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A repeat proton magnetic resonance spectroscopy study in social phobia.

Publication ,  Journal Article
Tupler, LA; Davidson, JR; Smith, RD; Lazeyras, F; Charles, HC; Krishnan, KR
Published in: Biol Psychiatry
September 15, 1997

Peak spectral amplitudes for choline moieties (Cho), creatine (Cr), N-acetylaspartate (NAA), and myo-inositol (mI) were examined using proton magnetic resonance spectroscopy in 19 social-phobia patients and 10 controls. Compared with controls, social phobics demonstrated significantly lower NAA/Cho and higher Cho/Cr, mI/Cr, and mI/NAA amplitudes in cortical gray matter. Higher mI/Cr and mI/NAA amplitudes for social phobics were also observed in subcortical gray matter. Minimal between-group differences were noted for white matter. Symptom severity correlated inversely with amplitudes primarily in subcortical gray matter, and to a lesser extent in cortical gray matter. Inclusion of age and sex in statistical modeling strengthened comparisons with controls but eliminated those for symptom severity. No changes were observed in any amplitude measure following at least 8 weeks of clonazepam treatment, nor was a relationship observed between amplitudes and cumulative clonazepam dose. The possible psychobiological implications of our findings in social phobia are discussed.

Duke Scholars

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

September 15, 1997

Volume

42

Issue

6

Start / End Page

419 / 424

Location

United States

Related Subject Headings

  • Psychiatry
  • Phobic Disorders
  • Models, Biological
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Inositol
  • Humans
  • GABA Modulators
  • Female
 

Citation

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ICMJE
MLA
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Tupler, L. A., Davidson, J. R., Smith, R. D., Lazeyras, F., Charles, H. C., & Krishnan, K. R. (1997). A repeat proton magnetic resonance spectroscopy study in social phobia. Biol Psychiatry, 42(6), 419–424. https://doi.org/10.1016/S0006-3223(96)00501-X
Tupler, L. A., J. R. Davidson, R. D. Smith, F. Lazeyras, H. C. Charles, and K. R. Krishnan. “A repeat proton magnetic resonance spectroscopy study in social phobia.Biol Psychiatry 42, no. 6 (September 15, 1997): 419–24. https://doi.org/10.1016/S0006-3223(96)00501-X.
Tupler LA, Davidson JR, Smith RD, Lazeyras F, Charles HC, Krishnan KR. A repeat proton magnetic resonance spectroscopy study in social phobia. Biol Psychiatry. 1997 Sep 15;42(6):419–24.
Tupler, L. A., et al. “A repeat proton magnetic resonance spectroscopy study in social phobia.Biol Psychiatry, vol. 42, no. 6, Sept. 1997, pp. 419–24. Pubmed, doi:10.1016/S0006-3223(96)00501-X.
Tupler LA, Davidson JR, Smith RD, Lazeyras F, Charles HC, Krishnan KR. A repeat proton magnetic resonance spectroscopy study in social phobia. Biol Psychiatry. 1997 Sep 15;42(6):419–424.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

September 15, 1997

Volume

42

Issue

6

Start / End Page

419 / 424

Location

United States

Related Subject Headings

  • Psychiatry
  • Phobic Disorders
  • Models, Biological
  • Middle Aged
  • Male
  • Magnetic Resonance Spectroscopy
  • Inositol
  • Humans
  • GABA Modulators
  • Female