item Cite

Value of biomarkers in osteoarthritis: current status and perspectives.

Journal Article Ann Rheum Dis · November 2013 Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article w ... Full text Link to item Cite

THE EFFECTS OF CHONDROITIN SULFATE ON INFLAMMASOME ACTIVATION

Journal Article BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY · September 1, 2013 Link to item Cite

Osteoarthritis

Journal Article · August 29, 2013 Full text Cite

Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression.

Journal Article Arthritis Rheum · July 2013 OBJECTIVE: To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. METHODS: Longitudinal (baseline, 12-month, and 24-month) knee radiographs were available for 60 female subjects with k ... Full text Link to item Cite

Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop.

Journal Article Osteoarthritis Cartilage · July 2013 UNLABELLED: The sixth Osteoarthritis Research Society International (OARSI) Workshop on Imaging in Osteoarthritis combined with the third osteoarthritis (OA) Biomarkers Workshop is the first to bring together the imaging and molecular biomarker communities ... Full text Link to item Cite

THE EFFECTS OF CHONDROITIN SULPHATE ON INFLAMMASOME ACTIVATION

Journal Article ANNALS OF THE RHEUMATIC DISEASES · June 1, 2013 Link to item Cite

Prolonged local delivery of IL-1Ra prevents post-traumatic arthritis in mice

Journal Article Osteoarthritis and Cartilage · April 2013 Full text Cite

The effects of chondroitin sulphate on inflammasome activation

Conference Osteoarthritis and Cartilage · April 2013 Full text Cite

Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study.

Journal Article BMC Musculoskelet Disord · March 27, 2013 BACKGROUND: Little is known about the relationships of circulating levels of biomarkers of cartilage degradation with biomechanical outcomes relevant to knee osteoarthritis (OA) or biomarker changes following non-pharmacological interventions. The objectiv ... Full text Open Access Link to item Cite

Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice.

Journal Article Arthritis Rheum · March 2013 OBJECTIVE: To examine the relationship between inflammation and posttraumatic arthritis (PTA) in a murine intraarticular fracture model. METHODS: Male C57BL/6 and MRL/MpJ "superhealer" mice received tibial plateau fractures using a previously established m ... Full text Link to item Cite

Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees.

Journal Article Osteoarthritis Cartilage · March 2013 OBJECTIVE: To evaluate the interaction of articular cartilage (AC) and subchondral bone (SB) through analysis of osteoarthritis (OA)-related genes of site-matched tissue. DESIGN: We developed a novel method for isolating site-matched overlying AC and under ... Full text Link to item Cite

Brief report: differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: the Johnston County Osteoarthritis Project.

Journal Article Arthritis Rheum · February 2013 OBJECTIVE: To determine differences in the phenotypes (patterns) of multiple-joint symptomatic osteoarthritis (OA) involvement by race and sex. METHODS: A cross-sectional analysis of symptomatic OA phenotypes was performed in a community-based cohort, comp ... Full text Link to item Cite

Value of biomarkers in osteoarthritis: Current status and perspectives

Journal Article Annals of the Rheumatic Diseases · 2013 Osteoarthritis affects the whole joint structure with progressive changes in cartilage, menisci, ligaments and subchondral bone, and synovial inflammation. Biomarkers are being developed to quantify joint remodelling and disease progression. This article w ... Full text Cite

Genome-wide expression profiles of subchondral bone in osteoarthritis.

Journal Article Arthritis Res Ther · 2013 INTRODUCTION: The aim of this study was to evaluate, for the first time, the differences in gene expression profiles of normal and osteoarthritic (OA) subchondral bone in human subjects. METHODS: Following histological assessment of the integrity of overly ... Full text Open Access Link to item Cite

Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.

Journal Article Cell Transplant · 2013 Joint injury dramatically enhances the onset of osteoarthritis (OA) and is responsible for an estimated 12% of OA. Posttraumatic arthritis (PTA) is especially common after intra-articular fracture, and no disease-modifying therapies are currently available ... Full text Link to item Cite

Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family.

Journal Article PLoS One · 2013 Given the importance of cardiovascular disease (CVD) to public health and the demonstrated heritability of both disease status and its related risk factors, identifying the genetic variation underlying these susceptibilities is a critical step in understan ... Full text Open Access Link to item Cite

Osteoarthritis

Chapter · November 15, 2012 Full text Cite

Association between serum and urine biomarkers and lumbar spine individual radiographic features: the Johnston County Osteoarthritis Project.

Journal Article Osteoarthritis Cartilage · November 2012 OBJECTIVE: (1) To determine associations between radiographic features of lumbosacral (LS) spine disc space narrowing (DSN) and osteophytes (OST) and joint metabolism biomarkers (serum cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), colla ... Full text Link to item Cite

The role of cartilage degradation biomarkers in understanding the development of post-traumatic osteoarthritis following acute articular cartilage damage - A review

Journal Article European Musculoskeletal Review · October 3, 2012 It is known that patients who suffer acute anterior cruciate ligament (ACL) injury are highly likely to develop post-traumatic osteoarthritis (PTOA) later in life. ACL injury is associated with concomitant acute articular damage. It is unclear why patients ... Cite

Lumbar spine radiographic features and demographic, clinical, and radiographic knee, hip, and hand osteoarthritis.

Journal Article Arthritis Care Res (Hoboken) · October 2012 OBJECTIVE: To determine the prevalence of lumbar spine individual radiographic features (IRFs) of disc space narrowing (DSN), osteophytes (OST), and facet joint osteoarthritis (FOA); to describe the frequencies of demographic, clinical, and radiographic kn ... Full text Link to item Cite

Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice.

Journal Article Arthritis Rheum · October 2012 OBJECTIVE: Obesity and joint injury are primary risk factors for osteoarthritis (OA) that involve potential alterations in the biomechanical and inflammatory environments of the joint. Posttraumatic arthritis is a frequent long-term complication of intraar ... Full text Link to item Cite

High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old.

Journal Article Age Ageing · September 2012 OBJECTIVE: to explore the relationship between blood lipids/lipoproteins and cognitive function in the Chinese oldest-old. DESIGN: multivariate statistical analysis using cross-sectional data. SETTING: community-based setting in longevity areas in China. S ... Full text Link to item Cite

Daily Variation of Serum Acylcarnitines and Amino Acids.

Journal Article Metabolomics · August 2012 To characterize daily variation of amino acids (AAs) and acylcarnitines (ACs) in response to feeding and activity, we measured serum metabolites at various times and after various activities during the day. Subjects were admitted overnight for serial serum ... Full text Link to item Cite

Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study.

Journal Article Pain · June 2012 Overweight and obese patients with osteoarthritis (OA) experience more OA pain and disability than patients who are not overweight. This study examined the long-term efficacy of a combined pain coping skills training (PCST) and lifestyle behavioral weight ... Full text Link to item Cite

High sensitivity C-reactive protein associated with different health predictors in middle-aged and oldest old Chinese.

Journal Article Biomed Environ Sci · June 2012 OBJECTIVE: To describe the distribution of plasma high sensitivity C-reactive protein (hsCRP) and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China. METHODS: 268 individuals aged between 40 ... Full text Link to item Cite

DIO2 modifies inflammatory responses in chondrocytes.

Journal Article Osteoarthritis Cartilage · May 2012 OBJECTIVE: Selenium neutralizes interleukin-1β (IL-1β) induced inflammatory responses in chondrocytes. We investigated potential mechanisms for this through in vitro knock down of three major selenoproteins, Iodothyronine Deiodinase-2 (DIO2), Glutathione P ... Full text Link to item Cite

Kinematic and dynamic gait compensations resulting from knee instability in a rat model of osteoarthritis.

Journal Article Arthritis Res Ther · April 17, 2012 INTRODUCTION: Osteoarthritis (OA) results in pain and disability; however, preclinical OA models often focus on joint-level changes. Gait analysis is one method used to evaluate both preclinical OA models and OA patients. The objective of this study is to ... Full text Open Access Link to item Cite

Effects of intraarticular IL1-Ra for acute anterior cruciate ligament knee injury: a randomized controlled pilot trial (NCT00332254).

