Hal Cecil Charles | Scholars@Duke

Hal Cecil Charles
Associate Professor of Radiology

Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development. He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab has developed approaches for imaging lung function (ventilation and V/Q) in humans with 19F MRI.

Current Appointments & Affiliations

Associate Professor of Radiology, Radiology, Clinical Science Departments 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1987

Contact Information

2424 Erwin Road, Suite 301, Hock Plaza, Durham, NC 27705
Box 2702 Med Ctr, Durham, NC 27710
cecil.charles@duke.edu (919) 684-7921
Radiology

Background
Education, Training, & Certifications
- Ph.D., University of New Orleans 1981
Duke Appointment History
- Associate Professor of Radiology, Radiology, Clinical Science Departments 1997 - 2018
- Associate Professor in Radiology, Radiology, Clinical Science Departments 1995 - 1997
- Assistant Professor in Radiology, Radiology, Clinical Science Departments 1987 - 1995
Recognition
Awards & Honors
- Fellow of the Society. International Society of Magnetic Resonance in Medicine. April 2009
Expertise
Subject Headings
Research
Selected Grants
- Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI awarded by National Institutes of Health 2012 - 2018
- PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health 2002 - 2009
- PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health 2002 - 2008
- Child Neglect: Psychobiological Consequences awarded by National Institutes of Health 2000 - 2007
- Adolescent Alcohol Abuse, PTSD & Hippocampal Development awarded by National Institutes of Health 2002 - 2006
- Predicting Human Tumor Response by 31p MRS awarded by National Institutes of Health 1995 - 2001
- Scor In Heart Failure awarded by National Institutes of Health 1995 - 1999
- Depression In Late Life awarded by National Institutes of Health 1995 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1997 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1995 - 1999
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1987 - 1999
- Alzheimers Disease -- Antemortem Markers awarded by National Institutes of Health 1995 - 1999
- Predicting Human Tumor Response By 31p Mrs awarded by National Institutes of Health 1995 - 1999
- Cortisol Cognition Brain Atrophy And Depression awarded by National Institutes of Health 1996 - 1998
- Alzheimer'S Disease: Antemortem Markers awarded by National Institutes of Health 1995 - 1998
- Alzheimers Disease-- Antemortem Markers awarded by National Institutes of Health 1995 - 1998
- Cortisol Cognition Brain Atrophy And Depression awarded by National Institutes of Health 1989 - 1997
- Hyperthermia And Perfusion Effects In Cancer Therapy awarded by National Institutes of Health 1993 - 1995
- Specific Applications Of Pet And Mrs In Brain Tumors awarded by National Institutes of Health 1994 - 1995
- Scor In Coronary And Vascular Diseases awarded by National Institutes of Health 1992 - 1994
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Zapol, WM, Charles, HC, Martin, AR, Sá, RC, Yu, B, Ichinose, F, MacIntyre, N, Mammarappallil, J, Moon, R, Chen, JZ, Geier, ET, Darquenne, C, Prisk, GK, and Katz, I. "Pulmonary Delivery of Therapeutic and Diagnostic Gases." Journal of Aerosol Medicine and Pulmonary Drug Delivery 31, no. 2 (April 2018): 78-87. Full Text Open Access Copy
  - Kraus, VB, Collins, JE, Charles, HC, Pieper, CF, Whitley, L, Losina, E, Nevitt, M, Hoffmann, S, Roemer, F, Guermazi, A, Hunter, DJ, and OA Biomarkers Consortium, . "Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium." Arthritis & Rheumatology (Hoboken, N.J.) 70, no. 1 (January 2018): 80-87. Full Text
  - Huang, C, Shan, L, Charles, HC, Wirth, W, Niethammer, M, and Zhu, H. "Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data." Ieee Transactions on Medical Imaging 34, no. 9 (September 2015): 1914-1927. Full Text
  - Shan, L, Zach, C, Charles, C, and Niethammer, M. "Automatic atlas-based three-label cartilage segmentation from MR knee images." Medical Image Analysis 18, no. 7 (October 2014): 1233-1246. Full Text
  - "Physiorack: An integrated MRI safe/conditional, Gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function." Journal of Magnetic Resonance Imaging 39, no. 3 (March 1, 2014): 735-741. Full Text
  - Halaweish, AF, and Charles, HC. "Physiorack: an integrated MRI safe/conditional, gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function." J Magn Reson Imaging 39, no. 3 (March 2014): 735-741. Full Text Link to Item
  - Halaweish, AF, Moon, RE, Foster, WM, Soher, BJ, McAdams, HP, MacFall, JR, Ainslie, MD, MacIntyre, NR, and Charles, HC. "Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans." Chest 144, no. 4 (October 2013): 1300-1310. Full Text Link to Item
  - Kraus, VB, Feng, S, Wang, S, White, S, Ainslie, M, Graverand, M-PHL, Brett, A, Eckstein, F, Hunter, DJ, Lane, NE, Taljanovic, MS, Schnitzer, T, and Charles, HC. "Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression." Arthritis Rheum 65, no. 7 (July 2013): 1812-1821. Full Text Link to Item
  - Shan, L, Charles, C, and Niethammer, M. "Longitudinal three-label segmentation of knee cartilage." 2013 Ieee 10th International Symposium on Biomedical Imaging (April 2013). Full Text
  - Huang, C, Shan, L, Charles, C, Niethammer, M, and Zhu, H. "Diseased region detection of longitudinal knee MRI data." Information processing in medical imaging : proceedings of the .. conference 23 (2013): 632-643.
