Scholars@Duke
Hal Cecil Charles

Hal Cecil Charles

Adjunct Associate Professor in the Department of Radiology
Radiology
cecil.charles@duke.edu
Box 2702 Med Ctr, Durham, NC 27710
2424 Erwin Road, Suite 301, Hock Plaza, Durham, NC 27705
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Selected Publications

Effect of gait and velocity on in-vivo tibial loading in humans

Conference AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY · March 1, 2020 Link to item Cite

Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.

Journal Article JCI Insight · January 30, 2020 We hypothesized that dynamic perfluorinated gas MRI would sensitively detect mild cystic fibrosis (CF) lung disease. This cross-sectional study enrolled 20 healthy volunteers and 24 stable subjects with CF, including a subgroup of subjects with normal forc ... Full text Link to item Cite

Utilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury.

Journal Article Mil Med · January 7, 2020 INTRODUCTION: There is mounting evidence of respiratory problems related to military service in the Middle East in the past two decades due to environmental exposures during deployment (eg, sand storms and burn pits). This pilot study tests the hypothesis ... Full text Link to item Cite

Imaging Collateral Ventilation - Strategies Using 19F Perfluorinated Gas Magnetic Resonance Imaging

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Pulmonary Delivery of Therapeutic and Diagnostic Gases.

Journal Article J Aerosol Med Pulm Drug Deliv · April 2018 The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseo ... Full text Open Access Link to item Cite

Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Rheumatol · January 2018 OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structural worsening). METHODS: The Foundation for the National Institutes of He ... Full text Link to item Cite

Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data.

Journal Article IEEE Trans Med Imaging · September 2015 Magnetic resonance imaging (MRI) has become an important imaging technique for quantifying the spatial location and magnitude/direction of longitudinal cartilage morphology changes in patients with osteoarthritis (OA). Although several analytical methods, ... Full text Link to item Cite

Automatic atlas-based three-label cartilage segmentation from MR knee images.

Journal Article Med Image Anal · October 2014 Osteoarthritis (OA) is the most common form of joint disease and often characterized by cartilage changes. Accurate quantitative methods are needed to rapidly screen large image databases to assess changes in cartilage morphology. We therefore propose a ne ... Full text Link to item Cite

Physiorack: an integrated MRI safe/conditional, gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function.

Journal Article J Magn Reson Imaging · March 2014 PURPOSE: To evaluate the use of a modular MRI conditional respiratory monitoring and gating solution, designed to facilitate proper monitoring of subjects' vital signals and their respiratory efforts, during free-breathing and breathheld 19F, oxygen-enhanc ... Full text Link to item Cite

Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.

Journal Article Chest · October 2013 BACKGROUND: Fluorine-enhanced MRI is a relatively inexpensive and straightforward technique that facilitates regional assessments of pulmonary ventilation. In this report, we assess its suitability through the use of perfluoropropane (PFP) in a cohort of h ... Full text Link to item Cite

Longitudinal three-label segmentation of knee cartilage

Journal Article Proceedings - International Symposium on Biomedical Imaging · August 22, 2013 Automatic accurate segmentation methods are needed to assess longitudinal cartilage changes in osteoarthritis (OA). We propose a novel general spatio-temporal three-label segmentation method to encourage segmentation consistency across time in longitudinal ... Full text Cite

Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression.

Journal Article Arthritis Rheum · July 2013 OBJECTIVE: To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. METHODS: Longitudinal (baseline, 12-month, and 24-month) knee radiographs were available for 60 female subjects with k ... Full text Link to item Cite

Diseased region detection of longitudinal knee MRI data.

Journal Article Information processing in medical imaging : proceedings of the ... conference · 2013 Statistical analysis of longitudinal cartilage changes in osteoarthritis (OA) is of great importance and still a challenge in knee MRI data analysis. A major challenge is to establish a reliable correspondence across subjects within the same latent subpopu ... Cite

Multi-Breath Steady-State Ventilation Distribution Via 19fluorine-Enhanced Mri

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Diseased region detection of longitudinal knee MRI data.

Journal Article Inf Process Med Imaging · 2013 Statistical analysis of longitudinal cartilage changes in osteoarthritis (OA) is of great importance and still a challenge in knee MRI data analysis. A major challenge is to establish a reliable correspondence across subjects within the same latent subpopu ... Full text Link to item Cite

Automatic multi-atlas-based cartilage segmentation from knee MR images

Journal Article Proceedings - International Symposium on Biomedical Imaging · August 15, 2012 In this paper, we propose a multi-atlas-based method to automatically segment the femoral and tibial cartilage from T1 weighted magnetic resonance (MR) knee images. The segmentation result is a joint decision of the spatial priors from a multi-atlas regist ... Full text Cite

Effect of gait and velocity on in-vivo tibial loading in humans

Conference AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY · March 1, 2020 Link to item Cite

Dynamic perfluorinated gas MRI reveals abnormal ventilation despite normal FEV1 in cystic fibrosis.

Journal Article JCI Insight · January 30, 2020 We hypothesized that dynamic perfluorinated gas MRI would sensitively detect mild cystic fibrosis (CF) lung disease. This cross-sectional study enrolled 20 healthy volunteers and 24 stable subjects with CF, including a subgroup of subjects with normal forc ... Full text Link to item Cite

Utilization of 19F MRI for Identification of Iraq-Afghanistan War Lung Injury.

Journal Article Mil Med · January 7, 2020 INTRODUCTION: There is mounting evidence of respiratory problems related to military service in the Middle East in the past two decades due to environmental exposures during deployment (eg, sand storms and burn pits). This pilot study tests the hypothesis ... Full text Link to item Cite

Imaging Collateral Ventilation - Strategies Using 19F Perfluorinated Gas Magnetic Resonance Imaging

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2020 Cite

Pulmonary Delivery of Therapeutic and Diagnostic Gases.

