Hal Cecil Charles | Scholars@Duke

Hal Cecil Charles
Associate Professor of Radiology

Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development. He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab has developed approaches for imaging lung function (ventilation and V/Q) in humans with 19F MRI.

Current Appointments & Affiliations

Associate Professor of Radiology, Radiology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1987

Contact Information

2424 Erwin Road, Suite 301, Hock Plaza, Durham, NC 27705
Box 2702 Med Ctr, Durham, NC 27710
cecil.charles@duke.edu (919) 684-7921
Radiology

Background
Education, Training, & Certifications
- Ph.D., University of New Orleans 1981
Duke Appointment History
- Associate Professor of Radiology, Radiology, Clinical Science Departments 1997 - 2018
- Associate Professor in Radiology, Radiology, Clinical Science Departments 1995 - 1997
- Assistant Professor in Radiology, Radiology, Clinical Science Departments 1987 - 1995
Recognition
Awards & Honors
- Fellow of the Society. International Society of Magnetic Resonance in Medicine. April 2009
Expertise
Subject Headings
Research
Selected Grants
- Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health 2012 - 2018
- PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health 2002 - 2009
- PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health 2002 - 2008
- Child Neglect: Psychobiological Consequences awarded by National Institutes of Health 2000 - 2007
- Adolescent Alcohol Abuse, PTSD & Hippocampal Development awarded by National Institutes of Health 2002 - 2006
- Predicting Human Tumor Response by 31p MRS awarded by National Institutes of Health 1995 - 2001
- Scor In Heart Failure awarded by National Institutes of Health 1995 - 1999
- Depression In Late Life awarded by National Institutes of Health 1995 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1997 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1995 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1987 - 1999
- Alzheimers Disease -- Antemortem Markers awarded by National Institutes of Health 1995 - 1999
- Predicting Human Tumor Response By 31p Mrs awarded by National Institutes of Health 1995 - 1999
- Cortisol Cognition Brain Atrophy And Depression awarded by National Institutes of Health 1996 - 1998
- Alzheimer'S Disease: Antemortem Markers awarded by National Institutes of Health 1995 - 1998
- Alzheimers Disease-- Antemortem Markers awarded by National Institutes of Health 1995 - 1998
- Cortisol Cognition Brain Atrophy And Depression awarded by National Institutes of Health 1989 - 1997
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1993 - 1995
- Specific Applications Of Pet And Mrs In Brain Tumors awarded by National Institutes of Health 1994 - 1995
- Scor In Coronary And Vascular Diseases awarded by National Institutes of Health 1992 - 1994
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Goralski, Jennifer L., Sang Hun Chung, Tyler M. Glass, Agathe S. Ceppe, Esther O. Akinnagbe-Zusterzeel, Aaron T. Trimble, Richard C. Boucher, et al. “Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.” Jci Insight 5, no. 2 (January 30, 2020). https://doi.org/10.1172/jci.insight.133400.
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  - Mammarappallil, Joseph G., Scott Shofer, Martha S. Carraway, Jesse Tucker, Samantha Womack, Maureen Ainslie, and H Cecil Charles. “Utilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury.” Mil Med 185, no. Suppl 1 (January 7, 2020): 50–56. https://doi.org/10.1093/milmed/usz284.
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  - Zapol, Warren M., H Cecil Charles, Andrew R. Martin, Rui C. Sá, Binglan Yu, Fumito Ichinose, Neil MacIntyre, et al. “Pulmonary Delivery of Therapeutic and Diagnostic Gases.” J Aerosol Med Pulm Drug Deliv 31, no. 2 (April 2018): 78–87. https://doi.org/10.1089/jamp.2017.1431.
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  - Kraus, Virginia Byers, Jamie E. Collins, H Cecil Charles, Carl F. Pieper, Lawrence Whitley, Elena Losina, Michael Nevitt, et al. “Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.” Arthritis Rheumatol 70, no. 1 (January 2018): 80–87. https://doi.org/10.1002/art.40348.
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  - Huang, Chao, Liang Shan, H Cecil Charles, Wolfgang Wirth, Marc Niethammer, and Hongtu Zhu. “Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data.” Ieee Trans Med Imaging 34, no. 9 (September 2015): 1914–27. https://doi.org/10.1109/TMI.2015.2415675.
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  - Shan, Liang, Christopher Zach, Cecil Charles, and Marc Niethammer. “Automatic atlas-based three-label cartilage segmentation from MR knee images.” Med Image Anal 18, no. 7 (October 2014): 1233–46. https://doi.org/10.1016/j.media.2014.05.008.
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  - Halaweish, Ahmed F., and H Cecil Charles. “Physiorack: an integrated MRI safe/conditional, gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function.” J Magn Reson Imaging 39, no. 3 (March 2014): 735–41. https://doi.org/10.1002/jmri.24219.
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  - Halaweish, Ahmed F., Richard E. Moon, W Michael Foster, Brian J. Soher, H Page McAdams, James R. MacFall, Maureen D. Ainslie, Neil R. MacIntyre, and H Cecil Charles. “Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.” Chest 144, no. 4 (October 2013): 1300–1310. https://doi.org/10.1378/chest.12-2597.
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  - Shan, L., C. Charles, and M. Niethammer. “Longitudinal three-label segmentation of knee cartilage.” Proceedings International Symposium on Biomedical Imaging, August 22, 2013, 1376–79. https://doi.org/10.1109/ISBI.2013.6556789.
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  - Kraus, Virginia Byers, Sheng Feng, ShengChu Wang, Scott White, Maureen Ainslie, Marie-Pierre Hellio Le Graverand, Alan Brett, et al. “Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression.” Arthritis Rheum 65, no. 7 (July 2013): 1812–21. https://doi.org/10.1002/art.37970.
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  - Huang, C., L. Shan, C. Charles, M. Niethammer, and H. Zhu. “Diseased region detection of longitudinal knee MRI data.” Information Processing in Medical Imaging : Proceedings of the ... Conference 23 (2013): 632–43.
  - Huang, Chao, Liang Shan, Cecil Charles, Marc Niethammer, and Hongtu Zhu. “Diseased region detection of longitudinal knee MRI data.” Inf Process Med Imaging 23 (2013): 632–43. https://doi.org/10.1007/978-3-642-38868-2_53.