  - Huang, C, Shan, L, Charles, C, Niethammer, M, and Zhu, H. "Diseased region detection of longitudinal knee MRI data." Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 7917 LNCS (2013): 632-643. Full Text
  - Shan, L, Charles, C, and Niethammer, M. "Automatic multi-atlas-based cartilage segmentation from knee MR images." 2012 9th Ieee International Symposium on Biomedical Imaging (Isbi) (May 2012). Full Text
  - Shan, L, Charles, C, and Niethammer, M. "Automatic atlas-based three-label cartilage segmentation from MR knee images." 2012 Ieee Workshop on Mathematical Methods in Biomedical Image Analysis (January 2012). Full Text
  - Eckstein, F, Le Graverand, MPH, Charles, HC, Hunter, DJ, Kraus, VB, Sunyer, T, Nemirovskyi, O, Wyman, BT, Buck, R, A9001140, and investigators, . "Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis." Ann Rheum Dis 70, no. 7 (July 2011): 1223-1230. Full Text Link to Item
  - Chuckpaiwong, B, Charles, HC, Kraus, VB, Guilak, F, and Nunley, JA. "Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI." Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society 28, no. 9 (September 2010): 1149-1154. Full Text
  - Shan, L, Zach, C, Styner, M, Charles, C, and Niethammer, M. "Automatic bone segmentation and alignment from MR knee images." Medical Imaging 2010: Image Processing (March 4, 2010). Full Text
  - McDaniel, G, Mitchell, KL, Charles, C, and Kraus, VB. "A comparison of five approaches to measurement of anatomic knee alignment from radiographs." Osteoarthritis and Cartilage 18, no. 2 (February 2010): 273-277. Full Text
  - Dewhirst, MW, Thrall, DE, Palmer, G, Schroeder, T, Vujaskovic, Z, Cecil Charles, H, Macfall, J, and Wong, T. "Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy." Int J Hyperthermia 26, no. 3 (2010): 283-293. (Review) Full Text Link to Item
  - Le Graverand, M-PH, Buck, RJ, Wyman, BT, Vignon, E, Mazzuca, SA, Brandt, KD, Piperno, M, Charles, HC, Hudelmaier, M, Hunter, DJ, Jackson, C, Kraus, VB, Link, TM, Majumdar, S, Prasad, PV, Schnitzer, TJ, Vaz, A, Wirth, W, and Eckstein, F. "Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography." Ann Rheum Dis 69, no. 1 (January 2010): 155-162. Full Text Link to Item
  - Kraus, VB, Feng, S, Wang, S, White, S, Ainslie, M, Brett, A, Holmes, A, and Charles, HC. "Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression." Arthritis Rheum 60, no. 12 (December 2009): 3711-3722. Full Text Link to Item
  - Hellio Le Graverand, M-P, Buck, RJ, Wyman, BT, Vignon, E, Mazzuca, SA, Brandt, KD, Piperno, M, Charles, HC, Hudelmaier, M, Hunter, DJ, Jackson, C, Kraus, VB, Link, TM, Majumdar, S, Prasad, PV, Schnitzer, TJ, Vaz, A, Wirth, W, and Eckstein, F. "Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis." Osteoarthritis Cartilage 17, no. 9 (September 2009): 1177-1185. Full Text Link to Item
  - Viglianti, BL, Lora-Michiels, M, Poulson, JM, Lan, L, Yu, D, Sanders, L, Craciunescu, O, Vujaskovic, Z, Thrall, DE, Macfall, J, Charles, CH, Wong, T, and Dewhirst, MW. "Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 15, no. 15 (August 2009): 4993-5001. Full Text
  - Thompson, PM, Bartzokis, G, Hayashi, KM, Klunder, AD, Lu, PH, Edwards, N, Hong, MS, Yu, M, Geaga, JA, Toga, AW, Charles, C, Perkins, DO, McEvoy, J, Hamer, RM, Tohen, M, Tollefson, GD, Lieberman, JA, and HGDH Study Group, . "Time-lapse mapping of cortical changes in schizophrenia with different treatments." Cerebral Cortex (New York, N.Y. : 1991) 19, no. 5 (May 2009): 1107-1123. Full Text
  - Stauffer, PR, Craciunescu, OI, Maccarini, PF, Wyatt, C, Arunachalam, K, Arabe, O, Stakhursky, V, Soher, B, MacFall, JR, Li, Z, Joines, WT, Rangarao, S, Cheng, KS, Das, SK, Martins, CD, Charles, C, Dewhirst, MW, Wong, T, Jones, E, and Vujaskovic, Z. "Clinical utility of magnetic resonance thermal imaging (MRTI) for realtime guidance of deep hyperthermia." Progress in Biomedical Optics and Imaging Proceedings of Spie 7181 (2009). Full Text
  - Wyatt, C, Soher, B, Maccarini, P, Charles, HC, Stauffer, P, and Macfall, J. "Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours." International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 25, no. 6 (January 2009): 422-433. Full Text
  - Eckstein, F, Buck, RJ, Burstein, D, Charles, HC, Crim, J, Hudelmaier, M, Hunter, DJ, Hutchins, G, Jackson, C, Kraus, VB, Lane, NE, Link, TM, Majumdar, LS, Mazzuca, S, Prasad, PV, Schnitzer, TJ, Taljanovic, MS, Vaz, A, Wyman, B, Le Graverand, M-PH, and A9001140 Study Group, . "Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial." Annals of the Rheumatic Diseases 67, no. 12 (December 2008): 1683-1688. Full Text
  - Mazzuca, SA, Hellio Le Graverand, M-P, Vignon, E, Hunter, DJ, Jackson, CG, Kraus, VB, Link, TM, Schnitzer, TJ, Vaz, A, and Charles, HC. "Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees." Osteoarthritis Cartilage 16, no. 12 (December 2008): 1555-1559. Full Text Link to Item
  - Le Graverand, M-PH, Vignon, EP, Brandt, KD, Mazzuca, SA, Piperno, M, Buck, R, Charles, HC, Hunter, DJ, Jackson, CG, Kraus, VB, Link, TM, Schnitzer, TJ, Vaz, A, and Wyman, B. "Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees." Ann Rheum Dis 67, no. 11 (November 2008): 1562-1566. Full Text Link to Item
  - Forkner, IF, Piantadosi, CA, Charles, HC, Scafetta, N, and Moon, RE. "Hyperoxia-induced decrease in organ blood flow [10]." Anesthesiology 108, no. 1 (January 1, 2008): 169-170. (Letter) Full Text
  - Forkner, IF, Piantadosi, CA, Charles, HC, Scafetta, N, and Moon, RE. "In reply (Anesthesiology (2008) 108, (169-170))." Anesthesiology 108, no. 3 (January 1, 2008): 546-null.