Journal Article J Aerosol Med Pulm Drug Deliv · April 2018 The 21st Congress for the International Society for Aerosols in Medicine included, for the first time, a session on Pulmonary Delivery of Therapeutic and Diagnostic Gases. The rationale for such a session within ISAM is that the pulmonary delivery of gaseo ... Full text Open Access Link to item Cite

Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis: The Osteoarthritis Research Society International/Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium.

Journal Article Arthritis Rheumatol · January 2018 OBJECTIVE: To evaluate radiographic subchondral trabecular bone texture (TBT) as a predictor of clinically relevant osteoarthritis (OA) progression (combination of symptom and structural worsening). METHODS: The Foundation for the National Institutes of He ... Full text Link to item Cite

Diseased Region Detection of Longitudinal Knee Magnetic Resonance Imaging Data.

Journal Article IEEE Trans Med Imaging · September 2015 Magnetic resonance imaging (MRI) has become an important imaging technique for quantifying the spatial location and magnitude/direction of longitudinal cartilage morphology changes in patients with osteoarthritis (OA). Although several analytical methods, ... Full text Link to item Cite

Automatic atlas-based three-label cartilage segmentation from MR knee images.

Journal Article Med Image Anal · October 2014 Osteoarthritis (OA) is the most common form of joint disease and often characterized by cartilage changes. Accurate quantitative methods are needed to rapidly screen large image databases to assess changes in cartilage morphology. We therefore propose a ne ... Full text Link to item Cite

Physiorack: an integrated MRI safe/conditional, gas delivery, respiratory gating, and subject monitoring solution for structural and functional assessments of pulmonary function.

Journal Article J Magn Reson Imaging · March 2014 PURPOSE: To evaluate the use of a modular MRI conditional respiratory monitoring and gating solution, designed to facilitate proper monitoring of subjects' vital signals and their respiratory efforts, during free-breathing and breathheld 19F, oxygen-enhanc ... Full text Link to item Cite

Perfluoropropane gas as a magnetic resonance lung imaging contrast agent in humans.

Journal Article Chest · October 2013 BACKGROUND: Fluorine-enhanced MRI is a relatively inexpensive and straightforward technique that facilitates regional assessments of pulmonary ventilation. In this report, we assess its suitability through the use of perfluoropropane (PFP) in a cohort of h ... Full text Link to item Cite

Longitudinal three-label segmentation of knee cartilage

Journal Article Proceedings - International Symposium on Biomedical Imaging · August 22, 2013 Automatic accurate segmentation methods are needed to assess longitudinal cartilage changes in osteoarthritis (OA). We propose a novel general spatio-temporal three-label segmentation method to encourage segmentation consistency across time in longitudinal ... Full text Cite

Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression.

Journal Article Arthritis Rheum · July 2013 OBJECTIVE: To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. METHODS: Longitudinal (baseline, 12-month, and 24-month) knee radiographs were available for 60 female subjects with k ... Full text Link to item Cite

Diseased region detection of longitudinal knee MRI data.

Journal Article Information processing in medical imaging : proceedings of the ... conference · 2013 Statistical analysis of longitudinal cartilage changes in osteoarthritis (OA) is of great importance and still a challenge in knee MRI data analysis. A major challenge is to establish a reliable correspondence across subjects within the same latent subpopu ... Cite

Multi-Breath Steady-State Ventilation Distribution Via 19fluorine-Enhanced Mri

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Diseased region detection of longitudinal knee MRI data.

Journal Article Inf Process Med Imaging · 2013 Statistical analysis of longitudinal cartilage changes in osteoarthritis (OA) is of great importance and still a challenge in knee MRI data analysis. A major challenge is to establish a reliable correspondence across subjects within the same latent subpopu ... Full text Link to item Cite

Automatic multi-atlas-based cartilage segmentation from knee MR images

Journal Article Proceedings - International Symposium on Biomedical Imaging · August 15, 2012 In this paper, we propose a multi-atlas-based method to automatically segment the femoral and tibial cartilage from T1 weighted magnetic resonance (MR) knee images. The segmentation result is a joint decision of the spatial priors from a multi-atlas regist ... Full text Cite

Automatic atlas-based three-label cartilage segmentation from MR knee images

Journal Article Proceedings of the Workshop on Mathematical Methods in Biomedical Image Analysis · April 24, 2012 This paper proposes a method to build a bone-cartilage atlas of the knee and to use it to automatically segment femoral and tibial cartilage from T1 weighted magnetic resonance (MR) images. Anisotropic spatial regularization is incorporated into a three-la ... Full text Cite

Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis.

Journal Article Ann Rheum Dis · July 2011 OBJECTIVE: To examine the relationship of baseline clinical, radiographic, molecular and MRI measures with structural progression (subregional MRI-based femorotibial cartilage loss) in knee osteoarthritis (OA). METHODS: Single knees of 75 female participan ... Full text Link to item Cite

Initial Experience With Perfluorinated Gases As Lung Imaging Contrast Agents In Humans

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2011 Link to item Cite

Automatic bone segmentation and alignment from MR knee images

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · December 1, 2010 Automatic image analysis of magnetic resonance (MR) images of the knee is simplified by bringing the knee into a reference position. While the knee is typically put into a reference position during image acquisition, this alignment will generally not be pe ... Full text Cite

Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.

Journal Article J Orthop Res · September 2010 Obesity, as a primary risk factor for osteoarthritis (OA), has been shown to alter joint loading, but may also result in metabolic changes characterized by chronic, low-level inflammation due to increased circulating levels of adipose-derived cytokines, or ... Full text Link to item Cite

A comparison of five approaches to measurement of anatomic knee alignment from radiographs.

Journal Article Osteoarthritis Cartilage · February 2010 OBJECTIVE: The recent recognition of the correlation of the hip-knee-ankle angle (HKA) with femur-tibia angle (FTA) on a standard knee radiograph has led to the increasing inclusion of FTA assessments in OA studies due to its clinical relevance, cost effec ... Full text Link to item Cite

Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography.