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  - Shan, L., C. Charles, and M. Niethammer. “Automatic multi-atlas-based cartilage segmentation from knee MR images.” Proceedings International Symposium on Biomedical Imaging, August 15, 2012, 1028–31. https://doi.org/10.1109/ISBI.2012.6235733.
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  - Shan, L., C. Charles, and M. Niethammer. “Automatic atlas-based three-label cartilage segmentation from MR knee images.” Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis, April 24, 2012, 241–46. https://doi.org/10.1109/MMBIA.2012.6164757.
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  - Eckstein, F., MP Hellio Le Graverand, H. C. Charles, D. J. Hunter, V. B. Kraus, T. Sunyer, O. Nemirovskyi, B. T. Wyman, R. Buck, and R. A9001140, investigators. “Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis.” Ann Rheum Dis 70, no. 7 (July 2011): 1223–30. https://doi.org/10.1136/ard.2010.141382.
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  - Shan, L., C. Zach, M. Styner, C. Charles, and M. Niethammer. “Automatic bone segmentation and alignment from MR knee images.” Progress in Biomedical Optics and Imaging Proceedings of Spie 7623, no. PART 1 (December 1, 2010). https://doi.org/10.1117/12.841167.
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  - Chuckpaiwong, Bavornrit, Hal Cecil Charles, Virginia B. Kraus, Farshid Guilak, and James A. Nunley. “Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.” J Orthop Res 28, no. 9 (September 2010): 1149–54. https://doi.org/10.1002/jor.21125.
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  - McDaniel, G., K. L. Mitchell, C. Charles, and V. B. Kraus. “A comparison of five approaches to measurement of anatomic knee alignment from radiographs.” Osteoarthritis Cartilage 18, no. 2 (February 2010): 273–77. https://doi.org/10.1016/j.joca.2009.10.005.
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  - Dewhirst, Mark W., Donald E. Thrall, Gregory Palmer, Thies Schroeder, Zeljko Vujaskovic, H. Cecil Charles, James Macfall, and Terence Wong. “Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy.” Int J Hyperthermia 26, no. 3 (2010): 283–93. https://doi.org/10.3109/02656730903286214.
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  - Le Graverand, M-P Hellio, R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, et al. “Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography.” Ann Rheum Dis 69, no. 1 (January 2010): 155–62. https://doi.org/10.1136/ard.2008.099762.
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  - Kraus, Virginia Byers, Sheng Feng, ShengChu Wang, Scott White, Maureen Ainslie, Alan Brett, Anthony Holmes, and H Cecil Charles. “Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression.” Arthritis Rheum 60, no. 12 (December 2009): 3711–22. https://doi.org/10.1002/art.25012.
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  - Hellio Le Graverand, M. -. P., R. J. Buck, B. T. Wyman, E. Vignon, S. A. Mazzuca, K. D. Brandt, M. Piperno, et al. “Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis.” Osteoarthritis Cartilage 17, no. 9 (September 2009): 1177–85. https://doi.org/10.1016/j.joca.2009.03.008.
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  - Viglianti, Benjamin L., Michael Lora-Michiels, Jeanie M. Poulson, Lan Lan, Daohai Yu, Linda Sanders, Oana Craciunescu, et al. “Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.” Clin Cancer Res 15, no. 15 (August 1, 2009): 4993–5001. https://doi.org/10.1158/1078-0432.CCR-08-2222.
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  - Thompson, Paul M., George Bartzokis, Kiralee M. Hayashi, Andrea D. Klunder, Po H. Lu, Nancy Edwards, Michael S. Hong, et al. “Time-lapse mapping of cortical changes in schizophrenia with different treatments.” Cereb Cortex 19, no. 5 (May 2009): 1107–23. https://doi.org/10.1093/cercor/bhn152.
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  - Stauffer, Pr, Oi Craciunescu, P. Maccarini, C. Wyatt, K. Arunachalam, O. Arabe, V. Stakhursky, et al. “Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.” Proc Spie Int Soc Opt Eng 7181 (February 25, 2009). https://doi.org/10.1117/12.812188.
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  - Wyatt, Cory, Brian Soher, Paolo Maccarini, H Cecil Charles, Paul Stauffer, and James Macfall. “Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours.” Int J Hyperthermia 25, no. 6 (2009): 422–33. https://doi.org/10.1080/02656730903133762.
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  - Eckstein, F., R. J. Buck, D. Burstein, H. C. Charles, J. Crim, M. Hudelmaier, D. J. Hunter, et al. “Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial.” Ann Rheum Dis 67, no. 12 (December 2008): 1683–88. https://doi.org/10.1136/ard.2007.076919.
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  - Mazzuca, S. A., M. -. P. Hellio Le Graverand, E. Vignon, D. J. Hunter, C. G. Jackson, V. B. Kraus, T. M. Link, T. J. Schnitzer, A. Vaz, and H. C. Charles. “Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees.” Osteoarthritis Cartilage 16, no. 12 (December 2008): 1555–59. https://doi.org/10.1016/j.joca.2008.04.010.
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  - Le Graverand, M-P Hellio, E. P. Vignon, K. D. Brandt, S. A. Mazzuca, M. Piperno, R. Buck, H. C. Charles, et al. “Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees.” Ann Rheum Dis 67, no. 11 (November 2008): 1562–66. https://doi.org/10.1136/ard.2007.077834.
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  - Forkner, I. F., C. A. Piantadosi, H. C. Charles, N. Scafetta, and R. E. Moon. “Hyperoxia-induced decrease in organ blood flow [10].” Anesthesiology 108, no. 1 (January 1, 2008): 169–70. https://doi.org/10.1097/01.anes.0000296643.13634.41.
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  - Forkner, I. F., C. A. Piantadosi, H. C. Charles, N. Scafetta, and R. E. Moon. “In reply (Anesthesiology (2008) 108, (169-170)).” Anesthesiology 108, no. 3 (January 1, 2008).
