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Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.

Publication ,  Journal Article
Eckstein, F; Charles, HC; Buck, RJ; Kraus, VB; Remmers, AE; Hudelmaier, M; Wirth, W; Evelhoch, JL
Published in: Arthritis Rheum
October 2005

OBJECTIVE: Quantitative magnetic resonance imaging (MRI) of articular cartilage represents a powerful tool in osteoarthritis (OA) research, but has so far been confined to a field strength of 1.5T. The aim of this study was to evaluate the precision of quantitative MRI assessments of human cartilage morphology at 3.0T and to correlate the measurements at 3.0T with validated measurements at 1.5T. METHODS: MR images of the knee of 15 participants with OA and 15 healthy control subjects were acquired using Siemens 1.5T and 3.0T scanners. Double oblique coronal scans were obtained at 1.5T with a 1.5-mm partition thickness, at 3.0T with a 1.5-mm partition thickness, and at 3.0T with a 1.0-mm partition thickness. Cartilage volume, thickness, and surface area of the femorotibial cartilage plates were quantified using proprietary software. RESULTS: For 1.5-mm partition thickness at 1.5T, the precision error was 3.0% and 2.6% for cartilage volume and cartilage thickness, respectively. The error was smaller for a 1.5-mm partition thickness at 3.0T (2.6% and 2.5%) and still smaller for a 1.0-mm partition thickness at 3.0T (2.1% and 2.0%). Correlation coefficients between values obtained at 3.0T and 1.5T were high (r > or = 0.96), with no significant deviation between the two field strengths. CONCLUSION: Quantitative MRI measurement of cartilage morphology at 3.0T (partition thickness 1 mm) was found to be accurate and tended to be more reproducible than at 1.5T (partition thickness 1.5 mm). Imaging at 3.0T may therefore provide superior ability to detect changes in cartilage status over time and to determine responses to treatment with structure-modifying drugs.

Duke Scholars

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

October 2005

Volume

52

Issue

10

Start / End Page

3132 / 3136

Location

United States

Related Subject Headings

  • Tibia
  • Reproducibility of Results
  • Osteoarthritis, Knee
  • Middle Aged
  • Magnetic Resonance Imaging
  • Knee Joint
  • Humans
  • Femur
  • Female
  • Cartilage
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Eckstein, F., Charles, H. C., Buck, R. J., Kraus, V. B., Remmers, A. E., Hudelmaier, M., … Evelhoch, J. L. (2005). Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum, 52(10), 3132–3136. https://doi.org/10.1002/art.21348
Eckstein, Felix, H Cecil Charles, Robert J. Buck, Virginia B. Kraus, Ann E. Remmers, Martin Hudelmaier, Wolfgang Wirth, and Jeffrey L. Evelhoch. “Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.Arthritis Rheum 52, no. 10 (October 2005): 3132–36. https://doi.org/10.1002/art.21348.
Eckstein F, Charles HC, Buck RJ, Kraus VB, Remmers AE, Hudelmaier M, et al. Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum. 2005 Oct;52(10):3132–6.
Eckstein, Felix, et al. “Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.Arthritis Rheum, vol. 52, no. 10, Oct. 2005, pp. 3132–36. Pubmed, doi:10.1002/art.21348.
Eckstein F, Charles HC, Buck RJ, Kraus VB, Remmers AE, Hudelmaier M, Wirth W, Evelhoch JL. Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T. Arthritis Rheum. 2005 Oct;52(10):3132–3136.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

October 2005

Volume

52

Issue

10

Start / End Page

3132 / 3136

Location

United States

Related Subject Headings

  • Tibia
  • Reproducibility of Results
  • Osteoarthritis, Knee
  • Middle Aged
  • Magnetic Resonance Imaging
  • Knee Joint
  • Humans
  • Femur
  • Female
  • Cartilage