Journal Article Ann Rheum Dis · January 2010 Featured Publication OBJECTIVE: Cartilage morphology displays sensitivity to change in osteoarthritis (OA) with quantitative MRI (qMRI). However, (sub)regional cartilage thickness change at 3.0 Tesla (T) has not been directly compared with radiographic progression of joint spa ... Full text Link to item Cite

Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy.

Journal Article Int J Hyperthermia · 2010 The purpose of this review is to examine the roles that functional imaging may play in prediction of treatment response and determination of overall prognosis in patients who are enrolled in thermotherapy trials, either in combination with radiotherapy, ch ... Full text Link to item Cite

Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression.

Journal Article Arthritis Rheum · December 2009 Featured Publication OBJECTIVE: To evaluate the effectiveness of using subchondral bone texture observed on a radiograph taken at baseline to predict progression of knee osteoarthritis (OA) over a 3-year period. METHODS: A total of 138 participants in the Prediction of Osteoar ... Full text Link to item Cite

Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis.

Journal Article Osteoarthritis Cartilage · September 2009 Featured Publication OBJECTIVE: To identify subregional differences in femorotibial cartilage morphology between healthy controls and women with different grades of radiographic knee osteoarthritis (OA). DESIGN: 158 women aged > or =40 years were studied. Weight-bearing extend ... Full text Link to item Cite

Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · August 1, 2009 PURPOSE: This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome. EXPERIME ... Full text Link to item Cite

Time-lapse mapping of cortical changes in schizophrenia with different treatments.

Journal Article Cereb Cortex · May 2009 Using time-lapse maps, we visualized the dynamics of schizophrenia progression, revealing spreading cortical changes that depend on the type of antipsychotic treatment. Dynamic, 4-dimensional models of disease progression were created from 4 repeated high- ... Full text Link to item Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours.

Journal Article Int J Hyperthermia · 2009 Featured Publication PURPOSE: MR thermometry using the proton resonance frequency shift (PRFS) method has been used to measure temperature changes during clinical hyperthermia treatment. However, frequency drift of the MRI system can add large errors to the measured temperatur ... Full text Link to item Cite

Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial.

Journal Article Ann Rheum Dis · December 2008 Featured Publication OBJECTIVE: Quantitative MRI (qMRI) of cartilage morphology is a promising tool for disease-modifying osteoarthritis drug (DMOAD) development. Recent studies at single sites have indicated that measurements at 3.0 Tesla (T) are more reproducible (precise) t ... Full text Link to item Cite

Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees.

Journal Article Osteoarthritis Cartilage · December 2008 Featured Publication OBJECTIVE: This study evaluated the longitudinal performance of a modified Lyon schuss (LS) knee examination in the detection of radiographic joint space narrowing (JSN) in knees with osteoarthritis (OA). The modified LS exam entails two to four iterative ... Full text Link to item Cite

Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees.

Journal Article Ann Rheum Dis · November 2008 Featured Publication OBJECTIVE: The Lyon Schuss (LS) and fixed flexion (FF) views of the knee are superior to a conventional standing anteroposterior view in evaluating joint space narrowing (JSN) in osteoarthritis (OA). Both position the knee identically but only the LS align ... Full text Link to item Cite

Hyperoxia-induced decrease in organ blood flow [10]

Journal Article Anesthesiology · January 1, 2008 Full text Cite

In reply (Anesthesiology (2008) 108, (169-170))

Journal Article Anesthesiology · January 1, 2008 Cite

Optimization of the fixed-flexion knee radiograph.

Journal Article Osteoarthritis Cartilage · November 2007 Featured Publication PURPOSE: To develop a user-friendly method of achieving optimal radiographs for measurement of joint space width of the knee with minimal radiation exposure. In order to accomplish this the X-ray technologist must (1) be able to identify the anterior and p ... Full text Link to item Cite

Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve.

Journal Article Neurobiol Aging · November 2007 Featured Publication Major predictors of Alzheimer's disease (AD) include apolipoprotein E (APOE)-epsilon4, hippocampal atrophy on magnetic resonance imaging (MRI), and memory dysfunction prior to diagnosis. We examined 159 normal elderly subjects with MRI and the California V ... Full text Link to item Cite

Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA).

Journal Article Magn Reson Med · August 2007 Featured Publication MRI-based cartilage morphometry was previously validated in the absence of gadopentate dimeglumine (Gd-DTPA). However, Gd-DTPA is required for compositional (proteoglycan) imaging using delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). Therefore, the ... Full text Link to item Cite

Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study.

Journal Article Lancet Neurol · June 2007 Featured Publication OBJECTIVE: To assess the effect of rivastigmine in patients with mild cognitive impairment (MCI) on the time to clinical diagnosis of Alzheimer's disease (AD) and the rate of cognitive decline. METHODS: The study was a double-blind, randomised, placebo-con ... Full text Link to item Cite

Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · October 1, 2006 PURPOSE: The objective was to test whether tumor pH and (31)P magnetic resonance spectroscopic end points were related to treatment outcome in pet canine patients with spontaneous soft tissue sarcomas treated with thermoradiotherapy. EXPERIMENTAL DESIGN: F ... Full text Link to item Cite

In vivo 31P MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial.

Journal Article NMR Biomed · June 2006 The standardization and reproducibility of techniques required to acquire anatomically localized 31P MR spectra non-invasively while studying tumors in cancer patients in a multi-institutional group at 1.5 T are reported. This initial group of patients was ... Full text Link to item Cite

A review of 1H MR spectroscopy findings in Alzheimer's disease.

Journal Article Neuroimaging Clin N Am · November 2005 Hydrogen-1 MR spectroscopy (MRS) studies demonstrate metabolic differences between patients who have Alzheimer's disease (AD) and cognitive normal age-matched controls. Clinical MRS also shows regional variations in metabolites between patients who have AD ... Full text Link to item Cite

Quality of life during treatment with haloperidol or olanzapine in the year following a first psychotic episode.