  - Charles, H. C., V. B. Kraus, M. Ainslie, and M. -. P. Hellio Le Graverand-Gastineau. “Optimization of the fixed-flexion knee radiograph.” Osteoarthritis Cartilage 15, no. 11 (November 2007): 1221–24. https://doi.org/10.1016/j.joca.2007.05.012.
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  - Tupler, Larry A., K Ranga R. Krishnan, Daniel L. Greenberg, Santica M. Marcovina, Martha E. Payne, James R. MacFall, H Cecil Charles, and P Murali Doraiswamy. “Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve.” Neurobiol Aging 28, no. 11 (November 2007): 1644–56. https://doi.org/10.1016/j.neurobiolaging.2006.07.001.
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  - Eckstein, Felix, Robert J. Buck, Bradley T. Wyman, John J. Kotyk, Marie-Pierre Hellio Le Graverand, Ann E. Remmers, Jeffrey L. Evelhoch, Martin Hudelmaier, and H Cecil Charles. “Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).” Magn Reson Med 58, no. 2 (August 2007): 402–6. https://doi.org/10.1002/mrm.21290.
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  - Feldman, Howard H., Steven Ferris, Bengt Winblad, Nikolaos Sfikas, Linda Mancione, Yunsheng He, Sibel Tekin, et al. “Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study.” Lancet Neurol 6, no. 6 (June 2007): 501–12. https://doi.org/10.1016/S1474-4422(07)70109-6.
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  - Lora-Michiels, Michaël, Daohai Yu, Linda Sanders, Jean M. Poulson, Chieko Azuma, Beth Case, Zeljko Vujaskovic, Donald E. Thrall, H Cecil Charles, and Mark W. Dewhirst. “Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.” Clin Cancer Res 12, no. 19 (October 1, 2006): 5733–40. https://doi.org/10.1158/1078-0432.CCR-05-2669.
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  - Arias-Mendoza, F., G. S. Payne, K. L. Zakian, A. J. Schwarz, M. Stubbs, R. Stoyanova, D. Ballon, et al. “In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial.” Nmr Biomed 19, no. 4 (June 2006): 504–12. https://doi.org/10.1002/nbm.1057.
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  - Soher, Brian J., P Murali Doraiswamy, and H Cecil Charles. “A review of 1H MR spectroscopy findings in Alzheimer's disease.” Neuroimaging Clin N Am 15, no. 4 (November 2005): 847–xi. https://doi.org/10.1016/j.nic.2005.09.013.
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  - Strakowski, Stephen M., Jacqueline L. Johnson, Melissa P. Delbello, Robert M. Hamer, Alan I. Green, Mauricio Tohen, Jeffrey A. Lieberman, Ira Glick, Jayendra K. Patel, and Jayendra K. HGDH Research Group. “Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode.” Schizophr Res 78, no. 2–3 (October 15, 2005): 161–69. https://doi.org/10.1016/j.schres.2005.04.017.
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  - Eckstein, Felix, H Cecil Charles, Robert J. Buck, Virginia B. Kraus, Ann E. Remmers, Martin Hudelmaier, Wolfgang Wirth, and Jeffrey L. Evelhoch. “Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.” Arthritis Rheum 52, no. 10 (October 2005): 3132–36. https://doi.org/10.1002/art.21348.
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  - Lieberman, Jeffrey A., Gary D. Tollefson, Cecil Charles, Robert Zipursky, Tonmoy Sharma, Rene S. Kahn, Richard S. E. Keefe, et al. “Antipsychotic drug effects on brain morphology in first-episode psychosis.” Arch Gen Psychiatry 62, no. 4 (April 2005): 361–70. https://doi.org/10.1001/archpsyc.62.4.361.
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  - Dewhirst, Mark W., Jean M. Poulson, Daohai Yu, Linda Sanders, Michaël Lora-Michiels, Zeljko Vujaskovic, Ellen L. Jones, et al. “Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy.” Int J Radiat Oncol Biol Phys 61, no. 2 (February 1, 2005): 480–91. https://doi.org/10.1016/j.ijrobp.2004.06.211.
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  - Chakos, Miranda H., Scott A. Schobel, Hongbin Gu, Guido Gerig, Daniel Bradford, Cecil Charles, and Jeffrey A. Lieberman. “Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia.” Br J Psychiatry 186 (January 2005): 26–31. https://doi.org/10.1192/bjp.186.1.26.
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  - Farlow, M. R., Y. He, S. Tekin, J. Xu, R. Lane, and H. C. Charles. “Impact of APOE in mild cognitive impairment.” Neurology 63, no. 10 (November 23, 2004): 1898–1901. https://doi.org/10.1212/01.wnl.0000144279.21502.b7.
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  - Arias-Mendoza, F., K. Zakian, A. Schwartz, F. A. Howe, J. A. Koutcher, M. O. Leach, J. R. Griffiths, et al. “Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies.” Nmr Biomed 17, no. 6 (October 2004): 382–91. https://doi.org/10.1002/nbm.915.
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  - Slikker, William, Amy Pogge, Ronald Walker, Arion Chatziiannou, Cecil Charles, and Mark Ellisman. “Neuroimaging: strategies to illuminate environment-disease linkages. Session II. Summary and research needs.” Neurotoxicology 25, no. 4 (June 2004): 501–2. https://doi.org/10.1016/j.neuro.2003.09.011.
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  - Krishnan, K Ranga Rama, H Cecil Charles, P Murali Doraiswamy, Jacobo Mintzer, Richard Weisler, Xin Yu, Carlos Perdomo, John R. Ieni, and Sharon Rogers. “Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.” Am J Psychiatry 160, no. 11 (November 2003): 2003–11. https://doi.org/10.1176/appi.ajp.160.11.2003.
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  - Vythilingam, Meena, H Cecil Charles, Larry A. Tupler, Timothy Blitchington, Lisalynn Kelly, and K Ranga Rama Krishnan. “Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.” Biol Psychiatry 54, no. 7 (October 1, 2003): 744–50. https://doi.org/10.1016/s0006-3223(02)01908-x.
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  - Kim, Dennis M., Stavra A. Xanthakos, Larry A. Tupler, Daniel P. Barboriak, H Cecil Charles, James R. MacFall, and K Ranga Rama Krishnan. “MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.” Psychiatry Res 114, no. 3 (July 1, 2002): 149–61. https://doi.org/10.1016/s0925-4927(02)00024-0.