Journal Article Osteoarthritis Cartilage · April 2012 OBJECTIVE: To evaluate the clinical effectiveness of intraarticular IL-1 receptor antagonist (IL-1Ra) for anterior cruciate ligament (ACL) tear. METHODS: Eleven patients with acute ACL tear confirmed by magnetic resonance imaging (MRI) were randomized to r ... Full text Link to item Cite

Biologics in relapsing polychondritis: a literature review.

Journal Article Semin Arthritis Rheum · April 2012 BACKGROUND: There is no standardized therapeutic protocol for relapsing polychondritis (RP). Emergence of biologics holds much hope in the management of this connective tissue disease. OBJECTIVES: To evaluate the efficacy and safety of biologics in patient ... Full text Link to item Cite

Protein modification by deamidation indicates variations in joint extracellular matrix turnover.

Journal Article J Biol Chem · February 10, 2012 As extracellular proteins age, they undergo and accumulate nonenzymatic post-translational modifications that cannot be repaired. We hypothesized that these could be used to systemically monitor loss of extracellular matrix due to chronic arthritic disease ... Full text Link to item Cite

Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise.

Journal Article Arthritis Rheum · February 2012 OBJECTIVE: To test the hypotheses that obesity due to a very high-fat diet induces knee osteoarthritis (OA), and that short-term wheel-running exercise protects against obesity-induced knee OA by reducing systemic inflammation and metabolic dysregulation. ... Full text Link to item Cite

Caloric restriction alters the metabolic response to a mixed-meal: results from a randomized, controlled trial.

Journal Article PLoS One · 2012 OBJECTIVES: To determine if caloric restriction (CR) would cause changes in plasma metabolic intermediates in response to a mixed meal, suggestive of changes in the capacity to adapt fuel oxidation to fuel availability or metabolic flexibility, and to dete ... Full text Open Access Link to item Cite

The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records.

Journal Article Am J Transl Res · 2012 BACKGROUND: Facing critically low return per dollar invested on clinical research and clinical care, the American biomedical enterprise is in need of a significant transformation. A confluence of high-throughput "omic" technologies and increasing adoption ... Link to item Cite

Critical appraisal of four IL-6 immunoassays.

Journal Article PLoS One · 2012 BACKGROUND: Interleukin-6 (IL-6) contributes to numerous inflammatory, metabolic, and physiologic pathways of disease. We evaluated four IL-6 immunoassays in order to identify a reliable assay for studies of metabolic and physical function. Serial plasma s ... Full text Open Access Link to item Cite

Changes in midbrain pain receptor expression, gait and behavioral sensitivity in a rat model of radiculopathy.

Journal Article Open Orthop J · 2012 Intervertebral disc herniation may contribute to inflammatory processes that associate with radicular pain and motor deficits. Molecular changes at the affected dorsal root ganglion (DRG), spinal cord, and even midbrain, have been documented in rat models ... Full text Open Access Link to item Cite

Relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults.

Journal Article J Gerontol A Biol Sci Med Sci · December 2011 BACKGROUND: We wished to determine if a marker of endothelial dysfunction/activation soluble vascular cell adhesion molecule (s-VCAM)-was related to functional status and mortality in community-dwelling older adults independent of the known effects of mark ... Full text Link to item Cite

Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: the Johnston County Osteoarthritis project.

Journal Article Arthritis Rheum · December 2011 OBJECTIVE: To define and contrast multiple joint radiographic osteoarthritis (OA) phenotypes describing hand and whole-body radiographic OA among African Americans and Caucasians. METHODS: We conducted a cross-sectional analysis in the Johnston County Oste ... Full text Link to item Cite

Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: the Johnston County Osteoarthritis Project.

Journal Article Environ Res · November 2011 PURPOSE: To examine associations between biomarkers of joint tissue metabolism and whole blood lead (Pb), separately for men and women in an African American and Caucasian population, which may reflect an underlying pathology. METHODS: Participants in the ... Full text Link to item Cite

Biologics In Relapsing Polychondritis: a Literature Review

Conference ARTHRITIS AND RHEUMATISM · October 1, 2011 Link to item Cite

177 GAIT COMPENSATIONS IN A RAT MEDIAL MENISCUS TRANSECTION MODEL OF OSTEOARTHRITIS

Journal Article Osteoarthritis and Cartilage · September 2011 Full text Cite

Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA.

Journal Article Osteoarthritis Cartilage · September 2011 On November fourth and fifth 2010 a group of more than 100 international investigators gathered in Atlanta for the second Osteoarthritis (OA) Biomarkers Global Initiative workshop titled "Genetics and Genomics: New Targets in OA". The first workshop took p ... Full text Link to item Cite

Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms?

Journal Article Arthritis Rheum · August 2011 OBJECTIVE: To explore the ability of osteoarthritis (OA)-related biomarkers to predict incident radiographic knee OA in a large sample of African American and Caucasian men and women. METHODS: Baseline levels of serum cartilage oligomeric matrix protein (C ... Full text Link to item Cite

Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis.

Journal Article Ann Rheum Dis · July 2011 OBJECTIVE: To examine the relationship of baseline clinical, radiographic, molecular and MRI measures with structural progression (subregional MRI-based femorotibial cartilage loss) in knee osteoarthritis (OA). METHODS: Single knees of 75 female participan ... Full text Link to item Cite

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee.

Journal Article Osteoarthritis Cartilage · July 2011 OBJECTIVE: Post-traumatic arthritis is a frequent cause of disability and occurs most commonly and predictably after articular fracture. The objective of this investigation was to examine the effect of fracture severity on acute joint pathology in a novel ... Full text Link to item Cite

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis.

Journal Article Arthritis Rheum · July 2011 OBJECTIVE: To evaluate whether gene expression profiles could serve as biomarkers of symptomatic knee osteoarthritis (OA) by examining gene expression profiles in peripheral blood leukocytes (PBLs) from patients with OA compared with those from non-OA cont ... Full text Link to item Cite

Association of knee and ankle osteoarthritis with physical performance.

Journal Article Osteoarthritis Cartilage · June 2011 OBJECTIVE: The direct measurement of the ability to perform physical tasks yields information about factors contributing to poor function and insights into strategies for preventing disability. Our goal was to evaluate the relationship of walking speed and ... Full text Link to item Cite

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis.

Journal Article Osteoarthritis Cartilage · May 2011 Featured Publication OBJECTIVE: Osteoarthritis (OA) is a chronic and slowly progressive disease for which biomarkers may be able to provide a more rapid indication of therapeutic responses to therapy than is currently available; this could accelerate and facilitate OA drug dis ... Full text Link to item Cite

Plasma acylcarnitines are associated with physical performance in elderly men.

Journal Article J Gerontol A Biol Sci Med Sci · May 2011 BACKGROUND: Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults. METHODS: A targeted mass spectrometry-based platform was used to identify and quantify 45 plasma acylcarnitines in 77 older men with a mean ... Full text Link to item Cite

Osteoarthritis year 2010 in review: biochemical markers.

Journal Article Osteoarthritis Cartilage · April 2011 Featured Publication At the 2010 Osteoarthritis Research Society International (OARSI) congress in Brussels I was asked to present on "Biochemical Markers" in the "Year in Review" session. This provided an opportunity to summarize ongoing work and consensus building in the ost ... Full text Link to item Cite

Performance of global assessments of hip, knee, and back symptom change.

Journal Article Clin Rheumatol · March 2011 The objective of this study is to compare patients' global assessments of change in knee, hip, and back symptoms with actual changes over time in pain, function, and radiographic severity. The participants (n = 894, 80% female, mean age = 66 years) complet ... Full text Link to item Cite

Response to Letter to the Editor: 'India ink and cartilage'

Journal Article Osteoarthritis and Cartilage · March 1, 2011 Full text Cite

Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.