Journal Article Schizophr Res · October 15, 2005 OBJECTIVES: Schizophrenia causes significant impairments of quality of life. As treatment approaches have advanced, more attention has been given to re-integrating patients into their psychosocial environments, rather than simply monitoring psychotic sympt ... Full text Link to item Cite

Accuracy and precision of quantitative assessment of cartilage morphology by magnetic resonance imaging at 3.0T.

Journal Article Arthritis Rheum · October 2005 Featured Publication OBJECTIVE: Quantitative magnetic resonance imaging (MRI) of articular cartilage represents a powerful tool in osteoarthritis (OA) research, but has so far been confined to a field strength of 1.5T. The aim of this study was to evaluate the precision of qua ... Full text Link to item Cite

Antipsychotic drug effects on brain morphology in first-episode psychosis.

Journal Article Arch Gen Psychiatry · April 2005 BACKGROUND: Pathomorphologic brain changes occurring as early as first-episode schizophrenia have been extensively described. Longitudinal studies have demonstrated that these changes may be progressive and associated with clinical outcome. This raises the ... Full text Link to item Cite

Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Int J Radiat Oncol Biol Phys · February 1, 2005 Featured Publication PURPOSE: In a prior study, the combination of (31)P magnetic resonance spectroscopy (MRS)-based intracellular pH (pHi) and T2 relaxation time was highly predictive of the pathologic complete response (pCR) rate in a small series of patients with soft tissu ... Full text Link to item Cite

Duration of illness and treatment effects on hippocampal volume in male patients with schizophrenia.

Journal Article Br J Psychiatry · January 2005 BACKGROUND: Reduced hippocampal volume is a consistently described structural abnormality in schizophrenia but its cause and timing are not known. AIMS: To examine the relationship of duration of schizophrenic illness and treatment effects with hippocampal ... Full text Link to item Cite

Impact of APOE in mild cognitive impairment.

Journal Article Neurology · November 23, 2004 Featured Publication OBJECTIVE: The authors aimed to use baseline data of an ongoing large, prospective study in subjects with mild cognitive impairment (MCI) to investigate the impact of APOE genotype on the symptom profile of the condition. METHODS: Cognitive assessments inc ... Full text Link to item Cite

Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies.

Journal Article NMR Biomed · October 2004 Featured Publication A multi-institutional group has been created to demonstrate the utility of in vivo 31P magnetic resonance spectroscopy (31P-MRS) to study human cancers in vivo. This review is concerned with the novel problems concerning quality control in this large multi ... Full text Link to item Cite

Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.

Journal Article Am J Psychiatry · November 2003 Featured Publication OBJECTIVE: The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer's disease. METHOD: In this randomized, double-blind, placebo-controlled pilot study, 67 patients with ... Full text Link to item Cite

Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.

Journal Article Biol Psychiatry · October 1, 2003 Featured Publication BACKGROUND: The results of prior proton magnetic resonance spectroscopy ((1)H-MRS) studies in unipolar major depressive disorder (MDD) evaluating choline (Cho)/creatine (Cr) and N-acetyl-L-aspartate (NAA)/Cr ratios are mixed. These single-voxel or one-dime ... Full text Link to item Cite

MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.

Journal Article Psychiatry Res · July 1, 2002 Featured Publication Signal intensity (SI) values of gray- and white-matter brain regions of interest (ROIs) were obtained from T(2)- and proton density-weighted magnetic resonance (MR) images of 58 normal subjects aged 22-82 years (31 females, 52.3+/-18.8 years; 27 males, 54. ... Full text Link to item Cite

Learning and recall in subjects at genetic risk for Alzheimer's disease.

Journal Article J Neuropsychiatry Clin Neurosci · 2002 Featured Publication Deficits in delayed recall of learned information may be an early marker of Alzheimer's disease (AD). The apolipoprotein E E4 allele and a positive family history (FH) are both genetic risk factors for AD. The authors cross-sectionally compared performance ... Full text Link to item Cite

Multi-site validation of image analysis methods - Assessing intra and inter-site variability

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2002 In this work, we present a unique set of 3D MRI brain data that is appropriate for testing the intra and inter-site variability of image analysis methods. A single subject was scanned two times within a 24 hour time window each at five different MR sites o ... Full text Cite

Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging.

Journal Article Ultrasound Med Biol · August 2001 Featured Publication Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional ( ... Full text Link to item Cite

Outcome in children with fetal mild ventriculomegaly: a case series.

Journal Article Schizophr Res · March 30, 2001 Featured Publication Mild enlargement of the lateral ventricles is associated with schizophrenia and other neurodevelopmental disorders. While it has been hypothesized that ventricle abnormalities associated with neurodevelopmental disorders arise during fetal brain developmen ... Full text Link to item Cite

Brain 1H-MR spectroscopy in subjects at risk for Alzheimer's disease

Journal Article NEUROBIOLOGY OF AGING · March 1, 2001 Link to item Cite

Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.

Journal Article Neurology · June 13, 2000 Featured Publication Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased ... Full text Link to item Cite

The relationship between intracellular and extracellular pH in spontaneous canine tumors.

Journal Article Clin Cancer Res · June 2000 Featured Publication Recently, it has been suggested that the cellular uptake of chemotherapeutic drugs may be dependent on the pH gradient between the intracellular (pHi) and extracellular (pHe) compartments. It has been demonstrated in murine tumor models that the extracellu ... Link to item Cite

Magnetic resonance spectroscopy in Alzheimer's disease: focus on N-acetylaspartate.

Journal Article Acta Neurol Scand Suppl · 2000 Featured Publication This paper reviews published post-mortem brain and in-vivo proton magnetic resonance spectroscopy (1H-MRS) studies in Alzheimer's disease (AD) and focuses on the emerging role of N-acetylaspartate (NAA) as a prognostic marker of neuronal function. Post-mor ... Full text Link to item Cite

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2000 Featured Publication PURPOSE: The objectives of this study were to evaluate effects of hyperthermia on tumor oxygenation, extracellular pH (pHe), and blood flow in 13 dogs with spontaneous soft tissue sarcomas prior to and after local hyperthermia. METHODS AND MATERIALS: Tumor ... Full text Link to item Cite

Brain magnetic resonance spectroscopy: Role in assessing outcomes in Alzheimer's disease

Journal Article CNS Drugs · January 1, 2000 Contemporary 1H-magnetic resonance spectroscopy (MRS) techniques can estimate the levels of brain metabolites with a high reproducibility and add only 10 minutes to a routine or volumetric magnetic resonance imaging scan. In patients with Alzheimer's disea ... Full text Cite

Hyperpolarized 3He-enhanced MR imaging of lung transplant recipients: preliminary results.