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  - Chen, J Gene, Christopher L. Edwards, Suman Vidyarthi, Suresh Pitchumoni, Sara Tabrizi, Dan Barboriak, H Cecil Charles, and P Murali Doraiswamy. “Learning and recall in subjects at genetic risk for Alzheimer's disease.” J Neuropsychiatry Clin Neurosci 14, no. 1 (2002): 58–63. https://doi.org/10.1176/jnp.14.1.58.
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  - Styner, M. A., H. C. Charles, J. Park, and G. Gerig. “Multi-site validation of image analysis methods - Assessing intra and inter-site variability.” Proceedings of Spie the International Society for Optical Engineering 4684 I (January 1, 2002): 278–86. https://doi.org/10.1117/12.467167.
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  - Gilmore, J. H., G. Gerig, B. Specter, H. C. Charles, J. S. Wilber, B. S. Hertzberg, and M. A. Kliewer. “Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging.” Ultrasound Med Biol 27, no. 8 (August 2001): 1143–46. https://doi.org/10.1016/s0301-5629(01)00400-8.
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  - Gilmore, J. H., J. J. van Tol, H. Lewis Streicher, K. Williamson, S. B. Cohen, R. S. Greenwood, H. C. Charles, et al. “Outcome in children with fetal mild ventriculomegaly: a case series.” Schizophr Res 48, no. 2–3 (March 30, 2001): 219–26. https://doi.org/10.1016/s0920-9964(00)00140-7.
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  - Doraiswamy, P. M., D. Barboriak, K. R. R. Krishnan, G. Chen, J. Smith, and H. C. Charles. “Brain 1H-MR spectroscopy in subjects at risk for Alzheimer's disease.” Neurobiology of Aging 22, no. 2 (March 1, 2001): 336–37.
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  - Barboriak, D. P., P. M. Doraiswamy, K. R. Krishnan, S. Vidyarthi, J. Sylvester, and H. C. Charles. “Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.” Neurology 54, no. 11 (June 13, 2000): 2150–53. https://doi.org/10.1212/wnl.54.11.2150.
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  - Prescott, D. M., H. C. Charles, J. M. Poulson, R. L. Page, D. E. Thrall, Z. Vujaskovic, and M. W. Dewhirst. “The relationship between intracellular and extracellular pH in spontaneous canine tumors.” Clin Cancer Res 6, no. 6 (June 2000): 2501–5.
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  - Chen, J. G., H. C. Charles, D. P. Barboriak, and P. M. Doraiswamy. “Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate.” Acta Neurol Scand Suppl 176 (2000): 20–26. https://doi.org/10.1034/j.1600-0404.2000.00303.x.
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  - Doraiswamy, P. M., J. G. Chen, and H. C. Charles. “Brain magnetic resonance spectroscopy: Role in assessing outcomes in Alzheimer's disease.” Cns Drugs 14, no. 6 (January 1, 2000): 457–72. https://doi.org/10.2165/00023210-200014060-00004.
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  - Vujaskovic, Z., J. M. Poulson, A. A. Gaskin, D. E. Thrall, R. L. Page, H. C. Charles, J. R. MacFall, et al. “Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment.” Int J Radiat Oncol Biol Phys 46, no. 1 (January 1, 2000): 179–85. https://doi.org/10.1016/s0360-3016(99)00362-4.
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  - McAdams, H. P., S. M. Palmer, L. F. Donnelly, H. C. Charles, V. F. Tapson, and J. R. MacFall. “Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results.” Ajr Am J Roentgenol 173, no. 4 (October 1999): 955–59. https://doi.org/10.2214/ajr.173.4.10511156.
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  - Donnelly, L. F., J. R. MacFall, H. P. McAdams, J. M. Majure, J. Smith, D. P. Frush, P. Bogonad, H. C. Charles, and C. E. Ravin. “Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.” Radiology 212, no. 3 (September 1999): 885–89. https://doi.org/10.1148/radiology.212.3.r99se20885.
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  - Van Hove, J. L., F. Lazeyras, S. H. Zeisel, T. Bottiglieri, K. Hyland, H. C. Charles, L. Gray, J. Jaeken, and S. G. Kahler. “One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.” J Inherit Metab Dis 21, no. 8 (December 1998): 799–811. https://doi.org/10.1023/a:1005462400552.
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  - Doraiswamy, P. M., H. C. Charles, and K. R. Krishnan. “Prediction of cognitive decline in early Alzheimer's disease.” Lancet 352, no. 9141 (November 21, 1998): 1678. https://doi.org/10.1016/S0140-6736(05)61449-3.
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  - Lazeyras, F., H. C. Charles, L. A. Tupler, R. Erickson, O. B. Boyko, and K. R. Krishnan. “Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy.” Psychiatry Res 82, no. 2 (May 20, 1998): 95–106. https://doi.org/10.1016/s0925-4927(98)00010-9.
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  - Carter, D. L., J. R. MacFall, S. T. Clegg, X. Wan, D. M. Prescott, H. C. Charles, and T. V. Samulski. “Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma.” Int J Radiat Oncol Biol Phys 40, no. 4 (March 1, 1998): 815–22. https://doi.org/10.1016/s0360-3016(97)00855-9.
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  - Chakos, M. H., S. Esposito, C. Charles, and J. A. Lieberman. “Clinical applications of neuroimaging in psychiatry.” Magn Reson Imaging Clin N Am 6, no. 1 (February 1998): 155–64.
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  - Dewhirst, M. W., L. Prosnitz, D. Thrall, D. Prescott, S. Clegg, C. Charles, J. MacFall, et al. “Hyperthermic treatment of malignant diseases: current status and a view toward the future.” Semin Oncol 24, no. 6 (December 1997): 616–25.
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  - Rosenberg, B. S., H. Green, F. Schachat, H. C. Charles, K. F. Adams, M. H. Hawthorne, B. D. Duscha, M. Sloniger, and M. J. Sullivan. “Normal skeletal muscle contractile function in patients with chronic heart failure.” Circulation 96, no. 8 (October 21, 1997): 1785–1785.