Journal Article Proc Natl Acad Sci U S A · February 1, 2011 Uric acid (UA) is known to activate the NLRP3 (Nacht, leucine-rich repeat and pyrin domain containing protein 3) inflammasome. When activated, the NLRP3 (also known as NALP3) inflammasome leads to the production of IL-18 and IL-1β. In this cohort of subjec ... Full text Link to item Cite

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.

Journal Article J Clin Endocrinol Metab · February 2011 OBJECTIVES: The objective of the study was to evaluate whether serum concentrations of metabolic intermediates are related to adiposity and insulin sensitivity (Si) in overweight healthy subjects and compare changes in metabolic intermediates with similar ... Full text Link to item Cite

Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity.

Journal Article Diabetes Care · January 2011 OBJECTIVE: To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators. RESEARCH DESIGN AND METHODS: Ta ... Full text Open Access Link to item Cite

Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes.

Journal Article Osteoarthritis Cartilage · January 2011 OBJECTIVE: Several lines of evidence show that selenium (Se) has potential protective effects in osteoarthritis (OA), however the exact mechanism is still unclear. As interleukin-1β (IL-1β) is one of the key proinflammatory cytokines contributing to the pr ... Full text Link to item Cite

Quantification of the whole-body burden of radiographic osteoarthritis using factor analysis.

Journal Article Arthritis Res Ther · 2011 INTRODUCTION: Although osteoarthritis (OA) commonly involves multiple joints, no widely accepted method for quantifying whole-body OA burden exists. Therefore, our aim was to apply factor analytic methods to radiographic OA (rOA) grades across multiple joi ... Full text Open Access Link to item Cite

Erratum: Posttraumatic osteoarthritis: Pathogenesis and pharmacological treatment options (Arthritis Research & Therapy (2010) 12: 211 DOI: 10.1186/ar3046)

Journal Article Arthritis Research and Therapy · November 9, 2010 After publication of our recent article [1], we noticed that Virginia Kraus had been inadvertently omitted as coauthor. The author list is now complete and the competing interests section modified accordingly. ... Full text Cite

Patellar skin surface temperature by thermography reflects knee osteoarthritis severity.

Journal Article Clin Med Insights Arthritis Musculoskelet Disord · October 15, 2010 BACKGROUND: Digital infrared thermal imaging is a means of measuring the heat radiated from the skin surface. Our goal was to develop and assess the reproducibility of serial infrared measurements of the knee and to assess the association of knee temperatu ... Full text Open Access Link to item Cite

The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the guinea pig.

Journal Article Osteoarthritis Cartilage · October 2010 OBJECTIVE: This review focuses on the criteria for assessing osteoarthritis (OA) in the guinea pig at the macroscopic and microscopic levels, and recommends particular assessment criteria to assist standardization in the conduct and reporting of preclinica ... Full text Link to item Cite

Basic methods in histopathology of joint tissues.

Journal Article Osteoarthritis Cartilage · October 2010 Histological and histochemical methods are important tools in the evaluation of joint tissue samples for degenerative joint diseases, both in humans and in animal models. In this respect, standardized, simple, and reliable techniques are mandatory. This ch ... Full text Link to item Cite

Histopathology atlas of animal model systems - overview of guiding principles.

Journal Article Osteoarthritis Cartilage · October 2010 Animal model systems represent an important adjunct and surrogate for studies of osteoarthritis (OA) in humans. They provide a means to study OA pathophysiology as well as aid in the development of therapeutic agents and biological markers for diagnosing a ... Full text Link to item Cite

109 INFLAMMASOME ACTIVATION IN OSTEOARTHRITIS BY URIC ACID

Conference Osteoarthritis and Cartilage · October 2010 Full text Cite

CALORIC RESTRICTION AND IMPROVEMENTS IN METABOLIC FLEXIBILITY

Journal Article GERONTOLOGIST · October 1, 2010 Link to item Cite

Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.

Journal Article J Orthop Res · September 2010 Obesity, as a primary risk factor for osteoarthritis (OA), has been shown to alter joint loading, but may also result in metabolic changes characterized by chronic, low-level inflammation due to increased circulating levels of adipose-derived cytokines, or ... Full text Link to item Cite

Summary of the OA biomarkers workshop 2009--biochemical biomarkers: biology, validation, and clinical studies.

Journal Article Osteoarthritis Cartilage · June 2010 Osteoarthritis (OA) biomarkers that can measure and predict the full spectrum of disease progression and outcomes are needed, but few, if any, such biomarkers have been validated for this purpose. The Osteoarthritis Research Society International (OARSI) h ... Full text Link to item Cite

Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project.

Journal Article Osteoarthritis Cartilage · June 2010 PURPOSE: To test whether serum transforming growth factor-beta 1 (TGF-beta1) predicts incident and progressive hip or knee radiographic OA (rOA). METHODS: Serum TGF-beta1 was measured for 330 participants aged 45 years and older in the Johnston County Oste ... Full text Link to item Cite

Targets to tackle--the pathophysiology of the disease.

Journal Article Curr Drug Targets · May 2010 Osteoarthritis, the degeneration of the joints, is the leading source of physical disability with severely impaired quality of life due to pain and loss of joint functioning in industrialized nations. Clinically, degeneration affects mostly the large weigh ... Full text Link to item Cite

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations.

Journal Article Ann Rheum Dis · May 2010 BACKGROUND: A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs. OBJECTIVE: To determine whether inflammatory genetic markers could stratify patients with knee OA into hig ... Full text Open Access Link to item Cite

Waiting for action on the osteoarthritis front.

Journal Article Curr Drug Targets · May 2010 Full text Link to item Cite

A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials.

Journal Article Curr Drug Targets · May 2010 This narrative review outlines the work done in other fields with regards biomarker validation and qualification and the lessons that we may learn from this experience. Defining a universally agreed upon path for biomarker validation and qualification is u ... Full text Link to item Cite

First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis.

Journal Article PLoS One · March 17, 2010 BACKGROUND: Osteoarthritis (OA) is a debilitating chronic multijoint disease of global proportions. OA presence and severity is usually documented by x-ray imaging but whole body imaging is impractical due to radiation exposure, time and cost. Systemic (se ... Full text Open Access Link to item Cite

Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · March 2010 OBJECTIVE: A major barrier inhibiting the discovery of structural modifying agents for osteoarthritis (OA) is an incomplete understanding of early disease events. Herein, we investigated the time course of collagen II cleavage and fibril disruption in the ... Full text Link to item Cite

Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family.

Journal Article Arthritis Rheum · March 2010 OBJECTIVE: The genetic contributions to the multifactorial disorder osteoarthritis (OA) have been increasingly recognized. The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify gene ... Full text Link to item Cite

A comparison of five approaches to measurement of anatomic knee alignment from radiographs.

Journal Article Osteoarthritis Cartilage · February 2010 OBJECTIVE: The recent recognition of the correlation of the hip-knee-ankle angle (HKA) with femur-tibia angle (FTA) on a standard knee radiograph has led to the increasing inclusion of FTA assessments in OA studies due to its clinical relevance, cost effec ... Full text Link to item Cite

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).

Journal Article Arthritis Res Ther · 2010 INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury. In this study, to better understand the early biological changes whic ... Full text Open Access Link to item Cite

Serum cartilage oligomeric matrix protein (COMP) level is a marker of disease activity in relapsing polychondritis.

Journal Article Clin Exp Rheumatol · 2010 OBJECTIVES: Relapsing polychondritis (RP) is a rare and severe disease which may lead to destruction of elastic cartilages. Until now, no reliable biomarker of disease activity in RP has been available. This study was designed to measure serum levels of ca ... Link to item Cite

Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography.

Journal Article Ann Rheum Dis · January 2010 OBJECTIVE: Cartilage morphology displays sensitivity to change in osteoarthritis (OA) with quantitative MRI (qMRI). However, (sub)regional cartilage thickness change at 3.0 Tesla (T) has not been directly compared with radiographic progression of joint spa ... Full text Link to item Cite

Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.