Journal Article AJR Am J Roentgenol · October 1999 OBJECTIVE: Bronchiolitis obliterans syndrome is the major cause of long-term graft failure in lung transplant recipients and may be partially reversible if diagnosed early and treated. Diagnosis is difficult because findings of transbronchial biopsy are of ... Full text Link to item Cite

Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations.

Journal Article Radiology · September 1999 Four patients with cystic fibrosis (CF) were examined with combined hyperpolarized helium 3-enhanced and conventional proton magnetic resonance (MR) imaging. After inhalation of the polarized 3He gas, single breath-hold, gradient-echo images (resonant freq ... Full text Link to item Cite

One-methyl group metabolism in non-ketotic hyperglycinaemia: mildly elevated cerebrospinal fluid homocysteine levels.

Journal Article J Inherit Metab Dis · December 1998 Non-ketotic hyperglycinaemia (NKH) is a rare, severe brain disease caused by deficient glycine cleavage enzyme complex activity resulting in elevated glycine concentrations. Recent experience suggests that factors in addition to glycine kinetics are involv ... Full text Link to item Cite

Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy.

Journal Article Psychiatry Res · May 20, 1998 Alzheimer's disease (AD) is a progressive disorder associated with disruption of neuronal function and neuronal loss. N-acetylaspartate (NAA) is a marker of neuronal content and can be assessed using proton (1H) magnetic resonance spectroscopy (MRS). We ut ... Full text Link to item Cite

Magnetic resonance thermometry during hyperthermia for human high-grade sarcoma.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 1998 PURPOSE: To determine the feasibility of measuring temperature noninvasively with magnetic resonance imaging during hyperthermia treatment of human tumors. METHODS: The proton chemical shift detected using phase-difference magnetic resonance imaging (MRI) ... Full text Link to item Cite

Clinical applications of neuroimaging in psychiatry.

Journal Article Magn Reson Imaging Clin N Am · February 1998 New techniques are dramatically expanding current clinical applications of neuroimaging in neuropsychiatry. Neuroimaging research that examines brain structure and function relationships in neuropsychiatric disorders is also enhancing our understanding of ... Link to item Cite

Hyperthermic treatment of malignant diseases: current status and a view toward the future.

Journal Article Semin Oncol · December 1997 New studies in hyperthermia at the basic science, engineering, and clinical level have stimulated renewed enthusiasm for re-investigating its potential as an anticancer therapy. This article reviews the salient features of these recent results and points o ... Link to item Cite

A repeat proton magnetic resonance spectroscopy study in social phobia.

Journal Article Biol Psychiatry · September 15, 1997 Peak spectral amplitudes for choline moieties (Cho), creatine (Cr), N-acetylaspartate (NAA), and myo-inositol (mI) were examined using proton magnetic resonance spectroscopy in 19 social-phobia patients and 10 controls. Compared with controls, social phobi ... Full text Link to item Cite

Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas.

Journal Article Cancer Res · December 1, 1996 The adverse prognostic impact of tumor hypoxia has been demonstrated in human malignancy. We report the effects of radiotherapy and hyperthermia (HT) on soft tissue sarcoma oxygenation and the relationship between treatment-induced changes in oxygenation a ... Link to item Cite

Proton-decoupled phosphorus-31 magnetic resonance spectroscopy in the evaluation of native and well-functioning transplanted kidneys.

Journal Article Acad Radiol · December 1996 RATIONALE AND OBJECTIVES: To evaluate whether decoupling improves signal-to-noise ratio and frequency resolution of in vivo kidney spectra, and to compare native and well-functioning transplant kidneys. METHODS: Proton decoupling in conjunction with three- ... Full text Link to item Cite

Accuracy and reproducibility of brain and tissue volumes using a magnetic resonance segmentation method.

Journal Article Psychiatry Res · October 7, 1996 Magnetic resonance (MR) imaging now allows the qualitative and quantitative assessment of the human brain in vivo. As MR imaging resolution has improved, precise measurement of small brain structures has become possible. Methods of measuring brain regions ... Full text Link to item Cite

1H MRI phase thermometry in vivo in canine brain, muscle, and tumor tissue.

Journal Article Med Phys · October 1996 The temperature sensitivity of the chemical shift of water (approximately 0.01 ppm/degree C) provides a potential method to monitor temperature changes in vivo or in vitro through the changes in phase of a gradient-echo magnetic resonance (MR) image. This ... Full text Link to item Cite

Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET.

Journal Article J Nucl Med · September 1996 UNLABELLED: The purpose of this study was to investigate the potential role of FDG-PET in the monitoring of neoadjuvant therapy of soft-tissue and musculoskeletal sarcomas. METHODS: Nine patients were studied. Neoadjuvant therapy consisted of either chemot ... Link to item Cite

Human lung air spaces: potential for MR imaging with hyperpolarized He-3.

Journal Article Radiology · August 1996 Two healthy volunteers who had inhaled approximately 0.75 L of laser-polarized helium-3 gas underwent magnetic resonance imaging at 1.5 T with fast gradient-echo pulse sequences and small flip angles ( < 10 degrees). Thick-section (20 mm) coronal images, t ... Full text Link to item Cite

Cognitive functioning and brain magnetic resonance imaging in children with sickle cell disease

Journal Article Pediatrics · June 13, 1996 Objective. Brain magnetic resonance imaging (MRI) and neuropsychological evaluations were conducted to determine whether neuroradiographic evidence of infarct in children with sickle cell disease between ages 6 and 12 years would result in impairment in co ... Cite

Magnetic resonance imaging of Alzheimer's disease.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · May 1996 1. Although dementia is caused by a heterogeneous group of diseases and pathologic states, Alzheimer's disease is the largest cause, estimated to account for 50 to 75% of all dementias. 2. Unfortunately, confirmation of Alzheimer's disease (AD) requires po ... Full text Link to item Cite

Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain.