  - Charles, HC, Kraus, VB, Ainslie, M, and Hellio Le Graverand-Gastineau, M-P. "Optimization of the fixed-flexion knee radiograph." Osteoarthritis Cartilage 15, no. 11 (November 2007): 1221-1224. Full Text Link to Item
  - Tupler, LA, Krishnan, KRR, Greenberg, DL, Marcovina, SM, Payne, ME, MacFall, JR, Charles, HC, and Doraiswamy, PM. "Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve." Neurobiology of Aging 28, no. 11 (November 2007): 1644-1656. Full Text
  - Eckstein, F, Buck, RJ, Wyman, BT, Kotyk, JJ, Le Graverand, M-PH, Remmers, AE, Evelhoch, JL, Hudelmaier, M, and Charles, HC. "Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA)." Magn Reson Med 58, no. 2 (August 2007): 402-406. Full Text Link to Item
  - Feldman, HH, Ferris, S, Winblad, B, Sfikas, N, Mancione, L, He, Y, Tekin, S, Burns, A, Cummings, J, del Ser, T, Inzitari, D, Orgogozo, J-M, Sauer, H, Scheltens, P, Scarpini, E, Herrmann, N, Farlow, M, Potkin, S, Charles, HC, Fox, NC, and Lane, R. "Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study." Lancet Neurol 6, no. 6 (June 2007): 501-512. Full Text Link to Item
  - Lora-Michiels, M, Yu, D, Sanders, L, Poulson, JM, Azuma, C, Case, B, Vujaskovic, Z, Thrall, DE, Charles, HC, and Dewhirst, MW. "Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 12, no. 19 (October 2006): 5733-5740. Full Text
  - Arias-Mendoza, F, Payne, GS, Zakian, KL, Schwarz, AJ, Stubbs, M, Stoyanova, R, Ballon, D, Howe, FA, Koutcher, JA, Leach, MO, Griffiths, JR, Heerschap, A, Glickson, JD, Nelson, SJ, Evelhoch, JL, Charles, HC, and Brown, TR. "In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial." NMR Biomed 19, no. 4 (June 2006): 504-512. Full Text Link to Item
  - Soher, BJ, Doraiswamy, PM, and Charles, HC. "A review of 1H MR spectroscopy findings in Alzheimer's disease." Neuroimaging Clin N Am 15, no. 4 (November 2005): 847-xi. (Review) Full Text Link to Item
  - Eckstein, F, Charles, HC, Buck, RJ, Kraus, VB, Remmers, AE, Hudelmaier, M, Wirth, W, and Evelhoch, JL. "Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T." Arthritis and Rheumatism 52, no. 10 (October 2005): 3132-3136. Full Text
  - Strakowski, SM, Johnson, JL, Delbello, MP, Hamer, RM, Green, AI, Tohen, M, Lieberman, JA, Glick, I, Patel, JK, and HGDH Research Group, . "Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode." Schizophrenia Research 78, no. 2-3 (October 2005): 161-169. Full Text
  - Lieberman, JA, Tollefson, GD, Charles, C, Zipursky, R, Sharma, T, Kahn, RS, Keefe, RSE, Green, AI, Gur, RE, McEvoy, J, Perkins, D, Hamer, RM, Gu, H, Tohen, M, and HGDH Study Group, . "Antipsychotic drug effects on brain morphology in first-episode psychosis." Archives of General Psychiatry 62, no. 4 (April 2005): 361-370. Full Text
  - Dewhirst, MW, Poulson, JM, Yu, D, Sanders, L, Lora-Michiels, M, Vujaskovic, Z, Jones, EL, Samulski, TV, Powers, BE, Brizel, DM, Prosnitz, LR, and Charles, HC. "Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy." Int J Radiat Oncol Biol Phys 61, no. 2 (February 1, 2005): 480-491. Full Text Link to Item
  - Chakos, MH, Schobel, SA, Gu, H, Gerig, G, Bradford, D, Charles, C, and Lieberman, JA. "Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia." British Journal of Psychiatry 186, no. JAN. (2005): 26-31. Full Text
  - Farlow, MR, He, Y, Tekin, S, Xu, J, Lane, R, and Charles, HC. "Impact of APOE in mild cognitive impairment." Neurology 63, no. 10 (November 2004): 1898-1901. Full Text
  - Arias-Mendoza, F, Zakian, K, Schwartz, A, Howe, FA, Koutcher, JA, Leach, MO, Griffiths, JR, Heerschap, A, Glickson, JD, Nelson, SJ, Evelhoch, JL, Charles, HC, Brown, TR, and Cooperative Group on MRS Applications in Cancer, . "Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies." Nmr in Biomedicine 17, no. 6 (October 2004): 382-391. (Review) Full Text
  - Jr, WS, Pogge, A, Walker, R, Chatziiannou, A, Charles, C, and Ellisman, M. "Neuroimaging: Strategies to illuminate environment-disease linkages: Session II. Summary and research needs." NeuroToxicology 25, no. 4 SPEC. ISS. (2004): 501-502. Full Text
  - Krishnan, KRR, Charles, HC, Doraiswamy, PM, Mintzer, J, Weisler, R, Yu, X, Perdomo, C, Ieni, JR, and Rogers, S. "Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease." The American Journal of Psychiatry 160, no. 11 (November 2003): 2003-2011. Full Text
  - Vythilingam, M, Charles, HC, Tupler, LA, Blitchington, T, Kelly, L, and Krishnan, KRR. "Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study." Biol Psychiatry 54, no. 7 (October 1, 2003): 744-750. Link to Item
  - Kim, DM, Xanthakos, SA, Tupler, LA, Barboriak, DP, Charles, HC, MacFall, JR, and Krishnan, KRR. "MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex." Psychiatry Res 114, no. 3 (July 1, 2002): 149-161. Link to Item
  - Chen, JG, Edwards, CL, Vidyarthi, S, Pitchumoni, S, Tabrizi, S, Barboriak, D, Charles, HC, and Doraiswamy, PM. "Learning and recall in subjects at genetic risk for Alzheimer's disease." The Journal of Neuropsychiatry and Clinical Neurosciences 14, no. 1 (January 2002): 58-63. Full Text