Journal Article Arthritis Res Ther · 2010 INTRODUCTION: Obesity is a major risk factor for the development of osteoarthritis in both weight-bearing and nonweight-bearing joints. The mechanisms by which obesity influences the structural or symptomatic features of osteoarthritis are not well underst ... Full text Open Access Link to item Cite

Femorotibial cartilage morphology: reproducibility of different metrics and femoral regions, and sensitivity to change in disease.

Journal Article Cells Tissues Organs · 2010 This study was designed to characterize the reproducibility and sensitivity to change of magnetic resonance imaging-based cartilage morphology metrics and femoral regions of interest (ROIs), in order to provide preferable outcome measures in longitudinal s ... Full text Link to item Cite

Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression.

Journal Article Arthritis Rheum · December 2009 OBJECTIVE: To evaluate the effectiveness of using subchondral bone texture observed on a radiograph taken at baseline to predict progression of knee osteoarthritis (OA) over a 3-year period. METHODS: A total of 138 participants in the Prediction of Osteoar ... Full text Link to item Cite

Racial differences in gait mechanics associated with knee osteoarthritis.

Journal Article Aging Clin Exp Res · December 2009 BACKGROUND AND AIMS: This study examines racial differences in gait mechanics in persons with knee osteoarthritis and the influence of anthropometrics, educational level, radiographic disease severity (rOA), and self-report measures of pain and disability ... Full text Link to item Cite

Association of bone scintigraphic abnormalities with knee malalignment and pain.

Journal Article Ann Rheum Dis · November 2009 OBJECTIVE: The information content of knee bone scintigraphy was evaluated, including pattern, localisation and intensity of retention relative to radiographic features of knee osteoarthritis, knee alignment and knee symptoms. METHODS: A total of 308 knees ... Full text Link to item Cite

Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation.

Journal Article Arthritis Rheum · November 2009 OBJECTIVE: To evaluate the association of serum and synovial fluid cartilage oligomeric matrix protein (COMP) with systemic and local measures of osteoarthritis (OA) activity by bone scintigraphy. METHODS: Samples of serum and knee joint synovial fluid (27 ... Full text Link to item Cite

The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis.

Journal Article Arch Phys Med Rehabil · November 2009 OBJECTIVE: To examine the degree to which 2 commonly used measures of pain and disability, the Arthritis Impact Measurement Scales (AIMS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), relate to objective gait measurements. ... Full text Link to item Cite

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis.

Journal Article Arthritis Rheum · October 2009 OBJECTIVE: To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology. METHODS: Leptin-deficient ( ... Full text Link to item Cite

Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · September 2009 OBJECTIVE: To identify subregional differences in femorotibial cartilage morphology between healthy controls and women with different grades of radiographic knee osteoarthritis (OA). DESIGN: 158 women aged > or =40 years were studied. Weight-bearing extend ... Full text Link to item Cite

Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.

Journal Article Arthritis Rheum · September 2009 OBJECTIVE: In mice with Col9a1 gene inactivation (Col9a1(-/-)), osteoarthritis (OA) and intervertebral disc degeneration develop prematurely. The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be assoc ... Full text Link to item Cite

Reappraisal of OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage endpoints in rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis: the OMERACT 9 v2 criteria.

Journal Article J Rheumatol · August 2009 OBJECTIVES: A draft set of criteria for the validation of soluble biomarkers reflecting damage endpoints was proposed at OMERACT 8. At OMERACT 9 we aimed to scrutinize the necessity for each of these criteria according to the objectives of the working grou ... Full text Link to item Cite

Transglutaminase 2 is a marker of chondrocyte hypertrophy and osteoarthritis severity in the Hartley guinea pig model of knee OA.

Journal Article Osteoarthritis Cartilage · August 2009 OBJECTIVE: The transglutaminase (TG) isoenzyme TG2, which catalyzes protein cross-linking via transamidation, influences healing phenotype in multiple forms of tissue injury. Moreover, TG2 knockout suppresses cartilage destruction but promotes osteophyte f ... Full text Link to item Cite

Proposal for levels of evidence schema for validation of a soluble biomarker reflecting damage endpoints in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, and recommendations for study design.

Journal Article J Rheumatol · August 2009 OBJECTIVE: At OMERACT 8 a framework for levels of evidence was proposed for the validation of biomarkers as surrogate outcome measures. We aimed to adapt this scheme in order to apply it in the setting of soluble biomarkers proposed to replace the measurem ... Full text Link to item Cite

Testing of the OMERACT 8 draft validation criteria for a soluble biomarker reflecting structural damage in rheumatoid arthritis: a systematic literature search on 5 candidate biomarkers.

Journal Article J Rheumatol · August 2009 OBJECTIVE: To test the OMERACT 8 draft validation criteria for soluble biomarkers by assessing the strength of literature evidence in support of 5 candidate biomarkers. METHODS: A systematic literature search was conducted on the 5 soluble biomarkers RANKL ... Full text Link to item Cite

Failure of serum transforming growth factor-beta (TGF-beta1) as a biomarker of radiographic osteoarthritis at the knee and hip: a cross-sectional analysis in the Johnston County Osteoarthritis Project.

Journal Article Osteoarthritis Cartilage · June 2009 PURPOSE: To assess associations between serum transforming growth factor-beta (TGF-beta1) and radiographic knee and hip osteoarthritis (rOA) in African American (AA) and White men and women. METHODS: Baseline data from 330 participants in the Johnston Coun ... Full text Link to item Cite

Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.

Journal Article Arthritis Rheum · May 2009 OBJECTIVE: To evaluate 10 biomarkers in magnetic resonance imaging (MRI)-determined, pre-radiographically defined osteoarthritis (pre-ROA) and radiographically defined OA (ROA) in a population-based cohort of subjects with symptomatic knee pain. METHODS: T ... Full text Link to item Cite

Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability.

Journal Article J Pain Symptom Manage · May 2009 This study examined the degree to which pain catastrophizing and pain-related fear explain pain, psychological disability, physical disability, and walking speed in patients with osteoarthritis (OA) of the knee. Participants in this study were 106 individu ... Full text Link to item Cite

Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy.

Journal Article Spine (Phila Pa 1976) · April 1, 2009 STUDY DESIGN: The authors investigated gait abnormalities and mechanical hypersensitivity associated with invertebral disc herniation in a rat model of radiculopathy. Further evaluation involved assessing how nucleus pulposus (NP) injury affected systemic ... Full text Link to item Cite

Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate.

Journal Article Arthritis Res Ther · 2009 INTRODUCTION: Aging proteins undergo non-enzymatic post-translational modification, including isomerization and racemization. We hypothesized that cartilage with many long-lived components could accumulate non-enzymatically modified amino acids in the form ... Full text Open Access Link to item Cite

Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages.

Journal Article Arthritis Res Ther · 2009 INTRODUCTION: Certain amino acids within proteins have been reported to change from the L form to the D form over time. This process is known as racemization and is most likely to occur in long-lived low-turnover tissues such as normal cartilage. We hypoth ... Full text Open Access Link to item Cite

Sex differences in biomechanics associated with knee osteoarthritis.

Journal Article J Women Aging · 2009 Osteoarthritis of the knee is seen more frequently in females than males. However, few studies have examined the interplay of gender, gait mechanics, pain, and disability in persons with osteoarthritis. This study examines the influence of anthropometrics, ... Full text Link to item Cite

Variation in osteoarthritis biomarkers from activity not food consumption.

Journal Article Clin Chim Acta · December 2008 BACKGROUND: To optimize sampling and to understand sources of variation in biomarkers for osteoarthritis (OA), we evaluated variation due to activity and food consumption. METHODS: Twenty participants, with radiographic knee OA, provided serial serum and u ... Full text Link to item Cite

Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial.

Journal Article Ann Rheum Dis · December 2008 OBJECTIVE: Quantitative MRI (qMRI) of cartilage morphology is a promising tool for disease-modifying osteoarthritis drug (DMOAD) development. Recent studies at single sites have indicated that measurements at 3.0 Tesla (T) are more reproducible (precise) t ... Full text Link to item Cite

Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels.