Journal Article Magn Reson Med · April 1996 The application of proton (1H) magnetic resonance spectroscopic imaging (MRSI) allows for noninvasive, localized analyses of brain biochemistry; however, minimal work has been devoted to the evaluation of 1H MRSI reproducibility. This study examined the re ... Full text Link to item Cite

Nuclear magnetic resonance spectroscopy: a review of neuropsychiatric applications.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · July 1995 1. Magnetic resonance spectroscopy (MRS) is a powerful new neuropsychiatric research tool which allows for the noninvasive investigation of in vivo biochemistry. This review focuses on the recent applications of MRS to in vivo neuropsychiatric research. 2. ... Full text Link to item Cite

Skeletal muscle pH assessed by biochemical and 31P-MRS methods during exercise and recovery in men.

Journal Article J Appl Physiol (1985) · November 1994 The present study was designed to compare evaluation of skeletal muscle metabolism (vastus lateralis) evaluated by 31P-magnetic resonance spectroscopy (MRS) and biochemical analysis. During identical isometric knee extensor exercise protocols to fatigue in ... Full text Link to item Cite

Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · November 1994 1. Seven subjects with depression and matched controls were studied using proton spectroscopy to test the hypothesis that choline will be elevated in depression. 2. The proton spectroscopy was repeated after recovery from depression. 3. The study confirmed ... Full text Link to item Cite

Proton spectroscopy of human brain: effects of age and sex.

Journal Article Prog Neuropsychopharmacol Biol Psychiatry · October 1994 1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic i ... Full text Link to item Cite

Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods.

Journal Article Psychiatry Res · September 1994 Volumetric magnetic resonance imaging (MRI) methods for the measurement of various neuroanatomical regions are of great interest in studies of neuropsychiatric disorders. Both manual and semiautomated methods have been developed. Manual methods include tra ... Full text Link to item Cite

Therapy monitoring in human and canine soft tissue sarcomas using magnetic resonance imaging and spectroscopy.

Journal Article Int J Radiat Oncol Biol Phys · January 15, 1994 PURPOSE: The goals of this study were to determine whether magnetic resonance parameters (a) can identify early during therapy those patients most likely to respond to hyperthermia and radiotherapy, (b) can provide prior to or early during therapy informat ... Full text Link to item Cite

MR imaging and spectroscopy for prognostic evaluation in soft-tissue sarcomas.

Journal Article Radiology · January 1994 PURPOSE: To enable prediction of tumor response to a particular treatment. MATERIALS AND METHODS: The authors studied the value of hydrogen-1 T2 and phosphorus-31 magnetic resonance (MR) spectroscopic metabolic determinations as indicators of prognosis in ... Full text Link to item Cite

Effects of therapy on the 1H NMR spectrum of a human glioma line.

Journal Article Magn Reson Imaging · 1994 Currently it is difficult to predict the efficacy of any therapeutic modality in individual patients. If it could be shown that successful therapy causes some chemical alteration in the tumor before gross alteration in size becomes radiologically visible, ... Full text Link to item Cite

Magnetic resonance spectroscopy in social phobia: preliminary findings.

Journal Article J Clin Psychiatry · December 1993 Proton localized magnetic resonance spectroscopy was studied in 20 social phobics and 20 age- and sex-matched controls. Stimulated Echo Acquisition Mode volume element localization was used with chemical shift imaging. Choline and creatine signal-to-noise ... Link to item Cite

Magnetic‐resonance morphometry: Image‐analysis methodology development for affective disorder

Journal Article Depression · January 1, 1993 In this article we review some important methodological issues for measurement of brain structures and lesions visualized on magnetic resonance (MR) imaging. Such issues include the method of sectioning, number of slices, shape of the structure, orientatio ... Full text Cite

Manipulation of intra- and extracellular pH in spontaneous canine tumours by use of hyperglycaemia.

Journal Article Int J Hyperthermia · 1993 We evaluated the use of hyperglycaemia to reduce tumour pH in dog with spontaneous tumours. Dogs were randomized to two groups: control and glucose. Intravenous administration of 20% glucose was used to induce and maintain hyperglycaemia. Extra- and intrac ... Full text Link to item Cite

Biology of social phobia

Journal Article European Neuropsychopharmacology · January 1, 1993 Full text Cite

Measurement of preretinal oxygen tension in the vitrectomized human eye using fluorine-19 magnetic resonance spectroscopy.

Journal Article Arch Ophthalmol · August 1992 We obtained oxygen measurements from a human eye that contained small preretinal droplets of perfluorotributylamine (FTBA) by using fluorine-19 magnetic resonance spectroscopy. These droplets were the remainder of a larger volume of FTBA that was used as a ... Full text Link to item Cite

An overview of digital spectrometers for MR imaging. Instrumentation Subcommittee of the SMRI Basic Science Council.

Journal Article J Magn Reson Imaging · 1992 Most magnetic resonance (MR) imaging systems were originally designed with analog spectrometers, since that was the "state of the art" in the late 1970s, when they were developed. Advances in technology have allowed the design of radio-frequency electronic ... Full text Link to item Cite

Non-invasive thermometry using magnetic resonance diffusion imaging: potential for application in hyperthermic oncology.

Journal Article Int J Hyperthermia · 1992 The proposition to use non-invasive thermometry based on magnetic resonance diffusion imaging for applications in therapeutic hyperthermia is examined. The measurement of proton motion predominantly associated with the self-diffusion of water can be charac ... Full text Link to item Cite

Cine phase-contrast magnetic resonance imaging for analysis of flow phenomena in experimental aortic dissection.