  - Styner, MA, Charles, HC, Park, J, and Gerig, G. "Multi-site validation of image analysis methods - Assessing intra and inter-site variability." Proceedings of Spie the International Society for Optical Engineering 4684 I (January 1, 2002): 278-286. Full Text
  - Gilmore, JH, Gerig, G, Specter, B, Charles, HC, Wilber, JS, Hertzberg, BS, and Kliewer, MA. "Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging." Ultrasound in Medicine & Biology 27, no. 8 (August 2001): 1143-1146. Full Text
  - Gilmore, JH, van Tol, JJ, Lewis Streicher, H, Williamson, K, Cohen, SB, Greenwood, RS, Charles, HC, Kliewer, MA, Whitt, JK, Silva, SG, Hertzberg, BS, and Chescheir, NC. "Outcome in children with fetal mild ventriculomegaly: a case series." Schizophrenia Research 48, no. 2-3 (March 2001): 219-226. Full Text
  - Doraiswamy, PM, Barboriak, D, Krishnan, KRR, Chen, G, Smith, J, and Charles, HC. "Brain 1H-MR spectroscopy in subjects at risk for Alzheimer's disease." NEUROBIOLOGY OF AGING 22, no. 2 (2001): 336-337. Link to Item
  - Barboriak, DP, Doraiswamy, PM, Krishnan, KR, Vidyarthi, S, Sylvester, J, and Charles, HC. "Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype." Neurology 54, no. 11 (June 13, 2000): 2150-2153. Link to Item
  - Prescott, DM, Charles, HC, Poulson, JM, Page, RL, Thrall, DE, Vujaskovic, Z, and Dewhirst, MW. "The relationship between intracellular and extracellular pH in spontaneous canine tumors." Clin Cancer Res 6, no. 6 (June 2000): 2501-2505. Link to Item
  - Chen, JG, Charles, HC, Barboriak, DP, and Doraiswamy, PM. "Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate." Acta Neurol Scand Suppl 176 (2000): 20-26. (Review) Link to Item
  - Doraiswamy, PM, Chen, JG, and Charles, HC. "Brain magnetic resonance spectroscopy: Role in assessing outcomes in Alzheimer's disease." Cns Drugs 14, no. 6 (January 1, 2000): 457-472. (Review) Full Text
  - Vujaskovic, Z, Poulson, JM, Gaskin, AA, Thrall, DE, Page, RL, Charles, HC, MacFall, JR, Brizel, DM, Meyer, RE, Prescott, DM, Samulski, TV, and Dewhirst, MW. "Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment." International Journal of Radiation Oncology, Biology, Physics 46, no. 1 (January 2000): 179-185. Full Text
  - McAdams, HP, Palmer, SM, Donnelly, LF, Charles, HC, Tapson, VF, and MacFall, JR. "Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results." Ajr. American Journal of Roentgenology 173, no. 4 (October 1999): 955-959. Full Text
  - Donnelly, LF, MacFall, JR, McAdams, HP, Majure, JM, Smith, J, Frush, DP, Bogonad, P, Charles, HC, and Ravin, CE. "Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations." Radiology 212, no. 3 (September 1999): 885-889. Full Text Link to Item
  - Van Hove, JL, Lazeyras, F, Zeisel, SH, Bottiglieri, T, Hyland, K, Charles, HC, Gray, L, Jaeken, J, and Kahler, SG. "One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels." Journal of Inherited Metabolic Disease 21, no. 8 (December 1998): 799-811. Full Text
  - Doraiswamy, PM, Charles, HC, and Krishnan, KR. "Prediction of cognitive decline in early Alzheimer's disease." Lancet 352, no. 9141 (November 21, 1998): 1678-. (Letter) Full Text Link to Item
  - Lazeyras, F, Charles, HC, Tupler, LA, Erickson, R, Boyko, OB, and Krishnan, KR. "Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy." Psychiatry Research 82, no. 2 (May 1998): 95-106. Full Text
  - Carter, DL, MacFall, JR, Clegg, ST, Wan, X, Prescott, DM, Charles, HC, and Samulski, TV. "Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma." Int J Radiat Oncol Biol Phys 40, no. 4 (March 1, 1998): 815-822. Link to Item
  - Chakos, MH, Esposito, S, Charles, C, and Lieberman, JA. "Clinical applications of neuroimaging in psychiatry." Magnetic Resonance Imaging Clinics of North America 6, no. 1 (1998): 155-164.
  - Dewhirst, MW, Prosnitz, L, Thrall, D, Prescott, D, Clegg, S, Charles, C, MacFall, J, Rosner, G, Samulski, T, Gillette, E, and LaRue, S. "Hyperthermic treatment of malignant diseases: current status and a view toward the future." Seminars in Oncology 24, no. 6 (December 1997): 616-625. (Review)
  - Rosenberg, BS, Green, H, Schachat, F, Charles, HC, Adams, KF, Hawthorne, MH, Duscha, BD, Sloniger, M, and Sullivan, MJ. "Normal skeletal muscle contractile function in patients with chronic heart failure." CIRCULATION 96, no. 8 (October 21, 1997): 1785-1785. Link to Item
  - Tupler, LA, Davidson, JR, Smith, RD, Lazeyras, F, Charles, HC, and Krishnan, KR. "A repeat proton magnetic resonance spectroscopy study in social phobia." Biol Psychiatry 42, no. 6 (September 15, 1997): 419-424. Full Text Link to Item
  - Brizel, DM, Scully, SP, Harrelson, JM, Layfield, LJ, Dodge, RK, Charles, HC, Samulski, TV, Prosnitz, LR, and Dewhirst, MW. "Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas." Cancer Research 56, no. 23 (December 1996): 5347-5350.