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  - Tupler, L. A., J. R. Davidson, R. D. Smith, F. Lazeyras, H. C. Charles, and K. R. Krishnan. “A repeat proton magnetic resonance spectroscopy study in social phobia.” Biol Psychiatry 42, no. 6 (September 15, 1997): 419–24. https://doi.org/10.1016/S0006-3223(96)00501-X.
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  - Brizel, D. M., S. P. Scully, J. M. Harrelson, L. J. Layfield, R. K. Dodge, H. C. Charles, T. V. Samulski, L. R. Prosnitz, and M. W. Dewhirst. “Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.” Cancer Res 56, no. 23 (December 1, 1996): 5347–50.
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  - Vallée, J. P., F. Lazeyras, H. D. Sostman, S. R. Smith, D. W. Butterly, C. E. Spritzer, and H. C. Charles. “Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys.” Acad Radiol 3, no. 12 (December 1996): 1030–37. https://doi.org/10.1016/s1076-6332(96)80040-7.
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  - Byrum, C. E., J. R. MacFall, H. C. Charles, V. R. Chitilla, O. B. Boyko, L. Upchurch, J. S. Smith, et al. “Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method.” Psychiatry Res 67, no. 3 (October 7, 1996): 215–34. https://doi.org/10.1016/0925-4927(96)02790-4.
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  - MacFall, J. R., D. M. Prescott, H. C. Charles, and T. V. Samulski. “1H MRI phase thermometry in vivo in canine brain, muscle, and tumor tissue.” Med Phys 23, no. 10 (October 1996): 1775–82. https://doi.org/10.1118/1.597760.
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  - Jones, D. N., G. B. McCowage, H. D. Sostman, D. M. Brizel, L. Layfield, H. C. Charles, M. W. Dewhirst, et al. “Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.” J Nucl Med 37, no. 9 (September 1996): 1438–44.
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  - MacFall, J. R., H. C. Charles, R. D. Black, H. Middleton, J. C. Swartz, B. Saam, B. Driehuys, et al. “Human lung air spaces: potential for MR imaging with hyperpolarized He-3.” Radiology 200, no. 2 (August 1996): 553–58. https://doi.org/10.1148/radiology.200.2.8685356.
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  - Daniel Armstrong, F., R. J. Thompson, M. D. Winfred Wang, M. D. Robert Zimmerman, H. Charles, M. D. Pegelow, M. D. Scott Miller, et al. “Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease.” Pediatrics 97, no. 6 I (June 13, 1996): 864–70.
  - Xanthakos, S., K. R. Krishnan, D. M. Kim, and H. C. Charles. “Magnetic resonance imaging of Alzheimer's disease.” Prog Neuropsychopharmacol Biol Psychiatry 20, no. 4 (May 1996): 597–626. https://doi.org/10.1016/0278-5846(96)00035-8.
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  - Charles, H. C., F. Lazeyras, L. A. Tupler, and K. R. Krishnan. “Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain.” Magn Reson Med 35, no. 4 (April 1996): 606–10. https://doi.org/10.1002/mrm.1910350422.
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  - Miner, C. M., J. R. Davidson, N. L. Potts, L. A. Tupler, H. C. Charles, and K. R. Krishnan. “Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia.” Biol Psychiatry 38, no. 10 (November 15, 1995): 696–98. https://doi.org/10.1016/0006-3223(95)00287-1.
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  - Passe, T. J., H. C. Charles, P. Rajagopalan, and K. R. Krishnan. “Nuclear magnetic resonance spectroscopy: a review of neuropsychiatric applications.” Prog Neuropsychopharmacol Biol Psychiatry 19, no. 4 (July 1995): 541–63. https://doi.org/10.1016/0278-5846(95)00101-z.
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  - Leach, M. O., D. Arnold, T. R. Brown, H. C. Charles, J. D. de Certaines, J. L. Evelhoch, A. R. Margulis, W. G. Negendank, S. J. Nelson, and F. Podo. “International workshop on standardization in clinical MRS measurements: proceedings and recommendations.” Technol Health Care 2, no. 4 (December 1994): 217–34.
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  - Charles, H. C., F. Lazeyras, K. R. Krishnan, O. B. Boyko, M. Payne, and D. Moore. “Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.” Prog Neuropsychopharmacol Biol Psychiatry 18, no. 7 (November 1994): 1121–27. https://doi.org/10.1016/0278-5846(94)90115-5.
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  - Sullivan, M. J., B. Saltin, R. Negro-Vilar, B. D. Duscha, and H. C. Charles. “Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men.” J Appl Physiol (1985) 77, no. 5 (November 1994): 2194–2200. https://doi.org/10.1152/jappl.1994.77.5.2194.
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  - Charles, H. C., F. Lazeyras, K. R. Krishnan, O. B. Boyko, L. J. Patterson, P. M. Doraiswamy, and W. M. McDonald. “Proton spectroscopy of human brain: effects of age and sex.” Prog Neuropsychopharmacol Biol Psychiatry 18, no. 6 (October 1994): 995–1004. https://doi.org/10.1016/0278-5846(94)90125-2.
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  - Leach, M. O., D. Arnold, T. R. Brown, H. C. Charles, J. D. de Certaines, J. L. Evelhoch, A. R. Margulis, W. G. Negendank, S. J. Nelson, and F. Podo. “International Workshop on Standardization in Clinical Magnetic Resonance Spectroscopy Measurements: proceedings and recommendations.” Acad Radiol 1, no. 2 (October 1994): 171–86. https://doi.org/10.1016/s1076-6332(05)80838-4.
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  - MacFall, J. R., C. E. Byrum, I. Parashos, B. Early, H. C. Charles, V. Chittilla, O. B. Boyko, L. Upchurch, and K. R. Krishnan. “Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods.” Psychiatry Res 55, no. 3 (September 1994): 167–77. https://doi.org/10.1016/0925-4927(94)90024-8.
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  - JONES, D. N., D. M. BRIZEL, H. C. CHARLES, M. W. DEWHIRST, H. S. FRIEDMAN, G. MCCOWAGE, D. M. PRESCOTT, H. D. SOSTMAN, and R. E. COLEMAN. “MONITORING OF RESPONSE TO NEOADJUVANT THERAPY OF SOFT-TISSUE AND MUSCULOSKELETAL SARCOMAS USING F-18-FDG PET.” Journal of Nuclear Medicine 35, no. 5 (May 1, 1994): P38–P38.