Journal Article Invest Radiol · December 1991 Using a 1.5 T magnetic resonance imaging (MRI) system, cine phase-contrast and magnitude images were obtained in three phantoms that simulated different anatomic configurations of aortic dissection. The dissection phantoms were made of compliant materials, ... Full text Link to item Cite

More on the feasibility of using MRI for noninvasive thermometry in hyperthermia

Journal Article American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD · December 1, 1991 A combination of RF heating and MR imaging equipment has been constructed in a fashion that allows simultaneous heating and MR diffusion imaging. Isolation between the RF heating and RF imaging frequencies is accomplished by means of filtering. This system ... Cite

Evaluation of BA1112 rhabdomyosarcoma oxygenation with microelectrodes, optical spectrophotometry, radiosensitivity, and magnetic resonance spectroscopy.

Journal Article Magn Reson Med · August 1991 We studied tumor tissue oxygenation in the BA1112 rhabdomyosarcoma using micro-electrode pO2 measurements, optical spectrophotometry, analyses of cell survival after irradiation, and 31P magnetic resonance spectroscopy (MRS). Studies were carried out in WA ... Full text Link to item Cite

Muscle activity localization with 31P spectroscopy and calculated T2-weighted 1H images.

Journal Article Invest Radiol · April 1991 Using 31P spectroscopy and magnetic resonance imaging (MRI), the authors studied changes in muscle phosphorous metabolites and T2 with isometric knee extension to evaluate the potential role of T2 images in coil placement for exercise spectroscopy studies. ... Full text Link to item Cite

1990 ARRS Executive Council Award. Renal transplant rejection: diagnosis with 31P MR spectroscopy.

Journal Article AJR Am J Roentgenol · January 1991 We evaluated the role of 31P MR spectroscopy in the diagnosis of renal transplant allograft dysfunction. Thirty-six 31P MR spectroscopy examinations were prospectively performed in 35 patients with renal allografts. The study was performed in two phases. I ... Full text Link to item Cite

Soft-tissue sarcomas: detection of metabolic heterogeneity with P-31 MR spectroscopy.

Journal Article Radiology · September 1990 Regional variations in metabolic parameters derived with multivoxel, localized phosphorus-31 magnetic resonance (MR) spectroscopy in spontaneous human-soft-tissue sarcomas were compared with variations in the same parameters in normal human legs. In additi ... Full text Link to item Cite

Soft-tissue sarcomas: MR imaging and MR spectroscopy for prognosis and therapy monitoring. Work in progress.

Journal Article Radiology · March 1990 The authors studied the usefulness of hydrogen-1 T2 measurements and phosphorus-31 magnetic resonance (MR) spectroscopy as indicators of prognosis and monitors of response to therapy in a group of patients with soft-tissue sarcomas. All eight patients were ... Full text Link to item Cite

Truncated sinc slice excitation for 31P spectroscopic imaging.

Journal Article Magn Reson Imaging · 1990 The shortest possible delay (Td) between slice selection and data acquisition is important for producing high quality 31P spectra. In single slice multivoxel spectroscopic imaging, conventional excitation using sinc-shaped rf pulses within typical gradient ... Full text Link to item Cite

A COMPARISON OF SLICE SELECTION-STRATEGIES FOR P-31 SPECTROSCOPIC IMAGING

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · July 1, 1989 Link to item Cite

INTEGRATION OF MRS AND MR FOR EVALUATION OF NEOPLASTIC DISEASE IN THE BRAIN

Journal Article AMERICAN JOURNAL OF NEURORADIOLOGY · July 1, 1989 Link to item Cite

Chemical shift imaging of atherosclerosis at 7.0 Tesla.

Journal Article Invest Radiol · January 1989 Chemical shift imaging (CSI) was performed on cadaveric atherosclerotic fibrous plaques, periaortic adipose tissue, and cholesterol standards using a 7.0 Tesla horizontal bore prototype imaging spectrometer. Proton spectroscopy of intact tissue and deutera ... Full text Link to item Cite

Cardiac applications of MR spectroscopy and spectroscopic imaging

Journal Article CardioVascular and Interventional Radiology · January 1, 1989 Cite

Integrated MR imaging and spectroscopy with chemical shift imaging of P-31 at 1.5 T: initial clinical experience.

Journal Article Radiology · October 1988 A section-selective three-dimensional phosphorus-31 chemical shift imaging (CSI) experiment was evaluated as the spatial localization method for spectroscopy in an integrated clinical magnetic resonance (MR) imaging and spectroscopy examination. The result ... Full text Link to item Cite

INVITRO CHEMICAL-SHIFT IMAGING OF ATHEROSCLEROSIS AT 7.0-TESLA

Journal Article INVESTIGATIVE RADIOLOGY · September 1, 1988 Link to item Cite

Human in vivo phosphate metabolite imaging with 31P NMR.

Journal Article Magn Reson Med · July 1988 Phosphorus (31P) spectroscopic images showing the distribution of high-energy phosphate metabolites in the human brain have been obtained at 1.5 T in scan times of 8.5 to 34 min at 27 and 64 cm3 spatial resolution using pulsed phase-encoding gradient magne ... Full text Link to item Cite

A simple method for processing NMR spectra in which acquisition is delayed: applications to in vivo localized 31P NMR spectra acquired using the DRESS technique.

Journal Article Magn Reson Med · May 1988 It is a requirement of many localized NMR spectroscopy experiments, such as DRESS, that collection of the free induction decay be delayed a significant time after the middle of the last pulse. This leads to distortion of the spectra and seriously impedes t ... Full text Link to item Cite

Evaluation of choroidal neovascular membranes by Octopus perimetry.

Journal Article Retina · 1988 A Sargon user-defined Octopus program was devised to quantitate central visual field changes following laser photocoagulation for choroidal neovascular membranes. The program was found to be reliable in testing the nine patients studied. All patients had a ... Full text Link to item Cite

Intravitreal liposome-encapsulated drugs: a preliminary human report.