Journal Article Arthritis Rheum · December 2008 OBJECTIVE: Extensive joint hypermobility, lower serum cartilage oligomeric matrix protein (COMP) levels, and early-onset osteoarthritis (OA) are phenotypes of inherited pseudoachondroplasia and multiple epiphyseal dysplasia. However, few studies have evalu ... Full text Link to item Cite

Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees.

Journal Article Osteoarthritis Cartilage · December 2008 OBJECTIVE: This study evaluated the longitudinal performance of a modified Lyon schuss (LS) knee examination in the detection of radiographic joint space narrowing (JSN) in knees with osteoarthritis (OA). The modified LS exam entails two to four iterative ... Full text Link to item Cite

Novel synovial fluid recovery method allows for quantification of a marker of arthritis in mice.

Journal Article Osteoarthritis Cartilage · December 2008 OBJECTIVE: We evaluated three methodologies--a calcium sodium alginate compound (CSAC), polyacrylate beads (PABs), and Whatman paper recovery (WPR)--for the ability to recover synovial fluid (SF) from mouse knees in a manner that facilitated biochemical ma ... Full text Link to item Cite

Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees.

Journal Article Ann Rheum Dis · November 2008 OBJECTIVE: The Lyon Schuss (LS) and fixed flexion (FF) views of the knee are superior to a conventional standing anteroposterior view in evaluating joint space narrowing (JSN) in osteoarthritis (OA). Both position the knee identically but only the LS align ... Full text Link to item Cite

PIIANP and HELIXII diurnal variation.

Journal Article Osteoarthritis Cartilage · October 2008 OBJECTIVE: Serum levels of procollagen type IIA N-terminal propeptide (sPIIANP) and type-II collagen helical peptide (sHELIXII) biomarkers were evaluated for variation diurnally and with physical activity and food in participants with osteoarthritis (OA) o ... Full text Link to item Cite

Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians.

Journal Article Osteoarthritis Cartilage · October 2008 OBJECTIVE: An association between osteoarthritis (OA) and functional polymorphisms in the aspartic acid (d) repeat of the asporin (ASPN) gene was reported in Japanese and Han Chinese populations. The aim of this study was to assess the association of varia ... Full text Link to item Cite

Biomarkers associated with clinical phenotypes of hand osteoarthritis in a large multigenerational family: the CARRIAGE family study.

Journal Article Osteoarthritis Cartilage · September 2008 OBJECTIVE: To evaluate biological markers as potential quantitative traits of clinical osteoarthritis (OA) in a large multigenerational family in the Carolinas of the USA known as the CARRIAGE (CARolinas Region Interaction of Aging, Genes and Environment) ... Full text Link to item Cite

Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain.

Journal Article Pain · June 2008 Featured Publication This study examined arthritis self-efficacy and self-efficacy for resisting eating as predictors of pain, disability, and eating behaviors in overweight or obese patients with osteoarthritis (OA) of the knee. Patients (N=174) with a body mass index between ... Full text Link to item Cite

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse.

Journal Article Arthritis Rheum · March 2008 OBJECTIVE: Posttraumatic arthritis is a frequent long-term complication of intraarticular fractures. A model of a closed intraarticular fracture in C57BL/6 mice that progresses to posttraumatic arthritis has been developed. The MRL/MpJ mouse has shown uniq ... Full text Link to item Cite

Joint-specific hand symptoms and self-reported and performance-based functional status in African Americans and Caucasians: The Johnston County Osteoarthritis Project.

Journal Article Ann Rheum Dis · December 2007 Featured Publication OBJECTIVE: To assess associations between joint-specific hand symptoms and self-reported and performance-based functional status. METHODS: Participants were from the population-based Johnston County Osteoarthritis Project. Symptoms in the distal interphala ... Full text Link to item Cite

Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic.

Journal Article Arthritis Rheum · November 2007 Featured Publication OBJECTIVE: Interleukin-1 receptor antagonist (IL-1Ra) has been evaluated for the intraarticular treatment of osteoarthritis. Such administration of proteins may have limited utility because of their rapid clearance and short half-life in the joint. The fus ... Full text Link to item Cite

Optimization of the fixed-flexion knee radiograph.

Journal Article Osteoarthritis Cartilage · November 2007 Featured Publication PURPOSE: To develop a user-friendly method of achieving optimal radiographs for measurement of joint space width of the knee with minimal radiation exposure. In order to accomplish this the X-ray technologist must (1) be able to identify the anterior and p ... Full text Link to item Cite

Measurement of synovial fluid volume using urea.

Journal Article Osteoarthritis Cartilage · October 2007 Featured Publication OBJECTIVE: To examine the utility of using urea concentrations for determining Synovial Fluid (SF) joint volume in effused and non-effused joints. METHODS: Knee joint SF was aspirated from 159 human study participants with symptomatic osteoarthritis of at ... Full text Link to item Cite

Type II collagen markers in osteoarthritis: what do they indicate?

Journal Article Curr Opin Rheumatol · September 2007 PURPOSE OF REVIEW: We provide a critical review of recent in-vitro, animal and human clinical studies on type II collagen biomarkers. In describing the human studies, we have applied the BIPED (burden of disease, investigative, prognostic, efficacy of inte ... Full text Link to item Cite

Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis.

Journal Article Osteoarthritis Cartilage · August 2007 Featured Publication OBJECTIVE: High-sensitivity C-reactive protein (hsCRP) in serum is used as a marker of risk for cardiovascular disease (CVD); however CRP is a non-specific acute phase reactant. We evaluated the association between hsCRP concentrations and the most common ... Full text Link to item Cite

Validity and factor structure of the AUSCAN Osteoarthritis Hand Index in a community-based sample.

Journal Article Osteoarthritis Cartilage · July 2007 Featured Publication OBJECTIVE: The AUStralian CANadian Osteoarthritis Hand Index (AUSCAN) is a self-report assessment of hand pain, stiffness, and function. Prior studies have examined its validity in small clinical samples and family-based samples. This study examined measur ... Full text Link to item Cite

A longitudinal analysis of serum cytokines in the Hartley guinea pig model of osteoarthritis.

Journal Article Osteoarthritis Cartilage · March 2007 Featured Publication OBJECTIVE: To evaluate chosen serum cytokines and their association with osteoarthritis (OA) in the guinea pig. METHODS: The levels of 18 cytokines were measured in Hartley guinea pig serum at time points ranging from 3 weeks to 18 months of age. These lev ... Full text Link to item Cite

Testing of the preliminary OMERACT validation criteria for a biomarker to be regarded as reflecting structural damage endpoints in rheumatoid arthritis clinical trials: the example of C-reactive protein.

Journal Article J Rheumatol · March 2007 OBJECTIVE: A list of 14 criteria for guiding the validation of a soluble biomarker as reflecting structural damage endpoints in rheumatoid arthritis (RA) clinical trials was drafted by an international working group after a Delphi consensus exercise. C-rea ... Link to item Cite

Synovial fluid metabolites in osteonecrosis.

Journal Article Rheumatology (Oxford) · March 2007 OBJECTIVES: Osteonecrosis of the femoral head results from interruption of the vascular supply and eventual death of the cellular portion of bone. Effective methods of monitoring response to treatment are needed. Our aim was to evaluate synovial fluid meta ... Full text Link to item Cite

Development of draft validation criteria for a soluble biomarker to be regarded as a valid biomarker reflecting structural damage endpoints in rheumatoid arthritis and spondyloarthritis clinical trials.

Journal Article J Rheumatol · March 2007 OBJECTIVE: Recent work has shown that several soluble biomarkers, detectable in peripheral blood, synovial fluid, and/or urine, reflect remodeling of joint tissues and may therefore constitute outcome measures that reflect joint damage. Consequently, it is ... Link to item Cite

Serum C-Reactive Protein (CRP), Target for Therapy or Trouble?

