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P. Murali Doraiswamy

Professor of Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences
2400 Pratt Street North Pavil, 6th Floor, Room 6032, Durham, NC 27710
2400 Pratt Street North Pavil, Box 102505, Durham, NC 27710

Overview


Murali Doraiswamy MBBS FRCP is Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine where he is a highly cited physician scientist at the Duke Institute for Brain Sciences.  He is also a Senior Fellow at the Duke Center for the Study of Aging and an Affiliate Faculty at the Duke Center for Precision Medicine and Applied Genomics as well as the Duke Microbiome Center.  He directs a clinical trials unit that has been involved in the development of many modern diagnostic tests, apps, algorithms, and therapeutics in wide use today.  Prof Doraiswamy has been an advisor to leading government agencies, businesses and advocacy groups including the NIH, FDA, and WHO as well as numerous life science companies. He has served as the chair of the World Economic Forum’s Global Agenda Council on Brain Research and co-chaired the innovation advisory council for one of the world’s largest social impact funds dedicated to promoting innovative solutions to reverse age related disorders.  He has lectured at leading global forums to advance the forefront of aging and neuroscience research.  Moreover as an investigator on numerous landmark trials and co-author on more than 400 publications, he has received several awards in recognition of his scientific work.  Additionally, he is a leading advocate for increasing funding for brain and behavioral research to help address great looming challenges in society posed by modern developments in the 21st century. His research has been featured in media outlets such as BBC, The New York Times, Scientific American, The Wall Street Journal, National Public Radio, CBS Evening news, The Dr Oz Show, Oprah, and TIME. He has appeared in acclaimed documentaries such as (Dis)Honesty: The Truth about Lies and Mysteries of the Brain. He is the co-author of a popular book The Alzheiemr's Action Plan. Prof. Doraiswamy also serves on the board of several global charities.  

Current Appointments & Affiliations


Professor of Psychiatry and Behavioral Sciences · 2021 - Present Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences, Psychiatry & Behavioral Sciences
Professor in Medicine · 2009 - Present Medicine, Geriatrics and Palliative Care, Medicine
Senior Fellow of the Center for the Study of Aging and Human Development · 1995 - Present Center for the Study of Aging and Human Development, Institutes and Centers
Faculty Network Member of the Duke Institute for Brain Sciences · 2008 - Present Duke Institute for Brain Sciences, University Institutes and Centers
Affiliate of the Duke Initiative for Science & Society · 2014 - Present Duke Science & Society, University Initiatives & Academic Support Units
Affiliate in the Duke Center for Applied Genomics and Precision Medicine · 2016 - Present The Precision Medicine Program, Medicine

In the News


Published December 3, 2024
Research & Innovation Seed Grants Total Nearly $2 Million
Published May 17, 2024
What Your Zip Code Means for the Risk of Alzheimer’s
Published July 12, 2023
Could AI-powered Robot “Companions” Combat Human Loneliness?

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Recent Publications


Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease.

Journal Article Nat Commun · February 24, 2025 Impaired glucose uptake in the brain is an early presymptomatic manifestation of Alzheimer's disease (AD), with symptom-free periods of varying duration that likely reflect individual differences in metabolic resilience. We propose a systemic "bioenergetic ... Full text Link to item Cite

Identifying proteomic prognostic markers for Alzheimer's disease with survival machine learning: The Framingham Heart Study.

Journal Article J Prev Alzheimers Dis · February 2025 BACKGROUND: Protein abundance levels, sensitive to both physiological changes and external interventions, are useful for assessing the Alzheimer's disease (AD) risk and treatment efficacy. However, identifying proteomic prognostic markers for AD is challen ... Full text Link to item Cite

Weight, habitual fibre intake, and microbiome composition predict tolerance to fructan supplementation.

Journal Article Int J Food Sci Nutr · September 2024 Fructans are commonly used as dietary fibre supplements for their ability to promote the growth of beneficial gut microbes. However, fructan consumption has been associated with various dosage-dependent side effects. We characterised side effects in an exp ... Full text Link to item Cite
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Recent Grants


Duke University Psychiatry Physician-Scientist Residency Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029

Cognitive training and neuroplasticity in Mild Cognitive Impairment

ResearchPrincipal Investigator · Awarded by Columbia University · 2017 - 2029

Plasma proteins, sex and Alzheimer's disease: Proteome-wide analyses of the UK Biobank and Framingham Heart Study

ResearchPrincipal Investigator · Awarded by Cure Alzheimer's Fund · 2025 - 2027

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