Journal Article Int Ophthalmol · 1988 Intravitreal liposome-encapsulated antibiotics and antiviral drugs were used in patients with acute toxoplasmosis retinochoroiditis, presumed propionibacterium acne endophthalmitis after cataract surgery, and presumed cytomegalovirus retinitis associated w ... Full text Link to item Cite

Internal trans-pars plana filtering procedure in humans.

Journal Article Int Ophthalmol · January 1988 Two patients (two eyes) with end-stage, medically uncontrollable glaucoma underwent transvitreal pars plana filtering procedures with a contact Nd:YAG laser with a sapphire probe. Intraocular pressure was being maintained without medication four months aft ... Full text Link to item Cite

Quantification of macular ischaemia in sickle cell retinopathy.

Journal Article Br J Ophthalmol · July 1987 Macular ischaemia has a central role in the pathophysiology and prognosis of retinal macular disease. We attempted to quantitate two of its major components as follows: vascular nonperfusion, by measuring the foveal avascular zone (FAZ), using fluorescein ... Full text Link to item Cite

Electroretinographic findings in sickle cell retinopathy.

Journal Article Arch Ophthalmol · July 1987 We obtained electroretinograms (ERGs) from normal subjects and from patients with sickle cell disease. The ERG components (a-wave, b-wave, and oscillatory potentials) obtained from normal subjects and patients without peripheral retinal neovascularization ... Full text Link to item Cite

Quantification of diabetic macular edema.

Journal Article Arch Ophthalmol · February 1987 In a cross-sectional study, 34 diabetic patients with clinically significant macular edema underwent visual acuity testing, stereo fundus photography (graded for retinal thickening and hard exudates), fluorescein angiography (evaluated for macular leakage ... Full text Link to item Cite

A clinicopathologic study of dye laser photocoagulation on primate retina.

Journal Article Retina · 1987 Chorioretinal lesions produced by dye laser photocoagulation were examined on normal monkey retinas, using angiographic and histopathologic techniques. Retinal burns produced by green (514 nm), yellow (577 nm), orange (600 nm), and red (630 nm) laser light ... Link to item Cite

Reproducibility of relaxation and spin-density parameters in phantoms and the human brain measured by MR imaging at 1.5 T.

Journal Article Magn Reson Med · October 1986 The reproducibility of T1, T2, and proton density, measured in phantoms and the human brain was evaluated by proton imaging techniques. The sequence used to derive T1 and density values was a multiple-saturation recovery which consists of four pairs of 90 ... Full text Link to item Cite

Respiratory effects in two-dimensional Fourier transform MR imaging.

Journal Article Radiology · September 1986 Respiratory and other regular motions during two-dimensional Fourier transform magnetic resonance imaging produce image artifacts consisting of local blurring and more or less regularly spaced "ghost" images propagating along the direction of the phase-enc ... Full text Link to item Cite

Quantification of contrast in clinical MR brain imaging at high magnetic field.

Journal Article Invest Radiol · July 1985 The relative contrast between two tissues in a magnetic resonance (MR) image is shown to be quantifiable for any combination of pulse timing parameters, provided the intrinsic parameters are known. Based on multiple inversion-recovery and spin echo images, ... Full text Link to item Cite

MR measurement of normal and pathologic brainstem diameters.

Journal Article AJNR Am J Neuroradiol · 1985 The dimensions of the brainstem were measured on magnetic resonance (MR) images to provide criteria for detecting brainstem enlargement. Twenty-eight normal adult subjects had MR imaging with sagittal partial-saturation and spin-echo sequences. Four patien ... Link to item Cite

Slice-interleaved depth-resolved surface-coil spectroscopy (SLIT DRESS) for rapid 31P NMR in Vivo

Journal Article Journal of Magnetic Resonance (1969) · January 1, 1985 Full text Cite

ANALYTICAL ASPECTS OF MAGNETIC-RESONANCE IMAGING

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · January 1, 1984 Link to item Cite

Involvement of the sympathetic nervous system in the urinary bladder internal sphincter and in penile erection in the anesthetized cat.

Journal Article Invest Urol · March 1978 Male cats were anesthetized with pentobarbital. In one series of experiments a Foley catheter was placed suprapubically in the urinary bladder and physiologic saline, under a constant head of pressure, was allowed to flow at a constant rate through the bla ... Link to item Cite

Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3.

Journal Article Arch Int Pharmacodyn Ther · October 1977 The oxygen atoms in the esteratic moiety of acetyl-seco-hemicholinium No. 3 (AcHC-3) were replaced with carbon to form the ether, ketone and aliphatic analogs. Also, the thio and acetylthio-seco analogs of hemicholinium No. 3 (HC-3) were studied. When eval ... Link to item Cite

Biological evaluation of some terphenyl analogs of hemicholinium No. 3.

Journal Article Arch Int Pharmacodyn Ther · October 1977 Link to item Cite

Cardiovascular and neuromuscular effects of dimethyl sulfoxide in anesthetized rabbits.

Journal Article J Pharm Sci · February 1977 In rabbits anesthetized with pentobarbital, the carotid arterial blood pressure and bilateral contractions of the gastrocnemius muscles due to electrical stimulation of the sciatic nerves were recorded. Intravenous administration of up to 1 ml of dimethyl ... Full text Link to item Cite

Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships.

Journal Article J Med Chem · January 1977 As a continuation of our efforts to develop and study inhibitors which act presynaptically on neuromuscular function, sulfur analogues of hemicholinium-3 (HC-3, 1) and acetyl-seco-hemicholinium-3 (AcHC-3, 3) were prepared. In each case sulfur is substitute ... Full text Link to item Cite

Synthesis and structure-toxicity relationships of three new stable analogues of acetyl-seco-hemicholinium-3.

Journal Article J Med Chem · June 1976 In order to develop and study inhibitors of neuromuscular function which act presynaptically, three stable analogues of acetyl-seco-hemicholinum-3 (AcHC-3,2) were prepared. These analogues have 2-ethoxyethyltrimethylammonium, 4-oxopentyltrimethylammonium, ... Full text Link to item Cite