Journal Article Biomark Insights · February 7, 2007 High sensitivity serum C-reactive protein (hs-CRP) has come into clinical use as a marker of risk for cardiovascular disease (CVD). In addition to a role as a marker of disease, CRP has also been implicated in the pathogenesis of CVD. Specific small-molecu ... Open Access Link to item Cite

Collagen biomarkers for arthritis applications.

Journal Article Biomark Insights · February 7, 2007 Open Access Link to item Cite

The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes.

Journal Article Osteoarthritis Cartilage · February 2007 Featured Publication PURPOSE: The primary goal of the Genetics of Generalized Osteoarthritis (GOGO) study is to identify chromosomal regions associated with increased susceptibility to generalized osteoarthritis (OA). Here we describe the study design and phenotype of the 2728 ... Full text Link to item Cite

Biochemistry of amino acid racemization and clinical application to musculoskeletal disease.

Journal Article Clin Biochem · December 2006 During aging, proteins are subject to numerous forms of damage. Several types of non-enzymatic post-translational modifications have been described in aging proteins, including oxidation, nitration, glycation, and racemization. Racemization of amino acids ... Full text Link to item Cite

Relationship of global assessment of change to AUSCAN and pinch and grip strength among individuals with hand osteoarthritis.

Journal Article Osteoarthritis Cartilage · December 2006 OBJECTIVE: This study assessed the utility and construct validity of a new patient global assessment of symptom change for hand osteoarthritis (OA) by examining its associations with change over time in grip strength, pinch strength, and AUStralian CANadia ... Full text Link to item Cite

A thermally responsive biopolymer for intra-articular drug delivery.

Journal Article J Control Release · October 10, 2006 Intra-articular drug delivery is the preferred standard for targeting pharmacologic treatment directly to joints to reduce undesirable side effects associated with systemic drug delivery. In this study, a biologically based drug delivery vehicle was design ... Full text Link to item Cite

Assessment of the utility of biomarkers of osteoarthritis in the guinea pig.

Journal Article Osteoarthritis Cartilage · September 2006 Featured Publication OBJECTIVE: To identify biochemical markers of osteoarthritis (OA) in the guinea pig, we characterized four biomarkers and 17 cytokines for age- and strain-related differences. METHODS: Two guinea pig strains were examined in this study: (1) the Hartley (OA ... Full text Link to item Cite

Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis.

Journal Article Arthritis Rheum · August 2006 Featured Publication OBJECTIVE: To evaluate diurnal variation of biomarkers in subjects with osteoarthritis (OA) of the knee. METHODS: Twenty subjects with radiographic knee OA were admitted to the General Clinical Research Center of Duke University for an overnight stay to un ... Full text Link to item Cite

Classification of osteoarthritis biomarkers: a proposed approach.

Journal Article Osteoarthritis Cartilage · August 2006 Featured Publication OBJECTIVE: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for OA are developed and tested in clinical studies, b ... Full text Link to item Cite

Protein racemization as a biomarker of osteoarthritis

Conference CLINICAL CHEMISTRY · June 1, 2006 Link to item Cite

Do biochemical markers have a role in osteoarthritis diagnosis and treatment?

Journal Article Best Pract Res Clin Rheumatol · February 2006 Featured Publication It is possible to use biomarkers in cohort studies and in clinical trials to increase our understanding of disease, to elucidate disease mechanisms, and to bolster a clinical impression of the disease state of osteoarthritis. Whether it will be possible to ... Full text Link to item Cite

Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index.

Journal Article Arthritis Rheum · February 2006 OBJECTIVE: The Australian/Canadian (AUSCAN) Osteoarthritis Hand Index is a self-report assessment of pain, stiffness, and function in patients with hand osteoarthritis (OA). Small studies have confirmed the reliability, construct validity, and responsivene ... Full text Link to item Cite

The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants.

Journal Article Osteoarthritis Cartilage · December 2005 OBJECTIVE: Macromolecules of the articular cartilage extracellular matrix released into synovial fluid, blood, or urine can serve as potentially useful biomarkers of the severity of osteoarthritis (OA). Biomechanical factors play an important role in OA pa ... Full text Link to item Cite

Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.

Journal Article Arthritis Rheum · October 2005 OBJECTIVE: Quantitative magnetic resonance imaging (MRI) of articular cartilage represents a powerful tool in osteoarthritis (OA) research, but has so far been confined to a field strength of 1.5T. The aim of this study was to evaluate the precision of qua ... Full text Link to item Cite

Biomarkers in osteoarthritis.

Journal Article Curr Opin Rheumatol · September 2005 PURPOSE OF REVIEW: Biomarker discovery and validation for osteoarthritis have accelerated over the past several years, coincident with an evolving understanding of joint tissue molecules and their complex interactions, and the compelling need for improved ... Full text Link to item Cite

Variation of serum hyaluronan with activity in individuals with knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · September 2005 Featured Publication PURPOSE: Serum hyaluronan (HA) was evaluated for diurnal variation in participants with osteoarthritis (OA) of the knee. METHODS: Twenty participants with radiographic OA of at least one knee were admitted overnight to the General Clinical Research Center ... Full text Link to item Cite

Identification of an urinary metabolite profile associated with osteoarthritis.

Journal Article Osteoarthritis Cartilage · September 2005 OBJECTIVE: Osteoarthritis (OA) is one of the most common diseases among the elderly. The main characteristic is the progressive destruction of articular cartilage. We lack quantitative and sensitive biomarkers for OA to detect changes in the joints in an e ... Full text Link to item Cite

Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint.

Journal Article Arthritis Rheum · September 2005 OBJECTIVE: To evaluate the dehydroascorbate (DHA) transport mechanisms in human chondrocytes. METHODS: The transport of L-(14)C-DHA in human chondrocytes was analyzed under various conditions, including the use of RNA interference (RNAi), to determine the ... Full text Link to item Cite

Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis.

Journal Article Arthritis Rheum · August 2005 OBJECTIVE: To describe the health state preferences of patients with osteoarthritis (OA) according to the level of pain and disability and the extent of gastrointestinal side effects from nonsteroidal antiinflammatory drugs (NSAIDs). METHODS: Using combina ... Full text Link to item Cite

Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR.

Journal Article Ann Biomed Eng · August 2005 Intervertebral disc (IVD) cells experience a broad range of physicochemical stimuli under physiologic conditions, including alterations in their osmotic environment. Cellular responses to altered osmolarity have been documented at the transcriptional and p ... Full text Link to item Cite

Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.

Journal Article Biochim Biophys Acta · June 30, 2005 Collagen II is the major protein component of articular cartilage and forms the collagen fibril network, which provides the tensile strength of cartilage. Collagen II synthesis is enhanced by ascorbic acid (vitamin C) at both a transcriptional and post-tra ... Full text Link to item Cite

A comparative assessment of alignment angle of the knee by radiographic and physical examination methods.

Journal Article Arthritis Rheum · June 2005 OBJECTIVE: To compare the knee-alignment angle from a full-limb radiograph (mechanical axis) with the anatomic-axis angle as measured by physical examination using a goniometer and by 2 other radiographic methods. METHODS: The knee-alignment angle was meas ... Full text Link to item Cite

Relationship of radiographic and clinical variables to pinch and grip strength among individuals with osteoarthritis.

Journal Article Arthritis Rheum · May 2005 OBJECTIVE: Little is known about how specific radiographic features are related to hand strength in osteoarthritis (OA). This study examined associations of radiographic variables with pinch and grip strength among individuals with radiographic hand OA. ME ... Full text Link to item Cite

Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project.

Journal Article Arthritis Rheum · January 2005 OBJECTIVE: Serum hyaluronan (HA) has been proposed as a potential biomarker of osteoarthritis (OA). We examined associations between serum HA and radiographic OA in an ethnically diverse, population-based sample. METHODS: Participants were selected from th ... Full text Link to item Cite

Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation.

Journal Article Arthritis Rheum · November 2004 OBJECTIVE: There is evidence that autoimmunity plays a significant role in the pathogenesis of relapsing polychondritis (RP). This study was designed to investigate circulating levels of various cytokines in relation to the etiology of this rare disorder, ... Full text Link to item Cite

Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc.

