
Proton spectroscopy of human brain: effects of age and sex.
1. The present study was done to assess the brain metabolites measured by proton magnetic resonance spectroscopy (MRS) in normal individuals. 2. Proton spectroscopy STEAM voxel technique with chemical shift imaging was used to provide localized metabolic information from the brains of 34 normal volunteers (15 males) between the ages of 21 and 75 years. 3. Choline, Creatine and N-acetyl aspartate (NAA) was lower in white matter than gray matter. Choline/NAA and choline/creatine ratios were also lower in white matter. The choline, creatine and NAA were lower in older subjects in the voxel representing cortical and subcortical gray matter. There were no differences between males and females. 4. This preliminary study suggests that age matching is essential for comparative studies of disease states using proton MRS.
Duke Scholars
Published In
DOI
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Publication Date
Volume
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Start / End Page
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Related Subject Headings
- Sex Characteristics
- Psychiatry
- Middle Aged
- Male
- Magnetic Resonance Spectroscopy
- Magnetic Resonance Imaging
- Humans
- Female
- Creatine
- Choline
Citation

Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sex Characteristics
- Psychiatry
- Middle Aged
- Male
- Magnetic Resonance Spectroscopy
- Magnetic Resonance Imaging
- Humans
- Female
- Creatine
- Choline