  - Vallée, JP, Lazeyras, F, Sostman, HD, Smith, SR, Butterly, DW, Spritzer, CE, and Charles, HC. "Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys." Acad Radiol 3, no. 12 (December 1996): 1030-1037. Link to Item
  - Byrum, CE, MacFall, JR, Charles, HC, Chitilla, VR, Boyko, OB, Upchurch, L, Smith, JS, Rajagopalan, P, Passe, T, Kim, D, Xanthakos, S, Ranga, K, and Krishnan, R. "Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method." Psychiatry Res 67, no. 3 (October 7, 1996): 215-234. Link to Item
  - MacFall, JR, Prescott, DM, Charles, HC, and Samulski, TV. "1H MRI phase thermometry in vivo in canine brain, muscle, and tumor tissue." Med Phys 23, no. 10 (October 1996): 1775-1782. Full Text Link to Item
  - Jones, DN, McCowage, GB, Sostman, HD, Brizel, DM, Layfield, L, Charles, HC, Dewhirst, MW, Prescott, DM, Friedman, HS, Harrelson, JM, Scully, SP, and Coleman, RE. "Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET." J Nucl Med 37, no. 9 (September 1996): 1438-1444. Link to Item
  - MacFall, JR, Charles, HC, Black, RD, Middleton, H, Swartz, JC, Saam, B, Driehuys, B, Erickson, C, Happer, W, Cates, GD, Johnson, GA, and Ravin, CE. "Human lung air spaces: potential for MR imaging with hyperpolarized He-3." Radiology 200, no. 2 (August 1996): 553-558. Full Text Link to Item
  - Daniel Armstrong, F, Thompson, RJ, Winfred Wang, MD, Robert Zimmerman, MD, Charles, H, Pegelow, MD, Scott Miller, MD, Franklin Moser, MD, Jacqueline Bello, MD, Hurtig, A, and Vass, K. "Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease." Pediatrics 97, no. 6 I (June 13, 1996): 864-870.
  - Xanthakos, S, Krishnan, KR, Kim, DM, and Charles, HC. "Magnetic resonance imaging of Alzheimer's disease." Progress in Neuro Psychopharmacology & Biological Psychiatry 20, no. 4 (May 1996): 597-626. (Review) Full Text
  - Charles, HC, Lazeyras, F, Tupler, LA, and Krishnan, KR. "Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain." Magn Reson Med 35, no. 4 (April 1996): 606-610. Link to Item
  - MacFall, JR, Prescott, DM, Charles, HC, and Samulski, TV. "¹H MRI phase thermometry in vivo in canine brain, muscle, and tumor tissue." Medical Physics 23, no. 10 (1996): 1775-1782. Full Text
  - Miner, CM, Davidson, JR, Potts, NL, Tupler, LA, Charles, HC, and Krishnan, KR. "Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia." Biol Psychiatry 38, no. 10 (November 15, 1995): 696-698. Full Text Link to Item
  - Passe, TJ, Charles, HC, Rajagopalan, P, and Krishnan, KR. "Nuclear magnetic resonance spectroscopy: a review of neuropsychiatric applications." Prog Neuropsychopharmacol Biol Psychiatry 19, no. 4 (July 1995): 541-563. (Review) Link to Item
  - Leach, MO, Arnold, D, Brown, TR, Charles, HC, de Certaines, JD, Evelhoch, JL, Margulis, AR, Negendank, WG, Nelson, SJ, and Podo, F. "International workshop on standardization in clinical MRS measurements: proceedings and recommendations." Technology and Health Care : Official Journal of the European Society for Engineering and Medicine 2, no. 4 (December 1994): 217-234.
  - Charles, HC, Lazeyras, F, Krishnan, KR, Boyko, OB, Payne, M, and Moore, D. "Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy." Progress in Neuro Psychopharmacology & Biological Psychiatry 18, no. 7 (November 1994): 1121-1127. Full Text
  - Sullivan, MJ, Saltin, B, Negro-Vilar, R, Duscha, BD, and Charles, HC. "Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men." Journal of Applied Physiology (Bethesda, Md. : 1985) 77, no. 5 (November 1994): 2194-2200. Full Text
  - Charles, HC, Lazeyras, F, Krishnan, KR, Boyko, OB, Patterson, LJ, Doraiswamy, PM, and McDonald, WM. "Proton spectroscopy of human brain: effects of age and sex." Progress in Neuro Psychopharmacology & Biological Psychiatry 18, no. 6 (October 1994): 995-1004. Full Text
  - Leach, MO, Arnold, D, Brown, TR, Charles, HC, de Certaines, JD, Evelhoch, JL, Margulis, AR, Negendank, WG, Nelson, SJ, and Podo, F. "International Workshop on Standardization in Clinical Magnetic Resonance Spectroscopy Measurements: proceedings and recommendations." Acad Radiol 1, no. 2 (October 1994): 171-186. Link to Item
  - MacFall, JR, Byrum, CE, Parashos, I, Early, B, Charles, HC, Chittilla, V, Boyko, OB, Upchurch, L, and Krishnan, KR. "Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods." Psychiatry Res 55, no. 3 (September 1994): 167-177. Link to Item
