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Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies.

Publication ,  Journal Article
Arias-Mendoza, F; Zakian, K; Schwartz, A; Howe, FA; Koutcher, JA; Leach, MO; Griffiths, JR; Heerschap, A; Glickson, JD; Nelson, SJ; Charles, HC ...
Published in: NMR Biomed
October 2004

A multi-institutional group has been created to demonstrate the utility of in vivo 31P magnetic resonance spectroscopy (31P-MRS) to study human cancers in vivo. This review is concerned with the novel problems concerning quality control in this large multinational trial of 31P MRS. Our results show that the careful and systematic performance of the quality control tests depicted here (standardized dual 1H/31P tuned radiofrequency probe, quality control procedures, routine use of 1H irradiation while acquiring 31P MR signals) has ensured comparable results between the different institutions. In studies made in vitro, the root-mean-square error was 3.6 %, and in muscle of healthy volunteers in vivo the coefficients of variance for the ratios phosphocreatine/nucleotide-triphosphates, phosphocreatine/noise and nucleotide-triphosphate/noise were 12.2, 7.0 and 10.8 %, respectively. The standardization of the acquisition protocol for in vivo-localized 31P MR spectroscopy across the different institutions has resulted in comparable in vivo data, decreasing the possible problems related to a research study carried out under a multi-institutional setting.

Duke Scholars

Published In

NMR Biomed

DOI

ISSN

0952-3480

Publication Date

October 2004

Volume

17

Issue

6

Start / End Page

382 / 391

Location

England

Related Subject Headings

  • Sensitivity and Specificity
  • Research Design
  • Research
  • Reproducibility of Results
  • Reference Standards
  • Quality Assurance, Health Care
  • Phosphorylcholine
  • Phosphorus Isotopes
  • Nuclear Medicine & Medical Imaging
  • Neoplasms
 

Citation

APA
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ICMJE
MLA
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Arias-Mendoza, F., Zakian, K., Schwartz, A., Howe, F. A., Koutcher, J. A., Leach, M. O., … Cooperative Group on MRS Applications in Cancer, . (2004). Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies. NMR Biomed, 17(6), 382–391. https://doi.org/10.1002/nbm.915
Arias-Mendoza, F., K. Zakian, A. Schwartz, F. A. Howe, J. A. Koutcher, M. O. Leach, J. R. Griffiths, et al. “Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies.NMR Biomed 17, no. 6 (October 2004): 382–91. https://doi.org/10.1002/nbm.915.
Arias-Mendoza F, Zakian K, Schwartz A, Howe FA, Koutcher JA, Leach MO, et al. Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies. NMR Biomed. 2004 Oct;17(6):382–91.
Arias-Mendoza, F., et al. “Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies.NMR Biomed, vol. 17, no. 6, Oct. 2004, pp. 382–91. Pubmed, doi:10.1002/nbm.915.
Arias-Mendoza F, Zakian K, Schwartz A, Howe FA, Koutcher JA, Leach MO, Griffiths JR, Heerschap A, Glickson JD, Nelson SJ, Evelhoch JL, Charles HC, Brown TR, Cooperative Group on MRS Applications in Cancer. Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies. NMR Biomed. 2004 Oct;17(6):382–391.
Journal cover image

Published In

NMR Biomed

DOI

ISSN

0952-3480

Publication Date

October 2004

Volume

17

Issue

6

Start / End Page

382 / 391

Location

England

Related Subject Headings

  • Sensitivity and Specificity
  • Research Design
  • Research
  • Reproducibility of Results
  • Reference Standards
  • Quality Assurance, Health Care
  • Phosphorylcholine
  • Phosphorus Isotopes
  • Nuclear Medicine & Medical Imaging
  • Neoplasms