Journal Article Spine (Phila Pa 1976) · October 15, 2004 STUDY DESIGN: Matrix protein gene expression was determined for cells of the anulus fibrosus (AF) and nucleus pulposus (NP) regions of the intervertebral disc when cultured in AF or NP cell-conditioned medium. OBJECTIVES: To investigate changes in mRNA lev ... Full text Link to item Cite

Comparison of knee alignment angle by x-ray and goniometer.

Conference ARTHRITIS AND RHEUMATISM · September 1, 2004 Link to item Cite

Assessment of hand osteoarthritis: correlation between thermographic and radiographic methods.

Journal Article Rheumatology (Oxford) · July 2004 OBJECTIVE: Anatomical stages of digital osteoarthritis (OA) have been characterized radiographically as progressing through sequential phases from normal to osteophyte formation, progressive loss of joint space, joint erosion and joint remodelling. Our stu ... Full text Link to item Cite

Articular hypermobility is a protective factor for hand osteoarthritis.

Journal Article Arthritis Rheum · July 2004 OBJECTIVE: Very few studies have evaluated the association of articular hypermobility and radiographic osteoarthritis (OA) in humans. We assessed hypermobility and its relationship to radiographic hand OA in a family-based study. METHODS: A total of 1,043 ... Full text Link to item Cite

Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model.

Journal Article Arthritis Rheum · June 2004 OBJECTIVE: To determine whether ascorbic acid might be of benefit for the treatment of spontaneous osteoarthritis (OA) when administered over a long period of time. METHODS: We investigated the effects of 8 months' exposure to low, medium, and high doses o ... Full text Link to item Cite

The role of biomechanics and inflammation in cartilage injury and repair.

Journal Article Clin Orthop Relat Res · June 2004 Osteoarthritis is a painful and debilitating disease characterized by progressive degenerative changes in the articular cartilage and other joint tissues. Biomechanical factors play a critical role in the initiation and progression of this disease, as evid ... Full text Link to item Cite

Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method.

Journal Article Osteoarthritis Cartilage · May 2004 OBJECTIVE: To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis. METHODS: Cartilage-bone samples from the medial femoral condyle and tibial plateau of 12 month-old guinea pig knees were s ... Full text Open Access Link to item Cite

Genetics of osteoarthritis.

Journal Article Curr Rheumatol Rep · February 2004 Osteoarthritis (OA) is a major cause of morbidity, physical limitation, and health care use, including total joint arthroplasty. That OA has a genetic component has been known for some time, but only recently has formal study of this occurred. Twin studies ... Full text Link to item Cite

Using epidemiologic studies to identify surrogates for radiographic outcome

Conference OSTEOARTHRITIS AND CARTILAGE · January 1, 2004 Link to item Cite

Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis.

Journal Article Arthritis Rheum · October 2003 Herein we describe the case of a man who was diagnosed as having relapsing polychondritis (RP) when he was 18 years of age and was treated over the course of 2 years with numerous immunosuppressive agents, including tumor necrosis factor alpha (TNFalpha) i ... Full text Link to item Cite

Ascorbic acid accumulates in cartilage in vivo.

Journal Article Clin Chim Acta · August 2003 BACKGROUND: Ascorbic acid plays an important role in collagen synthesis. Though ascorbic acid concentrations in many tissues and in plasma have been characterized, little is known about in vivo levels in cartilage. MATERIALS AND METHODS: To discern the rol ... Full text Link to item Cite

Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic Guinea pigs.

Journal Article J Nutr · June 2003 Osteoarthritis (OA), one of the most common diseases among the elderly, is characterized by the progressive destruction of joint tissues. Its etiology is largely unclear and no effective disease-modifying treatment is currently available. Metabolic fingerp ... Full text Link to item Cite

Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis.

Journal Article Foot Ankle Clin · June 2003 The management of arthritis pain should be individualized to the needs and characteristics of the patient. The decision to use nonsteroidal anti-inflammatory drugs (NSAIDs), and in particular the cyclooxygenase-2 (COX-2) inhibitors, is multidimensional. Th ... Full text Link to item Cite

Serum C-reactive protein (CRP) levels and osteoarthritis

Conference CLINICAL CHEMISTRY · June 1, 2003 Link to item Cite

Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project.

Journal Article Arthritis Rheum · March 2003 OBJECTIVE: Previous descriptions of potential biomarkers of osteoarthritis (OA) have been limited to Caucasians. In the present study, we examined associations between serum levels of cartilage oligomeric matrix protein (COMP) and ethnicity (African Americ ... Full text Link to item Cite

Monoclonal antibodies to human cartilage oligomeric matrix protein: epitope mapping and characterization of sandwich ELISA.

Journal Article Clin Chim Acta · February 2003 BACKGROUND: Cartilage oligomeric matrix protein/thrombospondin 5 (COMP/TSP 5) is one of the most promising serologic markers with regard to an ability to prognose development of osteoarthritis (OA). Our aim was to map the epitopes of three monoclonal antib ... Full text Link to item Cite

A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis.

Journal Article Osteoarthritis Cartilage · October 2002 Featured Publication OBJECTIVE: To evaluate the interaction of bone and cartilage in knee osteoarthritis (OA) pathogenesis in two guinea-pig strains with appreciable differences in bone metabolism. DESIGN: Two guinea-pig strains were evaluated for their susceptibilities to OA ... Full text Link to item Cite

Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage.

Journal Article J Biomech · September 2002 Few methods exist to study cartilage mechanics in small animal joints due to the difficulties associated with handling small tissue samples. In this study, we apply an osmotic loading method to quantify the intrinsic material properties of articular cartil ... Full text Link to item Cite

Serum cartilage oligomeric matrix protein and clinical signs and symptoms of potential pre-radiographic hip and knee pathology.

Journal Article Osteoarthritis Cartilage · September 2002 OBJECTIVE: To examine the cross-sectional relationship between serum cartilage oligomeric matrix protein (COMP) and hip and knee clinical signs and symptoms in a sample of adults without radiographic hip or knee osteoarthritis (OA). DESIGN: A total of 145 ... Full text Link to item Cite

Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · September 2002 OBJECTIVE: To evaluate the prognostic utility of serum COMP level measured with a new sandwich ELISA, by correlating COMP level with outcome measures of osteoarthritis (OA) progression. DESIGN: Patients (N=48) had symptomatic primary knee OA of Kellgren-La ... Full text Link to item Cite

Serum c-reactive protein (CRP) and osteoarthritis (OA).

Conference ARTHRITIS AND RHEUMATISM · September 1, 2002 Link to item Cite

Precision and accuracy of a transportable dual-energy X-ray absorptiometry unit for bone mineral measurements in guinea pigs.

Journal Article Calcif Tissue Int · March 2002 Dual energy X-ray absorptiometry (DXA) is a valuable tool for measuring bone mineral content (BMC) and bone mineral density (BMD) in small-animal research. The present study was devised to establish guidelines and to define sites for bone mineral measureme ... Full text Link to item Cite

The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants.

Journal Article Matrix Biol · March 2002 Featured Publication Ascorbic acid has been associated with the slowing of osteoarthritis progression in guinea pig and man. The goal of this study was to evaluate transcriptional and translational regulation of cartilage matrix components by ascorbic acid. Guinea pig articula ... Full text Link to item Cite

Urea as a passive transport marker for arthritis biomarker studies.

Journal Article Arthritis Rheum · February 2002 Featured Publication OBJECTIVE: To develop a method to correct for the unknown dilution of synovial fluid that occurs during lavage of a joint, we evaluated the utility of urea, a molecule that is neither synthesized nor metabolized by joint tissues, as a means of correcting f ... Full text Link to item Cite

Synovial fluid biomarker levels predict articular cartilage damage following complete medial meniscectomy in the canine knee.