  - JONES, DN, BRIZEL, DM, CHARLES, HC, DEWHIRST, MW, FRIEDMAN, HS, MCCOWAGE, G, PRESCOTT, DM, SOSTMAN, HD, and COLEMAN, RE. "MONITORING OF RESPONSE TO NEOADJUVANT THERAPY OF SOFT-TISSUE AND MUSCULOSKELETAL SARCOMAS USING F-18-FDG PET." JOURNAL OF NUCLEAR MEDICINE 35, no. 5 (May 1994): P38-P38. Link to Item
  - Prescott, DM, Charles, HC, Sostman, HD, Dodge, RK, Thrall, DE, Page, RL, Tucker, JA, Harrelson, JM, Leopold, KA, and Oleson, JR. "Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy." Int J Radiat Oncol Biol Phys 28, no. 2 (January 15, 1994): 415-423. Link to Item
  - Cazzaniga, S, Schold, SC, Sostman, HD, and Charles, HC. "Effects of therapy on the 1H NMR spectrum of a human glioma line." Magn Reson Imaging 12, no. 6 (1994): 945-950. Link to Item
  - Sostman, HD, Prescott, DM, Dewhirst, MW, Dodge, RK, Thrall, DE, Page, RL, Tucker, JA, Harrelson, JM, Reece, G, and Leopold, KA. "MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas." Radiology 190, no. 1 (January 1994): 269-275. Full Text
  - Davidson, JR, Krishnan, KR, Charles, HC, Boyko, O, Potts, NL, Ford, SM, and Patterson, L. "Magnetic resonance spectroscopy in social phobia: preliminary findings." J Clin Psychiatry 54 Suppl (December 1993): 19-25. Link to Item
  - Prescott, DM, Charles, HC, Sostman, HD, Page, RL, Thrall, DE, Moore, D, Oleson, JR, and Dewhirst, MW. "Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia." International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 9, no. 5 (September 1993): 745-754. Full Text
  - Davidson, JRT, Potts, N, Krishnan, R, Boyko, O, Charles, C, Smith, R, Ford, S, Tupler, LA, and Wilson, W. "Biology of social phobia." European Neuropsychopharmacology 3, no. 3 (January 1, 1993): 192-193. Full Text
  - Krishnan, KRR, Boyko, OB, McDonald, WM, Charles, HC, Macfall, JR, Tupler, LA, and Upchurch, LW. "Magnetic‐resonance morphometry: Image‐analysis methodology development for affective disorder." Depression 1, no. 3 (January 1, 1993): 159-171. Full Text
  - Samulski, TV, MacFall, J, Zhang, Y, Grant, W, and Charles, C. "Non-invasive thermometry using magnetic resonance diffusion imaging: potential for application in hyperthermic oncology." Int J Hyperthermia 8, no. 6 (November 1992): 819-829. Link to Item
  - Wilson, CA, Berkowitz, BA, McCuen, BW, and Charles, HC. "Measurement of preretinal oxygen tension in the vitrectomized human eye using fluorine-19 magnetic resonance spectroscopy." Arch Ophthalmol 110, no. 8 (August 1992): 1098-1100. Link to Item
  - Holland, GN, and Macfall, JR. "An overview of digital spectrometers for MR imaging." Journal of Magnetic Resonance Imaging 2, no. 2 (March 1992): 241-246. Full Text
  - Iwai, F, Sostman, HD, Evans, AJ, Nadel, SN, Hedlund, LW, Beam, CA, Charles, HC, and Spritzer, CE. "Cine phase-contrast magnetic resonance imaging for analysis of flow phenomena in experimental aortic dissection." Invest Radiol 26, no. 12 (December 1991): 1071-1078. Link to Item
  - Samulski, TV, MacFall, J, Zhang, Y, Palmer, D, Charles, C, and Grant, W. "More on the feasibility of using MRI for noninvasive thermometry in hyperthermia." American Society of Mechanical Engineers, Heat Transfer Division, (Publication) Htd 189 (December 1, 1991): 57-60.
  - Sostman, HD, Rockwell, S, Sylvia, AL, Madwed, D, Cofer, G, Charles, HC, Negro-Vilar, R, and Moore, D. "Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy." Magn Reson Med 20, no. 2 (August 1991): 253-267. Link to Item
  - Sostman, HD, and Charles, HC. "Bone and soft tissue lesions: diagnosis with combined H-1 MR imaging and P-31 MR spectroscopy." Invest Radiol 26, no. 8 (August 1991): 769-770. Link to Item
  - Weidman, ER, Charles, HC, Negro-Vilar, R, Sullivan, MJ, and MacFall, JR. "Muscle activity localization with 31P spectroscopy and calculated T2-weighted 1H images." Investigative Radiology 26, no. 4 (April 1991): 309-316.
  - Grist, TM, Charles, HC, and Sostman, HD. "1990 ARRS Executive Council Award. Renal transplant rejection: diagnosis with 31P MR spectroscopy." AJR Am J Roentgenol 156, no. 1 (January 1991): 105-112. Full Text Link to Item
  - Grist, TM, Charles, HC, and Sostman, HD. "Renal transplant rejection: Diagnosis with ³¹P MR spectroscopy." American Journal of Roentgenology 156, no. 1 (1991): 105-112.
