Overview
Dr. Charles is an Associate Professor of Radiology, a chemist and an expert in MR imaging and spectroscopy with over 40 years of experience in nuclear magnetic resonance. He serves as the Scientific Director of the Duke Center for Advanced Magnetic Resonance Development. He has had extensive experience in conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. He is also director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab has developed approaches for imaging lung function (ventilation and V/Q) in humans with 19F MRI.
Current Appointments & Affiliations
Adjunct Associate Professor in the Department of Radiology
·
2022 - Present
Radiology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
1987 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Effect of gait and velocity on in-vivo tibial loading in humans
Conference AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY · March 1, 2020 Link to item CiteDynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.
Journal Article JCI Insight · January 30, 2020 We hypothesized that dynamic perfluorinated gas MRI would sensitively detect mild cystic fibrosis (CF) lung disease. This cross-sectional study enrolled 20 healthy volunteers and 24 stable subjects with CF, including a subgroup of subjects with normal forc ... Full text Link to item CiteUtilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury.
Journal Article Mil Med · January 7, 2020 INTRODUCTION: There is mounting evidence of respiratory problems related to military service in the Middle East in the past two decades due to environmental exposures during deployment (eg, sand storms and burn pits). This pilot study tests the hypothesis ... Full text Link to item CiteRecent Grants
Human Lung Regional Ventilation Defect Severity Measured by Fluorine-19 Gas MRI
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2018PTSD & Childhood Sexual Abuse: Psychobiology
ResearchConsultant · Awarded by National Institutes of Health · 2002 - 2009Child Neglect: Psychobiological Consequences
ResearchConsultant · Awarded by National Institutes of Health · 2000 - 2007View All Grants
Education, Training & Certifications
University of New Orleans ·
1981
Ph.D.