Journal Article J Orthop Res · January 2002 The purposes of this study were to document the histological changes present in the tibial plateaus 12 weeks after complete medial meniscectomy in dogs and to determine if synovial lavage fluid biomarker levels are predictive of the severity of joint damag ... Full text Link to item Cite

Serum cartilage oligomeric matrix protein reflects the presence of clinically diagnosed synovitis in patients with knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · October 2001 OBJECTIVE: Cartilage oligomeric matrix protein (COMP) is a component of articular cartilage whose serum levels show a strong correlation with radiographic osteoarthritis (OA) status. It has recently been found, however, that COMP is also produced in synovi ... Full text Link to item Cite

Intervertebral disc cells exhibit differences in gene expression in alginate and monolayer culture.

Journal Article Spine (Phila Pa 1976) · August 15, 2001 STUDY DESIGN: The mRNA levels of aggrecan and collagen were quantified in intervertebral disc cells cultured under three conditions: primary alginate culture, monolayer culture, and re-encapsulation in alginate after monolayer culture. OBJECTIVES: To compa ... Full text Link to item Cite

The effects of intravenous doxycycline therapy for rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial.

Journal Article Arthritis Rheum · May 2001 OBJECTIVE: To determine the feasibility, safety, and potential clinical efficacy of intravenous (IV) doxycycline therapy for rheumatoid arthritis (RA), as well as its possible effects on serum and urinary markers of collagen breakdown. METHODS: The explora ... Full text Link to item Cite

Age-related thymic atrophy in the guinea pig.

Journal Article Dev Comp Immunol · 2001 We have characterized age-related thymic atrophy in the guinea pig, including identification of antibodies that allow immunohistochemical assessment of thymopoiesis. Age-related thymic atrophy in guinea pigs more closely resembles what occurs in humans his ... Full text Link to item Cite

Collagen gene expression and mechanical properties of intervertebral disc cell-alginate cultures.

Journal Article J Orthop Res · January 2001 Cells of the intervertebral disc have a limited capacity for matrix repair that may contribute to the onset and progression of degenerative disc changes. In this study, the biosynthetic capacity of cells isolated from specific regions of the porcine interv ... Full text Link to item Cite

Reply

Journal Article Arthritis & Rheumatism · June 2000 Full text Cite

Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis.

Journal Article J Orthop Res · March 2000 Damage to the meniscus can lead to posttraumatic osteoarthritis. Early markers of joint injury and tissue disease may be useful in developing and administering clinical treatment. We investigated the effects of total medial meniscectomy on biomarkers measu ... Full text Link to item Cite

Biosynthesis of intervertebral disc matrix in vitro

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 1999 Cells of the intervertebral disc express genes for aggrecan and collagen in an in vitro alginate culture system. Despite evidence for significant biosynthesis, the cells appear unable to assemble a mechanically functional matrix in this in vitro system. ... Cite

Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.

Journal Article Arthritis Rheum · November 1999 OBJECTIVE: To characterize serum cartilage oligomeric matrix protein (COMP) levels by age and gender for a radiographically defined population free of hip and knee osteoarthritis (OA), and to examine the potential utility of COMP as a diagnostic biomarker ... Full text Link to item Cite

Reply

Journal Article Arthritis & Rheumatism · March 1999 Full text Cite

Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.

Journal Article Arthritis Rheum · May 1998 OBJECTIVE: To analyze the in vivo compartmental expression of collagenases 1 and 3 (MMP-1 and MMP-13) in the Hartley guinea pig model of spontaneously occurring osteoarthritis (OA) for the purpose of elucidating their roles in the pathogenesis of OA. METHO ... Full text Link to item Cite

Comparison of synovial fluid cartilage marker concentrations and chondral damage assessed arthroscopically in acute knee injury.

Journal Article Osteoarthritis Cartilage · November 1997 OBJECTIVE: To examine the correlation between synovial fluid cartilage markers and degree of cartilage damage determined by arthroscopic evaluation in subjects with acute knee injury. DESIGN: Chondral damage was quantified using a validated arthroscopic sc ... Full text Link to item Cite

Pathogenesis and treatment of osteoarthritis.

Journal Article Med Clin North Am · January 1997 OA represents the final common pathway of a number of pathologic processes. The challenge is to define and classify the subsets of OA to understand the causes and to devise specific therapies. Effective chondroprotective therapies will be most useful when ... Full text Link to item Cite

Collagenase in a guinea PK3 model of natural osteoarthrftis

Journal Article Journal of Investigative Medicine · January 1, 1996 The Hartley strain albino guinea pig spontaneously develops osteoarthritis (OA) of the knees and hips, reaching advanced stages by age 10-12 months1. Histological and biochemical characterization of the Hartley strain guinea pig model of OA has shown it to ... Cite

Interaction of the Dr1 inhibitory factor with the TATA binding protein is disrupted by adenovirus E1A.

Journal Article Proc Natl Acad Sci U S A · July 5, 1994 Past experiments have shown that the adenovirus E1A12S product activates the hsp70 promoter, dependent on the TATA element and dependent on N-terminal E1A sequences. Other experiments have identified a factor termed Dr1 that interacts with and inhibits the ... Full text Link to item Cite

E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.

Journal Article Mol Cell Biol · August 1993 The observation that adenovirus E1A gene products can inhibit differentiation of skeletal myocytes suggested that E1A may interfere with the activity of myogenic basic helix-loop-helix (bHLH) transcription factors. We have examined the ability of E1A to me ... Full text Link to item Cite

Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domains.

Journal Article Mol Cell Biol · October 1992 Recent studies have shown that the adenovirus E1A12S product can trans-activate transcription by activating the transcription factor E2F. However, E2F cannot be the only target for the E1A12S product, since several cellular promoters have been found to be ... Full text Link to item Cite

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

Journal Article Proc Natl Acad Sci U S A · May 15, 1992 The adenovirus E1A gene product, the simian virus 40 large tumor antigen, and the human papillomavirus E7 protein share a short amino acid sequence that constitutes a domain required for the transforming activity of these proteins. These sequences are also ... Full text Link to item Cite

Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.

Journal Article J Virol · December 1991 The human papillomavirus E7 gene product is an oncoprotein with properties similar to those of the adenovirus E1A proteins. The human papillomavirus E7 proteins possess substantial amino acid sequence similarity to portions of conserved regions 1 and 2 of ... Full text Link to item Cite

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

Journal Article Genes Dev · July 1991 Recent experiments have shown that the cellular E2F transcription factor is found in complexes with cellular proteins and that one such complex contains the cyclin-A protein. Isolation of a cellular activity, which we term E2F-BF, can reconstitute the E2F- ... Full text Link to item Cite

Demonstration of phenotypic abnormalities of thymic epithelium in thymoma including two cases with abundant Langerhans cells.

Journal Article Am J Pathol · September 1988 A panel of monoclonal antibodies that phenotypically define stages of normal human thymic epithelial (TE) cell maturation was used to compare thymic epithelium of nine thymomas with hyperplastic thymic epithelium in myasthenia gravis (MG) and thymic epithe ... Link to item Cite

Ureaplasma urealyticum septic arthritis in hypogammaglobulinemia.

Journal Article J Rheumatol · February 1988 We describe a hypogammaglobulinemic man with erosive oligoarticular septic arthritis due to Ureaplasma urealyticum. His clinical course was complicated by a subcutaneous abscess. Multiple synovial cultures were negative until finally cultures specific for ... Link to item Cite

Straw lung.

Journal Article N Engl J Med · April 4, 1985 Full text Link to item Cite

Benzodiazepine receptor declines in hippocampal formation following limbic seizures.

Journal Article Brain Res · October 31, 1983 Electrolytic lesions of entorhinal cortex have previously been shown to consistently produce limbic seizures. We report a bilateral and symmetrical decline in benzodiazepine receptor number in dentate gyrus of the hippocampal formation in unilateral entorh ... Full text Link to item Cite

Rare Osteoarthritis: Ochronosis and Kashin-Beck Disease

Other Rheumatology, 6th edition, Ed. MC Hochberg, AJ Silman, JS Smolen, ME Weinblatt, MH Weisman (Mosby Elsevier, Philadelphia). 2014;Chapter 185:1536-1540. Cite