  - Sostman, HD, and Charles, HC. "Bone and soft tissue lesions: Diagnosis with combined H–1 MR imaging and P–31 MR spectroscopy." Investigative Radiology 26, no. 8 (January 1, 1991): 769-770. (Review) Full Text
  - Sostman, HD, Charles, HC, Rockwell, S, Leopold, K, Beam, C, Madwed, D, Dewhirst, M, Cofer, G, Moore, D, and Burn, R. "Soft-tissue sarcomas: detection of metabolic heterogeneity with P-31 MR spectroscopy." Radiology 176, no. 3 (September 1990): 837-843. Full Text
  - Sostman, HD, and Charles, HC. "Noninvasive differentiation of tumors with use of localized H-1 spectroscopy in vivo: initial experience in patients with cerebral tumors." Invest Radiol 25, no. 9 (September 1990): 1047-1050. Link to Item
  - DEWHIRST, MW, SOSTMAN, HD, LEOPOLD, KA, CHARLES, HC, MOORE, D, BURN, RA, TUCKER, JA, HARRELSON, JM, and OLESON, JR. "SOFT-TISSUE SARCOMAS - MR IMAGING AND MR SPECTROSCOPY FOR PROGNOSIS AND THERAPY MONITORING - WORK IN PROGRESS." RADIOLOGY 174, no. 3 (March 1990): 847-853. Full Text Link to Item
  - Dewhirst, MW, Sostman, HD, Leopold, KA, Charles, HC, Moore, D, Burn, RA, Tucker, JA, Harrelson, JM, and Oleson, JR. "Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring. Work in progress." Radiology 174, no. 3 Pt 1 (March 1990): 847-853. Full Text
  - Charles, HC, Baker, ME, Hathorn, JW, and Sostman, D. "Differentiation of radiation fibrosis from recurrent neoplasia: a role for 31P MR spectroscopy?." AJR Am J Roentgenol 154, no. 1 (January 1990): 67-68. Full Text Link to Item
  - Dewhirst, MW, Sostman, HD, Leopold, KA, Charles, HC, Moore, D, Burn, RA, Tucker, JA, Harrelson, JM, and Oleson, JR. "Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring: Work in progress." Radiology 174, no. 3 (January 1, 1990): 847-853. Full Text
  - MacFall, JR, Charles, HC, and Prost, R. "Truncated sinc slice excitation for 31P spectroscopic imaging." Magnetic Resonance Imaging 8, no. 5 (January 1990): 619-624. Full Text
  - BOYKO, OB, PROST, RW, SCHOLD, SC, KARFIAS, C, and CHARLES, HC. "INTEGRATION OF MRS AND MR FOR EVALUATION OF NEOPLASTIC DISEASE IN THE BRAIN." AMERICAN JOURNAL OF NEURORADIOLOGY 10, no. 4 (1989): 893-893. Link to Item
  - Charles, HC. "Cardiac applications of MR spectroscopy and spectroscopic imaging." Cardiovascular and Interventional Radiology 12, no. 4 (January 1, 1989): 215-216.
  - MACFALL, J, PROST, RA, KARFIAS, C, and CHARLES, HC. "A COMPARISON OF SLICE SELECTION-STRATEGIES FOR P-31 SPECTROSCOPIC IMAGING." AMERICAN JOURNAL OF NEURORADIOLOGY 10, no. 4 (1989): 893-893. Link to Item
  - Maynor, CH, Charles, HC, Herfkens, RJ, Suddarth, SA, and Johnson, GA. "Chemical shift imaging of atherosclerosis at 7.0 Tesla." Invest Radiol 24, no. 1 (January 1989): 52-60. Link to Item
  - Lenkinski, RE, Holland, GA, Allman, T, Vogele, K, Kressel, HY, Grossman, RI, Charles, HC, Engeseth, HR, Flamig, D, and MacFall, JR. "Integrated MR imaging and spectroscopy with chemical shift imaging of P-31 at 1.5 T: initial clinical experience." Radiology 169, no. 1 (October 1988): 201-206. Full Text
  - MAYNOR, CH, CHARLES, HC, HERFKENS, RJ, SUDDARTH, SA, and JOHNSON, GA. "INVITRO CHEMICAL-SHIFT IMAGING OF ATHEROSCLEROSIS AT 7.0-TESLA." INVESTIGATIVE RADIOLOGY 23, no. 9 (September 1988): S3-S3. Link to Item
  - Bottomley, PA, Charles, HC, Roemer, PB, Flamig, D, Engeseth, H, Edelstein, WA, and Mueller, OM. "Human in vivo phosphate metabolite imaging with 31P NMR." Magn Reson Med 7, no. 3 (July 1988): 319-336. Link to Item
  - Allman, T, Holland, GA, Lenkinski, RE, and Charles, HC. "A simple method for processing NMR spectra in which acquisition is delayed: applications to in vivo localized 31P NMR spectra acquired using the DRESS technique." Magn Reson Med 7, no. 1 (May 1988): 88-94. Link to Item
  - Nichols, PF, Charles, HC, Read, JS, and Goldberg, MF. "Evaluation of choroidal neovascular membranes by Octopus perimetry." Retina 8, no. 1 (1988): 24-29. Link to Item
  - Peyman, GA, Charles, HC, Liu, KR, Khoobehi, B, and Niesman, M. "Intravitreal liposome-encapsulated drugs: a preliminary human report." Int Ophthalmol 12, no. 3 (1988): 175-182. Link to Item
  - Peyman, GA, Charles, HC, and Alghadyan, A. "Internal trans-pars plana filtering procedure in humans." Int Ophthalmol 11, no. 3 (January 1988): 159-162. Link to Item
  - Lee, CM, Charles, HC, Smith, RT, Peachey, NS, Cunha-Vaz, JG, and Goldberg, MF. "Quantification of macular ischaemia in sickle cell retinopathy." Br J Ophthalmol 71, no. 7 (July 1987): 540-545. Link to Item
  - Peachey, NS, Charles, HC, Lee, CM, Fishman, GA, Cunha-Vaz, JG, and Smith, RT. "Electroretinographic findings in sickle cell retinopathy." Arch Ophthalmol 105, no. 7 (July 1987): 934-938. Link to Item
  - Smith, RT, Lee, CM, Charles, HC, Farber, M, and Cunha-Vaz, JG. "Quantification of diabetic macular edema." Arch Ophthalmol 105, no. 2 (February 1987): 218-222. Link to Item
  - Borges, JM, Charles, HC, Lee, CM, Smith, RT, Cunha-Vaz, JG, Goldberg, MF, and Tso, MO. "A clinicopathologic study of dye laser photocoagulation on primate retina." Retina 7, no. 1 (1987): 46-57. Link to Item