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  - Prescott, D. M., H. C. Charles, H. D. Sostman, R. K. Dodge, D. E. Thrall, R. L. Page, J. A. Tucker, J. M. Harrelson, K. A. Leopold, and J. R. Oleson. “Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy.” Int J Radiat Oncol Biol Phys 28, no. 2 (January 15, 1994): 415–23. https://doi.org/10.1016/0360-3016(94)90065-5.
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  - Cazzaniga, S., S. C. Schold, H. D. Sostman, and H. C. Charles. “Effects of therapy on the 1H NMR spectrum of a human glioma line.” Magn Reson Imaging 12, no. 6 (1994): 945–50. https://doi.org/10.1016/0730-725x(94)92035-4.
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  - Sostman, H. D., D. M. Prescott, M. W. Dewhirst, R. K. Dodge, D. E. Thrall, R. L. Page, J. A. Tucker, J. M. Harrelson, G. Reece, and K. A. Leopold. “MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas.” Radiology 190, no. 1 (January 1994): 269–75. https://doi.org/10.1148/radiology.190.1.8259418.
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  - Davidson, J. R., K. R. Krishnan, H. C. Charles, O. Boyko, N. L. Potts, S. M. Ford, and L. Patterson. “Magnetic resonance spectroscopy in social phobia: preliminary findings.” J Clin Psychiatry 54 Suppl (December 1993): 19–25.
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  - Prescott, D. M., H. C. Charles, H. D. Sostman, R. L. Page, D. E. Thrall, D. Moore, J. R. Oleson, and M. W. Dewhirst. “Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia.” Int J Hyperthermia 9, no. 5 (September 1993): 745–54. https://doi.org/10.3109/02656739309032061.
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  - Davidson, J. R. T., N. Potts, R. Krishnan, O. Boyko, C. Charles, R. Smith, S. Ford, L. A. Tupler, and W. Wilson. “Biology of social phobia.” European Neuropsychopharmacology 3, no. 3 (January 1, 1993): 192–93. https://doi.org/10.1016/0924-977X(93)90019-I.
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  - Krishnan, K. R. R., O. B. Boyko, W. M. McDonald, H. C. Charles, J. R. Macfall, L. A. Tupler, and L. W. Upchurch. “Magnetic‐resonance morphometry: Image‐analysis methodology development for affective disorder.” Depression 1, no. 3 (January 1, 1993): 159–71. https://doi.org/10.1002/depr.3050010308.
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  - Samulski, T. V., J. MacFall, Y. Zhang, W. Grant, and C. Charles. “Non-invasive thermometry using magnetic resonance diffusion imaging: potential for application in hyperthermic oncology.” Int J Hyperthermia 8, no. 6 (November 1992): 819–29. https://doi.org/10.3109/02656739209005029.
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  - Wilson, C. A., B. A. Berkowitz, B. W. McCuen, and H. C. Charles. “Measurement of preretinal oxygen tension in the vitrectomized human eye using fluorine-19 magnetic resonance spectroscopy.” Arch Ophthalmol 110, no. 8 (August 1992): 1098–1100. https://doi.org/10.1001/archopht.1992.01080200078028.
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  - Holland, G. N., and J. R. MacFall. “An overview of digital spectrometers for MR imaging. Instrumentation Subcommittee of the SMRI Basic Science Council.” J Magn Reson Imaging 2, no. 2 (March 1992): 241–46. https://doi.org/10.1002/jmri.1880020221.
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  - Iwai, F., H. D. Sostman, A. J. Evans, S. N. Nadel, L. W. Hedlund, C. A. Beam, H. C. Charles, and C. E. Spritzer. “Cine phase-contrast magnetic resonance imaging for analysis of flow phenomena in experimental aortic dissection.” Invest Radiol 26, no. 12 (December 1991): 1071–78. https://doi.org/10.1097/00004424-199112000-00007.
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  - Samulski, T. V., J. MacFall, Y. Zhang, D. Palmer, C. Charles, and W. Grant. “More on the feasibility of using MRI for noninvasive thermometry in hyperthermia.” American Society of Mechanical Engineers, Heat Transfer Division, (Publication) Htd 189 (December 1, 1991): 57–60.
  - Sostman, H. D., S. Rockwell, A. L. Sylvia, D. Madwed, G. Cofer, H. C. Charles, R. Negro-Vilar, and D. Moore. “Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy.” Magn Reson Med 20, no. 2 (August 1991): 253–67. https://doi.org/10.1002/mrm.1910200208.
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  - Sostman, H. D., and H. C. Charles. “Bone and soft tissue lesions: diagnosis with combined H-1 MR imaging and P-31 MR spectroscopy.” Invest Radiol 26, no. 8 (August 1991): 769–70. https://doi.org/10.1097/00004424-199108000-00016.
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  - Weidman, E. R., H. C. Charles, R. Negro-Vilar, M. J. Sullivan, and J. R. MacFall. “Muscle activity localization with 31P spectroscopy and calculated T2-weighted 1H images.” Invest Radiol 26, no. 4 (April 1991): 309–16. https://doi.org/10.1097/00004424-199104000-00005.
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  - Grist, T. M., H. C. Charles, and H. D. Sostman. “1990 ARRS Executive Council Award. Renal transplant rejection: diagnosis with 31P MR spectroscopy.” Ajr Am J Roentgenol 156, no. 1 (January 1991): 105–12. https://doi.org/10.2214/ajr.156.1.1898541.
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  - Sostman, H. D., H. C. Charles, S. Rockwell, K. Leopold, C. Beam, D. Madwed, M. Dewhirst, G. Cofer, D. Moore, and R. Burn. “Soft-tissue sarcomas: detection of metabolic heterogeneity with P-31 MR spectroscopy.” Radiology 176, no. 3 (September 1990): 837–43. https://doi.org/10.1148/radiology.176.3.2389045.