  - Breger, RK, Wehrli, FW, Charles, HC, MacFall, JR, and Haughton, VM. "Reproducibility of relaxation and spin-density parameters in phantoms and the human brain measured by MR imaging at 1.5 T." Magn Reson Med 3, no. 5 (October 1986): 649-662. Link to Item
  - Axel, L, Summers, RM, Kressel, HY, and Charles, C. "Respiratory effects in two-dimensional Fourier transform MR imaging." Radiology 160, no. 3 (September 1986): 795-801. Full Text
  - Bottomley, PA, Scott Smith, L, Leue, WM, and Charles, C. "Slice-interleaved depth-resolved surface-coil spectroscopy (SLIT DRESS) for rapid 31P NMR in Vivo." Journal of Magnetic Resonance (1969) 64, no. 2 (September 1985): 347-351. Full Text
  - Wehrli, FW, Breger, RK, MacFall, JR, Daniels, DL, Haughton, VM, Charles, HC, and Williams, AL. "Quantification of contrast in clinical MR brain imaging at high magnetic field." Invest Radiol 20, no. 4 (July 1985): 360-369. Link to Item
  - Koehler, PR, Haughton, VM, Daniels, DL, Williams, AL, Yetkin, Z, Charles, HC, and Shutts, D. "MR measurement of normal and pathologic brainstem diameters." AJNR Am J Neuroradiol 6, no. 3 (May 1985): 425-427. Link to Item
  - Domer, FR, Chihal, DM, Charles, HC, and Koch, RC. "Synthesis, biological activity, and structure--activity/toxicity relationships of a series of terphenyl analogues of hemicholinium-3 and acetyl-seco-hemicholinium-3. 3." J Med Chem 23, no. 5 (May 1980): 541-545. Link to Item
  - Domer, FR, Charles, HC, Koch, RC, and Chihal, DM. "Biological evaluation of some norphenyl analogs of hemicholinium No. 3 and acetyl-seco-hemicholinium No. 3." Arch Int Pharmacodyn Ther 234, no. 2 (August 1978): 221-228. Link to Item
  - Domer, FR, Wessler, G, Brown, RL, and Charles, HC. "Involvement of the sympathetic nervous system in the urinary bladder internal sphincter and in penile erection in the anesthetized cat." Invest Urol 15, no. 5 (March 1978): 404-407. Link to Item
  - Domer, FR, Charles, HC, Chihal, DM, and Koch, RC. "Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3." Arch Int Pharmacodyn Ther 229, no. 2 (October 1977): 276-286. Link to Item
  - Domer, FR, Koch, RC, Charles, HC, and Chihal, DM. "Biological evaluation of some terphenyl analogs of hemicholinium No. 3." Arch Int Pharmacodyn Ther 229, no. 2 (October 1977): 251-260. Link to Item
  - Domer, FR, Chihal, DM, and Charles, HC. "Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits." J Pharm Sci 66, no. 2 (February 1977): 269-270. Link to Item
  - Domer, FR, Chihal, DM, Charles, HC, and Rege, AB. "Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships." J Med Chem 20, no. 1 (January 1977): 59-62. Link to Item
  - Haarstad, VB, Domer, FR, Chihal, DM, Rege, AB, and Charles, HC. "Synthesis and structure-toxicity relationships of three new stable analogues of acetyl-seco-hemicholinium-3." J Med Chem 19, no. 6 (June 1976): 760-763. Link to Item
- Conference Papers
  - Eckstein, F, Buck, RJ, Charles, HC, Hudelmaier, M, Wirth, W, Kraus, VB, and Evelhoch, JL. "Improved precision of quantitative cartilage measurements with magnetic resonance imaging at 3 T." 2004. Link to Item
  - Lieberman, JA, Charles, HC, Sharma, T, Zipursky, RB, Kahn, R, Gur, RE, Tohen, M, Green, AI, McEvoy, JP, Perkins, DO, Hamer, RM, Nemeroff, CB, Rothschild, AJ, Kuldau, JM, Strakowski, SM, and Tollefson, GD. "Antipsychotic treatment effects on progression of brain pathomorphology in first episode schizophrenia." April 15, 2003. Link to Item
  - Renshaw, PF, Yurgelun-Todd, DA, Wei, H, Charles, HC, Tohen, M, Sharma, T, Zipursky, RB, Kahn, R, Gur, RE, Green, AL, McEvoy, JP, Perkins, DO, Hamer, RM, Nemeroff, CB, Rothschild, AJ, Kuldau, JM, Strakowski, SM, Tollefson, GD, and Lieberman, JA. "Olanzapine induced reductions in frontal lobe lactate levels correlate with treatment response in first episode psychosis." April 15, 2003. Link to Item
  - Yurgelun-Todd, DA, Renshaw, PF, Wei, H, Keefe, RSE, Charles, HC, Tohen, M, Seidman, LJ, Christensen, BK, Hamer, RM, Sharma, T, Sitskoorn, MM, Gur, RC, Tollefson, GD, and Lieberman, JA. "Improved attention is associated with reductions in frontal lobe lactate levels in first episode psychosis." April 15, 2003. Link to Item
  - Charles, HC. "Magnetic resonance spectroscopic imaging and its potential application to clinical neurotoxicology." March 2003. Link to Item
Teaching & Mentoring
Advising & Mentoring
- Mentoring activities
  1. Faculty
    1. Deborah Prescott, DVM, PhD
    2. Joseph Mammaparralil, MD, PhD (Current)
    3. Kolby Sidhu, MD (Current)
  2. Fellows, doctoral, post docs
    1. Jean Paul Vallee, MD
    2. Francois Layzeras, PhD (post doc)
    3. Ahmed Halaweish, PhD (post doc)
  3. Resident
    1. Tom Grist, MD
  4. Medical students
    1. Eric Weidman
    2. Carolyn Maynor
    3. S Cazzaniga (with SC Schold)
  5. Graduate Students

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Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Subject Headings

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Selected Publications

Academic Articles

Conference Papers

Advising & Mentoring