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  - Sostman, H. D., and H. C. Charles. “Noninvasive differentiation of tumors with use of localized H-1 spectroscopy in vivo: initial experience in patients with cerebral tumors.” Invest Radiol 25, no. 9 (September 1990): 1047–50.
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  - Dewhirst, M. W., H. D. Sostman, K. A. Leopold, H. C. Charles, D. Moore, R. A. Burn, J. A. Tucker, J. M. Harrelson, and J. R. Oleson. “Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring. Work in progress.” Radiology 174, no. 3 Pt 1 (March 1990): 847–53. https://doi.org/10.1148/radiology.174.3.2154837.
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  - Charles, H. C., M. E. Baker, J. W. Hathorn, and D. Sostman. “Differentiation of radiation fibrosis from recurrent neoplasia: a role for 31P MR spectroscopy?” Ajr Am J Roentgenol 154, no. 1 (January 1990): 67–68. https://doi.org/10.2214/ajr.154.1.2104728.
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  - MacFall, J. R., H. C. Charles, and R. Prost. “Truncated sinc slice excitation for 31P spectroscopic imaging.” Magn Reson Imaging 8, no. 5 (1990): 619–24. https://doi.org/10.1016/0730-725x(90)90140-w.
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  - BOYKO, O. B., R. W. PROST, S. C. SCHOLD, C. KARFIAS, and H. C. CHARLES. “INTEGRATION OF MRS AND MR FOR EVALUATION OF NEOPLASTIC DISEASE IN THE BRAIN.” American Journal of Neuroradiology 10, no. 4 (July 1, 1989): 893–893.
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  - MACFALL, J., R. A. PROST, C. KARFIAS, and H. C. CHARLES. “A COMPARISON OF SLICE SELECTION-STRATEGIES FOR P-31 SPECTROSCOPIC IMAGING.” American Journal of Neuroradiology 10, no. 4 (July 1, 1989): 893–893.
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  - Charles, H. C. “Cardiac applications of MR spectroscopy and spectroscopic imaging.” Cardiovascular and Interventional Radiology 12, no. 4 (January 1, 1989): 215–16.
  - Maynor, C. H., H. C. Charles, R. J. Herfkens, S. A. Suddarth, and G. A. Johnson. “Chemical shift imaging of atherosclerosis at 7.0 Tesla.” Invest Radiol 24, no. 1 (January 1989): 52–60. https://doi.org/10.1097/00004424-198901000-00012.
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  - Lenkinski, R. E., G. A. Holland, T. Allman, K. Vogele, H. Y. Kressel, R. I. Grossman, H. C. Charles, H. R. Engeseth, D. Flamig, and J. R. MacFall. “Integrated MR imaging and spectroscopy with chemical shift imaging of P-31 at 1.5 T: initial clinical experience.” Radiology 169, no. 1 (October 1988): 201–6. https://doi.org/10.1148/radiology.169.1.3420258.
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  - MAYNOR, C. H., H. C. CHARLES, R. J. HERFKENS, S. A. SUDDARTH, and G. A. JOHNSON. “INVITRO CHEMICAL-SHIFT IMAGING OF ATHEROSCLEROSIS AT 7.0-TESLA.” Investigative Radiology 23, no. 9 (September 1, 1988): S3–S3.
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  - Bottomley, P. A., H. C. Charles, P. B. Roemer, D. Flamig, H. Engeseth, W. A. Edelstein, and O. M. Mueller. “Human in vivo phosphate metabolite imaging with 31P NMR.” Magn Reson Med 7, no. 3 (July 1988): 319–36. https://doi.org/10.1002/mrm.1910070309.
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  - Allman, T., G. A. Holland, R. E. Lenkinski, and H. C. Charles. “A simple method for processing NMR spectra in which acquisition is delayed: applications to in vivo localized 31P NMR spectra acquired using the DRESS technique.” Magn Reson Med 7, no. 1 (May 1988): 88–94. https://doi.org/10.1002/mrm.1910070110.
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  - Nichols, P. F., H. C. Charles, J. S. Read, and M. F. Goldberg. “Evaluation of choroidal neovascular membranes by Octopus perimetry.” Retina 8, no. 1 (1988): 24–29. https://doi.org/10.1097/00006982-198808010-00006.
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  - Peyman, G. A., H. C. Charles, K. R. Liu, B. Khoobehi, and M. Niesman. “Intravitreal liposome-encapsulated drugs: a preliminary human report.” Int Ophthalmol 12, no. 3 (1988): 175–82. https://doi.org/10.1007/BF00130002.
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  - Peyman, G. A., H. C. Charles, and A. Alghadyan. “Internal trans-pars plana filtering procedure in humans.” Int Ophthalmol 11, no. 3 (January 1988): 159–62. https://doi.org/10.1007/BF00130617.
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  - Lee, C. M., H. C. Charles, R. T. Smith, N. S. Peachey, J. G. Cunha-Vaz, and M. F. Goldberg. “Quantification of macular ischaemia in sickle cell retinopathy.” Br J Ophthalmol 71, no. 7 (July 1987): 540–45. https://doi.org/10.1136/bjo.71.7.540.
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  - Peachey, N. S., H. C. Charles, C. M. Lee, G. A. Fishman, J. G. Cunha-Vaz, and R. T. Smith. “Electroretinographic findings in sickle cell retinopathy.” Arch Ophthalmol 105, no. 7 (July 1987): 934–38. https://doi.org/10.1001/archopht.1987.01060070070031.
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  - Smith, R. T., C. M. Lee, H. C. Charles, M. Farber, and J. G. Cunha-Vaz. “Quantification of diabetic macular edema.” Arch Ophthalmol 105, no. 2 (February 1987): 218–22. https://doi.org/10.1001/archopht.1987.01060020072032.
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  - Borges, J. M., H. C. Charles, C. M. Lee, R. T. Smith, J. G. Cunha-Vaz, M. F. Goldberg, and M. O. Tso. “A clinicopathologic study of dye laser photocoagulation on primate retina.” Retina 7, no. 1 (1987): 46–57.
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  - Breger, R. K., F. W. Wehrli, H. C. Charles, J. R. MacFall, and V. M. Haughton. “Reproducibility of relaxation and spin-density parameters in phantoms and the human brain measured by MR imaging at 1.5 T.” Magn Reson Med 3, no. 5 (October 1986): 649–62. https://doi.org/10.1002/mrm.1910030502.
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  - Axel, L., R. M. Summers, H. Y. Kressel, and C. Charles. “Respiratory effects in two-dimensional Fourier transform MR imaging.” Radiology 160, no. 3 (September 1986): 795–801. https://doi.org/10.1148/radiology.160.3.3737920.
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  - Wehrli, F. W., R. K. Breger, J. R. MacFall, D. L. Daniels, V. M. Haughton, H. C. Charles, and A. L. Williams. “Quantification of contrast in clinical MR brain imaging at high magnetic field.” Invest Radiol 20, no. 4 (July 1985): 360–69. https://doi.org/10.1097/00004424-198507000-00005.
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  - Koehler, P. R., V. M. Haughton, D. L. Daniels, A. L. Williams, Z. Yetkin, H. C. Charles, and D. Shutts. “MR measurement of normal and pathologic brainstem diameters.” Ajnr Am J Neuroradiol 6, no. 3 (May 1985): 425–27.
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  - Bottomley, P. A., L. Scott Smith, W. M. Leue, and C. Charles. “Slice-interleaved depth-resolved surface-coil spectroscopy (SLIT DRESS) for rapid ³¹P NMR in Vivo.” Journal of Magnetic Resonance (1969) 64, no. 2 (January 1, 1985): 347–51. https://doi.org/10.1016/0022-2364(85)90363-4.
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  - Domer, F. R., D. M. Chihal, H. C. Charles, and R. C. Koch. “Synthesis, biological activity, and structure--activity/toxicity relationships of a series of terphenyl analogues of hemicholinium-3 and acetyl-seco-hemicholinium-3. 3.” Journal of Medicinal Chemistry 23, no. 5 (May 1980): 541–45. https://doi.org/10.1021/jm00179a013.
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  - Domer, F. R., H. C. Charles, R. C. Koch, and D. M. Chihal. “Biological evaluation of some norphenyl analogs of hemicholinium No. 3 and acetyl-seco-hemicholinium No. 3.” Arch Int Pharmacodyn Ther 234, no. 2 (August 1978): 221–28.
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  - Domer, F. R., G. Wessler, R. L. Brown, and H. C. Charles. “Involvement of the sympathetic nervous system in the urinary bladder internal sphincter and in penile erection in the anesthetized cat.” Invest Urol 15, no. 5 (March 1978): 404–7.
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  - Domer, F. R., H. C. Charles, D. M. Chihal, and R. C. Koch. “Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3.” Arch Int Pharmacodyn Ther 229, no. 2 (October 1977): 276–86.
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  - Domer, F. R., R. C. Koch, H. C. Charles, and D. M. Chihal. “Biological evaluation of some terphenyl analogs of hemicholinium No. 3.” Arch Int Pharmacodyn Ther 229, no. 2 (October 1977): 251–60.
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  - Domer, F. R., D. M. Chihal, and H. C. Charles. “Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.” J Pharm Sci 66, no. 2 (February 1977): 269–70. https://doi.org/10.1002/jps.2600660234.
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  - Domer, F. R., D. M. Chihal, H. C. Charles, and A. B. Rege. “Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships.” Journal of Medicinal Chemistry 20, no. 1 (January 1977): 59–62. https://doi.org/10.1021/jm00211a011.
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  - Haarstad, V. B., F. R. Domer, D. M. Chihal, A. B. Rege, and H. C. Charles. “Synthesis and structure-toxicity relationships of three new stable analogues of acetyl-seco-hemicholinium-3.” Journal of Medicinal Chemistry 19, no. 6 (June 1976): 760–63. https://doi.org/10.1021/jm00228a004.
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- Conference Papers
  - Eckstein, F., R. J. Buck, H. C. Charles, M. Hudelmaier, W. Wirth, V. B. Kraus, and J. L. Evelhoch. “Improved precision of quantitative cartilage measurements with magnetic resonance imaging at 3 T.” In Osteoarthritis and Cartilage, 12:S119–S119. W B SAUNDERS CO LTD, 2004.
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  - Lieberman, J. A., H. C. Charles, T. Sharma, R. B. Zipursky, R. Kahn, R. E. Gur, M. Tohen, et al. “Antipsychotic treatment effects on progression of brain pathomorphology in first episode schizophrenia.” In Biological Psychiatry, 53:178S-178S. ELSEVIER SCIENCE INC, 2003.
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  - Renshaw, P. F., D. A. Yurgelun-Todd, H. Wei, H. C. Charles, M. Tohen, T. Sharma, R. B. Zipursky, et al. “Olanzapine induced reductions in frontal lobe lactate levels correlate with treatment response in first episode psychosis.” In Biological Psychiatry, 53:67S-67S. ELSEVIER SCIENCE INC, 2003.
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  - Yurgelun-Todd, D. A., P. F. Renshaw, H. Wei, R. S. E. Keefe, H. C. Charles, M. Tohen, L. J. Seidman, et al. “Improved attention is associated with reductions in frontal lobe lactate levels in first episode psychosis.” In Biological Psychiatry, 53:156S-156S. ELSEVIER SCIENCE INC, 2003.
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  - Charles, H. C. “Magnetic resonance spectroscopic imaging and its potential application to clinical neurotoxicology.” In Neurotoxicology, 24:288–288. ELSEVIER SCIENCE BV, 2003.
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Teaching & Mentoring
Advising & Mentoring
- Mentoring activities
  1. Faculty
    1. Deborah Prescott, DVM, PhD
    2. Joseph Mammaparralil, MD, PhD (Current)
    3. Kolby Sidhu, MD (Current)
  2. Fellows, doctoral, post docs
    1. Jean Paul Vallee, MD
    2. Francois Layzeras, PhD (post doc)
    3. Ahmed Halaweish, PhD (post doc)
  3. Resident
    1. Tom Grist, MD
  4. Medical students
    1. Eric Weidman
    2. Carolyn Maynor
    3. S Cazzaniga (with SC Schold)
  5. Graduate Students

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Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Subject Headings

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Selected Publications

Academic Articles

Conference Papers

Advising & Mentoring